WERAM Information

Tag Content
WERAM ID WERAM-Hos-0142
Ensembl Protein ID ENSP00000270722.5
Uniprot Accession Q9HAZ2; PRD16_HUMAN; A6NHQ8; B1AJP7; B1AJP8; B1AJP9; B1WB48; Q8WYJ9; Q9C0I8
Genbank Protein ID NP_071397.3; NP_955533.2; XP_011540247.1
Protein Name PR domain zinc finger protein 16
Genbank Nucleotide ID NM_022114.3; NM_199454.2; XM_011541945.1
Gene Name PRDM16;MEL1;LVNC8;PFM13;CMD1LL
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000142611.16 ENST00000270722.9 ENSP00000270722.5
ENSG00000142611.16 ENST00000378391.6 ENSP00000367643.2
ENSG00000142611.16 ENST00000514189.5 ENSP00000421400.1
ENSG00000142611.16 ENST00000511072.5 ENSP00000426975.1
Details
Type Family Domain Substrates AA References (PMIDs)
HMT RIZ SET H3K9me1 K 25537518
Status Reviewed
Classification
Type Family E-value Score Start End
HMT RIZ 5.70e-46 157.7 83 211
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation.
Domain Profile
  HMT RIZ
            RIZ.txt   2 evelaessipkeglgvyakkkiekgekfGPfv............GekkileeveenanekliweisedkgevkyivDasdeeksnWlryvnv 81 
                        ++el+essip++glgv+ak+k+e+ge++GP+v            G+++il++ve++++e++i++ised g++k++vDa+++ +++Wl+y++v
  ENSP00000270722.5  83 DFELRESSIPGAGLGVWAKRKMEAGERLGPCVvvpraaaketdfGWEQILTDVEVSPQEGCITKISEDLGSEKFCVDANQAGAGSWLKYIRV 174
                        799***************************************************************************************** PP
            RIZ.txt  82 ArskeeqNLaalqineqifYktikdIepdeELLvwyk 118
                        A+s+++qNL+++qi+eqi+Yk+ikdIep+eELLv++k
  ENSP00000270722.5 175 ACSCDDQNLTMCQISEQIYYKVIKDIEPGEELLVHVK 211
                        **********************************985 PP
Protein Sequence
(Fasta)		MRSKARARKL AKSDGDVVNN MYEPNRDLLA SHSAEDEAED SAMSPIPVGP PSPFPTSEDF 60
TPKEGSPYEA PVYIPEDIPI PADFELRESS IPGAGLGVWA KRKMEAGERL GPCVVVPRAA 120
AKETDFGWEQ ILTDVEVSPQ EGCITKISED LGSEKFCVDA NQAGAGSWLK YIRVACSCDD 180
QNLTMCQISE QIYYKVIKDI EPGEELLVHV KEGVYPLGTV PPGLDEEPTF RCDECDELFQ 240
SKLDLRRHKK YTCGSVGAAL YEGLAEELKP EGLGGGSGQA HECKDCERMF PNKYSLEQHM 300
VIHTEEREYK CDQCPKAFNW KSNLIRHQMS HDSGKRFECE NCVKVFTDPS NLQRHIRSQH 360
VGARAHACPD CGKTFATSSG LKQHKHIHST VKPFICEVCH KSYTQFSNLC RHKRMHADCR 420
TQIKCKDCGQ MFSTTSSLNK HRRFCEGKNH YTPGGIFAPG LPLTPSPMMD KAKPSPSLNH 480
ASLGFNEYFP SRPHPGSLPF STAPPTFPAL TPGFPGIFPP SLYPRPPLLP PTSLLKSPLN 540
HTQDAKLPSP LGNPALPLVS AVSNSSQGTT AAAGPEEKFE SRLEDSCVEK LKTRSSDMSD 600
GSDFEDVNTT TGTDLDTTTG TGSDLDSDVD SDPDKDKGKG KSAEGQPKFG GGLAPPGAPN 660
SVAEVPVFYS QHSFFPPPDE QLLTATGAAG DSIKAIASIA EKYFGPGFMG MQEKKLGSLP 720
YHSAFPFQFL PNFPHSLYPF TDRALAHNLL VKAEPKSPRD ALKVGGPSAE CPFDLTTKPK 780
DVKPILPMPK GPSAPASGEE QPLDLSIGSR ARASQNGGGR EPRKNHVYGE RKLGAGEGLP 840
QVCPARMPQQ PPLHYAKPSP FFMDPIYSRV EKRKVTDPVG ALKEKYLRPS PLLFHPQMSA 900
IETMTEKLES FAAMKADSGS SLQPLPHHPF NFRSPPPTLS DPILRKGKER YTCRYCGKIF 960
PRSANLTRHL RTHTGEQPYR CKYCDRSFSI SSNLQRHVRN IHNKEKPFKC HLCNRCFGQQ 1020
TNLDRHLKKH EHENAPVSQH PGVLTNHLGT SASSPTSESD NHALLDEKED SYFSEIRNFI 1080
ANSEMNQAST RTEKRADMQI VDGSAQCPGL ASEKQEDVEE EDDDDLEEDD EDSLAGKSQD 1140
DTVSPAPEPQ AAYEDEEDEE PAASLAVGFD HTRRCAEDHE GGLLALEPMP TFGKGLDLRR 1200
AAEEAFEVKD VLNSTLDSEA LKHTLCRQAK NQAYAMMLSL SEDTPLHTPS QGSLDAWLKV 1260
TGATSESGAF HPINHL 1276
Nucleotide Sequence
(Fasta)		GCTGCTTCTG GACTCAAGGA GGAGGAGAGA GATTCCGCGA GCCGACACCA TGCGATCCAA 60
GGCGAGGGCG AGGAAGCTAG CCAAAAGTGA CGGTGACGTT GTAAATAATA TGTATGAGCC 120
CAACCGGGAC CTGCTGGCCA GCCACAGCGC GGAGGACGAG GCCGAGGACA GTGCCATGTC 180
GCCCATCCCC GTGGGGCCAC CGTCCCCCTT CCCCACCAGC GAGGACTTCA CCCCCAAGGA 240
GGGCTCGCCG TACGAGGCCC CTGTCTACAT TCCTGAAGAC ATTCCGATCC CAGCAGACTT 300
CGAGCTCCGA GAGTCCTCCA TCCCAGGGGC TGGCCTGGGG GTCTGGGCCA AGAGGAAGAT 360
GGAAGCCGGG GAGAGGCTGG GCCCCTGCGT GGTGGTGCCC CGGGCGGCGG CAAAGGAGAC 420
AGACTTCGGA TGGGAGCAAA TACTGACGGA CGTGGAAGTG TCGCCCCAGG AAGGCTGCAT 480
CACAAAGATC TCCGAAGACC TGGGCAGTGA GAAGTTCTGC GTGGATGCAA ATCAGGCGGG 540
GGCTGGCAGC TGGCTCAAGT ACATCCGTGT GGCGTGCTCC TGCGATGACC AGAACCTCAC 600
CATGTGTCAG ATCAGTGAGC AGATTTACTA TAAAGTCATT AAGGACATTG AGCCAGGTGA 660
GGAGCTGCTG GTGCACGTGA AGGAAGGCGT CTACCCCCTG GGCACAGTGC CGCCCGGCCT 720
GGACGAGGAG CCCACGTTCC GCTGTGACGA GTGTGACGAA CTCTTCCAGT CCAAGCTGGA 780
CCTGCGGCGC CATAAGAAGT ACACGTGTGG CTCAGTGGGG GCTGCGCTCT ACGAGGGCCT 840
GGCTGAGGAG CTCAAGCCCG AGGGCCTTGG CGGTGGCAGC GGCCAAGCCC ACGAGTGCAA 900
GGACTGCGAG CGGATGTTCC CCAACAAGTA CAGCCTGGAG CAGCACATGG TCATCCACAC 960
GGAGGAGCGC GAGTACAAAT GCGACCAGTG TCCCAAGGCC TTCAACTGGA AGTCCAACCT 1020
CATCCGCCAC CAGATGTCCC ACGACAGCGG CAAACGCTTC GAATGTGAAA ACTGCGTGAA 1080
GGTGTTCACG GACCCCAGCA ACCTTCAGCG GCACATCCGC TCGCAGCACG TGGGCGCTCG 1140
GGCCCACGCC TGCCCCGACT GCGGGAAGAC CTTCGCCACG TCCTCCGGCC TCAAGCAGCA 1200
CAAGCATATC CACAGCACGG TGAAGCCTTT CATATGTGAG GTCTGCCACA AGTCCTACAC 1260
GCAGTTCTCC AACCTGTGCC GGCACAAGCG GATGCACGCC GACTGCCGCA CGCAGATCAA 1320
GTGCAAGGAC TGTGGCCAGA TGTTCAGCAC TACCTCCTCC CTCAACAAGC ACCGGCGCTT 1380
CTGCGAGGGC AAGAACCATT ACACGCCGGG CGGCATCTTT GCCCCGGGCC TGCCCTTGAC 1440
CCCCAGCCCC ATGATGGACA AGGCAAAACC CTCCCCCAGC CTCAATCACG CCAGCCTGGG 1500
CTTCAACGAG TACTTTCCCT CCAGGCCGCA CCCGGGGAGC CTGCCCTTCT CCACGGCGCC 1560
TCCCACGTTC CCCGCACTCA CCCCCGGCTT CCCGGGCATC TTCCCTCCAT CCTTGTACCC 1620
CCGGCCGCCT CTGCTACCTC CCACATCGCT GCTCAAGAGC CCCCTGAACC ACACCCAGGA 1680
CGCCAAGCTC CCCAGTCCCC TGGGGAACCC AGCCCTGCCC CTGGTCTCCG CCGTCAGCAA 1740
CAGCAGCCAG GGCACGACGG CAGCTGCGGG GCCCGAGGAG AAGTTCGAGA GCCGCCTGGA 1800
GGACTCCTGT GTGGAGAAGC TGAAGACCAG GAGCAGCGAC ATGTCGGACG GCAGTGACTT 1860
TGAGGACGTC AACACCACCA CGGGGACCGA CCTGGACACG ACCACGGGGA CGGGCTCGGA 1920
CCTGGACAGC GACGTGGACA GCGACCCTGA CAAGGACAAG GGCAAGGGCA AGTCCGCCGA 1980
GGGCCAGCCC AAGTTTGGGG GCGGCTTGGC GCCCCCGGGG GCCCCGAACA GCGTGGCCGA 2040
GGTGCCTGTC TTCTATTCCC AGCACTCATT CTTCCCGCCA CCCGACGAGC AGCTGCTGAC 2100
TGCAACGGGC GCCGCCGGGG ACTCCATCAA GGCCATCGCA TCCATTGCCG AGAAGTACTT 2160
TGGCCCCGGC TTCATGGGGA TGCAGGAGAA GAAGCTGGGC TCGCTCCCCT ACCACTCGGC 2220
GTTCCCCTTC CAGTTCCTGC CCAACTTCCC CCACTCCCTT TACCCCTTCA CGGACCGAGC 2280
CCTCGCCCAC AACTTGCTGG TCAAGGCCGA GCCAAAGTCA CCCCGGGACG CCCTCAAGGT 2340
GGGCGGCCCC AGTGCCGAGT GCCCCTTTGA TCTCACCACC AAGCCCAAAG ACGTGAAGCC 2400
CATCCTGCCC ATGCCCAAGG GCCCCTCGGC CCCCGCATCC GGCGAGGAGC AGCCGCTGGA 2460
CCTGAGCATC GGCAGCCGGG CCCGTGCCAG CCAAAACGGC GGCGGGCGGG AGCCCCGCAA 2520
GAACCACGTC TATGGGGAAC GCAAGCTGGG CGCCGGCGAG GGGCTGCCCC AGGTGTGCCC 2580
GGCGCGGATG CCCCAGCAGC CCCCGCTCCA CTACGCCAAG CCCTCGCCCT TCTTCATGGA 2640
CCCCATCTAC AGCAGGGTAG AAAAGCGGAA GGTCACAGAC CCCGTGGGAG CCCTGAAGGA 2700
GAAGTACCTG CGGCCGTCCC CGCTGCTCTT CCACCCCCAG ATGTCAGCCA TAGAGACCAT 2760
GACAGAGAAG CTGGAGAGCT TTGCAGCCAT GAAGGCGGAC TCGGGCAGCT CCCTGCAGCC 2820
CCTCCCCCAC CACCCCTTCA ACTTCCGGTC CCCACCCCCA ACGCTCTCCG ACCCCATCCT 2880
CAGGAAGGGC AAGGAGCGAT ACACGTGCAG GTACTGTGGG AAGATCTTCC CCAGATCAGC 2940
CAATCTCACC AGACACCTGA GGACGCACAC TGGGGAGCAG CCGTACAGGT GTAAGTACTG 3000
CGACCGCTCC TTCAGCATCT CTTCGAACCT CCAGCGGCAC GTCCGGAACA TCCACAACAA 3060
GGAGAAGCCT TTCAAGTGCC ACCTGTGCAA CCGCTGCTTC GGGCAGCAGA CCAACCTGGA 3120
CCGGCACCTC AAGAAGCACG AGCACGAGAA CGCACCAGTG AGCCAGCACC CCGGGGTCCT 3180
CACGAACCAC CTGGGGACCA GCGCGTCCTC TCCCACCTCA GAGTCGGACA ACCACGCACT 3240
TTTAGACGAG AAAGAAGACT CTTATTTCTC GGAAATCAGA AACTTTATTG CCAATAGTGA 3300
GATGAACCAA GCATCAACGC GAACAGAGAA ACGGGCGGAC ATGCAGATCG TGGACGGCAG 3360
TGCCCAGTGT CCAGGCCTAG CCAGTGAGAA GCAGGAGGAC GTGGAGGAGG AGGACGACGA 3420
TGACCTGGAG GAGGACGATG AGGACAGCCT GGCCGGGAAG TCGCAGGATG ACACCGTGTC 3480
CCCCGCACCC GAGCCCCAGG CCGCCTACGA GGATGAGGAG GATGAGGAGC CAGCCGCCTC 3540
CCTGGCCGTG GGCTTTGACC ACACCCGAAG GTGTGCTGAG GACCACGAAG GCGGTCTGTT 3600
AGCTTTGGAG CCGATGCCGA CTTTTGGGAA GGGGCTGGAC CTCCGCAGAG CAGCTGAGGA 3660
AGCATTTGAA GTTAAAGATG TGCTTAATTC CACCTTAGAT TCTGAGGCTT TAAAACATAC 3720
ACTGTGCAGG CAGGCTAAGA ACCAGGCATA TGCAATGATG CTGTCCCTTT CCGAAGACAC 3780
TCCTCTCCAC ACCCCCTCCC AGGGTTCTCT GGACGCTTGG TTGAAGGTCA CTGGAGCCAC 3840
GTCGGAGTCT GGAGCATTTC ACCCCATCAA CCACCTCTGA CGGGCTGGGC AGCCGGGGGC 3900
CGGTGGCCAG AGCGAGGGCA CCAGCCACGA AGGACGGAGG CGGGCGGGGC CCCGGAGAAC 3960
CCTGTCCCTG CGTGTGGCCA CTCCTCAGCA TCCTCCCCAC CCACCATGGT TCATTCCGAC 4020
TTTTCCAATG GAAACTCAGA TCCCAAAAGT CCCTAAAGCA GTCGTAGAGT CTCACCATCT 4080
CCAAGGATTG GTCTTGAGAA CACTGTTCAG TGACGGCCAT GCAGGTGGCC GTCCAAAGAC 4140
AGCCAACGGA GCTGCCTCGC AGAATCAGCC AGTGGGCAGG TGGACGCTCT GCTGAGACAG 4200
AAGCTGGTGG CCACTGCCGG GTGCCCGCGT GGGGTCGCGG AAGGGAATGG ATAGACTGGT 4260
GTGCTCAAAA GAGAGAGATC ACTCAAATGA TTTTTATAAT GAAATGACAA GAATAACCCT 4320
TTTGGTAACC GTATTGACTG CAGAGTCTAT TTAAGCATGT GGTTTTAAAA ATAGACAGTA 4380
TTTTTTAAAA ATCAAAAAAT GACTTGCAAA TTGTTTTTTA AAAGTAATTT TGCATTGCTT 4440
TGAAATTTGA GCTCATTTGC AAACCCGAGT CTGCCTGGGA ACCCGCACTG TGCCTGGGTG 4500
TATTCTTTAT ACTGTAGATA ATGGAGAAAT TTTCTATCTC TGTCCCTATT TGTATAAGCC 4560
AAGGTGATGC TGGGTGCCCC GAGGCAGAAC AAGAGGCGCG GGGCCACACC CGTGAACCAT 4620
GCAGACGGCC GAAGAAGTCT TAGGCAGGGC GCCCTGGGCT GCAGGCCTGC CCGAGGCTGG 4680
GATGGGAAGT GTGCCTGCCC TCGTGTGACA TGGAATTGGT GTCAGGACCG CCACGTGGCC 4740
TTCAGAGGAA TCCACAGGTC CCCACCCAAG ATCCCTCAAT TATATGGGGA AGTCGAGGGC 4800
CTGTGGCTTG GATCCGCCAT GCAGAGATGT GGCCGGGCAC CCATCTTCCT TCCCTCCTCT 4860
GTCCCTGCCT CGGCCACCCC ACGCGGGAAC CCAGCGCCGT CCTCTGAAGG CAGGGCCTTG 4920
GCCACGTCCT GGGTCTCCCA CCTCCCACCT GACCCCAGCG GCTCCGGTGT CCTCCACGTG 4980
GCTGCCCTGG GGAGCAATCC CAGCGGATCG CTCCGGGCCA CCAAGCCGCA CCTGTGCCTG 5040
AGACTCCGGA TGGACGACAC AGTCGTCACG TCGCTCTTCC TGCGGGTTCT TGGCGAGACA 5100
CAGCTTGAGA ACAGAAGGGC GTCGGGGGAA CCTGCCGCAA GGAGCAGAGA CAGCACAGCC 5160
CCCCGGGCCC AGCCGCCTCC CTCTCTTGGG ACGCAACTTC TTCCCCACTC GGATGGGCTT 5220
TAAATTATTC CCATAGGGGC CAATTTCAAA TAATAATTTT TTTCCCTGAT GGAATTTACC 5280
TTAATCTGTA TATAACTTGT AATTTTTTCT AATTCATTTC TTTTCTTATT TTATTTCCTC 5340
CTTAACAGTA TTTTTGGCAT TAGACATTCT TATTGTGAAG AAATAATGTT AATATAAGTA 5400
TCTGGTGAAG GACCAAAACC GTGTGATAAG GTTGTGTGTC GTGTGGGAGT GGGGCGATTT 5460
TTTATGTGCC AAATACCCCC GTCCCCCCCA TGAATCCTGC TGTCCCTGCT GCCGTTTACC 5520
AGACAATCAT ATGTTTTTGT TAAATTTGCG TTTCAGTTAC ATTTGCATTT AAGACAAGTG 5580
TTCTATTTAT TTCTTGTATT GTTTGGAAGA AAAAATGATG ATAGAGTCCC AAAAAGAAGA 5640
GAAAAAAAAT GCCCAAGTTG CCCTTTAAAA AAAAAGAGCG TAAATACAAA CAGGAGTGGT 5700
GCAAGCCGCC TTGGTGTGGG TTTGTGTCAC GTGTGGACAT CTCCTCAGGC TTTGTGTCAC 5760
GCGTGGACAT CTCCTCAGGC TGTCCCCAGC GGTGACGGGA GGTGTCCTGG CTGCTCCAGG 5820
ACAAAAGACA ATCGTCTCTG TGGGTGCCGG GTGGTCCAGG CTTGCACTGA AGACGTGCCA 5880
CGGGGAGGCT CCTGCAGGAG GCTCAACCCG ACGGATCACA GTGAAAGGGA TTCCTCCCAC 5940
GCCAGATCTG CACAACGAGG CAAGACAGGA CCCACCTGTG CGTGCGCTGG GGCCATGGGG 6000
TGGCCCCGCC GGGGCAGCGG GGGAGCTGCC TGCAGAAGAG CCAGCTGGCG TGTCGGGAAG 6060
GATCCAGGAT CTGCAAACAC AACTGCTCAG GCCTTCTCAC GCGTTTCCAC AACATCCCCT 6120
GGGTCAGACC CACCAGGTAC CCCGTAGGAA TTTCCAGTTT CCCTTGATCT AGATGGGATT 6180
CTTATAAAAA TTCAACCTCA GACATAAACA CCCCATTTCT GTAAACCCAA ATTATATGGT 6240
TTCTTCTGCG AAAGAGTAAG GTGTGTGCTT TTTTTTTTTT GCAATATGAC CCCGTCTCTC 6300
TGAAGTGGGA CATTCGGACG GATGGAGCCC TCAGCGTGTC TTTTCAGCAG GAGCAGAACC 6360
GATGAGAGCC GCCCTTACCG TTGGTCTCCG GATCCCCCAG TCCCATCCCG CCGTTTTCGG 6420
CTGTCTTCCT AACCGTCCTG TCTTCTCTTG GCGCTCTTTC CTTCCACCTT TCCCAAGAGT 6480
CCTGGTTGCA CGTTTTAAGT CATATATTTT CGTCCCCCTG AAAATGATGG CAAGCCCAGT 6540
TTCTCCTGAG CATTCAGACC CCCAGGCCCC AGCACTTGGC GTTTTCAGGA GGCCCTGTTC 6600
TTAGAGCCCC TGACAAAGGC AGCACTTATT TCCTGGGCTG GTGCGCCCCA AAACACGGCC 6660
CCGACACTTA GTGTGGCCCC AGGCCCCAGC GAGCCTCGCC CTCCCAGTTT TGCTCTGCCC 6720
AGCAGTGTTG GTGCCCAGAG ATGACAAGGG CCAGGGAGCC TGGCCCGGGT GTGAGAATTC 6780
AGAGATTCTG GCCTCCAGCT GTCACCACAC CGTAACGGGG CCATGTAACT GTGCAGCATG 6840
GACAGGGATG CGACGGGGCA GCTGGCTGTG TCCATGGCCA GGTGGCCAGG GTCAGGGCTG 6900
CAAGCCAGGG GTCCAGGGCC CTTCCGTTCA GCCCAAATGC TGCCCCAATG CTAACTCCTT 6960
GGATTGTCAA CCCCCATCCC CCAAATGGAA ATTCCGAAGG AGGCCTCCTC GCACCTGCCC 7020
TCCGCTGCTC CTCAGACCCC AGCCCCCAGC GAGCCGACGT CCCCACCCGT TCCTGCTCTC 7080
ATCCCCAGGT TGGGCACGTG GGGTTCCTCC TCTGTGGGCC TGGCAGACCC TTCATGAGTG 7140
GGACCCAAGA TATCACTGAC TTCAACCCAG AGGATCGAGC CCCTGCACCC TGCCTGGGGC 7200
CCTGGGGTGT GGAGCAGTGG CTGGGGTGGG CGTGGTGTGG CCTGAGAGAC TGCCCAGCTG 7260
GAGAGGCCTT CCTTTACAAG GCCACGCGTG CAGCTGTCCC ATCCAGACCC CGACTGGCCA 7320
AGACCTCCAC GTCCCCAGAG TCCAGCCCTG GAAATTCCAA GGGCCCTGGC GTCCTCTGCC 7380
TTCCCCGCTT CCCCATGAGC GTCTGCAAAA CACTTGCCTG AATACATATC ACGTATTTTA 7440
GACTCGAAGC CTCAAAGCAC TGGATTGTGG TCCCCTGCCC CCTCTGTCCC GTCCCCCTGC 7500
CCAAGTGACT GAAACCTACT GAGCTATATT CACTGTGCTG TCCTAGGGGG AGGGAGAGCA 7560
GAGCTCGCCC CTGCACTGCA GCCTTGTGGG GGAGGGCAAG GCTCTCCTCC CAGCCAGGGA 7620
CGCCAGGACA TAGCTGCTCC TGGTCAGTGG AGGTCAGCCG GGTATCAAAA GCCATGAAAC 7680
TGTGTCTCTG TAGCAATGAG TGATACTGTG ACAAAACCAT CCTTGCATTC TTCCTAGAAG 7740
AGTTCCTCTG CTCCTTCCAT TCCATTTTTG TGTTTGTTTT GTTCTTTTCT GTCACTGATC 7800
CGTATTACCA CTTTTGGAAA AAAATAAATA AATAAATAAA TAAAAGGCAG CTTGAGTTTC 7860
CAAACGTGTG ATTCACTTGT GAACAAAAGT CATTCTAACA ATTGCCTTCA GCGTCACGTG 7920
CATTGCCACT GCGCTTTCGG CACGAGGGAT GCTGAGCCCT GGTGTCAGAG TCGTAATTTA 7980
AAGCGTGTGT GTATATGGAC TTTGTCCCTT AAGGTCGATA TAAAGAATCC TCGCAGAATC 8040
ACAGACCTGT GCCGCCCGCC ACCTTCTGCC ATTGTTACAT TACAGATTTG GTTTAGTTTT 8100
GTTTTGTTTT GTTTTTTCTT TTAGAACTGT ATAGTATTGA AAAAGAAATC AAATGTAAAT 8160
GTCTGGTTTT CATATAATGT TTAAAAAGAC CATTGAGAAG GAGGCTGGCG CTCGCCCCAT 8220
GTCCCCCTTG ATTGTAAATT GCTTCTGTTC TGTTTATAAG TAAACTGTGC ATGACTCCTG 8280
CTTAGCGGTC ATTATCGTGT CTGTTGGTGA AATTTTTATT AAAAGGAAAA TTCTGTAGAT 8340
GCACTTATTG AATATGTGAT TAGGATCTAC GTCTGAGACT AGGAGTCCTG AACTGCTGAC 8400
GCGAAAGAGG CGCAGTTCCC AATTAATACG GAAATCGCTG TGGGAGAAGA ATGAAATAAG 8460
ACGTGAAGTG TAGGAAATCA TGAAAAGAAC AATTTTGCAA ATTGCATTCT GATGCTTGTG 8520
ATGAACACAA ATGTACTTGT GTAGAGACAT TTCCTTAAGA GAAAGCCTAG GAGAAGCCGA 8580
TTTGGAGGTT AATGCTGTAG AATAGGACTG TATACCAAAT GTAATCTTTC CAATGCTCCA 8640
ATGAATTTAT ACATGAGATT GATATGCAAT AAATCTGTGT GCTTTTCTAA 8691
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0877--Alternative promoter usage
KW-0025--Alternative splicing
KW-0122--Cardiomyopathy
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR030413--Evi1/Prdm16
IPR001214--SET_dom
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
PROSITE

PS50280--SET
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00096--zf-C2H2
PF13912--zf-C2H2_6
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0017053--C:transcriptional repressor complex
GO:0033613--F:activating transcription factor binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0050873--P:brown fat cell differentiation
GO:0034968--P:histone lysine methylation
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0022008--P:neurogenesis
GO:0060021--P:palate development
GO:0090336--P:positive regulation of brown fat cell differentiation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043457--P:regulation of cellular respiration
GO:0035019--P:somatic stem cell population maintenance
GO:0043586--P:tongue development
GO:0006351--P:transcription, DNA-templated
GO:0050872--P:white fat cell differentiation
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0001 ENSPTRP00000052931.3 Pan troglodytes 98 0.0 2263
WERAM-Gog-0037 ENSGGOP00000003703.2 Gorilla gorilla 97 0.0 2191
WERAM-Mum-0162 ENSMUSP00000030902.6 Mus musculus 87 0.0 2108
WERAM-Otg-0063 ENSOGAP00000004519.2 Otolemur garnettii 88 0.0 2091
WERAM-Loa-0015 ENSLAFP00000000902.4 Loxodonta africana 88 0.0 2036
WERAM-Caf-0202 ENSCAFP00000028796.4 Canis familiaris 87 0.0 2026
WERAM-Aim-0102 ENSAMEP00000009899.1 Ailuropoda melanoleuca 87 0.0 2004
WERAM-Tut-0042 ENSTTRP00000003218.1 Tursiops truncatus 85 0.0 1937
WERAM-Mup-0081 ENSMPUP00000007423.1 Mustela putorius furo 87 0.0 1806
WERAM-Gaga-0010 ENSGALP00000001588.4 Gallus gallus 81 0.0 1764
WERAM-Tag-0043 ENSTGUP00000002902.1 Taeniopygia guttata 77 0.0 1754
WERAM-Tub-0069 ENSTBEP00000008639.1 Tupaia belangeri 86 0.0 1292
WERAM-Ptv-0167 ENSPVAP00000014389.1 Pteropus vampyrus 77 0.0 1291
WERAM-Dio-0079 ENSDORP00000007870.1 Dipodomys ordii 87 0.0 1280
WERAM-Poa-0017 ENSPPYP00000002283.2 Pongo abelii 96 0.0 1246
WERAM-Mim-0045 ENSMICP00000004383.1 Microcebus murinus 83 0.0 1078
WERAM-Bot-0024 ENSBTAP00000047652.2 Bos taurus 33 4e-32 138
WERAM-Ran-0144 ENSRNOP00000060531.1 Rattus norvegicus 36 9e-32 137
WERAM-Mam-0029 ENSMMUP00000005026.2 Macaca mulatta 32 2e-29 129
WERAM-Sus-0105 ENSSSCP00000015146.2 Sus scrofa 27 6e-29 127
WERAM-Ova-0204 ENSOARP00000020272.1 Ovis aries 26 3e-28 125
WERAM-Dan-0153 ENSDNOP00000019431.1 Dasypus novemcinctus 30 4e-28 125
WERAM-Paa-0150 ENSPANP00000007800.1 Papio anubis 26 1e-27 123
WERAM-Mod-0115 ENSMODP00000016775.4 Monodelphis domestica 26 2e-27 122
WERAM-Eqc-0022 ENSECAP00000003259.1 Equus caballus 27 4e-27 121
WERAM-Sah-0097 ENSSHAP00000011079.1 Sarcophilus harrisii 26 4e-27 121
WERAM-Ocp-0043 ENSOPRP00000003686.1 Ochotona princeps 26 8e-27 120
WERAM-Caj-0182 ENSCJAP00000031870.2 Callithrix jacchus 26 8e-27 120
WERAM-Myl-0113 ENSMLUP00000009157.2 Myotis lucifugus 25 8e-27 120
WERAM-Pes-0005 ENSPSIP00000002371.1 Pelodiscus sinensis 27 1e-26 120
WERAM-Xet-0015 ENSXETP00000004492.3 Xenopus tropicalis 25 1e-26 120
WERAM-Tas-0082 ENSTSYP00000008295.1 Tarsius syrichta 32 2e-26 119
WERAM-Prc-0084 ENSPCAP00000007153.1 Procavia capensis 31 2e-26 119
WERAM-Meg-0110 ENSMGAP00000011137.1 Meleagris gallopavo 31 1e-25 116
WERAM-Soa-0002 ENSSARP00000000218.1 Sorex araneus 31 1e-25 116
WERAM-Anp-0121 ENSAPLP00000013678.1 Anas platyrhynchos 31 1e-25 116
WERAM-Anc-0027 ENSACAP00000003308.3 Anolis carolinensis 25 3e-25 115
WERAM-Ora-0122 ENSOANP00000023793.3 Ornithorhynchus anatinus 25 4e-25 115
WERAM-Fia-0094 ENSFALP00000007850.1 Ficedula albicollis 24 5e-25 114
WERAM-Orc-0078 ENSOCUP00000007120.2 Oryctolagus cuniculus 26 8e-25 114
WERAM-Dar-0015 ENSDARP00000106969.1 Danio rerio 30 1e-24 113
WERAM-Chs-0043 ENSCSAP00000000098.1 Chlorocebus sabaeus 26 2e-24 112
WERAM-Orn-0032 ENSONIP00000003899.1 Oreochromis niloticus 31 2e-24 112
WERAM-Xim-0168 ENSXMAP00000013864.1 Xiphophorus maculatus 31 2e-24 112
WERAM-Orla-0174 ENSORLP00000020343.1 Oryzias latipes 36 3e-24 112
WERAM-Tar-0166 ENSTRUP00000035409.1 Takifugu rubripes 30 4e-24 112
WERAM-Ere-0093 ENSEEUP00000009413.1 Erinaceus europaeus 31 8e-24 110
WERAM-Ict-0060 ENSSTOP00000005349.2 Ictidomys tridecemlineatus 26 9e-24 110
WERAM-Leo-0089 ENSLOCP00000011948.1 Lepisosteus oculatus 35 1e-23 110
WERAM-Nol-0097 ENSNLEP00000011114.2 Nomascus leucogenys 31 2e-23 109
WERAM-Pof-0242 ENSPFOP00000019968.2 Poecilia formosa 26 1e-22 106
WERAM-Lac-0168 ENSLACP00000019977.1 Latimeria chalumnae 28 6e-22 104
WERAM-Cap-0072 ENSCPOP00000005323.2 Cavia porcellus 25 6e-22 104
WERAM-Gaa-0177 ENSGACP00000022065.1 Gasterosteus aculeatus 26 7e-22 104
WERAM-Ten-0207 ENSTNIP00000020889.1 Tetraodon nigroviridis 36 3e-21 102
WERAM-Asm-0083 ENSAMXP00000008799.1 Astyanax mexicanus 28 3e-21 102
WERAM-Gam-0121 ENSGMOP00000012620.1 Gadus morhua 27 7e-21 100
WERAM-Vip-0075 ENSVPAP00000006917.1 Vicugna pacos 25 9e-21 100
WERAM-Fec-0113 ENSFCAP00000009991.3 Felis catus 38 2e-20 99.4
WERAM-Ect-0142 ENSETEP00000015977.1 Echinops telfairi 38 4e-20 98.6
WERAM-Mae-0001 ENSMEUP00000000039.1 Macropus eugenii 38 1e-19 97.1
WERAM-Chh-0063 ENSCHOP00000006916.1 Choloepus hoffmanni 35 1e-18 93.2
Created Date 25-Jun-2016