| Tag |
Content |
| WERAM ID |
WERAM-Art-0151 |
| Ensembl Protein ID |
AT5G64610.1 |
| Uniprot Accession |
Q9FLF7; MYST1_ARATH; C0SVV9
|
| Genbank Protein ID |
NP_201266.1
|
| Protein Name |
Histone acetyltransferase of the MYST family 1 |
| Genbank Nucleotide ID |
NM_125857.2
|
| Gene Name |
HAM1;MYST1;HAG4;At5g64610;MUB3.13 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HAT |
MYST |
MYST-type HAT |
H4K5 |
K |
24653661
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HAT |
MYST |
5.00e-126 |
420.4 |
170 |
440 |
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
Histone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). |
Histone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925).
|
| Domain Profile |
HAT MYST
MYST.txt 2 kvkniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnlCllaklfld 99
kvkni +ielgkyei+twy+spfp+e++++ kl++cefcl+++k+ke+l+rh++kC+l++pPg+eiyr+++ls+fevdGkk+k+y+qnlC+laklfld
AT5G64610.1 170 KVKNIATIELGKYEIETWYFSPFPPEYNDCVKLFFCEFCLSFMKRKEQLQRHMRKCDLKHPPGDEIYRSSTLSMFEVDGKKNKVYAQNLCYLAKLFLD 267
799*********************************************************************************************** PP
MYST.txt 100 hktlyydvepflFYvltetdekgahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekPLsdlgllsYrsyWkevll 197
hktlyydv+ flFY+l+e+d++g+h+vGyFskek+s+e+ynlaCil+lPpyqrkGyGk+Li+fsYels+kegk+g+Pe+PLsdlgl+sYr yW+++ll
AT5G64610.1 268 HKTLYYDVDLFLFYILCECDDRGCHMVGYFSKEKHSEEAYNLACILTLPPYQRKGYGKFLIAFSYELSKKEGKVGTPERPLSDLGLVSYRGYWTRILL 365
************************************************************************************************** PP
MYST.txt 198 ellkekeekkkitikelskatgiaveDivstleslnlikekkgqyillksekiveellklakskkkklkvdeeklkwkp 276
++l k++k +i+ikels++t+i++eDi+stl+sl+li+++kgq++++++ k+++++lk+a + l+vd +k+ w+p
AT5G64610.1 366 DIL--KKHKGNISIKELSDMTAIKAEDILSTLQSLELIQYRKGQHVICADPKVLDRHLKAAG--RGGLDVDVSKMIWTP 440
***..89999***********************************************88887..889999999999987 PP
|
Protein Sequence
(Fasta) | MGSSADTETA MIIATPASNH NNPATNGGDA NQNHTSGAIL ALTNSESDAS KKRRMGVLPL 60
EVGTRVMCQW RDGKYHPVKV IERRKNYNGG HNDYEYYVHY TEFNRRLDEW IKLEQLDLDS 120
VECALDEKVE DKVTSLKMTR HQKRKIDETH VEGHEELDAA SLREHEEFTK VKNIATIELG 180
KYEIETWYFS PFPPEYNDCV KLFFCEFCLS FMKRKEQLQR HMRKCDLKHP PGDEIYRSST 240
LSMFEVDGKK NKVYAQNLCY LAKLFLDHKT LYYDVDLFLF YILCECDDRG CHMVGYFSKE 300
KHSEEAYNLA CILTLPPYQR KGYGKFLIAF SYELSKKEGK VGTPERPLSD LGLVSYRGYW 360
TRILLDILKK HKGNISIKEL SDMTAIKAED ILSTLQSLEL IQYRKGQHVI CADPKVLDRH 420
LKAAGRGGLD VDVSKMIWTP YKEQS 445Protein Fasta Sequence
>AT5G64610.1|HAM1;MYST1;HAG4;At5g64610;MUB3.13|Arabidopsis thaliana
MGSSADTETAMIIATPASNHNNPATNGGDANQNHTSGAILALTNSESDASKKRRMGVLPLEVGTRVMCQWRDGKYHPVKVIERRKNYNGGHNDYEYYVHYTEFNRRLDEWIKLEQLDLDSVECALDEKVEDKVTSLKMTRHQKRKIDETHVEGHEELDAASLREHEEFTKVKNIATIELGKYEIETWYFSPFPPEYNDCVKLFFCEFCLSFMKRKEQLQRHMRKCDLKHPPGDEIYRSSTLSMFEVDGKKNKVYAQNLCYLAKLFLDHKTLYYDVDLFLFYILCECDDRGCHMVGYFSKEKHSEEAYNLACILTLPPYQRKGYGKFLIAFSYELSKKEGKVGTPERPLSDLGLVSYRGYWTRILLDILKKHKGNISIKELSDMTAIKAEDILSTLQSLELIQYRKGQHVICADPKVLDRHLKAAGRGGLDVDVSKMIWTPYKEQS |
Nucleotide Sequence
(Fasta) | ATCTCCGACC CGACTAAAGA AATGGGATCG TCTGCGGATA CAGAGACGGC GATGATAATC 60
GCCACACCGG CGTCGAACCA TAATAATCCG GCAACCAACG GCGGAGATGC GAATCAGAAT 120
CATACTTCTG GTGCGATACT CGCTCTCACG AATTCAGAAT CGGATGCTTC GAAGAAGAGA 180
AGAATGGGGG TGCTTCCGCT CGAGGTTGGT ACTCGCGTGA TGTGTCAATG GAGAGACGGA 240
AAATACCATC CGGTGAAGGT TATCGAGCGC CGAAAGAATT ATAATGGTGG TCACAATGAT 300
TACGAGTACT ACGTTCATTA CACAGAGTTT AATAGAAGAT TGGATGAATG GATTAAGCTT 360
GAACAGCTTG ACCTTGATTC AGTAGAGTGT GCTTTAGATG AAAAAGTTGA AGACAAGGTG 420
ACTAGCTTGA AGATGACACG ACACCAGAAA CGGAAGATTG ATGAGACTCA TGTAGAGGGT 480
CATGAAGAGC TGGATGCTGC CAGTTTGCGT GAACACGAGG AGTTCACGAA AGTGAAGAAC 540
ATAGCTACGA TTGAGCTTGG GAAGTATGAG ATTGAGACGT GGTACTTCTC TCCTTTTCCT 600
CCAGAATACA ATGACTGCGT GAAGCTCTTT TTCTGTGAGT TTTGCCTCAG TTTTATGAAG 660
CGCAAAGAGC AGCTTCAAAG ACATATGAGG AAATGCGATT TGAAGCACCC CCCTGGGGAT 720
GAAATCTATC GAAGCTCTAC TTTGTCAATG TTTGAGGTGG ATGGCAAGAA GAATAAGGTC 780
TATGCACAGA ACCTCTGTTA TCTGGCAAAG TTATTTCTTG ACCACAAAAC TCTTTACTAT 840
GACGTTGATT TGTTCCTGTT CTATATTCTC TGTGAATGTG ATGATCGTGG ATGCCACATG 900
GTTGGATACT TTTCAAAGGA AAAACACTCA GAAGAAGCTT ACAACTTGGC TTGCATCCTT 960
ACACTTCCTC CATATCAAAG GAAGGGCTAT GGCAAATTCT TAATAGCCTT CTCCTATGAA 1020
CTCTCAAAGA AAGAGGGCAA AGTCGGGACA CCGGAAAGGC CGCTCTCTGA TCTAGGGTTA 1080
GTGAGTTACA GAGGTTACTG GACTCGGATT TTATTAGACA TTTTGAAAAA GCACAAGGGA 1140
AACATATCTA TCAAGGAGCT GAGCGACATG ACAGCGATTA AAGCAGAAGA TATATTAAGC 1200
ACCCTGCAGA GCTTGGAACT GATACAATAC AGGAAAGGAC AACACGTAAT CTGCGCGGAT 1260
CCTAAGGTAC TGGACCGACA CTTGAAAGCG GCAGGCCGAG GTGGTCTTGA TGTGGATGTG 1320
AGCAAAATGA TATGGACTCC TTACAAAGAG CAGAGCTAAG AGGGCATTAC ACTTCAAATA 1380
GTTATGGTTA TGGTCTACTT TTAATCTGCA TATCCTTAGA TGACTTTTGT CTGTAACAAT 1440
TTAACACGCA CTCTGTTCAA TAGATCTTGT AACTGTAGGA ATCTTTTGTC TGGATGGTAA 1500
AACGATCAGT AGTAACTTTG GTGTTTCATT CT
1533Nucleotide Fasta Sequence
>AT5G64610.1|MYST|Arabidopsis thaliana
ATCTCCGACCCGACTAAAGAAATGGGATCGTCTGCGGATACAGAGACGGCGATGATAATCGCCACACCGGCGTCGAACCATAATAATCCGGCAACCAACGGCGGAGATGCGAATCAGAATCATACTTCTGGTGCGATACTCGCTCTCACGAATTCAGAATCGGATGCTTCGAAGAAGAGAAGAATGGGGGTGCTTCCGCTCGAGGTTGGTACTCGCGTGATGTGTCAATGGAGAGACGGAAAATACCATCCGGTGAAGGTTATCGAGCGCCGAAAGAATTATAATGGTGGTCACAATGATTACGAGTACTACGTTCATTACACAGAGTTTAATAGAAGATTGGATGAATGGATTAAGCTTGAACAGCTTGACCTTGATTCAGTAGAGTGTGCTTTAGATGAAAAAGTTGAAGACAAGGTGACTAGCTTGAAGATGACACGACACCAGAAACGGAAGATTGATGAGACTCATGTAGAGGGTCATGAAGAGCTGGATGCTGCCAGTTTGCGTGAACACGAGGAGTTCACGAAAGTGAAGAACATAGCTACGATTGAGCTTGGGAAGTATGAGATTGAGACGTGGTACTTCTCTCCTTTTCCTCCAGAATACAATGACTGCGTGAAGCTCTTTTTCTGTGAGTTTTGCCTCAGTTTTATGAAGCGCAAAGAGCAGCTTCAAAGACATATGAGGAAATGCGATTTGAAGCACCCCCCTGGGGATGAAATCTATCGAAGCTCTACTTTGTCAATGTTTGAGGTGGATGGCAAGAAGAATAAGGTCTATGCACAGAACCTCTGTTATCTGGCAAAGTTATTTCTTGACCACAAAACTCTTTACTATGACGTTGATTTGTTCCTGTTCTATATTCTCTGTGAATGTGATGATCGTGGATGCCACATGGTTGGATACTTTTCAAAGGAAAAACACTCAGAAGAAGCTTACAACTTGGCTTGCATCCTTACACTTCCTCCATATCAAAGGAAGGGCTATGGCAAATTCTTAATAGCCTTCTCCTATGAACTCTCAAAGAAAGAGGGCAAAGTCGGGACACCGGAAAGGCCGCTCTCTGATCTAGGGTTAGTGAGTTACAGAGGTTACTGGACTCGGATTTTATTAGACATTTTGAAAAAGCACAAGGGAAACATATCTATCAAGGAGCTGAGCGACATGACAGCGATTAAAGCAGAAGATATATTAAGCACCCTGCAGAGCTTGGAACTGATACAATACAGGAAAGGACAACACGTAATCTGCGCGGATCCTAAGGTACTGGACCGACACTTGAAAGCGGCAGGCCGAGGTGGTCTTGATGTGGATGTGAGCAAAATGATATGGACTCCTTACAAAGAGCAGAGCTAAGAGGGCATTACACTTCAAATAGTTATGGTTATGGTCTACTTTTAATCTGCATATCCTTAGATGACTTTTGTCTGTAACAATTTAACACGCACTCTGTTCAATAGATCTTGTAACTGTAGGAATCTTTTGTCTGGATGGTAAAACGATCAGTAGTAACTTTGGTGTTTCATTCT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0007--Acetylation
KW-0010--Activator
KW-0012--Acyltransferase
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR016181--Acyl_CoA_acyltransferase
IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR002717--HAT_MYST-type
IPR025995--Tudor-knot
|
| PROSITE |
PS51726--MYST_HAT
|
| Pfam |
PF01853--MOZ_SAS
PF11717--Tudor-knot
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0004402--F:histone acetyltransferase activity
GO:0043995--F:histone acetyltransferase activity (H4-K5 specific)
GO:0046872--F:metal ion binding
GO:0006281--P:DNA repair
GO:0016573--P:histone acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:2000028--P:regulation of photoperiodism, flowering
GO:0006355--P:regulation of transcription, DNA-templated
GO:0010224--P:response to UV-B
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
