| Tag |
Content |
| WERAM ID |
WERAM-Sac-0041 |
| Ensembl Protein ID |
YOR025W |
| Uniprot Accession |
P53687; HST3_YEAST; D6W291; Q66R16
|
| Genbank Protein ID |
NP_014668.1
|
| Protein Name |
NAD-dependent histone deacetylase HST3 |
| Genbank Nucleotide ID |
NM_001183444.1
|
| Gene Name |
HST3;YOR025W;OR26.15 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
H3K56 |
K |
16818235
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
5.90e-80 |
266.8 |
44 |
344 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
NAD-dependent histone deacetylase, which contributes together with HST4 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance. |
NAD-dependent histone deacetylase, which contributes together with HST4 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance.
|
| Domain Profile |
HDAC SIR2
SIR2.txt 2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkke.....elpspeaifdldffrkdpkv..fyalakelyp.lgsakPtktHyflaelekkgk 94
+++k+l++s++i++ltGAGiS++aGIPDFRss+Gly+ +kk+ +++s++++fd+++fr+d k+ f +++++ly+ ++ akPtktH+f+a+l++++k
YOR025W 44 RVTKQLSRSRRIACLTGAGISCNAGIPDFRSSDGLYDLVKKDcsqywSIKSGREMFDISLFRDDFKIsiFAKFMERLYSnVQLAKPTKTHKFIAHLKDRNK 144
6899*************************************9999999*****************9999******************************** PP
SIR2.txt 95 llrlytQNiDgLerkaglked................klvelHGslatasCtkCkkefpreeikeklkakekvpkCekC..................kgvl 161
llr+ytQNiDgLe+++gl+ + ++v+lHG+l+t sCtkC ++fp++++++++ ++ ++p C++C g+l
YOR025W 145 LLRCYTQNIDGLEESIGLTLSnrklpltsfsshwknlDVVQLHGDLKTLSCTKCFQTFPWSRYWSRCLRRGELPLCPDCealinkrlnegkrtlgsnVGIL 245
*******************999**************************************************************************99*** PP
SIR2.txt 162 kpdivffgenlpeefleeveedlkea....dlllvlGtSlkvepvaslvkkavkkkvp....vllvnleevk...adkladlkllgdcdevveellkll 249
+p+iv++gen+p++++ ++ +l+ + d+l+++GtSlkv++v++lvkk +kk ++ ++lvn+++++ ++ ++d+++++dcd++v+ l +++
YOR025W 246 RPNIVLYGENHPSCEIITQGLNLDIIkgnpDFLIIMGTSLKVDGVKQLVKKLSKKIHDrgglIILVNKTPIGessWHGIIDYQIHSDCDNWVTFLESQI 344
******************999955544455*******************98888888888889********99999*****************998876 PP
|
Protein Sequence
(Fasta) | MTSVSPSPPA SRSGSMCSDL PSSLQTEKLA HIIGLDADDE VLRRVTKQLS RSRRIACLTG 60
AGISCNAGIP DFRSSDGLYD LVKKDCSQYW SIKSGREMFD ISLFRDDFKI SIFAKFMERL 120
YSNVQLAKPT KTHKFIAHLK DRNKLLRCYT QNIDGLEESI GLTLSNRKLP LTSFSSHWKN 180
LDVVQLHGDL KTLSCTKCFQ TFPWSRYWSR CLRRGELPLC PDCEALINKR LNEGKRTLGS 240
NVGILRPNIV LYGENHPSCE IITQGLNLDI IKGNPDFLII MGTSLKVDGV KQLVKKLSKK 300
IHDRGGLIIL VNKTPIGESS WHGIIDYQIH SDCDNWVTFL ESQIPDFFKT QDQIKKLRQL 360
KREASDLRKQ MKAQKDSIGT PPTTPLRTAQ GIDIQGNNEL NTKIKSLNTV KRKILSPENS 420
SEEDEEENLD TRKRAKIRPT FGDNQAS 447Protein Fasta Sequence
>YOR025W|HST3;YOR025W;OR26.15|Saccharomyces cerevisiae
MTSVSPSPPASRSGSMCSDLPSSLQTEKLAHIIGLDADDEVLRRVTKQLSRSRRIACLTGAGISCNAGIPDFRSSDGLYDLVKKDCSQYWSIKSGREMFDISLFRDDFKISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNIDGLEESIGLTLSNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSRCLRRGELPLCPDCEALINKRLNEGKRTLGSNVGILRPNIVLYGENHPSCEIITQGLNLDIIKGNPDFLIIMGTSLKVDGVKQLVKKLSKKIHDRGGLIILVNKTPIGESSWHGIIDYQIHSDCDNWVTFLESQIPDFFKTQDQIKKLRQLKREASDLRKQMKAQKDSIGTPPTTPLRTAQGIDIQGNNELNTKIKSLNTVKRKILSPENSSEEDEEENLDTRKRAKIRPTFGDNQAS |
Nucleotide Sequence
(Fasta) | ATGACTTCAG TATCGCCCTC GCCACCTGCC AGTCGATCGG GCTCAATGTG CTCCGACTTA 60
CCGTCCTCTT TGCAGACTGA GAAACTGGCA CATATTATAG GTCTTGATGC CGACGATGAA 120
GTTCTCCGGC GCGTAACCAA GCAGTTGAGC AGATCTAGGA GAATTGCTTG TCTGACTGGG 180
GCAGGCATTT CGTGCAACGC GGGCATTCCT GACTTTCGCT CTTCTGATGG GCTCTACGAC 240
CTAGTGAAAA AGGATTGTTC ACAGTATTGG TCTATCAAGT CCGGCAGGGA AATGTTTGAT 300
ATTTCGCTAT TTAGAGATGA CTTCAAAATA TCCATTTTTG CTAAATTTAT GGAGAGGCTC 360
TATTCAAATG TTCAATTGGC AAAGCCGACT AAGACGCACA AGTTCATTGC GCATCTAAAA 420
GATAGGAACA AACTGCTGCG CTGTTACACG CAAAACATCG ATGGGCTCGA AGAAAGCATA 480
GGACTTACTT TATCAAATAG GAAATTACCG CTTACCTCAT TTAGTTCACA TTGGAAAAAT 540
CTGGATGTCG TTCAGTTGCA CGGCGACCTG AAAACTCTTT CGTGTACAAA GTGCTTCCAG 600
ACTTTTCCCT GGAGCAGGTA CTGGTCTCGT TGTCTAAGAA GAGGTGAGTT ACCATTGTGT 660
CCGGATTGCG AAGCACTTAT CAACAAGAGA TTGAATGAAG GAAAGCGAAC TCTTGGTTCT 720
AATGTGGGTA TTCTAAGACC TAATATCGTC CTGTATGGTG AAAACCATCC ATCCTGTGAA 780
ATTATTACGC AAGGCCTAAA TCTTGACATA ATTAAAGGCA ATCCTGATTT TTTGATCATC 840
ATGGGTACAA GTTTGAAAGT TGATGGTGTG AAACAACTGG TAAAAAAATT AAGTAAGAAA 900
ATTCACGATC GTGGCGGCCT GATCATTCTC GTAAACAAGA CACCCATTGG CGAATCCTCT 960
TGGCACGGCA TTATAGACTA CCAAATCCAC TCAGATTGTG ATAATTGGGT CACATTTCTT 1020
GAATCCCAAA TACCAGATTT CTTCAAGACG CAAGATCAAA TTAAGAAGTT AAGACAGTTA 1080
AAAAGGGAGG CGAGCGACTT GAGAAAGCAA ATGAAGGCCC AAAAAGACTC AATCGGAACC 1140
CCCCCAACAA CCCCTCTACG AACTGCCCAG GGGATTGATA TTCAAGGAAA CAACGAATTG 1200
AATACAAAAA TAAAGTCGTT AAACACAGTT AAGAGAAAAA TACTGTCACC AGAAAACTCC 1260
AGTGAGGAAG ACGAAGAGGA AAACTTGGAT ACAAGAAAAC GCGCTAAGAT ACGACCAACT 1320
TTCGGTGACA ACCAAGCCTC ATAA
1345Nucleotide Fasta Sequence
>YOR025W|SIR2|Saccharomyces cerevisiae
ATGACTTCAGTATCGCCCTCGCCACCTGCCAGTCGATCGGGCTCAATGTGCTCCGACTTACCGTCCTCTTTGCAGACTGAGAAACTGGCACATATTATAGGTCTTGATGCCGACGATGAAGTTCTCCGGCGCGTAACCAAGCAGTTGAGCAGATCTAGGAGAATTGCTTGTCTGACTGGGGCAGGCATTTCGTGCAACGCGGGCATTCCTGACTTTCGCTCTTCTGATGGGCTCTACGACCTAGTGAAAAAGGATTGTTCACAGTATTGGTCTATCAAGTCCGGCAGGGAAATGTTTGATATTTCGCTATTTAGAGATGACTTCAAAATATCCATTTTTGCTAAATTTATGGAGAGGCTCTATTCAAATGTTCAATTGGCAAAGCCGACTAAGACGCACAAGTTCATTGCGCATCTAAAAGATAGGAACAAACTGCTGCGCTGTTACACGCAAAACATCGATGGGCTCGAAGAAAGCATAGGACTTACTTTATCAAATAGGAAATTACCGCTTACCTCATTTAGTTCACATTGGAAAAATCTGGATGTCGTTCAGTTGCACGGCGACCTGAAAACTCTTTCGTGTACAAAGTGCTTCCAGACTTTTCCCTGGAGCAGGTACTGGTCTCGTTGTCTAAGAAGAGGTGAGTTACCATTGTGTCCGGATTGCGAAGCACTTATCAACAAGAGATTGAATGAAGGAAAGCGAACTCTTGGTTCTAATGTGGGTATTCTAAGACCTAATATCGTCCTGTATGGTGAAAACCATCCATCCTGTGAAATTATTACGCAAGGCCTAAATCTTGACATAATTAAAGGCAATCCTGATTTTTTGATCATCATGGGTACAAGTTTGAAAGTTGATGGTGTGAAACAACTGGTAAAAAAATTAAGTAAGAAAATTCACGATCGTGGCGGCCTGATCATTCTCGTAAACAAGACACCCATTGGCGAATCCTCTTGGCACGGCATTATAGACTACCAAATCCACTCAGATTGTGATAATTGGGTCACATTTCTTGAATCCCAAATACCAGATTTCTTCAAGACGCAAGATCAAATTAAGAAGTTAAGACAGTTAAAAAGGGAGGCGAGCGACTTGAGAAAGCAAATGAAGGCCCAAAAAGACTCAATCGGAACCCCCCCAACAACCCCTCTACGAACTGCCCAGGGGATTGATATTCAAGGAAACAACGAATTGAATACAAAAATAAAGTCGTTAAACACAGTTAAGAGAAAAATACTGTCACCAGAAAACTCCAGTGAGGAAGACGAAGAGGAAAACTTGGATACAAGAAAACGCGCTAAGATACGACCAACTTTCGGTGACAACCAAGCCTCATAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0006348--P:chromatin silencing at telomere
GO:0016575--P:histone deacetylation
GO:0046459--P:short-chain fatty acid metabolic process
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
