WERAM Information
Tag | Content | ||||||||||||
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WERAM ID | WERAM-Hos-0205 | ||||||||||||
Ensembl Protein ID | ENSP00000432786.1 | ||||||||||||
Uniprot Accession | Q9Y2K7; KDM2A_HUMAN; D4QA03; E9PIL6; I3VM55; Q49A21; Q4G0M3; Q69YY8; Q9BVH5; Q9H7H5; Q9UK66 | ||||||||||||
Genbank Protein ID | NP_001243334.1; NP_036440.1; XP_011543163.1; XP_011543164.1 | ||||||||||||
Protein Name | Lysine-specific demethylase 2A | ||||||||||||
Genbank Nucleotide ID | NM_001256405.1; NM_012308.2; XM_011544861.1; XM_011544862.1 | ||||||||||||
Gene Name | KDM2A;FBXL11;JHDM1A | ||||||||||||
Ensembl Information |
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Details |
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Status | Reviewed | ||||||||||||
Classification |
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Organism | Homo sapiens | ||||||||||||
NCBI Taxa ID | 9606 | ||||||||||||
Functional Description (View) |
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. | ||||||||||||
Domain Profile | HDM JHDM1 JHDM1.txt 1 fsktkleelvkkpevvrqidlvdnvWpkalkekqtegtnaleemkyPkvqkyclmsvkncytdfhidfgGtsvyyhvlkGskvfwliPptek 92 |
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Protein Sequence (Fasta) | MEPEEERIRY SQRLRGTMRR RYEDDGISDD EIEGKRTFDL EEKLHTNKYN ANFVTFMEGK 60 DFNVEYIQRG GLRDPLIFKN SDGLGIKMPD PDFTVNDVKM CVGSRRMVDV MDVNTQKGIE 120 MTMAQWTRYY ETPEEEREKL YNVISLEFSH TRLENMVQRP STVDFIDWVD NMWPRHLKES 180 QTESTNAILE MQYPKVQKYC LMSVRGCYTD FHVDFGGTSV WYHIHQGGKV FWLIPPTAHN 240 LELYENWLLS GKQGDIFLGD RVSDCQRIEL KQGYTFVIPS GWIHAVYTPT DTLVFGGNFL 300 HSFNIPMQLK IYNIEDRTRV PNKFRYPFYY EMCWYVLERY VYCITNRSHL TKEFQKESLS 360 MDLELNGLES GNGDEEAVDR EPRRLSSRRS VLTSPVANGV NLDYDGLGKT CRSLPSLKKT 420 LAGDSSSDCS RGSHNGQVWD PQCAPRKDRQ VHLTHFELEG LRCLVDKLES LPLHKKCVPT 480 GIEDEDALIA DVKILLEELA NSDPKLALTG VPIVQWPKRD KLKFPTRPKV RVPTIPITKP 540 HTMKPAPRLT PVRPAAASPI VSGARRRRVR CRKCKACVQG ECGVCHYCRD MKKFGGPGRM 600 KQSCVLRQCL APRLPHSVTC SLCGEVDQNE ETQDFEKKLM ECCICNEIVH PGCLQMDGEG 660 LLNEELPNCW ECPKCYQEDS SEKAQKRKME ESDEEAVQAK VLRPLRSCDE PLTPPPHSPT 720 SMLQLIHDPV SPRGMVTRSS PGAGPSDHHS ASRDERFKRR QLLRLQATER TMVREKENNP 780 SGKKELSEVE KAKIRGSYLT VTLQRPTKEL HGTSIVPKLQ AITASSANLR HSPRVLVQHC 840 PARTPQRGDE EGLGGEEEEE EEEEEEDDSA EEGGAARLNG RGSWAQDGDE SWMQREVWMS 900 VFRYLSRREL CECMRVCKTW YKWCCDKRLW TKIDLSRCKA IVPQALSGII KRQPVSLDLS 960 WTNISKKQLT WLVNRLPGLK DLLLAGCSWS AVSALSTSSC PLLRTLDLRW AVGIKDPQIR 1020 DLLTPPADKP GQDNRSKLRN MTDFRLAGLD ITDATLRLII RHMPLLSRLD LSHCSHLTDQ 1080 SSNLLTAVGS STRYSLTELN MAGCNKLTDQ TLIYLRRIAN VTLIDLRGCK QITRKACEHF 1140 ISDLSINSLY CLSDEKLIQK IS 1162 |
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Nucleotide Sequence (Fasta) | GCAGGCGACC AGCCCCTGCT GGCCGAGGGC ACGGCGAGGA GGGCGCTCCC TGCGGCCGGG 60 GCCGGCCCGG GGCTCGGGCC CGGGCTGCTG ACCGCTGGCC TGGGGGAGGC GGGGGCGCCC 120 CGGGCTCGGC GCCGAGGGGT CGCGCTCCTC TCTCCTGACG CCTCCGACTC CCGGTCTCCA 180 AAGCCAGAAG AGAAGGTTTG ATTCAGCAAC TGTTTGCTCC CTTTTCCTGG TCGCTCTGAC 240 CCTCTCTGGA TACTGGGTTG ATCCACGGAA AAACCGAAGA CGACGTTTGG GATTTAATTA 300 TTCCTCTCAG CTTTGGAATC TTTTACTTCT CACTTGGACA AGAACTCAAG AGCAGAATCT 360 CCGTGTTGCA ATCTGGTTCC TAAGGAGGAA GAGGAAGGCA GCCCTGGAGT GGTTTCTTTA 420 CAGTAATTTC AACAGAAGAG TGAGAGATGG AACCCGAAGA AGAAAGGATT CGTTACAGCC 480 AGAGATTGCG TGGTACCATG CGACGACGCT ATGAAGATGA TGGCATTTCA GATGATGAAA 540 TTGAAGGAAA AAGAACTTTT GACTTGGAAG AGAAACTGCA CACCAACAAA TATAATGCCA 600 ATTTTGTTAC TTTTATGGAA GGAAAAGATT TTAATGTAGA GTATATTCAG CGGGGTGGCT 660 TGAGAGATCC TCTGATTTTC AAGAATTCTG ATGGACTCGG AATAAAAATG CCGGATCCAG 720 ACTTCACTGT GAATGATGTC AAAATGTGTG TGGGGAGTCG TCGCATGGTG GATGTCATGG 780 ACGTGAACAC ACAGAAAGGC ATTGAAATGA CCATGGCTCA GTGGACACGC TACTATGAGA 840 CCCCAGAGGA GGAGCGAGAG AAACTCTATA ATGTCATCAG CCTCGAGTTT AGCCACACCA 900 GGCTGGAGAA TATGGTGCAG AGGCCCTCCA CGGTGGATTT CATTGACTGG GTAGACAACA 960 TGTGGCCAAG GCACTTGAAG GAAAGCCAGA CTGAATCAAC AAATGCCATC TTGGAGATGC 1020 AGTACCCTAA AGTGCAGAAG TACTGTCTAA TGAGTGTTCG AGGCTGCTAT ACTGACTTCC 1080 ATGTGGACTT TGGTGGTACC TCTGTTTGGT ATCACATCCA TCAAGGGGGA AAGGTCTTCT 1140 GGCTCATCCC CCCTACAGCC CACAACCTGG AGCTGTACGA GAATTGGCTG CTGTCAGGGA 1200 AACAGGGAGA CATCTTTCTG GGTGACCGGG TATCAGATTG TCAGCGCATT GAGCTCAAGC 1260 AGGGCTATAC CTTCGTCATT CCCTCAGGCT GGATTCATGC TGTGTATACT CCTACAGACA 1320 CATTAGTGTT TGGGGGCAAT TTTTTGCATA GCTTCAACAT CCCTATGCAG TTAAAAATAT 1380 ACAACATTGA AGATCGGACA CGGGTTCCAA ATAAGTTTCG CTATCCATTC TACTATGAGA 1440 TGTGTTGGTA TGTGTTGGAG CGCTATGTGT ACTGCATAAC CAACCGTTCC CACCTAACTA 1500 AGGAATTTCA GAAAGAGTCC CTCAGCATGG ATTTGGAGTT AAATGGGTTG GAGTCTGGGA 1560 ATGGGGATGA GGAAGCAGTG GATCGAGAAC CCCGACGCTT GAGCAGCAGG CGTTCTGTCC 1620 TCACTAGCCC TGTAGCGAAT GGAGTCAACC TGGATTATGA TGGACTGGGC AAAACCTGCC 1680 GAAGTCTTCC AAGTCTGAAG AAAACTTTGG CTGGGGACTC ATCTTCTGAC TGTAGCCGGG 1740 GCTCCCACAA TGGACAAGTG TGGGATCCCC AGTGTGCTCC CCGAAAGGAC AGGCAAGTGC 1800 ATCTGACCCA TTTTGAGCTT GAAGGCCTTC GCTGCCTTGT AGATAAGTTG GAGTCTCTGC 1860 CACTGCACAA GAAATGTGTC CCCACAGGGA TAGAAGATGA AGATGCTCTC ATTGCTGATG 1920 TAAAGATTTT GCTGGAGGAG CTTGCCAACA GCGATCCCAA GTTAGCCCTC ACTGGAGTTC 1980 CTATAGTACA GTGGCCAAAA AGGGATAAGC TTAAATTCCC CACTCGGCCA AAGGTGCGGG 2040 TTCCTACCAT CCCCATTACG AAGCCTCACA CTATGAAACC AGCTCCACGG TTAACACCTG 2100 TGAGGCCAGC TGCTGCCTCC CCGATTGTGT CAGGAGCCAG ACGGAGACGA GTGCGATGTC 2160 GAAAATGCAA AGCCTGTGTG CAAGGAGAGT GTGGTGTTTG CCACTACTGC AGAGACATGA 2220 AGAAGTTTGG GGGGCCTGGA CGCATGAAGC AGTCCTGTGT CCTCCGACAG TGCTTGGCAC 2280 CCAGACTGCC TCACTCAGTC ACATGTTCCC TCTGTGGAGA GGTGGATCAG AATGAAGAGA 2340 CACAAGACTT TGAGAAGAAA CTCATGGAAT GCTGTATCTG CAATGAGATT GTTCATCCTG 2400 GCTGCCTCCA GATGGACGGA GAGGGGTTGC TTAACGAAGA ATTGCCAAAT TGCTGGGAAT 2460 GTCCAAAGTG CTACCAGGAG GACAGCTCGG AGAAAGCCCA GAAGCGGAAA ATGGAAGAGA 2520 GTGACGAAGA AGCTGTGCAA GCCAAAGTCC TGCGGCCCCT GCGGAGCTGC GATGAGCCTC 2580 TCACGCCCCC GCCTCATTCA CCCACTTCCA TGCTGCAGCT CATCCATGAC CCGGTTTCCC 2640 CCCGGGGTAT GGTGACTCGG TCATCCCCTG GGGCTGGCCC CAGCGACCAC CACAGTGCCA 2700 GCCGCGATGA GCGCTTCAAA CGGCGGCAGT TGCTGCGGCT GCAGGCCACA GAGCGCACCA 2760 TGGTACGGGA AAAGGAGAAC AATCCCAGCG GCAAAAAGGA GCTGTCTGAA GTTGAGAAAG 2820 CCAAGATCCG GGGATCGTAC CTCACTGTCA CGCTACAGAG GCCCACCAAA GAGCTCCACG 2880 GGACATCCAT TGTGCCCAAG CTGCAGGCCA TCACGGCCTC CTCTGCCAAC CTTCGCCATT 2940 CCCCCCGTGT GCTAGTGCAG CACTGCCCAG CCCGAACCCC CCAGCGTGGG GATGAGGAGG 3000 GGCTGGGGGG AGAGGAGGAG GAAGAGGAGG AGGAGGAGGA GGAAGATGAC AGTGCAGAGG 3060 AGGGGGGTGC AGCCAGGCTG AATGGCCGGG GCAGTTGGGC TCAGGATGGA GACGAAAGCT 3120 GGATGCAGCG GGAGGTCTGG ATGTCTGTCT TCCGCTACCT CAGCCGCAGA GAACTTTGTG 3180 AATGTATGCG AGTGTGCAAG ACGTGGTATA AATGGTGCTG CGACAAGAGA CTTTGGACAA 3240 AAATTGACTT GAGTAGGTGT AAGGCCATTG TGCCCCAGGC CCTCAGTGGC ATCATCAAGA 3300 GGCAGCCAGT CAGCCTTGAC CTCAGTTGGA CCAACATCTC TAAAAAGCAA CTGACATGGC 3360 TCGTCAATAG GCTGCCAGGA CTGAAAGACC TCCTCCTAGC AGGCTGCTCC TGGTCTGCAG 3420 TCTCTGCCCT CAGCACCTCC AGCTGCCCCC TTCTCAGGAC CCTTGATCTT CGGTGGGCAG 3480 TAGGAATCAA GGACCCTCAA ATTCGGGACT TGCTTACTCC ACCGGCTGAT AAACCAGGTC 3540 AGGACAATCG CAGCAAGCTC CGGAACATGA CCGACTTCCG GCTGGCAGGC CTTGACATCA 3600 CAGATGCCAC GCTTCGCCTC ATAATTCGCC ACATGCCCCT CCTGTCTCGA CTCGACCTCA 3660 GTCACTGCAG CCACCTTACA GATCAGTCCT CCAATCTACT CACTGCTGTC GGGTCTTCCA 3720 CTCGCTACTC TCTCACAGAG CTCAATATGG CAGGTTGCAA TAAATTGACA GACCAGACCC 3780 TGATCTACCT ACGGCGCATT GCCAACGTCA CCTTGATCGA CCTTCGAGGA TGCAAGCAGA 3840 TCACTCGAAA AGCCTGCGAG CACTTCATCT CAGACTTGTC CATCAACAGC CTCTACTGCC 3900 TGTCTGACGA GAAGCTGATA CAGAAGATCA GCTAAGACAC ACCCAGCCCA GATTCAACAG 3960 GAAACCGATC TTCCCCTGAC TCCCCACCGA GGAGAGCCTC TCCTCGACCC TGCACGGGCT 4020 CTGAGGCCAG CGTCACACTC CCTCTCTGCT CTCCTGTCCC TTGAGCCCTT CCTCTACAGG 4080 TGGGGCAGAG AGGGTGGTGG ACACCAGGCT TATCTGCCTG CTCCTCTCCC TCCTAAGGAA 4140 AAGGGAGTAG CAGATTGATC TGAGGGGAAA GCACAGGCTG TGCTGTCGAG GCGCCTGCTC 4200 GCTTACTCGC CTGCCAGGAG GCCGGGCTCT CAGTTTGGGG TGTTTGTGCA ACCTTCATCT 4260 GCACTGGGCC CTGTGCCCCT CCTCCCCATC CATGGTCCCC AGCAGTGCCT GGTTCTGAGC 4320 AAACTCCCAG GGAAGAAAAC GGCCCTGTCT CCATGGCCAG GTTCTTGTGG TGTCCAGTGC 4380 GCGTCTCTCC TCCATCACAC TCTCCCGGCT TGCGCAGGAG GGGCCAGCAG CCCCAGGAGT 4440 CCCAGACCCG TGCCGATCAC ACTGGTGCTG TTGAGATCTC CCAAACCTCA CGTCCTTAAC 4500 TGTGCTCTCC CTCCTTTCCT CTCCCTTGAG CTTGGTTCTG CCCAGCACTC GTGCTTGTTC 4560 ACATAATTAG GTTTCCCACC CCAGCCTACC CGACTTACTT GCTAGTCTCT ATGAGGTCCT 4620 TATTGCACTT ATTGGGGTTG AAGCTCTTCA GAGGAGCTGG AACTGTCTAC CCCAGGGACA 4680 CACCCATTTC GTTGCTACCC AAGTGGATTC TGAGACAGGC ACCATCTCCT TGTTCCCCCT 4740 CTCTCTTTTG CCTCCCACTG ACTGCCCTTT TCCATGTGTC TTCATTCTGC CTGAAGAAGG 4800 CTTTCCCAGG ATGCACGTCC TCAGAGGGAG CAGCCTATCT CCCCCAAGCT GGAGGCGGCA 4860 GAGGACTGGG CCAAGCCCCA ACCTGCCTCC CAGCCAGGCT CCTCCAGGCC TCTGGTTTAG 4920 CGGAGCCCCC TGAGCCCAGG CCTGTGTCTA GCCCCAGTGG CTCACTGAAC TTTCAGGGCA 4980 GTCAGGGGGT CCTGCTTAGA AGCCAGTCAC CAGCCCTCTG CCTGCAGCCA TGGAAGGGGG 5040 TGTGCACGTG CCTCTGTGTG TGTGGCTGAG TGTATTCTGC GCGTGTGTGT GGAGGGAGGG 5100 AGGGAGGGGA GCATGGTGTC TCCCGCTCCA CCGCCCTTTG TTGAGCCCCA TCAGCTGCCC 5160 CCTTTTACTT TGCATTGAAC GGCCTGTCCA AAGATCCTCT CTCTAGGGCA GCAGAGAGCT 5220 TTTTGCACTT TAAAAAAAAA AAGAAAGAAA GAAAGGTCGG AATTTCTTTT GGGTCAATAT 5280 TTTTAAGTGT GTGAGGAGAT GCTCAGTAGC AGCAGCCTAT GGCAAGAGCT TATAAATGAT 5340 TGATGCAAAT TTGCACTCTG CTCCCCCTCT GTAAGGATAC TGATAGCACA ACCTCTTCCC 5400 CCCACCCCGC CCCGCCTTTT GGTCGTCCAT CCCTGTCCCT TTCTGGCCCT CTTCCTGTAG 5460 CCCAGTCTCA GGCTTTCCTC TTCCTGAAGC CCTACAGAGT TAGGGAATGG AGCCCAGGCA 5520 CCAGGGGTCT AAAGTGTGAG CCACTGAGAA GAGAGACGCC AACTGCACCC TTGCCACTTC 5580 CAAAGCAATA GAGGCAGAGT GGTCCCCTCT TTGCCACCTA GGCCAGTTTT GACCCTGGCA 5640 TTAACTGGCC TTAGAAGAAA CTGGATCCTG GTAGGGGGTG GCATTTTGTT TGTTTCTTCC 5700 AATCTGCTGA ATCTTTTGAC TGCACCTTAC AAACAGCAGT CTGCTCCCAT GACCCTCTGC 5760 CCACTTCCAT TGGTCTCCAG GCCCCAATAA TCTGGGGTTG AAACTTTGAG GAAATGCCAG 5820 TGACTTATTC CAGAGTGCCT CAGTTAGGGG AACTTCTCTG TAAAGAACCC TGGGTATTGA 5880 GCAAAAACCT TATTATCGTT AATGACCTAT AATTGGAAGC TTCCTGCCTT TTTCTTTGGT 5940 TGCTCCTGTG GAAAATACTG AAAAGATTAC TTTGTTTTAT TTTGTTGTCT TTTTATAAAA 6000 GGGGAGGTGG AGAGACCCCT TCAGAGCAGG GATTGTGCCG GGAGAGTGCC TCTGACTTTG 6060 GGACATTTCA TCCACAGAAA TTTCCAAGCC AATGGTTTCT TTTGGGTTTT GGTTTTTATG 6120 TTTGTTTTTT GGGGTTTGGA AAAACATGCA TTTTTACCGT GCACGTAAAT TGGTCAGCAG 6180 AAAAGGGAGC CCAGAAAAGG CAGCAGATGG ACCATGCCCT TGCTGGGTTT TCCTTTTCTT 6240 TGGGACTGTG AGGGGAAATG GTTTTTAGAG GTGAGGGTTG GTCCATGTGG AGGAAAGAAG 6300 TGTCTCTGTT GGGGGACAGA GGAACCTGGG GAGTCCATCG CATGTCCTAC AATCTGCTCT 6360 TAGACACGGC CTTGCCAGGA GAGCCTGCCC TCAGACTGCA GGACCAGAAC CCCTGCCTCC 6420 ATCTTTCCAA GCACCGGGGC GAAAAACCAC AAAGGAAAGG AAGAAAATTT ATATATATAT 6480 AATATAAAAT CACTTGGTGA TTAAAAAAAT AACTGCTCCA TAAATAAAAC TCCTAAAGTC 6540 ACTTATGTTT AAAGGGTTTG GTTGTGTTTT TTGTTTTTCG GAGAAATATT GTAAATATAT 6600 ATTTTTTTGT TGCTGATTTA GAGTCAATCT CCAATGTTGT GCTAAAAAGT TTAAATTAAA 6660 TGTAAGCATT AAGGGGATAA GTCTTATGCT ATCTCAGTTG ACACATTGAG GTTATTTTGG 6720 GCCAGAGAAG GAGGAAGCTA GTTGGACTTT GTTTTGTTTT CCAAAAGTTC TCCACTATTG 6780 GTTTTAGAGA GAGCAAGGAC ATCTTTCCTC TGACACGTGG GAATGGGTGA TATTTGTGTA 6840 ATAAAATTTT TAAAAGACAA AAAAAGAAAT AGCCTCCAAT GGGAAATATT TTAATTTAGG 6900 TTTTGTTTTT GTTTGGGGGT TTTTGTTTTT TTAAAAAAAT AAAAAGGCTT TAAAAACAAA 6960 AACTAAA 6968 |
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Sequence Source | Ensembl | ||||||||||||
Keyword | KW-0002--3D-structure |
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Interpro | IPR001810--F-box_dom |
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PROSITE | PS51184--JMJC |
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Pfam | PF00646--F-box |
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Gene Ontology | GO:0005730--C:nucleolus |
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Orthology | |||||||||||||
Created Date | 25-Jun-2016 |