WERAM Information

Tag Content
WERAM ID WERAM-Cae-0012
Ensembl Protein ID F42A9.2.2
Uniprot Accession Q20318; LIN49_CAEEL
Genbank Protein ID NP_501475.1
Protein Name Protein lin-49
Genbank Nucleotide ID NM_069074.5
Gene Name LIN-49;F42A9.2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00003034 F42A9.2.2 F42A9.2.2
WBGene00003034 F42A9.2.1 F42A9.2.1
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain K 20923973
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 5.40e-13 49.4 531 592
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View)		 Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin.
Domain Profile
  Ac_Reader Bromodomain
  BROMO.txt   6 sepFrepvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 
                 ++F epv++      Y+dii++P+ L+ + e+  +g+Ys+++ + +Dv+l+++N+ ++n+ +  +
  F42A9.2.2 531 GKVFAEPVELV----GYTDIIENPICLKDMSEKAASGKYSTVAALSADVQLMLSNCATFNKGNRVY 592
                68999999996....9********************************************998766 PP
Protein Sequence
(Fasta)		MGRGRGVAIQ ETIEECRDTI SDRIQYNLGL NESKVVLMDI VTGPNQNVSL QERTKRWMAV 60
SVDARMTKFK KNFYPTNQKN SKNISKDLDP PIQRVDAHIV TPVAGKCGMP LQKFPEFKHD 120
HEKIKIERDA KYVDYSVDEF DMSWMSIMNA KRTKLGLEIF SVAIYEHWVD RLEKMCIWKP 180
KEFHKLKDEN GEELDDVCNI CLDGDTSNCN QIVYCDRCNL SVHQDCYGIP FIPEGCLECR 240
RCGISPAGRV NCVLCPSTTG AFKQVDQKRW VHVLCVIWVD ETHFGNTIFM ENVQNVEKAL 300
HDRRALSCLL CKNRQNARMG ACIQCSETKC TASFHVTCAR DSGLVMRINE TEDGQVNRFV 360
WCPKHAPPLT DADREMRQLM LRNARRENER KGPMISMPTL MKSMISTICV ERPFSDYSEI 420
IYFWYEKRLN RLGAPLLKNF TQGASKSRRL LPKSTICGQL KNVETCEMKK QVNAVKESLA 480
SGLEIFDMIV RREERKKDML NSYIRMFERG FKPTELLCQE VIEALKTIDA GKVFAEPVEL 540
VGYTDIIENP ICLKDMSEKA ASGKYSTVAA LSADVQLMLS NCATFNKGNR VYIKYGNTYR 600
KDSTPILEIA EKEEVERLAL KTDEKFMTQL LNGVMVEYNG WAQSRNEVAK EIPPPTPSRG 660
RGTGRRRQNP FLDVQELDTD DSKDSSALSE IPGSSKKSSR KRGIQDTKME EDEEIKPSTS 720
GTNAVASVPL LSSSRESKNK SKSSDADVSS PKSSWLGSPS TSQNLRRRVQ GFSGNESSPK 780
VHKKLSTDNP SNSNLRQTTL TNFFGTNPKT QQQVTFADMT ATPSGSGNKN VSQRSLFDTP 840
STSKASSFTS LSSTRPSTRS TSIIPTINKK NAFRMSSASI QSPLPTTKKI GVRAMATDDE 900
EEDIVIQPPP KEMTTQELEA EKLKSAENEA MSKFAHNQLV IVDGRAAKVI ESRLAHLASD 960
IHHEQRQSMM KKRREVLSEI PQAAVIYVEF FQKSNTLENF QWVTPDKVEL LDLNNIGQRS 1020
PKIPGLKAAK EWHQKVLNGE DV 1042
Nucleotide Sequence
(Fasta)		TTTTTTTAAT TTATGAAATA ATTTTGAAAT TCAGCTCACT GATTTACAAT TGAGAATAAT 60
GTTGTGAAGC TTAATTCTTT CATTTTTCTC ATTGATTATT TTGAGTTTTC GTAATATTTC 120
AAATTTCCAG CTCAATATAA TATTCATTTA CTCGGAATCA AATCAAAACG CCTCGACGTG 180
ATAAATTATC ATCCCGTCCT CATTCCAATA TGGGGCGGGG ACGTGGAGTT GCCATTCAGG 240
AGACTATTGA AGAATGTCGT GACACGATTT CGGATAGAAT TCAGTATAAT CTTGGTTTGA 300
ATGAAAGCAA AGTTGTTCTA ATGGATATAG TTACTGGTCC AAATCAAAAC GTTAGTTTAC 360
AAGAAAGAAC TAAAAGATGG ATGGCAGTGT CTGTGGACGC AAGAATGACA AAATTCAAAA 420
AGAATTTCTA CCCAACAAAT CAAAAAAATT CCAAGAATAT TTCGAAAGAT CTCGATCCAC 480
CTATTCAACG AGTAGATGCA CATATTGTAA CTCCAGTGGC TGGAAAATGT GGAATGCCTC 540
TTCAGAAATT TCCTGAATTC AAACACGATC ACGAGAAAAT CAAGATCGAA AGGGATGCGA 600
AATACGTTGA CTATTCAGTC GATGAATTTG ACATGAGTTG GATGTCTATT ATGAACGCGA 660
AAAGGACAAA ATTGGGTCTC GAAATATTTT CAGTCGCAAT TTACGAACAT TGGGTCGATC 720
GGCTGGAAAA AATGTGCATT TGGAAGCCGA AAGAGTTCCA TAAGCTGAAA GATGAAAACG 780
GAGAGGAACT TGATGATGTC TGTAACATTT GCCTTGATGG AGATACATCA AATTGCAATC 840
AAATCGTTTA TTGTGATCGT TGTAACCTGT CAGTTCATCA AGATTGTTAT GGTATACCAT 900
TCATACCAGA AGGATGTCTT GAATGTCGAA GATGTGGAAT ATCACCAGCA GGTCGTGTTA 960
ATTGTGTGTT ATGTCCATCA ACAACTGGAG CATTTAAACA AGTTGATCAA AAGAGATGGG 1020
TTCATGTTCT CTGTGTCATT TGGGTCGATG AAACACATTT TGGAAATACA ATTTTTATGG 1080
AAAATGTGCA AAATGTTGAG AAAGCATTAC ATGATCGTCG TGCTCTCAGC TGCCTCCTGT 1140
GCAAAAATCG ACAAAATGCT CGGATGGGAG CCTGTATTCA ATGCTCCGAG ACAAAATGTA 1200
CTGCTTCATT CCATGTTACA TGCGCTAGAG ACAGTGGTCT AGTGATGCGA ATAAATGAAA 1260
CAGAAGATGG ACAAGTTAAT CGATTTGTAT GGTGTCCAAA ACATGCTCCA CCGCTCACTG 1320
ATGCCGATCG AGAAATGAGA CAGTTGATGT TAAGGAATGC TAGACGAGAA AATGAAAGAA 1380
AAGGACCTAT GATAAGTATG CCAACTTTGA TGAAATCAAT GATTTCAACA ATCTGCGTCG 1440
AACGTCCATT CTCTGATTAC TCTGAAATCA TCTATTTTTG GTACGAAAAA CGATTGAATC 1500
GACTCGGAGC GCCTCTTCTC AAGAATTTTA CGCAAGGTGC ATCAAAGTCA CGCAGACTTT 1560
TACCCAAAAG TACGATTTGT GGTCAATTGA AGAATGTTGA AACTTGTGAA ATGAAGAAAC 1620
AAGTAAATGC AGTGAAAGAG TCATTAGCCT CTGGATTGGA AATTTTTGAT ATGATTGTTC 1680
GACGAGAAGA AAGGAAAAAG GATATGCTGA ACTCGTACAT CAGAATGTTT GAACGTGGTT 1740
TCAAACCGAC CGAACTGTTG TGTCAAGAAG TTATCGAAGC TTTGAAAACA ATCGATGCTG 1800
GAAAAGTTTT CGCGGAGCCG GTTGAGCTTG TAGGCTATAC TGATATCATC GAAAATCCAA 1860
TTTGCCTGAA AGATATGTCT GAAAAAGCTG CATCTGGCAA ATATTCCACC GTTGCTGCAC 1920
TGTCCGCTGA TGTTCAACTG ATGCTCTCAA ATTGTGCCAC TTTCAATAAG GGAAATCGTG 1980
TTTATATTAA GTACGGTAAC ACATACCGGA AGGACAGTAC TCCGATCTTA GAAATCGCTG 2040
AAAAAGAAGA AGTCGAGCGA TTAGCGTTGA AAACCGATGA GAAGTTTATG ACACAGTTAT 2100
TGAATGGAGT TATGGTTGAG TACAACGGAT GGGCACAATC ACGAAATGAA GTAGCTAAAG 2160
AAATTCCACC ACCAACACCG TCAAGAGGCA GAGGCACAGG AAGACGTCGT CAGAATCCAT 2220
TTTTAGATGT TCAGGAATTG GATACCGATG ATTCTAAGGA TTCTAGCGCA CTTTCAGAAA 2280
TACCTGGAAG CTCTAAGAAG TCGAGCAGGA AACGTGGAAT TCAGGATACT AAGATGGAGG 2340
AAGACGAAGA AATTAAACCA TCGACATCTG GAACAAACGC AGTGGCGTCT GTGCCGTTGC 2400
TCTCATCGTC CAGGGAGTCG AAAAATAAAT CTAAATCTTC TGATGCAGAC GTCTCAAGCC 2460
CAAAATCATC TTGGCTTGGA TCGCCCAGCA CTTCTCAGAA TTTGCGACGA CGTGTCCAAG 2520
GATTCTCGGG AAATGAATCA TCTCCCAAAG TTCACAAGAA ATTATCAACG GATAATCCAT 2580
CGAACAGTAA CCTTCGTCAG ACGACGTTAA CCAATTTTTT CGGGACAAAT CCAAAGACAC 2640
AGCAACAAGT GACATTTGCA GATATGACAG CGACACCTTC AGGAAGCGGA AATAAAAATG 2700
TTTCACAAAG ATCTCTATTT GACACTCCAA GTACCTCCAA AGCTTCATCT TTCACATCTC 2760
TATCATCTAC TCGCCCTTCA ACCAGAAGTA CTTCTATTAT TCCAACTATC AATAAGAAAA 2820
ATGCATTCCG AATGTCATCA GCATCTATTC AAAGTCCATT GCCAACGACG AAAAAGATTG 2880
GAGTTCGAGC TATGGCAACT GATGATGAAG AAGAAGATAT AGTTATTCAA CCTCCTCCAA 2940
AAGAAATGAC AACTCAAGAA TTGGAAGCTG AAAAACTGAA ATCAGCTGAA AATGAAGCTA 3000
TGTCAAAGTT CGCACACAAT CAATTGGTTA TTGTTGATGG AAGAGCTGCA AAAGTAATCG 3060
AATCTCGACT TGCTCACTTG GCTTCCGATA TTCATCACGA ACAAAGACAA TCAATGATGA 3120
AAAAGCGTCG GGAAGTACTC TCTGAAATCC CTCAAGCCGC AGTTATTTAT GTGGAATTCT 3180
TTCAAAAGTC GAACACTTTA GAGAATTTCC AATGGGTGAC GCCTGACAAA GTGGAACTTC 3240
TCGATTTGAA TAATATCGGC CAACGATCAC CTAAAATTCC CGGTTTGAAA GCTGCAAAAG 3300
AGTGGCACCA AAAAGTTCTC AACGGCGAAG ATGTCTAAGT CTCATCATTT ACATGACAAC 3360
AACTTTTCGT GTTTTCAGTC ATTTTACATT TTCAATCAAC AAAACTATTG TATTATATAT 3420
CATGTTATAC ATAATATTTT CTTATTCGTC TCCTCAATCA CCACTGAAAC GTGTTCCGAT 3480
TATCCGGAAA TTTTCCACAC TTATTGACAT TTCTTACCGT ATTTCCCATG GTTTTTTGTA 3540
TCATGTGATC CTCGCCCCCT TTAAAATTGT TCGCTAGAAA TTTACCAAAA CAGTAGAAAT 3600
CAACAAATTT ATCTATTTCT CTTTTGCAAA AACCAGTTTT TTTGGTCCCC GTTGACTCGT 3660
TGTTTCCTTT TTTCCATATC AATCGATCTA TCCTCACTCC GAATTTCACT ACTTTATCGC 3720
AAATTTTTGT CCATGGTTAA TTAATTGAAA CCAGAACAAT TGGAAATATT TACCTTTTTT 3780
CACGCAATTT ACTGTAAAAT ACCACGTCAA TAAATTTAAT TTTACGC 3828
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR019542--Enhancer_polycomb-like_N
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00439--Bromodomain
PF10513--EPL1
Gene Ontology

GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Drm-0049 FBpp0088092 Drosophila melanogaster 34 1e-84 312
WERAM-Meg-0087 ENSMGAP00000008535.2 Meleagris gallopavo 31 2e-74 278
WERAM-Lac-0075 ENSLACP00000009870.1 Latimeria chalumnae 30 7e-74 276
WERAM-Anp-0047 ENSAPLP00000005154.1 Anas platyrhynchos 30 2e-73 275
WERAM-Loa-0156 ENSLAFP00000013797.3 Loxodonta africana 31 2e-73 275
WERAM-Ten-0208 ENSTNIP00000021091.1 Tetraodon nigroviridis 30 2e-73 275
WERAM-Tar-0116 ENSTRUP00000024373.1 Takifugu rubripes 30 2e-73 275
WERAM-Fia-0158 ENSFALP00000013448.1 Ficedula albicollis 30 4e-73 274
WERAM-Myl-0145 ENSMLUP00000011787.2 Myotis lucifugus 30 4e-73 274
WERAM-Mup-0198 ENSMPUP00000017012.1 Mustela putorius furo 30 5e-73 273
WERAM-Ran-0051 ENSRNOP00000011246.4 Rattus norvegicus 30 5e-73 273
WERAM-Bot-0079 ENSBTAP00000010224.4 Bos taurus 30 6e-73 273
WERAM-Tag-0115 ENSTGUP00000008888.1 Taeniopygia guttata 30 7e-73 273
WERAM-Gaga-0073 ENSGALP00000010712.4 Gallus gallus 30 7e-73 273
WERAM-Orc-0099 ENSOCUP00000008703.3 Oryctolagus cuniculus 30 7e-73 273
WERAM-Fec-0139 ENSFCAP00000013165.2 Felis catus 30 7e-73 273
WERAM-Otg-0065 ENSOGAP00000004617.2 Otolemur garnettii 30 7e-73 273
WERAM-Sus-0081 ENSSSCP00000012306.2 Sus scrofa 30 8e-73 273
WERAM-Poa-0121 ENSPPYP00000015298.2 Pongo abelii 30 8e-73 273
WERAM-Ict-0026 ENSSTOP00000001851.2 Ictidomys tridecemlineatus 30 8e-73 273
WERAM-Eqc-0168 ENSECAP00000018684.1 Equus caballus 30 8e-73 273
WERAM-Mam-0044 ENSMMUP00000008038.2 Macaca mulatta 30 8e-73 273
WERAM-Hos-0169 ENSP00000410210.1 Homo sapiens 30 8e-73 273
WERAM-Aim-0183 ENSAMEP00000017228.1 Ailuropoda melanoleuca 30 8e-73 273
WERAM-Ova-0061 ENSOARP00000006758.1 Ovis aries 30 8e-73 273
WERAM-Mum-0007 ENSMUSP00000108744.1 Mus musculus 30 1e-72 272
WERAM-Orn-0211 ENSONIP00000021703.1 Oreochromis niloticus 30 2e-72 271
WERAM-Caf-0064 ENSCAFP00000008067.3 Canis familiaris 30 3e-72 271
WERAM-Nol-0039 ENSNLEP00000005007.1 Nomascus leucogenys 30 3e-72 271
WERAM-Cap-0106 ENSCPOP00000007873.2 Cavia porcellus 30 3e-72 271
WERAM-Dan-0021 ENSDNOP00000002125.2 Dasypus novemcinctus 30 4e-72 270
WERAM-Paa-0040 ENSPANP00000012100.1 Papio anubis 30 4e-72 270
WERAM-Orla-0117 ENSORLP00000013974.1 Oryzias latipes 29 4e-72 270
WERAM-Pof-0173 ENSPFOP00000014684.2 Poecilia formosa 30 4e-72 270
WERAM-Caj-0167 ENSCJAP00000029633.1 Callithrix jacchus 30 4e-72 270
WERAM-Ocp-0023 ENSOPRP00000002046.1 Ochotona princeps 30 4e-72 270
WERAM-Dio-0101 ENSDORP00000010350.1 Dipodomys ordii 30 5e-72 270
WERAM-Pat-0123 ENSPTRP00000051595.3 Pan troglodytes 30 5e-72 270
WERAM-Ere-0004 ENSEEUP00000000187.1 Erinaceus europaeus 29 9e-72 269
WERAM-Sah-0174 ENSSHAP00000018044.1 Sarcophilus harrisii 30 1e-71 269
WERAM-Xim-0216 ENSXMAP00000017517.1 Xiphophorus maculatus 30 1e-71 269
WERAM-Xet-0157 ENSXETP00000051065.3 Xenopus tropicalis 30 1e-71 269
WERAM-Tut-0114 ENSTTRP00000009263.1 Tursiops truncatus 30 1e-71 269
WERAM-Dar-0032 ENSDARP00000018937.7 Danio rerio 30 1e-71 268
WERAM-Leo-0167 ENSLOCP00000019767.1 Lepisosteus oculatus 30 2e-71 268
WERAM-Gaa-0002 ENSGACP00000000108.1 Gasterosteus aculeatus 31 2e-71 268
WERAM-Chh-0014 ENSCHOP00000001384.1 Choloepus hoffmanni 30 3e-71 268
WERAM-Gam-0197 ENSGMOP00000018873.1 Gadus morhua 30 4e-71 267
WERAM-Anc-0105 ENSACAP00000009930.3 Anolis carolinensis 29 6e-71 266
WERAM-Asm-0029 ENSAMXP00000003740.1 Astyanax mexicanus 30 7e-71 266
WERAM-Pes-0060 ENSPSIP00000008088.1 Pelodiscus sinensis 30 1e-70 265
WERAM-Mod-0045 ENSMODP00000006260.4 Monodelphis domestica 29 1e-70 265
WERAM-Miv-0018 MVLG_02627T0 Microbotryum violaceum 32 4e-70 264
WERAM-Lab-0029 EDR14442 Laccaria bicolor 33 3e-69 261
WERAM-Cii-0018 ENSCINP00000007020.3 Ciona intestinalis 30 4e-68 257
WERAM-Ora-0101 ENSOANP00000019142.1 Ornithorhynchus anatinus 30 9e-68 256
WERAM-Ect-0011 ENSETEP00000000678.1 Echinops telfairi 32 1e-67 256
WERAM-Tas-0083 ENSTSYP00000008412.1 Tarsius syrichta 31 2e-67 255
WERAM-Ptv-0120 ENSPVAP00000010463.1 Pteropus vampyrus 32 8e-67 253
WERAM-Mim-0137 ENSMICP00000013900.1 Microcebus murinus 31 4e-66 251
WERAM-Chs-0121 ENSCSAP00000006430.1 Chlorocebus sabaeus 28 1e-65 249
WERAM-Gog-0148 ENSGGOP00000013085.2 Gorilla gorilla 28 2e-65 248
WERAM-Crn-0022 AAW44024 Cryptococcus neoformans 30 2e-65 248
WERAM-Mae-0052 ENSMEUP00000005115.1 Macropus eugenii 28 5e-61 234
WERAM-Tub-0023 ENSTBEP00000002714.1 Tupaia belangeri 35 6e-60 230
WERAM-Prc-0137 ENSPCAP00000012464.1 Procavia capensis 43 3e-58 224
WERAM-Soa-0119 ENSSARP00000011569.1 Sorex araneus 43 6e-58 223
WERAM-Usm-0037 UM06029P0 Ustilago maydis 45 3e-56 218
WERAM-Spr-0043 CBQ71306 Sporisorium reilianum 41 7e-56 216
WERAM-Trv-0019 EHK16654 Trichoderma virens 38 2e-55 215
WERAM-Trr-0013 EGR50665 Trichoderma reesei 38 3e-55 214
WERAM-Map-0023 MAPG_06864T0 Magnaporthe poae 40 4e-55 214
WERAM-Gag-0007 GGTG_01676T0 Gaeumannomyces graminis 40 5e-55 214
WERAM-Mao-0028 MGG_10196T0 Magnaporthe oryzae 40 8e-55 213
WERAM-Nec-0004 EFNCRP00000000441 Neurospora crassa 39 1e-54 213
WERAM-Chg-0024 EAQ89137 Chaetomium globosum 39 2e-54 212
WERAM-Asc-0003 CADACLAP00000549 Aspergillus clavatus 40 2e-53 209
WERAM-Scs-0028 EDO04650 Sclerotinia sclerotiorum 39 2e-53 209
WERAM-Asni-0016 CADANGAP00005461 Aspergillus niger 40 3e-53 207
WERAM-Lem-0038 CBX94513 Leptosphaeria maculans 40 6e-53 207
WERAM-Asfu-0042 CADAFUAP00009619 Aspergillus fumigatus 40 1e-52 206
WERAM-Pyt-0019 EFQ90949 Pyrenophora teres 39 1e-52 206
WERAM-Aso-0016 CADAORAP00002251 Aspergillus oryzae 39 2e-52 205
WERAM-Asf-0001 CADAFLAP00000289 Aspergillus flavus 39 3e-52 204
WERAM-Zyt-0018 Mycgr3P40869 Zymoseptoria tritici 39 9e-52 203
WERAM-Ast-0022 CADATEAP00007043 Aspergillus terreus 38 1e-51 202
WERAM-Pug-0041 EHS62842 Puccinia graminis 43 2e-51 202
WERAM-Cis-0008 ENSCSAVP00000000906.1 Ciona savignyi 40 4e-51 201
WERAM-Coi-0025 EAS33674 Coccidioides immitis 38 4e-51 201
WERAM-Asn-0029 CADANIAP00007460 Aspergillus nidulans 38 1e-50 199
WERAM-Phn-0007 SNOT_00794 Phaeosphaeria nodorum 41 1e-49 196
WERAM-Tum-0028 CAZ85192 Tuber melanosporum 40 3e-49 195
WERAM-Kll-0019 CAG99327 Kluyveromyces lactis 32 7e-49 193
WERAM-Cag-0023 CAG61415 Candida glabrata 32 1e-47 189
WERAM-Asg-0007 AAS51419 Ashbya gossypii 26 2e-47 189
WERAM-Mel-0009 EGG11957 Melampsora laricipopulina 42 2e-47 189
WERAM-Caa-0017 KGT69884 Candida albicans 28 5e-46 184
WERAM-Sac-0052 YPR031W Saccharomyces cerevisiae 43 2e-45 182
WERAM-Scp-0027 SPBC17D11.04c.1:pep Schizosaccharomyces pombe 28 1e-44 179
Created Date 25-Jun-2016