WERAM Information


Tag Content
WERAM ID WERAM-Ect-0011
Ensembl Protein ID ENSETEP00000000678.1
Gene Name BRPF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSETEG00000000828.1 ENSETET00000000835.1 ENSETEP00000000678.1
Status Unreviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 5.40e-09 35.8 278 420
Ac_Reader Bromodomain 2.50e-07 30.4 649 697
Organism Echinops telfairi
Domain Profile
  Me_Reader PHD

               PHD.txt   3 iClvCgkddeg.ekemvqCdeCddwfHlkCvklplsslpegkswyCpsCke 52 
+C++C++ + + ++ ++ Cd C+ ++H++C+++p +peg +w+C++C +
ENSETEP00000000678.1 278 VCCICNDGECQsSNVILFCDMCNLAVHQECYGVP--YIPEG-QWLCRRCLQ 325
6888*6444441444999****************..*****.*******75 PP
PHD.txt 4 ClvCgkddegekemvqCdeCddwfHlkCv 32
C +C ++ g+ + q d ++ w H+ C
ENSETEP00000000678.1 333 CALC-PNKGGA--FKQTDDGR-WAHVVCA 357
6666.222221..33455565.9998885 PP
PHD.txt 3 iClvCgkddegekemvqCde..CddwfHlkCvklp 35
+C++C++++ g+ ++qC + C ++fH++C + +
ENSETEP00000000678.1 388 TCYICKQRGSGA--CIQCHKanCYTAFHVTCAQQA 420
7****8888885..9*****9**********9865 PP

  Ac_Reader Bromodomain

             BROMO.txt   2 ehevsepFrepvdp....q.leipdYydiikePmdLstikerleegnYs 45 
e++ +F+epv + + e+pdY d ik+Pmd+ t+k++le+ +Y
ENSETEP00000000678.1 649 EKDTGNIFSEPVPLsevtElDEVPDYLDHIKKPMDFFTMKQNLEAYRYL 697
566667787777763222335677*********************9996 PP

Protein Sequence
(Fasta)
MGVDFDVKTF CHNLRATKPP YECPVETCRK VYKSYSGIEY HLHHYDHDSP PPPQQTPLRK 60
HKKKGRQSRP SNKQSPSPSE VSQSPGREVM SYAQAQRMVE VDLHGRVHRI SIFDNLDVVS 120
EDEEVPEEVQ ENGSNKENTE APAAAPKSGK HKNKEKRKDS NHHHHHHHHS AAASTTPKLP 180
EVVYRELDQD TPDAPPRPTS YYRYIEKSAE ELDEEVEYDM DEEDYIWLDI MNERRKTEGV 240
SPIPQEIFEY LMDRLEKESY FESHNKGDPS ALVDEDAVCC ICNDGECQSS NVILFCDMCN 300
LAVHQECYGV PYIPEGQWLC RRCLQSPSRA VDCALCPNKG GAFKQTDDGR WAHVVCALWI 360
PEVCFANTVF LEPIDSIEHI PPARWKLTCY ICKQRGSGAC IQCHKANCYT AFHVTCAQQA 420
GLYMKMEPVR ETGANGTSFS VRKTAYCDIH TPPGSARRLP ALSHSEGEED EDEEEEDGKS 480
WSSEKVKKAK AKSRIKMKKA RKILAEKRAA APVVSVPCIP PHRLSKITNR LTIQRKSQFM 540
QRLHSYWTLK RQSRNGVPLL RRLQTHLQSQ RNCDQVGRDS EDKNWALKEQ LKSWQRLRHD 600
LERARLLVEL IRKREKLKRE MLKVQQLAME MQLTPFLILL RKTLEQLQEK DTGNIFSEPV 660
PLSEVTELDE VPDYLDHIKK PMDFFTMKQN LEAYRYLNFD YATDFLTFIV RKRFKSIARD 720
TLFYRATVQI HEKSGVHQAR RQAKKWGIGF ETGMHIPHSV AGDEAPHHTD DVAEEERLVL 780
LENQKHLPVE EQLKLLLERL DEVNSSKQSV GRSRRAKMIK KEMTALRRKL AHQREGGRAG 840
PERHGPSSRG ALAAQQAACD KDGQTDSAAE ESSSQETSKG LGPNMSSAPA HEVGRRTSVL 900
FSKKNPKTAG PPKRPGRPPK NRESQMTPSH GGSPVGPPQL PITGSLRQRK RGRSPRPSSS 960
SDSDSDKSTE DPPMDLPANG FSSGNQPVKK SFLVYRNDCS LPRSSSDSES SSSSSSSAAS 1020
DRTSTTPSKQ GRGKPSFSRG TFPEDSSEDS GTENEAYSVG TGRGVGXXXX XXXXXXXXXX 1080
XXXXXXXXXX XXXXXXXXXX XXXXXXXXII DPKMPREGMF HHGVPIPVPP LEVLKLGEQM 1140
TQEAREHLYL VLFFDNKRTW QWLPRTKLVP LGVNQDLDKE KMLEGRKSNI RKSVQIAYHR 1200
ALQHRSKVQG EQSSETSDSD
Nucleotide Sequence
(Fasta)
ATGGGGGTGG ACTTTGATGT GAAGACGTTC TGCCACAACT TGCGGGCGAC TAAGCCACCA 60
TACGAATGTC CCGTGGAGAC CTGCCGCAAG GTCTATAAGA GCTATAGTGG CATTGAGTAC 120
CACCTGCACC ACTATGATCA CGACAGCCCA CCACCCCCGC AGCAGACACC ACTCCGGAAA 180
CATAAGAAGA AGGGGCGGCA GTCTCGCCCG TCCAACAAGC AGTCGCCCAG CCCCTCGGAG 240
GTGTCGCAGT CGCCAGGCCG TGAGGTGATG AGCTATGCAC AGGCCCAGCG CATGGTGGAA 300
GTGGACCTGC ACGGCCGTGT CCACCGCATC AGCATCTTTG ACAACCTGGA TGTGGTGTCC 360
GAGGATGAGG AGGTCCCAGA GGAGGTGCAG GAGAATGGCA GCAACAAGGA GAACACCGAG 420
GCGCCGGCTG CTGCTCCCAA GTCAGGCAAA CATAAGAACA AGGAGAAGCG CAAGGACTCC 480
AACCACCACC ACCACCACCA CCACCACAGC GCTGCCGCCA GCACCACACC CAAGTTGCCC 540
GAGGTGGTGT ACCGGGAGCT GGACCAGGAT ACCCCTGATG CCCCGCCCCG ACCAACTTCC 600
TATTACCGGT ACATCGAGAA GTCGGCTGAG GAGCTGGACG AGGAGGTGGA GTACGACATG 660
GATGAGGAGG ACTACATCTG GCTGGACATC ATGAACGAGC GGCGGAAGAC GGAGGGCGTG 720
AGCCCCATCC CGCAGGAGAT CTTTGAGTAC CTGATGGACC GGCTGGAGAA GGAGTCGTAC 780
TTTGAAAGCC ACAACAAGGG CGACCCCAGT GCGCTGGTGG ACGAGGATGC CGTGTGCTGC 840
ATCTGCAATG ACGGTGAGTG CCAGAGCAGC AATGTCATCC TCTTCTGTGA CATGTGCAAC 900
CTGGCCGTGC ACCAGGAGTG CTACGGCGTC CCCTACATCC CTGAGGGCCA GTGGCTGTGC 960
CGCCGCTGCC TGCAGTCACC CTCCCGCGCC GTGGACTGTG CCCTGTGCCC CAACAAGGGC 1020
GGTGCCTTCA AGCAGACCGA TGATGGGCGC TGGGCCCACG TGGTATGCGC CCTGTGGATC 1080
CCCGAGGTCT GCTTCGCCAA CACCGTCTTC CTGGAGCCCA TTGACAGCAT CGAGCACATC 1140
CCACCTGCCC GCTGGAAGCT CACCTGCTAC ATCTGCAAGC AGCGGGGCTC GGGGGCCTGT 1200
ATCCAGTGCC ATAAGGCCAA TTGCTACACC GCCTTCCACG TGACGTGCGC CCAACAGGCC 1260
GGCCTCTACA TGAAGATGGA GCCTGTGCGG GAGACCGGGG CCAACGGCAC CTCCTTCAGT 1320
GTCCGCAAGA CGGCCTACTG CGATATCCAC ACACCCCCGG GCTCAGCCCG CCGCCTACCC 1380
GCCCTGTCCC ATAGCGAGGG TGAAGAGGAT GAGGATGAAG AAGAGGAAGA CGGCAAGAGC 1440
TGGAGCTCAG AGAAGGTCAA GAAGGCCAAG GCCAAGTCCC GGATCAAGAT GAAGAAGGCG 1500
CGGAAGATCC TGGCCGAGAA GCGAGCCGCA GCACCGGTGG TGTCGGTGCC CTGCATCCCC 1560
CCCCACAGAC TCAGCAAAAT CACCAACCGC CTGACCATCC AGAGGAAGAG CCAGTTCATG 1620
CAGAGGCTAC ACAGCTACTG GACATTGAAG CGGCAGTCTC GGAATGGGGT CCCCCTCCTG 1680
CGTCGCCTGC AGACACACCT GCAGTCTCAG AGGAACTGTG ACCAAGTCGG GAGAGATTCT 1740
GAGGACAAGA ACTGGGCCCT CAAAGAACAG CTCAAGTCGT GGCAGCGGCT GCGGCATGAT 1800
CTGGAGCGAG CTCGGCTGCT GGTGGAATTG ATCCGAAAGC GGGAGAAGCT CAAGCGGGAG 1860
ATGCTCAAGG TGCAGCAGCT TGCCATGGAG ATGCAGCTGA CGCCCTTCCT CATCCTGCTG 1920
CGGAAAACCT TGGAGCAGCT GCAGGAGAAG GATACGGGCA ACATCTTCAG CGAGCCGGTC 1980
CCTCTGTCCG AGGTAACCGA ATTGGATGAA GTCCCTGACT ACCTAGACCA CATCAAAAAG 2040
CCTATGGACT TTTTCACCAT GAAGCAGAAC TTGGAGGCTT ACCGCTACCT GAACTTTGAT 2100
TATGCGACGG ACTTTCTAAC CTTCATCGTC AGGAAACGCT TCAAGTCCAT CGCCAGGGAC 2160
ACCCTCTTCT ACCGGGCAAC AGTGCAGATC CATGAAAAGA GTGGTGTTCA CCAGGCCCGG 2220
CGCCAGGCCA AAAAATGGGG CATTGGCTTT GAGACGGGCA TGCATATCCC CCACAGCGTG 2280
GCTGGGGACG AGGCCCCACA TCACACTGAC GATGTAGCCG AGGAGGAGCG GCTGGTCCTG 2340
CTGGAGAACC AGAAGCACCT GCCCGTGGAA GAGCAGCTGA AGCTGCTGCT GGAGCGGCTG 2400
GATGAGGTGA ACTCCAGCAA GCAGAGCGTT GGCCGCTCAC GGCGTGCCAA GATGATCAAG 2460
AAAGAGATGA CGGCACTGCG GCGGAAGCTG GCCCACCAGA GAGAGGGCGG ACGGGCCGGG 2520
CCTGAGCGGC ACGGGCCCTC GAGCCGGGGC GCTCTAGCAG CCCAGCAGGC CGCCTGCGAC 2580
AAGGACGGGC AGACTGACAG TGCAGCTGAG GAGAGCAGCA GCCAGGAGAC GAGCAAAGGC 2640
CTGGGCCCCA ACATGTCCTC AGCCCCCGCA CATGAGGTGG GCAGGAGAAC CTCAGTTCTG 2700
TTCTCCAAAA AGAACCCGAA GACAGCTGGA CCGCCCAAGA GGCCGGGCCG GCCCCCCAAA 2760
AACCGGGAGA GCCAGATGAC CCCCAGCCAC GGAGGCAGTC CTGTGGGGCC CCCCCAGCTC 2820
CCCATCACGG GCTCCCTGCG TCAGCGTAAG CGGGGTAGGA GCCCCCGACC CAGCTCGAGC 2880
TCAGACAGCG ACAGTGATAA GTCCACAGAA GACCCCCCAA TGGACTTACC GGCGAATGGC 2940
TTCAGCAGTG GGAACCAGCC GGTGAAGAAG AGCTTCTTGG TGTACCGGAA TGACTGCAGC 3000
CTTCCCCGGA GCAGCTCGGA CTCGGAGTCC AGCAGCAGCA GCAGCAGCAG TGCAGCCTCA 3060
GATCGAACCA GCACAACGCC CTCAAAACAG GGCCGGGGCA AGCCCTCCTT CTCGAGGGGC 3120
ACCTTCCCAG AGGACAGCAG TGAGGATTCA GGCACTGAGA ATGAGGCCTA CTCCGTGGGC 3180
ACTGGCCGCG GCGTAGGCNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 3240
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 3300
NNNNNNNNNN NNNNNNNNNN NNNNATCATT GATCCAAAGA TGCCCCGGGA GGGTATGTTC 3360
CACCATGGGG TTCCCATCCC TGTGCCCCCA CTGGAGGTGC TGAAACTTGG GGAGCAGATG 3420
ACCCAAGAAG CACGTGAGCA TCTCTACCTC GTCCTCTTCT TTGACAACAA GCGAACCTGG 3480
CAGTGGCTGC CTAGGACCAA GCTGGTTCCT CTCGGAGTAA ACCAGGACCT GGACAAGGAG 3540
AAGATGCTGG AGGGCCGCAA GTCCAACATC CGCAAGTCGG TGCAGATCGC CTACCACAGG 3600
GCTCTGCAGC ACCGCAGCAA GGTGCAGGGC GAGCAGAGCA GTGAGACCAG TGACAGCGAC 3660
TGA 3664
Sequence Source Ensembl
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Nol-0039 ENSNLEP00000005007.1 Nomascus leucogenys 91 0.0 1882
WERAM-Caj-0167 ENSCJAP00000029633.1 Callithrix jacchus 91 0.0 1878
WERAM-Caf-0064 ENSCAFP00000008067.3 Canis familiaris 91 0.0 1878
WERAM-Paa-0040 ENSPANP00000012100.1 Papio anubis 91 0.0 1877
WERAM-Pat-0123 ENSPTRP00000051595.3 Pan troglodytes 91 0.0 1873
WERAM-Dan-0021 ENSDNOP00000002125.2 Dasypus novemcinctus 91 0.0 1869
WERAM-Tut-0114 ENSTTRP00000009263.1 Tursiops truncatus 91 0.0 1865
WERAM-Hos-0169 ENSP00000410210.1 Homo sapiens 90 0.0 1862
WERAM-Eqc-0168 ENSECAP00000018684.1 Equus caballus 91 0.0 1860
WERAM-Mam-0044 ENSMMUP00000008038.2 Macaca mulatta 90 0.0 1859
WERAM-Ran-0051 ENSRNOP00000011246.4 Rattus norvegicus 90 0.0 1857
WERAM-Mup-0198 ENSMPUP00000017012.1 Mustela putorius furo 90 0.0 1857
WERAM-Fec-0139 ENSFCAP00000013165.2 Felis catus 90 0.0 1856
WERAM-Poa-0121 ENSPPYP00000015298.2 Pongo abelii 90 0.0 1854
WERAM-Otg-0065 ENSOGAP00000004617.2 Otolemur garnettii 90 0.0 1850
WERAM-Cap-0106 ENSCPOP00000007873.2 Cavia porcellus 90 0.0 1848
WERAM-Sus-0081 ENSSSCP00000012306.2 Sus scrofa 90 0.0 1845
WERAM-Bot-0079 ENSBTAP00000010224.4 Bos taurus 90 0.0 1845
WERAM-Ocp-0023 ENSOPRP00000002046.1 Ochotona princeps 89 0.0 1819
WERAM-Dio-0101 ENSDORP00000010350.1 Dipodomys ordii 90 0.0 1817
WERAM-Mim-0137 ENSMICP00000013900.1 Microcebus murinus 89 0.0 1805
WERAM-Ptv-0120 ENSPVAP00000010463.1 Pteropus vampyrus 87 0.0 1768
WERAM-Mod-0045 ENSMODP00000006260.4 Monodelphis domestica 87 0.0 1754
WERAM-Sah-0174 ENSSHAP00000018044.1 Sarcophilus harrisii 87 0.0 1753
WERAM-Fia-0158 ENSFALP00000013448.1 Ficedula albicollis 85 0.0 1709
WERAM-Orc-0099 ENSOCUP00000008703.3 Oryctolagus cuniculus 89 0.0 1683
WERAM-Anc-0105 ENSACAP00000009930.3 Anolis carolinensis 83 0.0 1678
WERAM-Mae-0052 ENSMEUP00000005115.1 Macropus eugenii 84 0.0 1664
WERAM-Ict-0026 ENSSTOP00000001851.2 Ictidomys tridecemlineatus 93 0.0 1642
WERAM-Mum-0007 ENSMUSP00000108744.1 Mus musculus 92 0.0 1641
WERAM-Aim-0183 ENSAMEP00000017228.1 Ailuropoda melanoleuca 93 0.0 1639
WERAM-Myl-0145 ENSMLUP00000011787.2 Myotis lucifugus 93 0.0 1638
WERAM-Loa-0156 ENSLAFP00000013797.3 Loxodonta africana 93 0.0 1635
WERAM-Meg-0087 ENSMGAP00000008535.2 Meleagris gallopavo 82 0.0 1632
WERAM-Ova-0061 ENSOARP00000006758.1 Ovis aries 93 0.0 1625
WERAM-Prc-0137 ENSPCAP00000012464.1 Procavia capensis 82 0.0 1621
WERAM-Ere-0004 ENSEEUP00000000187.1 Erinaceus europaeus 90 0.0 1561
WERAM-Lac-0075 ENSLACP00000009870.1 Latimeria chalumnae 79 0.0 1552
WERAM-Gaga-0073 ENSGALP00000010712.4 Gallus gallus 84 0.0 1537
WERAM-Xet-0157 ENSXETP00000051065.3 Xenopus tropicalis 77 0.0 1534
WERAM-Chh-0014 ENSCHOP00000001384.1 Choloepus hoffmanni 93 0.0 1409
WERAM-Tag-0115 ENSTGUP00000008888.1 Taeniopygia guttata 84 0.0 1343
WERAM-Asm-0029 ENSAMXP00000003740.1 Astyanax mexicanus 64 0.0 1325
WERAM-Gam-0197 ENSGMOP00000018873.1 Gadus morhua 67 0.0 1295
WERAM-Xim-0216 ENSXMAP00000017517.1 Xiphophorus maculatus 63 0.0 1293
WERAM-Pof-0173 ENSPFOP00000014684.2 Poecilia formosa 63 0.0 1291
WERAM-Anp-0047 ENSAPLP00000005154.1 Anas platyrhynchos 79 0.0 1285
WERAM-Orn-0211 ENSONIP00000021703.1 Oreochromis niloticus 69 0.0 1172
WERAM-Tar-0116 ENSTRUP00000024373.1 Takifugu rubripes 69 0.0 1162
WERAM-Orla-0117 ENSORLP00000013974.1 Oryzias latipes 68 0.0 1155
WERAM-Ten-0208 ENSTNIP00000021091.1 Tetraodon nigroviridis 69 0.0 1150
WERAM-Gaa-0002 ENSGACP00000000108.1 Gasterosteus aculeatus 68 0.0 1144
WERAM-Ora-0101 ENSOANP00000019142.1 Ornithorhynchus anatinus 74 0.0 1126
WERAM-Pes-0128 ENSPSIP00000015060.1 Pelodiscus sinensis 84 0.0 1100
WERAM-Chs-0130 ENSCSAP00000006897.1 Chlorocebus sabaeus 87 0.0 1021
WERAM-Tub-0023 ENSTBEP00000002714.1 Tupaia belangeri 96 0.0 993
WERAM-Gog-0156 ENSGGOP00000013904.2 Gorilla gorilla 86 0.0 939
WERAM-Soa-0119 ENSSARP00000011569.1 Sorex araneus 95 0.0 877
WERAM-Dar-0227 ENSDARP00000132922.1 Danio rerio 70 0.0 820
WERAM-Leo-0167 ENSLOCP00000019767.1 Lepisosteus oculatus 58 0.0 748
WERAM-Tas-0057 ENSTSYP00000005253.1 Tarsius syrichta 93 0.0 732
WERAM-Cii-0018 ENSCINP00000007020.3 Ciona intestinalis 47 0.0 648
WERAM-Cis-0008 ENSCSAVP00000000906.1 Ciona savignyi 46 4e-178 623
WERAM-Drm-0049 FBpp0088092 Drosophila melanogaster 48 9e-153 539
WERAM-Vip-0027 ENSVPAP00000002662.1 Vicugna pacos 78 9e-99 359
WERAM-Crn-0022 AAW44024 Cryptococcus neoformans 39 3e-92 338
WERAM-Miv-0018 MVLG_02627T0 Microbotryum violaceum 39 3e-90 331
WERAM-Lab-0029 EDR14442 Laccaria bicolor 39 6e-86 317
WERAM-Pug-0038 EHS64083 Puccinia graminis 35 2e-83 308
WERAM-Pem-0069 ENSPMAP00000007494.1 Petromyzon marinus 56 2e-75 282
WERAM-Usm-0037 UM06029P0 Ustilago maydis 54 6e-75 280
WERAM-Spr-0043 CBQ71306 Sporisorium reilianum 54 1e-73 276
WERAM-Tum-0028 CAZ85192 Tuber melanosporum 49 1e-71 270
WERAM-Chg-0024 EAQ89137 Chaetomium globosum 37 4e-71 267
WERAM-Gag-0007 GGTG_01676T0 Gaeumannomyces graminis 35 1e-70 266
WERAM-Map-0023 MAPG_06864T0 Magnaporthe poae 35 2e-70 265
WERAM-Trr-0013 EGR50665 Trichoderma reesei 48 9e-69 259
WERAM-Trv-0019 EHK16654 Trichoderma virens 47 3e-68 258
WERAM-Scs-0028 EDO04650 Sclerotinia sclerotiorum 45 9e-68 256
WERAM-Zyt-0018 Mycgr3P40869 Zymoseptoria tritici 47 9e-68 256
WERAM-Mel-0009 EGG11957 Melampsora laricipopulina 56 9e-68 256
WERAM-Mao-0028 MGG_10196T0 Magnaporthe oryzae 47 4e-66 251
WERAM-Nec-0004 EFNCRP00000000441 Neurospora crassa 46 5e-66 251
WERAM-Asni-0016 CADANGAP00005461 Aspergillus niger 45 3e-65 248
WERAM-Aso-0016 CADAORAP00002251 Aspergillus oryzae 46 4e-65 248
WERAM-Asf-0001 CADAFLAP00000289 Aspergillus flavus 46 4e-65 247
WERAM-Coi-0025 EAS33674 Coccidioides immitis 46 6e-65 247
WERAM-Asfu-0042 CADAFUAP00009619 Aspergillus fumigatus 46 1e-64 246
WERAM-Ast-0022 CADATEAP00007043 Aspergillus terreus 46 2e-64 246
WERAM-Pyt-0019 EFQ90949 Pyrenophora teres 47 1e-63 243
WERAM-Asc-0003 CADACLAP00000549 Aspergillus clavatus 45 2e-63 241
WERAM-Lem-0038 CBX94513 Leptosphaeria maculans 46 4e-63 241
WERAM-Asn-0029 CADANIAP00007460 Aspergillus nidulans 45 1e-62 239
WERAM-Kll-0019 CAG99327 Kluyveromyces lactis 41 4e-62 238
WERAM-Asg-0007 AAS51419 Ashbya gossypii 42 2e-61 235
WERAM-Caa-0017 KGT69884 Candida albicans 54 6e-61 234
WERAM-Cag-0023 CAG61415 Candida glabrata 35 7e-61 233
WERAM-Phn-0007 SNOT_00794 Phaeosphaeria nodorum 53 3e-58 225
WERAM-Cae-0012 F42A9.2.2 Caenorhabditis elegans 32 5e-57 221
WERAM-Scp-0027 SPBC17D11.04c.1:pep Schizosaccharomyces pombe 43 5e-57 221
WERAM-Sac-0052 YPR031W Saccharomyces cerevisiae 41 7e-57 220
WERAM-Yal-0011 CAG81488 Yarrowia lipolytica 47 3e-50 198
Created Date 25-Jun-2016