| Tag |
Content |
| WERAM ID |
WERAM-Hos-0066 |
| Ensembl Protein ID |
ENSP00000219797.3 |
| Uniprot Accession |
Q9H7Z6; KAT8_HUMAN; A8K4Z1; G5E9P2; Q659G0; Q7LC17; Q8IY59; Q8WYB4; Q8WZ14; Q9HAC5; Q9NR35
|
| Genbank Protein ID |
NP_115564.2; NP_892003.2
|
| Protein Name |
Histone acetyltransferase KAT8 |
| Genbank Nucleotide ID |
NM_032188.2; NM_182958.2
|
| Gene Name |
KAT8;MOF;MYST1;PP7073 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HAT |
MYST |
MYST-type HAT |
H4K16 |
K |
19698979
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HAT |
MYST |
8.60e-129 |
430.9 |
175 |
447 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'. |
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.
|
| Domain Profile |
HAT MYST
MYST.txt 2 kvkniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnlCll 93
kvk+++ki++g+yei++wy+spfpe++ k++kl++ce+clky+k ++s++ hl +C++r+pPg+eiyrk+++sv+evdGk++k+ycqnlCll
ENSP00000219797.3 175 KVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLL 266
7899**************************************************************************************** PP
MYST.txt 94 aklfldhktlyydvepflFYvltetdekgahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekPLsdlgl 185
aklfldhktly+dvepf+FY+lte d++gah+vGyFskekes + +n+aCil+lPpyqr+GyGk+Li+fsYels+ e+++gsPekPLsdlg+
ENSP00000219797.3 267 AKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGK 358
******************************************************************************************** PP
MYST.txt 186 lsYrsyWkevllellkekeekkkitikelskatgiaveDivstleslnlikekkgqyillksekiveellklakskkkklkvdeeklkwkp 276
lsYrsyW++vlle+l ++ + +++ik+ls++t+i+++Di+stl+sln++k++kgq++++ + k+vee+lk+a+ kk+ ++vd+ +lkw+p
ENSP00000219797.3 359 LSYRSYWSWVLLEIL--RDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAP 447
***************..9999********************************************************************87 PP
|
Protein Sequence
(Fasta) | MAAQGAAAAV AAGTSGVAGE GEPGPGENAA AEGTAPSPGR VSPPTPARGE PEVTVEIGET 60
YLCRRPDSTW HSAEVIQSRV NDQEGREEFY VHYVGFNRRL DEWVDKNRLA LTKTVKDAVQ 120
KNSEKYLSEL AEQPERKITR NQKRKHDEIN HVQKTYAEMD PTTAALEKEH EAITKVKYVD 180
KIHIGNYEID AWYFSPFPED YGKQPKLWLC EYCLKYMKYE KSYRFHLGQC QWRQPPGKEI 240
YRKSNISVYE VDGKDHKIYC QNLCLLAKLF LDHKTLYFDV EPFVFYILTE VDRQGAHIVG 300
YFSKEKESPD GNNVACILTL PPYQRRGYGK FLIAFSYELS KLESTVGSPE KPLSDLGKLS 360
YRSYWSWVLL EILRDFRGTL SIKDLSQMTS ITQNDIISTL QSLNMVKYWK GQHVICVTPK 420
LVEEHLKSAQ YKKPPITVDS VCLKWAPPKH KQVKLSKK 458Protein Fasta Sequence
>ENSP00000219797.3|KAT8;MOF;MYST1;PP7073|Homo sapiens
MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK |
Nucleotide Sequence
(Fasta) | GTCACTTCCC TTCCCGCGAT GGCGGCACAG GGAGCTGCTG CGGCGGTTGC GGCGGGGACT 60
TCAGGGGTCG CGGGGGAGGG CGAGCCCGGG CCCGGGGAGA ATGCGGCCGC TGAGGGGACC 120
GCCCCATCCC CGGGCCGCGT CTCTCCGCCG ACCCCGGCGC GCGGCGAGCC GGAAGTCACG 180
GTGGAGATCG GAGAAACGTA CCTGTGCCGG CGACCGGATA GCACCTGGCA TTCTGCTGAA 240
GTGATCCAGT CTCGAGTGAA CGACCAGGAG GGCCGAGAGG AATTCTATGT ACACTACGTG 300
GGCTTTAACC GGCGGCTGGA CGAGTGGGTA GACAAGAACC GGCTGGCGCT GACCAAGACA 360
GTGAAGGATG CTGTACAGAA GAACTCAGAG AAGTACCTGA GCGAGCTCGC AGAGCAGCCT 420
GAGCGCAAGA TCACTCGCAA CCAAAAGCGC AAGCATGATG AGATCAACCA TGTGCAGAAG 480
ACTTATGCAG AGATGGACCC CACCACAGCA GCCTTGGAGA AGGAGCATGA GGCGATCACC 540
AAGGTGAAGT ATGTGGACAA GATCCACATC GGGAACTACG AAATTGATGC CTGGTATTTC 600
TCACCATTCC CCGAAGACTA TGGGAAACAG CCCAAGCTCT GGCTCTGCGA GTACTGCCTC 660
AAGTACATGA AATATGAGAA GAGCTACCGC TTCCACTTGG GTCAGTGCCA GTGGCGGCAG 720
CCCCCCGGGA AAGAGATCTA CCGCAAGAGC AACATCTCCG TGTACGAAGT TGATGGCAAA 780
GACCATAAGA TTTACTGTCA GAACCTGTGT CTGCTGGCCA AGCTTTTCCT GGACCATAAG 840
ACACTGTACT TTGACGTGGA GCCGTTCGTC TTTTACATCC TGACTGAGGT GGACCGGCAG 900
GGGGCCCACA TTGTTGGCTA CTTCTCCAAG GAGAAGGAGT CCCCGGATGG AAACAATGTG 960
GCCTGCATCC TGACCTTGCC CCCCTACCAA CGCCGCGGCT ACGGGAAGTT CCTCATCGCT 1020
TTCAGTTATG AGCTCTCCAA GCTGGAGAGC ACAGTCGGCT CCCCGGAGAA GCCACTGTCT 1080
GACCTGGGCA AGCTCAGCTA CCGCAGCTAC TGGTCCTGGG TGCTGCTAGA GATCCTGCGG 1140
GACTTCCGGG GCACACTGTC CATCAAGGAC CTCAGCCAGA TGACCAGTAT CACCCAAAAT 1200
GACATCATCA GTACCCTGCA ATCCCTCAAT ATGGTCAAGT ACTGGAAGGG CCAGCACGTG 1260
ATCTGTGTCA CACCCAAGCT GGTGGAGGAG CACCTCAAAA GTGCCCAGTA TAAGAAACCA 1320
CCCATCACAG TGGACTCCGT CTGCCTCAAG TGGGCACCCC CCAAGCACAA GCAAGTCAAG 1380
CTCTCCAAGA AGTGAGCAGC CTGGCCCCTG CTGTCGGACC TGAGCCTCCT GGCTCCCAGC 1440
CTGTAAATAT GTATAGACCT GTTTTGTCAT TTTTTTAATA AAGTCAGTTC TGGTGGCCCT 1500
GGACTTTGGA GGGGAAGGGG AGGCC
1526Nucleotide Fasta Sequence
>ENSP00000219797.3|MYST|Homo sapiens
GTCACTTCCCTTCCCGCGATGGCGGCACAGGGAGCTGCTGCGGCGGTTGCGGCGGGGACTTCAGGGGTCGCGGGGGAGGGCGAGCCCGGGCCCGGGGAGAATGCGGCCGCTGAGGGGACCGCCCCATCCCCGGGCCGCGTCTCTCCGCCGACCCCGGCGCGCGGCGAGCCGGAAGTCACGGTGGAGATCGGAGAAACGTACCTGTGCCGGCGACCGGATAGCACCTGGCATTCTGCTGAAGTGATCCAGTCTCGAGTGAACGACCAGGAGGGCCGAGAGGAATTCTATGTACACTACGTGGGCTTTAACCGGCGGCTGGACGAGTGGGTAGACAAGAACCGGCTGGCGCTGACCAAGACAGTGAAGGATGCTGTACAGAAGAACTCAGAGAAGTACCTGAGCGAGCTCGCAGAGCAGCCTGAGCGCAAGATCACTCGCAACCAAAAGCGCAAGCATGATGAGATCAACCATGTGCAGAAGACTTATGCAGAGATGGACCCCACCACAGCAGCCTTGGAGAAGGAGCATGAGGCGATCACCAAGGTGAAGTATGTGGACAAGATCCACATCGGGAACTACGAAATTGATGCCTGGTATTTCTCACCATTCCCCGAAGACTATGGGAAACAGCCCAAGCTCTGGCTCTGCGAGTACTGCCTCAAGTACATGAAATATGAGAAGAGCTACCGCTTCCACTTGGGTCAGTGCCAGTGGCGGCAGCCCCCCGGGAAAGAGATCTACCGCAAGAGCAACATCTCCGTGTACGAAGTTGATGGCAAAGACCATAAGATTTACTGTCAGAACCTGTGTCTGCTGGCCAAGCTTTTCCTGGACCATAAGACACTGTACTTTGACGTGGAGCCGTTCGTCTTTTACATCCTGACTGAGGTGGACCGGCAGGGGGCCCACATTGTTGGCTACTTCTCCAAGGAGAAGGAGTCCCCGGATGGAAACAATGTGGCCTGCATCCTGACCTTGCCCCCCTACCAACGCCGCGGCTACGGGAAGTTCCTCATCGCTTTCAGTTATGAGCTCTCCAAGCTGGAGAGCACAGTCGGCTCCCCGGAGAAGCCACTGTCTGACCTGGGCAAGCTCAGCTACCGCAGCTACTGGTCCTGGGTGCTGCTAGAGATCCTGCGGGACTTCCGGGGCACACTGTCCATCAAGGACCTCAGCCAGATGACCAGTATCACCCAAAATGACATCATCAGTACCCTGCAATCCCTCAATATGGTCAAGTACTGGAAGGGCCAGCACGTGATCTGTGTCACACCCAAGCTGGTGGAGGAGCACCTCAAAAGTGCCCAGTATAAGAAACCACCCATCACAGTGGACTCCGTCTGCCTCAAGTGGGCACCCCCCAAGCACAAGCAAGTCAAGCTCTCCAAGAAGTGAGCAGCCTGGCCCCTGCTGTCGGACCTGAGCCTCCTGGCTCCCAGCCTGTAAATATGTATAGACCTGTTTTGTCATTTTTTTAATAAAGTCAGTTCTGGTGGCCCTGGACTTTGGAGGGGAAGGGGAGGCC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR016181--Acyl_CoA_acyltransferase
IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR002717--HAT_MYST-type
IPR025995--Tudor-knot
|
| PROSITE |
PS51726--MYST_HAT
|
| Pfam |
PF01853--MOZ_SAS
PF11717--Tudor-knot
|
| Gene Ontology |
GO:0000123--C:histone acetyltransferase complex
GO:0000776--C:kinetochore
GO:0071339--C:MLL1 complex
GO:0072487--C:MSL complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016407--F:acetyltransferase activity
GO:0004402--F:histone acetyltransferase activity
GO:0046872--F:metal ion binding
GO:0035064--F:methylated histone binding
GO:0008134--F:transcription factor binding
GO:0016573--P:histone acetylation
GO:0043984--P:histone H4-K16 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0030099--P:myeloid cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010506--P:regulation of autophagy
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
