| Tag |
Content |
| WERAM ID |
WERAM-Sac-0012 |
| Ensembl Protein ID |
YER051W |
| Uniprot Accession |
P40034; JHD1_YEAST; D3DLV3
|
| Genbank Protein ID |
NP_010971.1
|
| Protein Name |
JmjC domain-containing histone demethylation protein 1 |
| Genbank Nucleotide ID |
NM_001178942.1
|
| Gene Name |
JHD1;JHDM1;Jhd1;YER051W |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDM |
JHDM1 |
Jmjc |
H3K36me2 |
K |
26821844; 17470555
|
| Me_Reader |
PHD |
PHD-type |
H3K4me |
K |
17142463
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDM |
JHDM1 |
7.70e-75 |
248.6 |
251 |
409 |
| Me_Reader |
PHD |
2.40e-14 |
51.7 |
5 |
71 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Does not demethylate H3 'Lys-4' nor 'Lys-79'. |
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Does not demethylate H3 'Lys-4' nor 'Lys-79'.
|
| Domain Profile |
HDM JHDM1
JHDM1.txt 11 kkpevvrqidlvdnvWpkalkekqtegtnaleemkyPkvqkyclmsvkncytdfhidfgGtsvyyhvlkGskvfwliPpteknlelyeewvlsgkqsdif 110
++p++vrq+dlvd++W+ +++ ++++g++a+e++ +Pkv+ky+lmsvk++ytdfh+df+Gtsvyy+v++G+k+f+l+Ppt++n+++y ew+l+++q+++f
YER051W 251 ERPTAVRQNDLVDKIWSFNGHLEKVNGEKAEENDPKPKVTKYILMSVKDAYTDFHLDFAGTSVYYNVISGQKKFLLFPPTQSNIDKYIEWSLKEDQNSVF 350
79************************************************************************************************** PP
JHDM1.txt 111 lgdrvekcqrvelkagdtlliPsGwihavytPvdslvfgGnflhslniktqlkiyeied 169
lgd++e+++++el+agd+++iP+G+ihavytPvdslvfgGnfl++++++t+lki+eie+
YER051W 351 LGDILEDGIAMELDAGDLFMIPAGYIHAVYTPVDSLVFGGNFLTIRDLETHLKIVEIEK 409
*********************************************************96 PP
Me_Reader PHD
PHD.txt 2 tiClvCg.kddegekemvqCdeCddwfHlkCvklplsslpeg.................kswyCpsCke 52
+iC++C+ kd+ g+ ++v+Cd+C++w+H+kCv+l+ +++++ ks++Cp++ke
YER051W 5 NICQHCQlKDNPGALIWVKCDSCPQWVHVKCVPLK--RIHYSnltssevlsypnsakqiKSYRCPNHKE 71
79****55***************************..555444567788899999999999******96 PP
|
Protein Sequence
(Fasta) | MQDPNICQHC QLKDNPGALI WVKCDSCPQW VHVKCVPLKR IHYSNLTSSE VLSYPNSAKQ 60
IKSYRCPNHK EGEYLTAYAL ITQKGKRQRN KENPEDSHIN KRYNFRKKKL LDYIALNEGE 120
SKRDKMNHPH KESFMKSFEK WKNGSNIINA ADFAEKFDNI DVPYKIIDPL NSGVYVPNVG 180
TDNGCLTVNY ITEMIGEDYH VDVMDVQSQM NENWNLGSWN EYFTNTEPDR RDRIRNVISL 240
EVSNIEGLEL ERPTAVRQND LVDKIWSFNG HLEKVNGEKA EENDPKPKVT KYILMSVKDA 300
YTDFHLDFAG TSVYYNVISG QKKFLLFPPT QSNIDKYIEW SLKEDQNSVF LGDILEDGIA 360
MELDAGDLFM IPAGYIHAVY TPVDSLVFGG NFLTIRDLET HLKIVEIEKL TKVPRRFTFP 420
KFDQVMGKLC EYLALDKNKI TSDVSDGDLL SRTTNCAIQS LHAYVIKPEV KYKPLNFTSK 480
KHLAKALADL IS 492Protein Fasta Sequence
>YER051W|JHD1;JHDM1;Jhd1;YER051W|Saccharomyces cerevisiae
MQDPNICQHCQLKDNPGALIWVKCDSCPQWVHVKCVPLKRIHYSNLTSSEVLSYPNSAKQIKSYRCPNHKEGEYLTAYALITQKGKRQRNKENPEDSHINKRYNFRKKKLLDYIALNEGESKRDKMNHPHKESFMKSFEKWKNGSNIINAADFAEKFDNIDVPYKIIDPLNSGVYVPNVGTDNGCLTVNYITEMIGEDYHVDVMDVQSQMNENWNLGSWNEYFTNTEPDRRDRIRNVISLEVSNIEGLELERPTAVRQNDLVDKIWSFNGHLEKVNGEKAEENDPKPKVTKYILMSVKDAYTDFHLDFAGTSVYYNVISGQKKFLLFPPTQSNIDKYIEWSLKEDQNSVFLGDILEDGIAMELDAGDLFMIPAGYIHAVYTPVDSLVFGGNFLTIRDLETHLKIVEIEKLTKVPRRFTFPKFDQVMGKLCEYLALDKNKITSDVSDGDLLSRTTNCAIQSLHAYVIKPEVKYKPLNFTSKKHLAKALADLIS |
Nucleotide Sequence
(Fasta) | ATGCAAGATC CCAATATTTG CCAGCATTGC CAGTTGAAGG ATAATCCAGG CGCATTAATT 60
TGGGTGAAGT GTGATAGTTG CCCGCAGTGG GTCCACGTGA AATGCGTGCC TTTGAAACGC 120
ATTCACTATT CAAATCTTAC AAGTTCTGAA GTTCTGTCTT ATCCAAATTC TGCGAAGCAA 180
ATCAAGAGCT ACCGTTGTCC TAATCATAAG GAAGGAGAAT ATCTTACCGC ATACGCTCTC 240
ATCACACAAA AAGGAAAGCG GCAAAGGAAT AAAGAAAACC CTGAAGATAG TCATATAAAT 300
AAGCGGTATA ATTTCAGAAA GAAGAAATTA CTTGACTATA TCGCTTTGAA TGAGGGTGAA 360
TCGAAAAGGG ATAAAATGAA TCACCCTCAT AAGGAGAGTT TCATGAAATC TTTTGAAAAA 420
TGGAAAAATG GCTCAAATAT TATAAACGCC GCTGACTTTG CTGAAAAGTT TGATAATATA 480
GATGTGCCGT ACAAGATCAT CGATCCACTG AATAGCGGAG TATATGTACC GAATGTGGGC 540
ACAGACAATG GATGCCTCAC AGTTAATTAT ATCACCGAAA TGATAGGCGA GGATTATCAT 600
GTTGATGTAA TGGACGTTCA ATCACAAATG AATGAAAATT GGAACTTGGG ATCTTGGAAT 660
GAATATTTTA CAAATACTGA ACCAGACAGG AGGGATCGAA TAAGGAATGT TATATCATTA 720
GAAGTCTCTA ATATTGAGGG ATTAGAACTA GAGAGGCCCA CTGCAGTTAG GCAGAATGAT 780
CTTGTTGATA AAATTTGGAG TTTCAATGGA CATTTAGAAA AAGTCAATGG GGAGAAGGCG 840
GAGGAGAATG ACCCCAAGCC AAAAGTGACC AAATATATTT TGATGTCTGT AAAGGATGCT 900
TATACGGATT TTCATTTGGA TTTTGCCGGT ACCTCTGTTT ATTATAACGT TATCTCAGGA 960
CAGAAGAAGT TTTTATTATT TCCACCTACC CAATCAAACA TAGATAAGTA TATTGAGTGG 1020
TCTTTAAAAG AAGACCAAAA TAGTGTTTTC CTCGGTGATA TTCTTGAGGA TGGTATTGCG 1080
ATGGAATTAG ATGCTGGTGA TTTGTTTATG ATTCCAGCTG GATATATTCA TGCAGTTTAT 1140
ACACCAGTAG ACTCTTTGGT ATTTGGAGGC AACTTTTTAA CCATCCGTGA TTTGGAGACA 1200
CACCTTAAAA TTGTGGAAAT TGAAAAGTTA ACAAAGGTTC CTAGAAGATT TACCTTCCCG 1260
AAGTTTGATC AAGTGATGGG TAAATTATGC GAGTATCTTG CGCTTGATAA AAATAAAATC 1320
ACTAGTGATG TCAGTGATGG GGATTTGCTT TCCAGGACCA CTAATTGCGC AATTCAATCA 1380
CTTCATGCAT ACGTTATAAA ACCTGAAGTT AAGTACAAGC CGTTAAATTT CACTTCAAAG 1440
AAGCATTTAG CGAAAGCTTT AGCCGATCTT ATTTCGTAA
Nucleotide Fasta Sequence
>YER051W|PHD|Saccharomyces cerevisiae
ATGCAAGATCCCAATATTTGCCAGCATTGCCAGTTGAAGGATAATCCAGGCGCATTAATTTGGGTGAAGTGTGATAGTTGCCCGCAGTGGGTCCACGTGAAATGCGTGCCTTTGAAACGCATTCACTATTCAAATCTTACAAGTTCTGAAGTTCTGTCTTATCCAAATTCTGCGAAGCAAATCAAGAGCTACCGTTGTCCTAATCATAAGGAAGGAGAATATCTTACCGCATACGCTCTCATCACACAAAAAGGAAAGCGGCAAAGGAATAAAGAAAACCCTGAAGATAGTCATATAAATAAGCGGTATAATTTCAGAAAGAAGAAATTACTTGACTATATCGCTTTGAATGAGGGTGAATCGAAAAGGGATAAAATGAATCACCCTCATAAGGAGAGTTTCATGAAATCTTTTGAAAAATGGAAAAATGGCTCAAATATTATAAACGCCGCTGACTTTGCTGAAAAGTTTGATAATATAGATGTGCCGTACAAGATCATCGATCCACTGAATAGCGGAGTATATGTACCGAATGTGGGCACAGACAATGGATGCCTCACAGTTAATTATATCACCGAAATGATAGGCGAGGATTATCATGTTGATGTAATGGACGTTCAATCACAAATGAATGAAAATTGGAACTTGGGATCTTGGAATGAATATTTTACAAATACTGAACCAGACAGGAGGGATCGAATAAGGAATGTTATATCATTAGAAGTCTCTAATATTGAGGGATTAGAACTAGAGAGGCCCACTGCAGTTAGGCAGAATGATCTTGTTGATAAAATTTGGAGTTTCAATGGACATTTAGAAAAAGTCAATGGGGAGAAGGCGGAGGAGAATGACCCCAAGCCAAAAGTGACCAAATATATTTTGATGTCTGTAAAGGATGCTTATACGGATTTTCATTTGGATTTTGCCGGTACCTCTGTTTATTATAACGTTATCTCAGGACAGAAGAAGTTTTTATTATTTCCACCTACCCAATCAAACATAGATAAGTATATTGAGTGGTCTTTAAAAGAAGACCAAAATAGTGTTTTCCTCGGTGATATTCTTGAGGATGGTATTGCGATGGAATTAGATGCTGGTGATTTGTTTATGATTCCAGCTGGATATATTCATGCAGTTTATACACCAGTAGACTCTTTGGTATTTGGAGGCAACTTTTTAACCATCCGTGATTTGGAGACACACCTTAAAATTGTGGAAATTGAAAAGTTAACAAAGGTTCCTAGAAGATTTACCTTCCCGAAGTTTGATCAAGTGATGGGTAAATTATGCGAGTATCTTGCGCTTGATAAAAATAAAATCACTAGTGATGTCAGTGATGGGGATTTGCTTTCCAGGACCACTAATTGCGCAATTCAATCACTTCATGCATACGTTATAAAACCTGAAGTTAAGTACAAGCCGTTAAATTTCACTTCAAAGAAGCATTTAGCGAAAGCTTTAGCCGATCTTATTTCGTAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR003347--JmjC_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD
|
| PROSITE |
PS51184--JMJC
|
| Pfam |
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0016577--P:histone demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
