WERAM Information

Tag Content
WERAM ID WERAM-Sac-0035
Ensembl Protein ID YMR127C
Uniprot Accession P40963; SAS2_YEAST; D6VZV0
Genbank Protein ID NP_013846.1
Protein Name Histone acetyltransferase SAS2
Genbank Nucleotide ID NM_001182628.1
Gene Name SAS2,ESO1;YMR127C;YM9553.03C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YMR127C YMR127C YMR127C
Details
Type Family Domain Substrates AA References (PMIDs)
HAT MYST MYST-type HAT H3K14; H4K16 K 26260510
Status Reviewed
Classification
Type Family E-value Score Start End
HAT MYST 1.20e-95 318.4 46 337
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)		 Histone acetyltransferase (HAT) subunit of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing and G0 control.
Domain Profile
  HAT MYST
  MYST.txt   2 kvkniekielg.kyeiktwyssp..fpeelkklkk...................lyicefclkytkskeslkrhlkkCklrkp.Pgneiyrkdklsvfevd 79 
               +++ni++i++g +++++twy s+  f++e+k+l +                   l++ce+c+kyt++++++  h+++C ++++ Pg+ +y++ ++++++v+
   YMR127C  46 NERNIRQIQFGlNKKFSTWYGSAvyFDPETKRLGCsetkgqlssvsnsqywldtLFVCEYCFKYTDDQTRFVGHVASCPFQYRvPGKIKYKSPEYTIRRVK 146
               579********************99*********************************************************99***************** PP
  MYST.txt  80 GkkqklycqnlCllaklfldhktlyydvepflFYvltetdekgahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekPL 180
               G+k++l+cq+lCl++kl+ld+k++y++v+++ FY+++et +  ++ +G+Fsk+  s++++nlaCil++Ppyqr+G+G lLiefsY+ls+ eg+i++Pe PL
   YMR127C 147 GSKYQLFCQCLCLFTKLYLDNKSMYFKVDHYEFYIVYETGS--TKPMGFFSKDLVSYQQNNLACILIFPPYQRRGLGLLLIEFSYKLSQLEGVISGPEVPL 245
               ***************************************99..99******************************************************** PP
  MYST.txt 181 sdlgllsYrsyWkevllell..kekeekkkitikelskatgiaveDivstleslnlikekkgqyillksekiveellklakskkkklkvdeeklkwk 275
               s++gl++Y++yW+++l+++l   + ++++k+t+++ls +tg++v+D++ tl++ln+i e++ q++l    ++++++lkl+ +k++++k+++e+l ++
   YMR127C 246 SPFGLIGYLKYWSQILCWHLieGDLAHYDKVTLEDLSIVTGMRVNDVILTLKHLNCIGENN-QIYL----QSLNSWLKLHGTKRNWFKLKDEYLLID 337
               ********************98899*********************************998.7777....899********************9876 PP
Protein Sequence
(Fasta)		MARSLSQSLT ATTQKLKGKK NGGKGKNKPS AKIKKTQKEM LYGILNERNI RQIQFGLNKK 60
FSTWYGSAVY FDPETKRLGC SETKGQLSSV SNSQYWLDTL FVCEYCFKYT DDQTRFVGHV 120
ASCPFQYRVP GKIKYKSPEY TIRRVKGSKY QLFCQCLCLF TKLYLDNKSM YFKVDHYEFY 180
IVYETGSTKP MGFFSKDLVS YQQNNLACIL IFPPYQRRGL GLLLIEFSYK LSQLEGVISG 240
PEVPLSPFGL IGYLKYWSQI LCWHLIEGDL AHYDKVTLED LSIVTGMRVN DVILTLKHLN 300
CIGENNQIYL QSLNSWLKLH GTKRNWFKLK DEYLLIDD 338
Nucleotide Sequence
(Fasta)		ATGGCAAGAT CTTTAAGTCA ATCACTCACA GCGACTACCC AGAAGCTAAA AGGAAAGAAG 60
AATGGTGGAA AAGGCAAGAA TAAGCCCTCA GCAAAAATTA AAAAAACTCA AAAAGAGATG 120
CTATATGGAA TACTGAACGA AAGGAACATA AGACAGATTC AGTTTGGACT GAATAAAAAA 180
TTCTCTACTT GGTATGGGAG CGCCGTTTAT TTCGATCCTG AAACAAAAAG GCTAGGGTGC 240
TCCGAGACCA AGGGTCAGCT TTCCTCTGTT TCTAACAGCC AATACTGGCT AGACACTCTT 300
TTCGTTTGTG AATACTGCTT CAAATACACG GATGATCAGA CGCGGTTTGT AGGACATGTT 360
GCAAGTTGTC CATTTCAATA TCGTGTTCCA GGCAAAATAA AATACAAGAG TCCTGAATAT 420
ACAATAAGAA GAGTAAAAGG ATCCAAGTAT CAACTCTTTT GCCAATGTCT TTGTCTTTTC 480
ACTAAGCTAT ATCTGGACAA TAAATCCATG TATTTCAAAG TAGATCATTA TGAATTTTAC 540
ATAGTTTATG AAACTGGATC AACAAAGCCG ATGGGATTCT TTTCGAAAGA TTTAGTGTCA 600
TATCAGCAAA ATAATCTAGC GTGCATCTTG ATATTTCCCC CATATCAACG ACGTGGATTA 660
GGCCTTTTAC TTATCGAGTT TTCATACAAA CTATCCCAAT TAGAAGGTGT AATATCAGGG 720
CCAGAAGTAC CGTTATCACC TTTTGGACTA ATCGGGTACT TGAAATATTG GTCACAGATA 780
CTCTGTTGGC ACCTTATTGA AGGTGACCTC GCCCATTATG ATAAAGTGAC CCTGGAGGAT 840
CTTTCCATCG TGACTGGAAT GAGAGTCAAT GATGTTATTT TGACCTTGAA GCACTTGAAC 900
TGTATTGGGG AGAATAACCA AATTTACTTG CAGTCATTGA ATAGCTGGTT GAAACTACAT 960
GGAACAAAAC GGAATTGGTT CAAATTAAAA GATGAATATT TGCTGATAGA TGACTAG 1018
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0012--Acyltransferase
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR002717--HAT_MYST-type
PROSITE

PS51726--MYST_HAT
Pfam

PF01853--MOZ_SAS
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0000784--C:nuclear chromosome, telomeric region
GO:0033255--C:SAS acetyltransferase complex
GO:0016407--F:acetyltransferase activity
GO:0004402--F:histone acetyltransferase activity
GO:0046872--F:metal ion binding
GO:0006348--P:chromatin silencing at telomere
GO:0016573--P:histone acetylation
GO:0043486--P:histone exchange
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Drm-0017 FBpp0070794 Drosophila melanogaster 35 1e-40 164
WERAM-Gaa-0150 ENSGACP00000019702.1 Gasterosteus aculeatus 41 8e-40 161
WERAM-Orn-0115 ENSONIP00000011877.1 Oreochromis niloticus 41 1e-39 161
WERAM-Dar-0067 ENSDARP00000122112.1 Danio rerio 41 1e-39 160
WERAM-Tar-0038 ENSTRUP00000009260.1 Takifugu rubripes 41 2e-39 160
WERAM-Xet-0014 ENSXETP00000004144.3 Xenopus tropicalis 41 2e-39 160
WERAM-Ten-0134 ENSTNIP00000014236.1 Tetraodon nigroviridis 41 2e-39 160
WERAM-Caj-0030 ENSCJAP00000005688.2 Callithrix jacchus 41 2e-39 160
WERAM-Anc-0070 ENSACAP00000006585.3 Anolis carolinensis 41 2e-39 160
WERAM-Gog-0152 ENSGGOP00000013275.2 Gorilla gorilla 41 2e-39 160
WERAM-Dio-0025 ENSDORP00000002820.1 Dipodomys ordii 41 2e-39 160
WERAM-Dan-0141 ENSDNOP00000026127.1 Dasypus novemcinctus 41 2e-39 160
WERAM-Otg-0153 ENSOGAP00000012952.2 Otolemur garnettii 41 2e-39 160
WERAM-Mae-0130 ENSMEUP00000013085.1 Macropus eugenii 41 2e-39 160
WERAM-Sus-0053 ENSSSCP00000008290.2 Sus scrofa 41 2e-39 160
WERAM-Mim-0016 ENSMICP00000001475.1 Microcebus murinus 41 2e-39 160
WERAM-Paa-0179 ENSPANP00000012576.1 Papio anubis 41 2e-39 160
WERAM-Chs-0062 ENSCSAP00000002043.1 Chlorocebus sabaeus 41 2e-39 160
WERAM-Fec-0033 ENSFCAP00000002400.3 Felis catus 41 2e-39 160
WERAM-Ptv-0023 ENSPVAP00000002916.1 Pteropus vampyrus 41 2e-39 160
WERAM-Myl-0050 ENSMLUP00000004352.2 Myotis lucifugus 41 2e-39 160
WERAM-Bot-0102 ENSBTAP00000013893.4 Bos taurus 41 2e-39 160
WERAM-Pes-0072 ENSPSIP00000008910.1 Pelodiscus sinensis 41 2e-39 160
WERAM-Hos-0066 ENSP00000219797.3 Homo sapiens 41 3e-39 159
WERAM-Tut-0176 ENSTTRP00000014739.1 Tursiops truncatus 41 3e-39 159
WERAM-Caf-0176 ENSCAFP00000024765.3 Canis familiaris 41 3e-39 159
WERAM-Eqc-0152 ENSECAP00000016311.1 Equus caballus 41 3e-39 159
WERAM-Ran-0127 ENSRNOP00000026527.3 Rattus norvegicus 41 3e-39 159
WERAM-Prc-0082 ENSPCAP00000007073.1 Procavia capensis 41 3e-39 159
WERAM-Cap-0007 ENSCPOP00000000899.2 Cavia porcellus 41 3e-39 159
WERAM-Aim-0083 ENSAMEP00000007621.1 Ailuropoda melanoleuca 41 3e-39 159
WERAM-Mum-0113 ENSMUSP00000033070.7 Mus musculus 41 3e-39 159
WERAM-Mod-0021 ENSMODP00000002268.2 Monodelphis domestica 41 3e-39 159
WERAM-Orla-0015 ENSORLP00000001403.1 Oryzias latipes 41 3e-39 159
WERAM-Poa-0066 ENSPPYP00000008256.2 Pongo abelii 41 3e-39 159
WERAM-Sah-0128 ENSSHAP00000013730.1 Sarcophilus harrisii 41 3e-39 159
WERAM-Ict-0010 ENSSTOP00000000580.2 Ictidomys tridecemlineatus 41 3e-39 159
WERAM-Xim-0019 ENSXMAP00000001783.1 Xiphophorus maculatus 40 3e-39 159
WERAM-Pof-0237 ENSPFOP00000019737.2 Poecilia formosa 40 4e-39 159
WERAM-Tub-0141 ENSTBEP00000015132.1 Tupaia belangeri 41 5e-39 159
WERAM-Cii-0076 ENSCINP00000035214.1 Ciona intestinalis 40 5e-39 159
WERAM-Orc-0016 ENSOCUP00000001983.2 Oryctolagus cuniculus 40 1e-38 157
WERAM-Nol-0176 ENSNLEP00000019626.1 Nomascus leucogenys 40 3e-38 156
WERAM-Asm-0039 ENSAMXP00000004916.1 Astyanax mexicanus 35 3e-38 156
WERAM-Leo-0031 ENSLOCP00000005426.1 Lepisosteus oculatus 33 5e-38 155
WERAM-Pem-0095 ENSPMAP00000009877.1 Petromyzon marinus 39 6e-38 155
WERAM-Miv-0035 MVLG_05264T0 Microbotryum violaceum 35 6e-38 155
WERAM-Ova-0091 ENSOARP00000009388.1 Ovis aries 40 1e-37 154
WERAM-Nec-0023 EFNCRP00000004537 Neurospora crassa 36 2e-37 154
WERAM-Fuo-0033 FOXG_11372P0 Fusarium oxysporum 38 2e-37 154
WERAM-Kop-0021 CAY69704 Komagataella pastoris 31 6e-37 152
WERAM-Mao-0013 MGG_04615T0 Magnaporthe oryzae 36 6e-37 152
WERAM-Ora-0060 ENSOANP00000009404.2 Ornithorhynchus anatinus 33 7e-37 151
WERAM-Cae-0044 K03D10.3 Caenorhabditis elegans 35 7e-37 151
WERAM-Lac-0049 ENSLACP00000007072.1 Latimeria chalumnae 32 7e-37 151
WERAM-Pyt-0015 EFQ92495 Pyrenophora teres 39 9e-37 151
WERAM-Pytr-0028 EDU42207 Pyrenophora triticirepentis 39 9e-37 151
WERAM-Map-0029 MAPG_08226T0 Magnaporthe poae 36 1e-36 151
WERAM-Lem-0041 CBX89959 Leptosphaeria maculans 38 2e-36 150
WERAM-Loa-0148 ENSLAFP00000013105.3 Loxodonta africana 36 2e-36 150
WERAM-Cym-0016 CML102CT Cyanidioschyzon merolae 38 2e-36 150
WERAM-Gam-0003 ENSGMOP00000000211.1 Gadus morhua 33 3e-36 150
WERAM-Ved-0036 EGY20514 Verticillium dahliae 35 3e-36 149
WERAM-Trv-0027 EHK15825 Trichoderma virens 35 3e-36 149
WERAM-Mup-0131 ENSMPUP00000011528.1 Mustela putorius furo 36 3e-36 149
WERAM-Pat-0029 ENSPTRP00000006709.4 Pan troglodytes 36 4e-36 149
WERAM-Php-0014 PP1S13_111V6.1 Physcomitrella patens 36 6e-36 148
WERAM-Ast-0028 CADATEAP00008199 Aspergillus terreus 40 6e-36 148
WERAM-Gag-0004 GGTG_01203T0 Gaeumannomyces graminis 35 7e-36 148
WERAM-Osl-0035 ABO97822 Ostreococcus lucimarinus 32 7e-36 148
WERAM-Ocp-0075 ENSOPRP00000006602.1 Ochotona princeps 32 8e-36 148
WERAM-Meg-0019 ENSMGAP00000001561.1 Meleagris gallopavo 32 1e-35 147
WERAM-Trr-0011 EGR51829 Trichoderma reesei 35 1e-35 147
WERAM-Gaga-0100 ENSGALP00000016147.4 Gallus gallus 32 1e-35 147
WERAM-Phn-0034 SNOT_16501 Phaeosphaeria nodorum 38 1e-35 147
WERAM-Anp-0058 ENSAPLP00000006419.1 Anas platyrhynchos 32 1e-35 147
WERAM-Coi-0003 EAS35401 Coccidioides immitis 39 2e-35 147
WERAM-Fia-0073 ENSFALP00000005432.1 Ficedula albicollis 32 3e-35 146
WERAM-Chg-0038 EAQ84933 Chaetomium globosum 35 3e-35 146
WERAM-Art-0151 AT5G64610.1 Arabidopsis thaliana 38 3e-35 146
WERAM-Ors-0074 OS07T0626600-01 Oryza sativa 34 3e-35 146
WERAM-Orr-0084 ORUFI07G24020.1 Oryza rufipogon 34 3e-35 146
WERAM-Orni-0080 ONIVA07G22490.1 Oryza nivara 34 3e-35 146
WERAM-Orm-0076 OMERI07G19290.1 Oryza meridionalis 34 3e-35 146
WERAM-Sob-0038 Sb02g039960.1 Sorghum bicolor 34 3e-35 146
WERAM-Sei-0114 Si029855m Setaria italica 34 3e-35 146
WERAM-Orb-0081 OBART07G22890.1 Oryza barthii 34 3e-35 146
WERAM-Ori-0077 BGIOSGA023877-PA Oryza indica 34 3e-35 146
WERAM-Org-0080 ORGLA07G0178500.1 Oryza glaberrima 34 3e-35 146
WERAM-Brr-0190 Bra037784.1-P Brassica rapa 38 3e-35 146
WERAM-Orp-0078 OPUNC07G21500.1 Oryza punctata 37 3e-35 146
WERAM-Arl-0115 fgenesh2_kg.8__ 2489__ AT5G64610.1 Arabidopsis lyrata 38 3e-35 146
WERAM-Zem-0033 GRMZM2G044126_P01 Zea mays 34 3e-35 146
WERAM-Orgl-0078 OGLUM07G22920.1 Oryza glumaepatula 34 3e-35 146
WERAM-Orbr-0089 OB07G28490.1 Oryza brachyantha 37 3e-35 146
WERAM-Cis-0037 ENSCSAVP00000008033.1 Ciona savignyi 35 4e-35 145
WERAM-Asc-0035 CADACLAP00008330 Aspergillus clavatus 39 4e-35 145
WERAM-Zyt-0007 Mycgr3P110775 Zymoseptoria tritici 32 5e-35 145
WERAM-Asfu-0016 CADAFUAP00003874 Aspergillus fumigatus 40 6e-35 145
WERAM-Brd-0008 BRADI1G20770.1 Brachypodium distachyon 34 7e-35 145
WERAM-Orl-0045 KN538920.1_FGP012 Oryza longistaminata 34 7e-35 145
WERAM-Tra-0047 Traes_2AS_72EE169B7.1 Triticum aestivum 34 7e-35 145
WERAM-Scj-0015 EEB07085 Schizosaccharomyces japonicus 33 7e-35 145
WERAM-Aet-0100 EMT32375 Aegilops tauschii 34 7e-35 145
WERAM-Lep-0080 LPERR07G19900.1 Leersia perrieri 34 8e-35 145
WERAM-Tru-0098 TRIUR3_34388-P1 Triticum urartu 34 8e-35 145
WERAM-Amt-0019 ERM94321 Amborella trichopoda 37 1e-34 144
WERAM-Hov-0011 MLOC_12053.1 Hordeum vulgare 34 1e-34 144
WERAM-Bro-0183 Bo9g173870.1 Brassica oleracea 37 1e-34 144
Created Date 25-Jun-2016