WERAM Information

Tag Content
WERAM ID WERAM-Hos-0110
Ensembl Protein ID ENSP00000364550.3
Uniprot Accession P41229; KDM5C_HUMAN; B0QZ44; B4E3I2; F5H3T1; Q5JUX3; Q5JUX4; Q5JUX5; Q7Z5S5
Genbank Protein ID NP_001140174.1; NP_001269551.1; NP_004178.2; XP_005262092.1; XP_011529128.1
Protein Name Lysine-specific demethylase 5C
Genbank Nucleotide ID NM_001146702.1; NM_001282622.1; NM_004187.3; XM_005262035.3; XM_011530826.1
Gene Name KDM5C;SMCX;JARID1C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000126012.11 ENST00000375401.7 ENSP00000364550.3
ENSG00000126012.11 ENST00000375379.7 ENSP00000364528.3
ENSG00000126012.11 ENST00000375383.7 ENSP00000364532.3
ENSG00000126012.11 ENST00000404049.7 ENSP00000385394.3
ENSG00000126012.11 ENST00000452825.7 ENSP00000445176.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JARID Jmjc H3K4me2/3 K 16983801; 20951770; 24172249; 20889125
Me_Reader PHD PHD1 H3K4me2/3 K 16983801; 20951770; 24172249; 20889125
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JARID 6.70e-103 344 468 634
Me_Reader PHD 1.00e-19 72.7 326 1249
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
Domain Profile
  HDM JARID
          JARID.txt   1 eyaesgwnlnnlpvleesvlahinadisgvkvpwlyvgmcfsafcwhvedhwsysinylhfgepkvwygvpgsaaekleevlkklapelfes 92 
                        eya+sgwnln++pvle+svl+hinadisg+kvpwlyvgm+fsafcwh+edhwsysinylh+gepk+wygvp+ aae+leev+kkl+pelf+s
  ENSP00000364550.3 468 EYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDS 559
                        7******************************************************************************************* PP
          JARID.txt  93 qpdllhqlvtllnpnilkeegvpvyrtnqkagefvitfprayhsgfnqgfnfaeavnfatvdwlaagreavesys 167
                        qpdllhqlvtl+npn+l+++gvpv+rtnq+agefvitfprayhsgfnqg+nfaeavnf+t+dwl+agr+++e+y+
  ENSP00000364550.3 560 QPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYR 634
                        **************************************************************************7 PP
  Me_Reader PHD
            PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 
                        +C++C++ de++k ++ Cd+Cdd +H+ C+ +pl ++p+g  w+Cp+C+
  ENSP00000364550.3 326 VCRMCSRGDEDDK-LLLCDGCDDNYHIFCLLPPLPEIPKG-VWRCPKCV 372
                        8****77777776.**************************.*******7 PP
            PHD.txt    2 tiClvCgkddegekemvqCdeCddwfHlkCvklp...lsslpeg..............kswyCpsCke 52  
                          iC+ Cg++ +g+  ++qCd C+dwfH++Cv++p    s+   +              ++++Cp C++
  ENSP00000364550.3 1186 SICV-CGQVLAGAG-ALQCDLCQDWFHGRCVSVPrllSSPR--PnptsspllawwewdTKFLCPLCMR 1249
                         58*9.******988.*******************8552222..2447789977777777777****97 PP
Protein Sequence
(Fasta)		MEPGSDDFLP PPECPVFEPS WAEFRDPLGY IAKIRPIAEK SGICKIRPPA DWQPPFAVEV 60
DNFRFTPRIQ RLNELEAQTR VKLNYLDQIA KFWEIQGSSL KIPNVERRIL DLYSLSKIVV 120
EEGGYEAICK DRRWARVAQR LNYPPGKNIG SLLRSHYERI VYPYEMYQSG ANLVQCNTRP 180
FDNEEKDKEY KPHSIPLRQS VQPSKFNSYG RRAKRLQPDP EPTEEDIEKN PELKKLQIYG 240
AGPKMMGLGL MAKDKTLRKK DKEGPECPPT VVVKEELGGD VKVESTSPKT FLESKEELSH 300
SPEPCTKMTM RLRRNHSNAQ FIESYVCRMC SRGDEDDKLL LCDGCDDNYH IFCLLPPLPE 360
IPKGVWRCPK CVMAECKRPP EAFGFEQATR EYTLQSFGEM ADSFKADYFN MPVHMVPTEL 420
VEKEFWRLVN SIEEDVTVEY GADIHSKEFG SGFPVSDSKR HLTPEEEEYA TSGWNLNVMP 480
VLEQSVLCHI NADISGMKVP WLYVGMVFSA FCWHIEDHWS YSINYLHWGE PKTWYGVPSL 540
AAEHLEEVMK KLTPELFDSQ PDLLHQLVTL MNPNTLMSHG VPVVRTNQCA GEFVITFPRA 600
YHSGFNQGYN FAEAVNFCTA DWLPAGRQCI EHYRRLRRYC VFSHEELICK MAACPEKLDL 660
NLAAAVHKEM FIMVQEERRL RKALLEKGIT EAEREAFELL PDDERQCIKC KTTCFLSALA 720
CYDCPDGLVC LSHINDLCKC SSSRQYLRYR YTLDELPAML HKLKVRAESF DTWANKVRVA 780
LEVEDGRKRS LEELRALESE ARERRFPNSE LLQQLKNCLS EAEACVSRAL GLVSGQEAGP 840
HRVAGLQMTL TELRAFLDQM NNLPCAMHQI GDVKGVLEQV EAYQAEAREA LASLPSSPGL 900
LQSLLERGRQ LGVEVPEAQQ LQRQVEQARW LDEVKRTLAP SARRGTLAVM RGLLVAGASV 960
APSPAVDKAQ AELQELLTIA ERWEEKAHLC LEARQKHPPA TLEAIIREAE NIPVHLPNIQ 1020
ALKEALAKAR AWIADVDEIQ NGDHYPCLDD LEGLVAVGRD LPVGLEELRQ LELQVLTAHS 1080
WREKASKTFL KKNSCYTLLE VLCPCADAGS DSTKRSRWME KELGLYKSDT ELLGLSAQDL 1140
RDPGSVIVAF KEGEQKEKEG ILQLRRTNSA KPSPLASSST ASSTTSICVC GQVLAGAGAL 1200
QCDLCQDWFH GRCVSVPRLL SSPRPNPTSS PLLAWWEWDT KFLCPLCMRS RRPRLETILA 1260
LLVALQRLPV RLPEGEALQC LTERAISWQG RARQALASED VTALLGRLAE LRQRLQAEPR 1320
PEEPPNYPAA PASDPLREGS GKDMPKVQGL LENGDSVTSP EKVAPEEGSG KRDLELLSSL 1380
LPQLTGPVLE LPEATRAPLE ELMMEGDLLE VTLDENHSIW QLLQAGQPPD LERIRTLLEL 1440
EKAERHGSRA RGRALERRRR RKVDRGGEGD DPAREELEPK RVRSSGPEAE EVQEEEELEE 1500
ETGGEGPPAP IPTTGSPSTQ ENQNGLEPAE GTTSGPSAPF STLTPRLHLP CPQQPPQQQL 1560
Nucleotide Sequence
(Fasta)		CTTGTTCCTC CGCCGTTGCA ATGAACTATT TTCTCTCAGT CCGGGGTGGT ACTTTTGAGT 60
AACCCCTTCC AAATAGAAAC CCATACCAGC CTATTTAGCT CGGTCTCCAC TATATGAAGG 120
TTTCCTAGGG CTTGGTGTGA CGCAACGTAT ACGAGGCTCG GAAGGACACC CCGCGGAAGG 180
ATCCGGTTTG TTGTGGTGTG GGGAGGGGAG ACGCTGACAA ACCAAGATGG CGGCGGCGGC 240
GCTGAAGGCC GCGGCGTTTG GGAGGTAACT GTGGTGGCGA AGGCTGCGGT AGTGGGGAGG 300
CAACCACACA GTTTGGAAGA AACGGAGCGG GACGAAGAGG CGGTAGCAGT AGAGTCAGCC 360
TGAGACTCTC AGAGCACGAC GGCCACACGC CCCCTTAGGC CCTCGGCGGG CGGCGGCTGC 420
CCCGCTTAGG GCCTAGCCTC CGAGCATTGC CTCGGCTTCA AACAGCGGCG GCGCCATGAG 480
TCCTTAAGGG CGGTCCAAGC CTCCCGATCC CTGGCCCAGA CCTCGGGCCC ACCATGGAGC 540
CGGGGTCCGA CGATTTCCTA CCGCCACCGG AGTGCCCGGT GTTCGAGCCT AGCTGGGCCG 600
AGTTCCGAGA CCCTCTTGGC TACATCGCGA AAATCAGGCC CATCGCAGAG AAATCGGGCA 660
TTTGCAAGAT CCGCCCACCC GCGGACTGGC AGCCACCCTT TGCTGTGGAA GTGGACAACT 720
TCAGGTTTAC CCCCCGAATC CAGAGGCTGA ATGAGCTAGA GGCCCAGACG AGAGTGAAAC 780
TGAACTACTT GGACCAGATT GCCAAATTCT GGGAAATCCA GGGCTCCTCC TTAAAGATTC 840
CCAATGTAGA ACGGCGGATC TTGGACCTCT ACAGTCTCAG CAAAATTGTG GTGGAGGAAG 900
GTGGTTATGA AGCTATCTGC AAGGACCGTC GGTGGGCTCG GGTAGCCCAG CGCCTCAACT 960
ATCCACCAGG CAAAAATATT GGCTCCTTGC TACGCTCCCA CTACGAACGC ATTGTTTATC 1020
CCTATGAAAT GTACCAGTCT GGAGCCAACC TTGTGCAGTG TAACACACGT CCATTTGATA 1080
ATGAGGAGAA GGACAAGGAA TACAAACCCC ACAGCATCCC CCTACGACAG TCTGTGCAGC 1140
CTTCCAAGTT CAACAGCTAT GGCCGGCGGG CCAAGAGACT GCAGCCTGAT CCGGAACCCA 1200
CAGAGGAAGA CATTGAGAAG AATCCAGAGC TGAAAAAGCT ACAGATCTAT GGGGCAGGCC 1260
CCAAGATGAT GGGCCTGGGC CTCATGGCCA AAGACAAGAC TCTGCGGAAG AAAGATAAGG 1320
AGGGGCCTGA GTGTCCCCCC ACAGTAGTGG TGAAGGAGGA GTTAGGTGGG GATGTGAAGG 1380
TGGAGTCAAC ATCGCCTAAG ACCTTCCTGG AGAGCAAGGA GGAGCTGAGT CACAGCCCAG 1440
AACCCTGCAC CAAGATGACC ATGAGGCTAC GGAGGAACCA CAGCAATGCC CAGTTTATTG 1500
AGTCATATGT CTGCCGGATG TGTTCTCGAG GGGATGAGGA TGACAAGCTC CTGCTGTGTG 1560
ATGGCTGTGA TGACAACTAC CACATCTTCT GCCTGCTGCC TCCTCTGCCT GAGATCCCCA 1620
AGGGTGTCTG GCGGTGCCCA AAGTGTGTCA TGGCGGAGTG TAAGCGGCCC CCAGAAGCCT 1680
TTGGCTTTGA GCAGGCTACC CGGGAATACA CTCTGCAGAG CTTTGGCGAG ATGGCCGACT 1740
CCTTTAAAGC TGACTACTTC AACATGCCCG TGCATATGGT GCCCACAGAA CTTGTGGAGA 1800
AGGAGTTCTG GAGGCTGGTA AATAGCATTG AGGAAGATGT GACTGTTGAG TATGGAGCTG 1860
ACATCCATTC CAAAGAATTT GGCAGCGGTT TCCCTGTCAG TGACAGTAAA CGGCACCTAA 1920
CCCCCGAAGA GGAGGAGTAT GCTACCAGTG GTTGGAACCT AAATGTGATG CCGGTGTTGG 1980
AACAGTCTGT ACTGTGCCAC ATCAATGCAG ATATCTCTGG CATGAAGGTG CCCTGGCTCT 2040
ACGTGGGCAT GGTCTTCTCA GCCTTTTGCT GGCATATTGA GGATCACTGG AGTTACTCCA 2100
TTAACTACCT CCACTGGGGT GAGCCGAAGA CCTGGTATGG GGTGCCCTCA CTTGCAGCAG 2160
AACATTTGGA AGAAGTGATG AAGAAGCTGA CACCTGAACT ATTTGATAGC CAGCCTGACC 2220
TCCTGCACCA ACTTGTCACC CTCATGAATC CCAACACCCT CATGTCCCAT GGTGTGCCAG 2280
TTGTCCGCAC AAACCAGTGT GCAGGAGAGT TTGTCATCAC CTTCCCCCGT GCTTACCACA 2340
GCGGCTTCAA CCAAGGCTAC AACTTTGCCG AGGCTGTCAA CTTTTGCACT GCTGACTGGT 2400
TGCCTGCTGG GCGCCAGTGC ATTGAGCACT ACCGCCGGCT CCGGAGATAC TGCGTCTTCT 2460
CCCATGAGGA GCTTATCTGC AAGATGGCTG CCTGCCCAGA GAAGCTAGAC CTGAACCTGG 2520
CGGCAGCTGT GCATAAGGAG ATGTTCATCA TGGTGCAAGA AGAGCGGCGT CTACGAAAGG 2580
CCCTGCTGGA GAAGGGTATC ACAGAGGCTG AGCGAGAGGC TTTCGAGCTG CTCCCAGATG 2640
ATGAGCGCCA GTGTATCAAG TGCAAGACTA CGTGTTTCCT GTCAGCCCTG GCCTGCTACG 2700
ACTGCCCAGA CGGCCTTGTC TGCCTTTCCC ACATCAATGA TCTCTGCAAG TGCTCCAGTA 2760
GCCGGCAGTA CCTGCGGTAT CGGTATACCT TGGATGAGCT TCCTGCCATG CTGCATAAGC 2820
TGAAGGTTCG GGCTGAGTCC TTTGACACCT GGGCCAACAA AGTGCGAGTG GCCCTGGAGG 2880
TGGAGGATGG GCGGAAGCGC AGCCTTGAAG AACTGAGGGC ACTAGAGTCT GAAGCCCGTG 2940
AGCGGAGGTT TCCTAATAGT GAGCTGCTGC AGCAACTAAA GAACTGCCTG AGTGAGGCAG 3000
AGGCTTGCGT GTCCCGAGCT CTGGGACTGG TCAGCGGCCA GGAAGCTGGC CCCCACAGGG 3060
TGGCTGGTCT ACAGATGACC CTGACTGAGC TCCGGGCCTT TCTGGACCAG ATGAACAACC 3120
TGCCTTGCGC CATGCACCAG ATTGGGGATG TCAAGGGTGT TCTGGAACAG GTGGAGGCCT 3180
ACCAGGCTGA GGCTCGTGAG GCCCTGGCCT CACTGCCCTC CAGTCCAGGG CTACTGCAGT 3240
CCCTGTTGGA GAGGGGGCGG CAGCTGGGGG TGGAGGTGCC TGAGGCCCAG CAGCTCCAGC 3300
GGCAGGTGGA ACAGGCGCGA TGGCTGGATG AGGTGAAACG CACACTGGCC CCCTCAGCCC 3360
GAAGGGGCAC CTTGGCTGTC ATGCGAGGAC TGTTGGTCGC GGGTGCCAGT GTAGCCCCTA 3420
GCCCTGCTGT GGATAAAGCC CAGGCCGAGC TGCAGGAACT GCTGACCATT GCTGAACGCT 3480
GGGAGGAGAA AGCCCACCTC TGCCTGGAGG CCAGGCAGAA GCATCCACCA GCCACACTTG 3540
AGGCCATAAT CCGTGAAGCG GAAAACATCC CTGTTCACCT GCCCAACATC CAGGCTCTCA 3600
AGGAGGCTCT TGCTAAGGCC CGGGCCTGGA TTGCTGATGT TGATGAGATC CAAAATGGTG 3660
ACCACTACCC CTGCCTGGAT GACTTGGAGG GCCTAGTAGC TGTGGGCCGG GACCTACCTG 3720
TGGGGCTGGA GGAGCTGAGA CAGCTAGAGC TACAGGTACT GACAGCGCAC TCCTGGAGGG 3780
AGAAGGCCTC CAAGACCTTC CTCAAGAAAA ATTCTTGCTA CACGCTGCTG GAGGTTCTCT 3840
GCCCATGTGC AGATGCCGGC TCAGACAGCA CCAAGCGCAG CCGGTGGATG GAGAAGGAGC 3900
TGGGGTTGTA CAAATCTGAC ACAGAGCTGC TGGGGCTGTC TGCGCAGGAC CTCAGGGACC 3960
CAGGCTCTGT GATCGTGGCC TTCAAGGAGG GGGAACAGAA GGAGAAGGAG GGTATCCTGC 4020
AGCTGCGTCG CACCAATTCG GCCAAGCCCA GTCCACTGGC ATCATCGAGC ACGGCCTCCT 4080
CTACAACCTC TATCTGTGTG TGTGGGCAGG TGCTGGCTGG GGCGGGAGCT CTGCAGTGTG 4140
ACCTGTGTCA GGACTGGTTC CATGGGCGGT GTGTGTCAGT GCCTCGCCTC CTCAGCTCTC 4200
CGAGGCCCAA TCCCACCTCA TCCCCACTGC TGGCCTGGTG GGAATGGGAC ACCAAATTCC 4260
TGTGTCCACT GTGTATGCGC TCAAGGCGCC CGCGCCTGGA GACCATCCTG GCACTGCTGG 4320
TAGCCCTGCA GAGACTGCCT GTGCGGCTGC CCGAGGGCGA GGCCCTGCAG TGCCTCACAG 4380
AGAGGGCCAT CAGCTGGCAA GGCCGCGCCA GGCAGGCTCT GGCCTCTGAA GATGTGACTG 4440
CTCTTTTGGG ACGGCTGGCT GAGCTCCGCC AACGGCTACA GGCTGAACCT AGACCTGAGG 4500
AGCCTCCTAA CTACCCTGCA GCCCCTGCTT CTGACCCCCT CAGAGAGGGC AGTGGCAAGG 4560
ATATGCCTAA GGTCCAGGGC TTACTGGAGA ATGGAGACAG TGTGACCAGT CCTGAGAAGG 4620
TAGCCCCGGA GGAGGGCTCA GGTAAGAGAG ATCTGGAGCT GCTGTCCTCG CTGTTGCCAC 4680
AGTTGACTGG CCCTGTGTTG GAACTGCCTG AGGCAACCCG GGCCCCCTTG GAGGAGCTCA 4740
TGATGGAGGG GGACCTGCTC GAGGTGACCC TGGATGAGAA CCACAGCATA TGGCAGCTGC 4800
TGCAGGCTGG ACAGCCCCCA GACCTGGAGA GGATCCGCAC ACTTCTGGAG CTGGAGAAGG 4860
CAGAGCGTCA CGGGAGTCGG GCTCGGGGCC GGGCCCTGGA GAGGCGGCGG CGGCGGAAGG 4920
TGGATCGGGG TGGGGAGGGC GATGACCCAG CCCGAGAGGA GCTAGAGCCA AAGAGGGTAC 4980
GGAGCTCAGG GCCAGAGGCT GAGGAGGTCC AGGAGGAGGA AGAGCTGGAG GAGGAGACTG 5040
GGGGTGAGGG CCCCCCTGCA CCCATCCCCA CCACTGGCAG CCCCAGCACC CAGGAGAACC 5100
AGAATGGCTT GGAACCGGCG GAAGGGACCA CTTCAGGCCC CTCGGCCCCT TTCTCCACTC 5160
TGACTCCCCG GCTGCATCTG CCCTGCCCAC AGCAGCCGCC TCAGCAACAG TTGTGACAGT 5220
GGCTGAGCCT AGCACAGACC CTGACAGAGA CCCCCCTCGG CCTCAAGGAT CCTCTTTCTG 5280
ACCATCAAGC CTGCTTCTTG GGGGGTGGGC GGGTAGGGGG GTGGCCATCC CTGCTACCCG 5340
CCCACCCCTG AGTCCCTTGA CTTTTGTATT CTGACTCCAA GGTATTGTTC AGACCTCAGC 5400
TCCTGGGGGC CGGCCCCTGG AGTCTTCCCT CCCTGGTAGC CTCTAACCAG CATTCCCAGA 5460
CACCTGAGGC AGATAGATGG ATGGGCTGGT GGGCAGGGGG GTGGCTGGGG CTGGGCCATC 5520
ACCATTCCAG AGACAAGGCC AGTGTATATG CAAACTGGGG GACTCTCCTC CCTTCTCTCC 5580
CCAGTTCTGG TCCTGGCCAG GCCATGCTAC ACTAACCCCT GCCCCCACTC TCCTCCCCTC 5640
TTTTCCTTCC TTCCTACCCC CTTCTCCCTC TCCCTTCCCC TGACTGTTCC ACCCAGGAGG 5700
AGGAAACTTC ACATAGCCGT GCTCACAGTT TTTTATTTTA AAGGAATTTG GCTGGGGAGC 5760
TGAACAGGGC TCCCTGTGAT CTGAAGAAAG CTTTTGGTGC TTGTCCTCAC AACCACCTCA 5820
GTCCTCCCTC CCTGTCCTCC CCTGTCTCCT TTCCTCCTCC TGGGTTCATG TTGTAATAAA 5880
AGAAGATTGT TGGTGTGTAA TTAATTTGTT CAAAAGAAAA AAAAAAGCAA AACAAGAAAC 5940
TTGGTTCCAA CTGAAGCCTA TTTTAATTTT ATTTTATTAT TTTCCTCTTG TTAGAAATAA 6000
AACCCTTAGA AACATTTTTT GGAAACATGT T 6032
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0225--Disease mutation
KW-0408--Iron
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0032452--F:histone demethylase activity
GO:0032453--F:histone demethylase activity (H3-K4 specific)
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270--F:zinc ion binding
GO:0034720--P:histone H3-K4 demethylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0048511--P:rhythmic process
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Gog-0089 ENSGGOP00000007521.2 Gorilla gorilla 100 0.0 2750
WERAM-Paa-0060 ENSPANP00000008466.1 Papio anubis 99 0.0 2715
WERAM-Otg-0056 ENSOGAP00000003880.2 Otolemur garnettii 97 0.0 2698
WERAM-Ict-0017 ENSSTOP00000001099.2 Ictidomys tridecemlineatus 98 0.0 2692
WERAM-Aim-0061 ENSAMEP00000005475.1 Ailuropoda melanoleuca 98 0.0 2691
WERAM-Mup-0108 ENSMPUP00000009622.1 Mustela putorius furo 97 0.0 2690
WERAM-Orc-0101 ENSOCUP00000008740.2 Oryctolagus cuniculus 98 0.0 2684
WERAM-Eqc-0209 ENSECAP00000022585.1 Equus caballus 98 0.0 2684
WERAM-Tut-0063 ENSTTRP00000004859.1 Tursiops truncatus 97 0.0 2681
WERAM-Ova-0093 ENSOARP00000009606.1 Ovis aries 97 0.0 2657
WERAM-Myl-0054 ENSMLUP00000004559.2 Myotis lucifugus 97 0.0 2657
WERAM-Bot-0140 ENSBTAP00000019893.5 Bos taurus 97 0.0 2650
WERAM-Chs-0153 ENSCSAP00000008766.1 Chlorocebus sabaeus 99 0.0 2625
WERAM-Mum-0069 ENSMUSP00000108203.1 Mus musculus 95 0.0 2625
WERAM-Dan-0159 ENSDNOP00000027101.1 Dasypus novemcinctus 98 0.0 2603
WERAM-Caf-0167 ENSCAFP00000023835.3 Canis familiaris 98 0.0 2597
WERAM-Mim-0074 ENSMICP00000007161.1 Microcebus murinus 95 0.0 2589
WERAM-Mam-0191 ENSMMUP00000027068.2 Macaca mulatta 99 0.0 2588
WERAM-Sus-0088 ENSSSCP00000013112.2 Sus scrofa 95 0.0 2580
WERAM-Nol-0172 ENSNLEP00000019325.2 Nomascus leucogenys 100 0.0 2573
WERAM-Prc-0127 ENSPCAP00000011494.1 Procavia capensis 94 0.0 2536
WERAM-Fec-0082 ENSFCAP00000006727.3 Felis catus 95 0.0 2496
WERAM-Poa-0197 ENSPPYP00000022803.2 Pongo abelii 96 0.0 2382
WERAM-Pat-0192 ENSPTRP00000038793.3 Pan troglodytes 85 0.0 2358
WERAM-Caj-0062 ENSCJAP00000010885.1 Callithrix jacchus 98 0.0 2295
WERAM-Ora-0111 ENSOANP00000021438.1 Ornithorhynchus anatinus 87 0.0 2244
WERAM-Mae-0078 ENSMEUP00000007759.1 Macropus eugenii 85 0.0 2216
WERAM-Ran-0254 ENSRNOP00000073953.1 Rattus norvegicus 77 0.0 2212
WERAM-Mod-0077 ENSMODP00000012203.3 Monodelphis domestica 81 0.0 2201
WERAM-Sah-0049 ENSSHAP00000005524.1 Sarcophilus harrisii 88 0.0 2112
WERAM-Lac-0120 ENSLACP00000014409.1 Latimeria chalumnae 74 0.0 2036
WERAM-Ere-0114 ENSEEUP00000012051.1 Erinaceus europaeus 95 0.0 2008
WERAM-Anc-0043 ENSACAP00000004863.3 Anolis carolinensis 79 0.0 1952
WERAM-Loa-0002 ENSLAFP00000000253.2 Loxodonta africana 89 0.0 1933
WERAM-Xet-0049 ENSXETP00000015599.3 Xenopus tropicalis 69 0.0 1888
WERAM-Vip-0044 ENSVPAP00000003974.1 Vicugna pacos 99 0.0 1808
WERAM-Orla-0155 ENSORLP00000018006.1 Oryzias latipes 66 0.0 1790
WERAM-Orn-0204 ENSONIP00000021218.1 Oreochromis niloticus 67 0.0 1782
WERAM-Dio-0006 ENSDORP00000000973.1 Dipodomys ordii 91 0.0 1771
WERAM-Dar-0014 ENSDARP00000110667.2 Danio rerio 63 0.0 1768
WERAM-Gaa-0127 ENSGACP00000016095.1 Gasterosteus aculeatus 65 0.0 1764
WERAM-Asm-0136 ENSAMXP00000013190.1 Astyanax mexicanus 65 0.0 1762
WERAM-Ten-0151 ENSTNIP00000000510.1 Tetraodon nigroviridis 65 0.0 1750
WERAM-Xim-0221 ENSXMAP00000018338.1 Xiphophorus maculatus 65 0.0 1749
WERAM-Gam-0221 ENSGMOP00000021154.1 Gadus morhua 65 0.0 1731
WERAM-Pof-0028 ENSPFOP00000002786.2 Poecilia formosa 62 0.0 1728
WERAM-Ptv-0041 ENSPVAP00000004453.1 Pteropus vampyrus 94 0.0 1637
WERAM-Tar-0003 ENSTRUP00000000685.1 Takifugu rubripes 65 0.0 1627
WERAM-Gaga-0123 ENSGALP00000021168.4 Gallus gallus 57 0.0 1429
WERAM-Tag-0155 ENSTGUP00000013014.1 Taeniopygia guttata 57 0.0 1422
WERAM-Fia-0057 ENSFALP00000004074.1 Ficedula albicollis 57 0.0 1415
WERAM-Soa-0132 ENSSARP00000013044.1 Sorex araneus 56 0.0 1389
WERAM-Cap-0110 ENSCPOP00000008106.2 Cavia porcellus 98 0.0 1385
WERAM-Pes-0046 ENSPSIP00000007266.1 Pelodiscus sinensis 57 0.0 1379
WERAM-Ect-0085 ENSETEP00000009806.1 Echinops telfairi 79 0.0 1357
WERAM-Anp-0001 ENSAPLP00000000531.1 Anas platyrhynchos 56 0.0 1355
WERAM-Leo-0177 ENSLOCP00000021020.1 Lepisosteus oculatus 55 0.0 1336
WERAM-Pem-0068 ENSPMAP00000007536.1 Petromyzon marinus 54 0.0 1320
WERAM-Chh-0061 ENSCHOP00000006896.1 Choloepus hoffmanni 54 0.0 1299
WERAM-Meg-0012 ENSMGAP00000000890.1 Meleagris gallopavo 52 0.0 1186
WERAM-Cis-0007 ENSCSAVP00000000871.1 Ciona savignyi 47 0.0 1118
WERAM-Tub-0140 ENSTBEP00000015071.1 Tupaia belangeri 99 0.0 1085
WERAM-Drm-0042 FBpp0311492 Drosophila melanogaster 46 0.0 1051
WERAM-Cii-0031 ENSCINP00000012442.3 Ciona intestinalis 47 0.0 951
WERAM-Tas-0106 ENSTSYP00000011121.1 Tarsius syrichta 53 0.0 921
WERAM-Ocp-0067 ENSOPRP00000005882.1 Ochotona princeps 60 0.0 721
WERAM-Asf-0028 CADAFLAP00010689 Aspergillus flavus 32 2e-138 491
WERAM-Aso-0031 CADAORAP00009644 Aspergillus oryzae 32 3e-138 491
WERAM-Asni-0025 CADANGAP00007970 Aspergillus niger 33 4e-136 484
WERAM-Ast-0008 CADATEAP00004027 Aspergillus terreus 31 4e-131 467
WERAM-Spr-0023 CBQ72974 Sporisorium reilianum 31 8e-124 443
WERAM-Cae-0018 ZK593.4a Caenorhabditis elegans 39 6e-119 427
WERAM-Miv-0011 MVLG_01737T0 Microbotryum violaceum 34 4e-118 424
WERAM-Usm-0016 UM02582P0 Ustilago maydis 34 3e-117 421
WERAM-Nec-0020 EFNCRP00000004299 Neurospora crassa 30 5e-117 420
WERAM-Brd-0017 BRADI1G29247.1 Brachypodium distachyon 33 1e-104 379
WERAM-Coi-0029 EAS31076 Coccidioides immitis 35 6e-104 377
WERAM-Asfu-0009 CADAFUAP00002555 Aspergillus fumigatus 36 1e-102 372
WERAM-Asn-0018 CADANIAP00004258 Aspergillus nidulans 30 4e-102 371
WERAM-Tum-0032 CAZ86330 Tuber melanosporum 33 4e-101 367
WERAM-Asc-0001 CADACLAP00000026 Aspergillus clavatus 35 5e-100 364
WERAM-Zyt-0030 Mycgr3P74352 Zymoseptoria tritici 29 8e-100 363
WERAM-Thc-0041 EOY24718 Theobroma cacao 44 9e-96 350
WERAM-Lab-0033 EDR12730 Laccaria bicolor 34 2e-95 348
WERAM-Sob-0138 Sb10g031260.1 Sorghum bicolor 35 2e-95 348
WERAM-Scs-0004 EDN96551 Sclerotinia sclerotiorum 33 5e-95 347
WERAM-Pytr-0035 EDU44093 Pyrenophora triticirepentis 33 2e-94 345
WERAM-Met-0120 AES94050 Medicago truncatula 43 4e-94 344
WERAM-Phn-0021 SNOT_11200 Phaeosphaeria nodorum 33 4e-94 344
WERAM-Mao-0014 MGG_04878T0 Magnaporthe oryzae 32 8e-94 343
WERAM-Pyt-0008 EFQ94561 Pyrenophora teres 34 1e-93 343
WERAM-Crn-0020 AAW43237 Cryptococcus neoformans 29 1e-93 343
WERAM-Sol-0104 Solyc08g081000.2.1 Solanum lycopersicum 43 2e-93 342
WERAM-Arl-0119 scaffold_200168.1 Arabidopsis lyrata 43 8e-93 340
WERAM-Prp-0007 EMJ11636 Prunus persica 43 1e-92 339
WERAM-Glm-0121 GLYMA11G02580.4 Glycine max 43 2e-92 338
WERAM-Bro-0173 Bo9g029100.1 Brassica oleracea 43 2e-92 338
WERAM-Gag-0021 GGTG_06066T0 Gaeumannomyces graminis 33 3e-92 338
WERAM-Sot-0035 PGSC0003DMT400029865 Solanum tuberosum 43 4e-92 337
WERAM-Brr-0139 Bra027644.1-P Brassica rapa 43 1e-91 336
WERAM-Lem-0001 CBY01560 Leptosphaeria maculans 39 3e-91 334
WERAM-Amt-0017 ERM95079 Amborella trichopoda 43 1e-90 333
WERAM-Aet-0037 EMT30548 Aegilops tauschii 42 2e-89 328
WERAM-Trv-0029 EHK20007 Trichoderma virens 40 3e-89 328
WERAM-Trr-0012 EGR49606 Trichoderma reesei 41 4e-89 328
WERAM-Map-0012 MAPG_04048T0 Magnaporthe poae 31 5e-89 327
WERAM-Tru-0011 TRIUR3_05779-P1 Triticum urartu 42 7e-89 327
WERAM-Tra-0285 Traes_7AL_6B05A3754.1 Triticum aestivum 43 9e-89 327
WERAM-Pot-0168 POPTR_0019s03550.2 Populus trichocarpa 42 1e-88 326
WERAM-Sei-0018 Si005667m Setaria italica 42 2e-88 325
WERAM-Php-0054 PP1S235_45V6.1 Physcomitrella patens 47 3e-87 321
Created Date 25-Jun-2016