WERAM Information

Tag Content
WERAM ID WERAM-Mum-0195
Ensembl Protein ID ENSMUSP00000076698.4
Uniprot Accession P59997; KDM2A_MOUSE; Q3U1M5; Q3UR56; Q3V3Q1; Q69ZT4
Genbank Protein ID NP_001001984.2
Protein Name Lysine-specific demethylase 2A
Genbank Nucleotide ID NM_001001984.2
Gene Name KDM2A;JHDM1A;Fbxl11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000054611.16 ENSMUST00000075856.10 ENSMUSP00000076698.4
ENSMUSG00000054611.16 ENSMUST00000047898.13 ENSMUSP00000047683.7
ENSMUSG00000054611.16 ENSMUST00000116571.8 ENSMUSP00000139651.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JHDM1 Jmjc H3K36me1/2 K 16983801; 20889125
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JHDM1 2.70e-95 318.2 148 316
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis (By similarity).
Domain Profile
  HDM JHDM1
             JHDM1.txt   1 fsktkleelvkkpevvrqidlvdnvWpkalkekqtegtnaleemkyPkvqkyclmsvkncytdfhidfgGtsvyyhvlkGskvfwliPp 89 
                           fs+t+le++v++p++v++id+vdn+Wp++lke+qte+tna+ em+yPkvqkyclmsv++cytdfh+dfgGtsv+yh+++G+kvfwliPp
  ENSMUSP00000076698.4 148 FSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPP 236
                           8**************************************************************************************** PP
             JHDM1.txt  90 teknlelyeewvlsgkqsdiflgdrvekcqrvelkagdtlliPsGwihavytPvdslvfgGnflhslniktqlkiyeied 169
                           t++nlelye+w+lsgkq+diflgdrv++cqr+elk+g+t++iPsGwihavytP+d+lvfgGnflhs+ni++qlkiy+ied
  ENSMUSP00000076698.4 237 TAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYSIED 316
                           ******************************************************************************97 PP
Protein Sequence
(Fasta)		MEPEEERIRY SQRLRGTMRR RYEDDGISDD EIEGKRTFDL EEKLQTNKYN ANFVTFMEGK 60
DFNVEYIQRG GLRDPLIFKN SDGLGIKMPD PDFTVNDVKM CVGSRRMVDV MDVNTQKGIE 120
MTMAQWTRYY ETPEEEREKL YNVISLEFSH TRLENMVQRP STVDFIDWVD NMWPRHLKES 180
QTESTNAILE MQYPKVQKYC LMSVRGCYTD FHVDFGGTSV WYHIHQGGKV FWLIPPTAHN 240
LELYENWLLS GKQGDIFLGD RVSDCQRIEL KQGYTFVIPS GWIHAVYTPT DTLVFGGNFL 300
HSFNIPMQLK IYSIEDRTRV PNKFRYPFYY EMCWYVLERY VYCITNRSHL TKDFQKESLS 360
MDMELNELES GNGDEEGVDR EARRMNNKRS VLTSPVANGV NLDYDGLGKA CRSLPSLKKT 420
LSGDSSSDST RGSHNGQVWD PQCSPKKDRQ VHLTHFELEG LRCLVDKLES LPLHKKCVPT 480
GIEDEDALIA DVKILLEELA SSDPKLALTG VPIVQWPKRD KLKFPTRPKV RVPTIPITKP 540
HTMKPAPRLT PVRPAAASPI VSGARRRRVR CRKCKACVQG ECGVCHYCRD MKKFGGPGRM 600
KQSCVLRQCL APRLPHSVTC SLCGEVDQNE ETQDFEKKLM ECCICNEIVH PGCLQMDGEG 660
LLNEELPNCW ECPKCYQEDS SDKAQKRKIE ESDEEAVQAK VLRPLRSCEE PLTPPPHSPT 720
SMLQLIHDPV SPRGMVTRSS PGAGPSDHHS ASRDERFKRR QLLRLQATER TMVREKENNP 780
SGKKELSEVE KAKIRGSYLT VTLQRPTKEL HGTSIVPKLQ AITASSANLR PNPRVLMQHC 840
PARNPQHGDE EGLGGEEEEE EEEEEDDSAE EGGAARLNGR GSWAQDGDES WMQREVWMSV 900
FRYLSRKELC ECMRVCKTWY KWCCDKRLWT KIDLSRCKAI VPQALSGIIK RQPVSLDLSW 960
TNISKKQLTW LVNRLPGLKD LLLAGCSWSA VSALSTSSCP LLRTLDLRWA VGIKDPQIRD 1020
LLTPPTDKPG QDNRSKLRNM TDFRLAGLDI TDATLRLIIR HMPLLSRLDL SHCSHLTDQS 1080
SNLLTAVGSS TRYSLTELNM AGCNKLTDQT LFFLRRIANV TLIDLRGCKQ ITRKACEHFI 1140
SDLSINSLYC LSDEKLIQKI S 1161
Nucleotide Sequence
(Fasta)		TGAGAATCTG ACGGGTTCAA AATGGCGGCG GCTGCTTCAG CGGATCCTCC TGTGTGAGGG 60
AAACAACACC CCTCCCCGGC AGCGGCGGCG GCGGCGGCGG CGGGCCGCAG AGCACCTTTC 120
CAGTTCCCGG GCCCGTCGCG GTTGTTTCCC TCCCGGGCAG TGGGCTCTTC GCGTGGAAGG 180
GCAACGTCAG GGGGCCCATC CCCCGGAGTC CCTCCTCTGC TACTGGGGAG TAGCTGGGGG 240
TGTACGGGGG ATCGTCCCGC AGCGCGGAGC CCCGGCTCAG GGGACGACGC AAAGGCAGCC 300
GAAGGCCCCC GGTCAGGGCG CTTCGCTGCT CCCGCCCTCT CCGCCCCCCG GGGCCGGGGC 360
CCGCGTTCCG GGGGGCCGGG CGGCGCGGGG AGCGTCGGCC GGGCGGGTCT CAGCTGATCG 420
GCCGCGGTTC CTGGGCTTCG GTAGCGGCTG TGGCCGGCTG AGGGTACCGA GAGGAGGGTG 480
TTTCCCGCGG CCCGGTTGAC CCGGGTCTCG GGCTGGGGCT GCTGACCGCC AGCTTGGGGG 540
AGTAGCCGAG TGGTCTTGCT TCCCTGACGC CTCGGACGCG GAGTCTGTAA AAGCCAGAAG 600
AGGAGGTTTG ATTCAGTAAC TGTTTCCTCT TTTCCGGGTC GCTCTGACCC TTCTCTGGAT 660
ACTGGGTTAA TACACAGAAA TACCGAAGAC GACGTTTGGG ATTTTATTTT GTCTGTGTTT 720
GGAATTTTAC TTCTCTCTTG GACAAGAACT CAAGAACAAA ATCCTCGGAA GAGGAAGGCA 780
TCCCTGGAGT GGTTTCTTTA CTGTACTTCC ATCAGAAGAG TGAGAGATGG AACCTGAAGA 840
AGAAAGGATT CGGTACAGCC AGAGATTGCG TGGTACCATG CGTCGTCGCT ATGAAGATGA 900
TGGCATTTCA GATGATGAAA TTGAAGGGAA AAGAACTTTT GACTTGGAAG AGAAGCTCCA 960
AACCAACAAA TATAATGCCA ATTTTGTTAC TTTTATGGAG GGAAAAGATT TTAATGTAGA 1020
GTATATCCAG CGGGGTGGCT TGAGAGACCC TCTCATTTTC AAGAATTCTG ATGGACTTGG 1080
AATAAAGATG CCGGATCCAG ACTTCACAGT GAATGATGTC AAAATGTGTG TGGGGAGTCG 1140
TCGGATGGTG GATGTCATGG ATGTGAACAC ACAGAAGGGG ATTGAAATGA CCATGGCACA 1200
ATGGACACGA TACTATGAGA CTCCAGAGGA AGAGCGAGAA AAACTCTATA ATGTTATCAG 1260
CCTAGAGTTT AGCCACACCA GGCTTGAGAA TATGGTGCAG CGGCCTTCCA CGGTGGATTT 1320
CATTGACTGG GTAGATAACA TGTGGCCAAG GCACTTGAAA GAAAGTCAGA CAGAATCAAC 1380
AAATGCCATC TTAGAGATGC AGTACCCTAA AGTGCAAAAG TACTGTCTAA TGAGTGTTCG 1440
AGGCTGCTAT ACTGACTTCC ATGTGGATTT TGGAGGTACT TCTGTTTGGT ATCACATCCA 1500
CCAAGGTGGA AAGGTCTTCT GGCTCATCCC CCCTACAGCC CACAACCTGG AGCTGTACGA 1560
GAATTGGCTG CTATCAGGGA AACAGGGAGA CATCTTTCTG GGTGACCGGG TGTCAGATTG 1620
CCAACGAATT GAGCTCAAGC AGGGCTATAC CTTCGTTATT CCCTCAGGTT GGATTCATGC 1680
TGTGTATACT CCTACAGACA CATTAGTGTT TGGAGGCAAT TTTTTGCATA GCTTCAACAT 1740
CCCCATGCAA TTAAAGATAT ACAGCATTGA AGATCGAACA CGGGTTCCAA ATAAATTCCG 1800
TTACCCATTT TACTATGAAA TGTGTTGGTA TGTGTTGGAG CGCTATGTAT ACTGCATAAC 1860
CAACCGATCC CACCTAACTA AGGATTTTCA GAAAGAATCC CTTAGCATGG ATATGGAGTT 1920
AAATGAGTTG GAGTCTGGAA ATGGTGATGA GGAAGGGGTG GACAGAGAAG CCCGACGCAT 1980
GAACAATAAG CGATCTGTGC TTACCAGCCC TGTTGCTAAT GGAGTGAACC TGGATTACGA 2040
TGGACTTGGC AAAGCCTGCC GAAGTCTTCC AAGTCTGAAG AAAACTTTGT CTGGAGACTC 2100
ATCCTCAGAC TCTACCCGGG GATCCCACAA TGGCCAAGTT TGGGATCCCC AATGTAGCCC 2160
TAAAAAGGAT AGGCAAGTGC ATCTCACCCA TTTTGAACTT GAAGGTCTTC GATGTCTTGT 2220
AGATAAGTTA GAGTCACTGC CACTGCACAA GAAGTGTGTC CCCACAGGAA TAGAAGACGA 2280
AGATGCTCTG ATTGCTGATG TAAAGATTTT GCTGGAAGAA CTTGCCAGTA GCGATCCCAA 2340
GTTAGCCCTC ACTGGAGTCC CTATAGTACA GTGGCCAAAA AGGGATAAGC TTAAATTCCC 2400
TACCAGGCCA AAGGTGAGGG TTCCTACAAT TCCCATCACA AAGCCTCACA CCATGAAGCC 2460
AGCTCCACGC TTAACACCTG TAAGGCCTGC TGCAGCCTCC CCCATTGTGT CAGGAGCCAG 2520
GCGGAGAAGA GTGCGGTGCA GGAAATGCAA AGCTTGTGTG CAAGGAGAAT GTGGAGTCTG 2580
CCACTACTGC AGGGACATGA AGAAATTTGG TGGACCTGGA CGCATGAAGC AATCCTGTGT 2640
CCTCCGACAG TGCTTAGCAC CCAGACTGCC TCATTCAGTT ACGTGTTCTC TCTGTGGAGA 2700
AGTAGATCAG AATGAAGAGA CCCAGGACTT TGAAAAGAAA CTCATGGAAT GCTGCATCTG 2760
CAACGAGATA GTTCATCCTG GCTGCCTCCA GATGGATGGA GAGGGGTTGC TGAACGAGGA 2820
ATTGCCAAAT TGCTGGGAGT GTCCAAAGTG TTACCAGGAA GACAGCTCGG ACAAAGCCCA 2880
GAAGCGGAAA ATAGAAGAGA GTGATGAAGA AGCTGTACAA GCCAAAGTCT TACGGCCCCT 2940
GAGGAGCTGC GAGGAGCCTC TCACACCCCC GCCTCACTCA CCTACTTCCA TGCTGCAGCT 3000
CATCCACGAC CCGGTTTCTC CCCGGGGTAT GGTGACTCGG TCATCCCCTG GGGCTGGCCC 3060
CAGCGACCAC CACAGTGCCA GCCGTGATGA ACGCTTCAAA CGGCGGCAGT TGCTGCGGCT 3120
ACAAGCCACC GAGCGCACCA TGGTACGGGA AAAGGAGAAC AATCCCAGCG GCAAAAAGGA 3180
GCTGTCTGAA GTTGAGAAAG CCAAGATCCG GGGATCGTAC CTCACTGTCA CTCTACAGAG 3240
GCCCACCAAA GAGCTCCACG GGACATCCAT TGTGCCCAAG CTGCAGGCCA TCACGGCCTC 3300
CTCTGCCAAC CTTCGCCCTA ACCCCCGCGT GCTAATGCAG CACTGCCCAG CCCGAAACCC 3360
CCAGCATGGG GATGAGGAGG GGCTTGGGGG AGAGGAGGAG GAAGAGGAGG AGGAGGAGGA 3420
AGATGACAGT GCAGAGGAGG GGGGTGCAGC CAGGCTGAAT GGCCGGGGCA GTTGGGCTCA 3480
GGATGGAGAC GAAAGCTGGA TGCAGCGGGA GGTCTGGATG TCTGTCTTCC GCTACCTCAG 3540
CCGCAAAGAA CTTTGTGAAT GTATGCGAGT GTGCAAGACA TGGTATAAAT GGTGCTGTGA 3600
TAAACGACTT TGGACAAAAA TTGACTTGAG TAGGTGTAAG GCCATCGTAC CACAAGCTCT 3660
CAGTGGTATC ATCAAGCGGC AGCCAGTAAG CCTCGACCTC AGCTGGACTA ACATCTCCAA 3720
AAAGCAGCTG ACATGGCTGG TCAATAGGCT GCCAGGATTA AAAGACCTCC TCCTAGCAGG 3780
CTGTTCCTGG TCTGCAGTAT CTGCCCTCAG CACTTCCAGC TGCCCGCTTC TCAGGACCCT 3840
TGATCTTCGG TGGGCAGTAG GAATTAAAGA CCCTCAAATT CGGGACTTGC TGACTCCACC 3900
CACAGATAAG CCAGGTCAAG ACAATCGAAG CAAACTCCGG AACATGACTG ACTTCCGGCT 3960
GGCAGGCCTT GACATCACAG ATGCTACTCT CCGACTCATC ATTCGCCACA TGCCCCTTTT 4020
GTCTCGACTT GACCTCAGTC ACTGCAGTCA CCTTACAGAT CAGTCCTCCA ACCTACTAAC 4080
TGCTGTCGGG TCTTCCACTC GATACTCCCT TACAGAGCTC AATATGGCAG GTTGCAATAA 4140
ATTGACAGAC CAGACCCTGT TCTTCCTAAG GCGAATTGCT AATGTCACCT TGATTGACCT 4200
TCGAGGATGC AAACAGATCA CGAGAAAAGC CTGTGAGCAC TTCATCTCAG ACTTGTCCAT 4260
CAACAGCCTC TACTGCCTGT CTGATGAGAA ACTGATACAG AAGATTAGCT AAGACATGCT 4320
CAGCCCAGAC TGAACAGGAA AATCTTCCCC TGCCTTCCCA CCAAGGAGAG TCTCTCCCTG 4380
ACCCTGCGCA GGCTCTGAGG CCAACGACAC ATTCCCTCTC TGCTCTCTTT TCTCTGAGCC 4440
CTTCTCCCAC AGGTGGGGCA GAGAGGTTGG TGGACACCAA GGTTATTGCC TGCTCCTCTC 4500
CCTCCCACGG AAAAGAAAGG AGAGGTTGAT CAAGGAGAAA GCACAGGCTG TGCTATCCCA 4560
GTTCCTGCTT GCTTGCTCGT CTGCCAGCTA GGAAGCTGGG CTCTCAGTTT GGGGGAATTT 4620
GTGCATCTTT CACCTGCACT GGGCCAAGAA CCCTACCTTC TCACCCATAG TCCCTAGCAG 4680
TGCCTGGTTC TGAGCATACT CTAGGGAGGA AGGCAGCCTT GCCTCCATGG CCAGATTCTC 4740
CTCATGGTGT CCGTTGCGTG TCTCTCCTCC GTTAAACTCT CCCGGCTTCT GCAGGAGGAG 4800
CCAACAGCCC TAGAAACACC AGGCCTGGCA GGTCTCAATG GTGCTGTGAG TTGTCTGAAG 4860
CTTTGCTCCA TGTCTGTCAT AGCCCTTTTT TCTTGTCCCT GAGCTTGATG CTGTCCAACA 4920
CTCATAATAC AGTCCCCATT CTGCCATCAC CCCCTAAACT TTTCCACTAG TCACCCACTT 4980
GTCCTTTGTT GCACTTACTT GGGGTTATCA AAAGCTCTTC AGAGGAGCTG GAACTCTGCC 5040
CCTCCCCCCC CCCCCCGAAA TGCCCATATC ATTGCTACCC AGGCATATTC TAAGACAGGC 5100
ATCATTAATA CTCCCCACCC ATTGCTGCCC ACCAACTGCC CTTTTCCATT TGTCCTCTTT 5160
CTGCCTGAGC AGGGCTTTTC TAGAATTTGT GTCCTCAGAA GGAGCAGCAT GTTTCTCCAG 5220
GTGGGGGAAA CAGAAGACTG GTTGAATCCC CACCTGCCTC TCTAAGCCAG GCTTTTCTGG 5280
GCTCTGGTTT AGCATGGCCC TCTGAGCCCA GGCCTGTGTA TAACCTAGCA GCTCACTGAC 5340
CTGGTGCCTT TTAAGGGGAG TCCTGATTGA AAACCTACCC TCTGCCTGCA GCCTTGGAAG 5400
TGTGTGTGCA TGTGCCTCTG TGTGTCTGGC TAAGTGTGCT GCACATATGT GCAGGGAAGG 5460
AGGGGAGCAT GATGGCTCCC ACTCCTCATC GCCCTTCTTC AAGCCCCATC AAGCTGCCCC 5520
CTTTGACTTT GCATTGAACG GCCTGTCCAA AGATCCTCTC TCTAGGGCAG CAGAGAGCTT 5580
TTTGCACTTT AGAAAAAAAA AAAAAATGAA AGAAAGAAAA TGGTCGGAAC TGTTCTGGGT 5640
CAATATTTAG AGTATGAGGA GATGCTCAGC AGAGGCCTGT GGCCAGAGTT TGTCAGTGAT 5700
ACATGCAAAT TTGCACTCTG CTCCCCATCT ATAGGAGATT GATAATTGAT AGCACAGCCT 5760
TGCCCCGCCT TCTCTTAGCC CCAAACATAT CCCTTCCCAC TTCCCACCCC ATTTCCTGGA 5820
ATCTAGCCTC AGACTTTCCT AAACTCCATC AAGAGGGGAC AGAGCCCGGG CACCATGAGT 5880
CTGAAGTGTG AACCGCCCAA GGAGAGATGC TAACTGTACC CTTGCCACTG CCAAAGCAAT 5940
AGAGGCAGAA GTGTCCCCTC TGCCACTCAG CCCAGCTTTG ACCCTGGCAA TAACCAGACT 6000
TTTTCCAGGA AAACTGGGTT TCTGGCAAGG GATGGCATTG TTTCTTCCAA TCTGCTGATT 6060
TCTCTTGGCT GCACCTTAAA AACAGCAGTC TGCTCCCTTG ACCCTCTGCC ATTCCATTGG 6120
TCTTCAGGTC CCAGAATCCT GGGCCTGAAA TGTTGAGGAA ACGCCAGTGA CTTATTCCAG 6180
AGTGCCTCAG TTGGGGGAAC TTCTGTAAAG AACCCTGGGT GTTGAGCAAA AACCTTATTA 6240
ATACTATTAA TGACCTATAA TTAGAAGCTT CCTGACTTTT TTTCTTTTTG GTTGCTCCTG 6300
TGGAAAATAC TAAAATTACT AAGTTTTGTT TGTTGTCTTT TTATGAAAGG GGAGGTGGAG 6360
AGACCCTTTC AGAGCAGGGA TTGTGCCGGG AGAGTGCCTC TGCCCTTTGG GACAGTTCAT 6420
CCACAGAAAT TTCTAAGCTG ATGGCTTGTC TGGGTTTTGG TCTTTGCATT TGAATTTAGA 6480
AAAAGCAAGC ATTTTACCGC ACAGAAATTT GTCAGTGGAA AAGGGAGCTC AGGGTGGTGG 6540
CAGATGGACT GACGCCCTTG CTGGGTCTTT TCTTTAGGAC TATGAGGGAG AATGGTTTTT 6600
AGAGGTGAGA GTTGGTCCTT GCAAAAAGAG AGAAGTGTCT CCGAGGACGT AGAACATGCG 6660
AGTTCATAGT CCTGCATCTA CTCTTAGCTG CAGTCTTGCC AGAGCCTGGC CTCAGACTGC 6720
AGGACCTGAC CTCTGCCTTC ATCTTTCCAC ATACTGGGGC AAAAAAACAC AAAGGAAAGG 6780
AAGAAAATTA TATATATATA ATTATATATA TATAATATAA AATCACTTGG TGATTAAAAA 6840
AATAACTGCT CAATAAATAA AACTCCTAAA GTCACTATGT TTAAAGGGTT TGGTTTTTTG 6900
GGGGTGGGTG GGAAATATTG TAAATATATA TTTTTTGTTG CTTATTTAGA GTCGATCTCC 6960
AATGTTGTGC TAAGATTTTT AAATTAAATG TAAGCATTAA GGGAATGAGT CTTAGGCCAC 7020
CAGCTGACAC ATTGGCATTA TTTTGGGTCA GGGAAGGAAG AAAGCTAGTT GGACTTTGTT 7080
TTCTAAAAGT TTCCCACTTG GTTTTAGAAA GAGCAAAGAT GTCTTTCTTC TGACACTTGG 7140
GAATGGGAGA TATTTGTGTA ATAAAATTTT TAAAAGACAA AAAAAGAAAT AGCCTCCAAT 7200
GGGAAATATT TTGATTTGGT TTTCTTTTTT GTTTTTGTTT TT 7243
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0238--DNA-binding
KW-0408--Iron
KW-0433--Leucine-rich repeat
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR019786--Zinc_finger_PHD-type_CS
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00646--F-box
PF02373--JmjC
PF16866--PHD_4
PF02008--zf-CXXC
Gene Ontology

GO:0000790--C:nuclear chromatin
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0001947--P:heart looping
GO:0070544--P:histone H3-K36 demethylation
GO:0001701--P:in utero embryonic development
GO:0035264--P:multicellular organism growth
GO:0043066--P:negative regulation of apoptotic process
GO:0010629--P:negative regulation of gene expression
GO:0001843--P:neural tube closure
GO:0060563--P:neuroepithelial cell differentiation
GO:0030182--P:neuron differentiation
GO:0010628--P:positive regulation of gene expression
GO:0033184--P:positive regulation of histone ubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0123 ENSRNOP00000051732.2 Rattus norvegicus 99 0.0 2170
WERAM-Caf-0130 ENSCAFP00000017359.4 Canis familiaris 97 0.0 2132
WERAM-Pat-0030 ENSPTRP00000006792.4 Pan troglodytes 97 0.0 2131
WERAM-Hos-0205 ENSP00000432786.1 Homo sapiens 97 0.0 2131
WERAM-Mup-0036 ENSMPUP00000003662.1 Mustela putorius furo 97 0.0 2130
WERAM-Orc-0097 ENSOCUP00000008602.2 Oryctolagus cuniculus 97 0.0 2128
WERAM-Caj-0008 ENSCJAP00000001914.2 Callithrix jacchus 97 0.0 2127
WERAM-Mam-0071 ENSMMUP00000011492.2 Macaca mulatta 97 0.0 2126
WERAM-Nol-0063 ENSNLEP00000007667.1 Nomascus leucogenys 97 0.0 2124
WERAM-Eqc-0212 ENSECAP00000022657.1 Equus caballus 96 0.0 2120
WERAM-Cap-0086 ENSCPOP00000006433.2 Cavia porcellus 97 0.0 2114
WERAM-Paa-0079 ENSPANP00000000080.1 Papio anubis 95 0.0 2110
WERAM-Dan-0017 ENSDNOP00000001589.3 Dasypus novemcinctus 96 0.0 2109
WERAM-Fec-0040 ENSFCAP00000003122.3 Felis catus 97 0.0 2100
WERAM-Chs-0099 ENSCSAP00000004730.1 Chlorocebus sabaeus 97 0.0 2095
WERAM-Loa-0069 ENSLAFP00000005271.4 Loxodonta africana 94 0.0 2092
WERAM-Mod-0060 ENSMODP00000009649.3 Monodelphis domestica 94 0.0 2078
WERAM-Tas-0128 ENSTSYP00000013512.1 Tarsius syrichta 95 0.0 2073
WERAM-Ocp-0120 ENSOPRP00000012395.2 Ochotona princeps 95 0.0 2067
WERAM-Ova-0096 ENSOARP00000010105.1 Ovis aries 95 0.0 2059
WERAM-Otg-0110 ENSOGAP00000009515.2 Otolemur garnettii 97 0.0 2035
WERAM-Soa-0015 ENSSARP00000001674.1 Sorex araneus 93 0.0 2014
WERAM-Mim-0039 ENSMICP00000003694.1 Microcebus murinus 90 0.0 1956
WERAM-Sah-0004 ENSSHAP00000000156.1 Sarcophilus harrisii 93 0.0 1945
WERAM-Fia-0152 ENSFALP00000012936.1 Ficedula albicollis 86 0.0 1922
WERAM-Tag-0090 ENSTGUP00000006171.1 Taeniopygia guttata 87 0.0 1912
WERAM-Ptv-0088 ENSPVAP00000008067.1 Pteropus vampyrus 90 0.0 1911
WERAM-Gaga-0126 ENSGALP00000021661.4 Gallus gallus 85 0.0 1900
WERAM-Anc-0079 ENSACAP00000007492.3 Anolis carolinensis 84 0.0 1871
WERAM-Bot-0214 ENSBTAP00000053688.2 Bos taurus 85 0.0 1823
WERAM-Ect-0067 ENSETEP00000007585.1 Echinops telfairi 88 0.0 1818
WERAM-Tub-0024 ENSTBEP00000002970.1 Tupaia belangeri 84 0.0 1718
WERAM-Meg-0106 ENSMGAP00000010708.2 Meleagris gallopavo 75 0.0 1611
WERAM-Vip-0108 ENSVPAP00000009910.1 Vicugna pacos 90 0.0 1456
WERAM-Ere-0091 ENSEEUP00000009301.1 Erinaceus europaeus 83 0.0 1405
WERAM-Aim-0009 ENSAMEP00000000617.1 Ailuropoda melanoleuca 87 0.0 1153
WERAM-Myl-0057 ENSMLUP00000004620.2 Myotis lucifugus 89 0.0 1148
WERAM-Gaa-0187 ENSGACP00000023440.1 Gasterosteus aculeatus 55 0.0 1137
WERAM-Tar-0167 ENSTRUP00000035595.1 Takifugu rubripes 54 0.0 1119
WERAM-Xim-0117 ENSXMAP00000009995.1 Xiphophorus maculatus 54 0.0 1115
WERAM-Orn-0218 ENSONIP00000022876.1 Oreochromis niloticus 53 0.0 1071
WERAM-Anp-0026 ENSAPLP00000003146.1 Anas platyrhynchos 78 0.0 1024
WERAM-Pof-0139 ENSPFOP00000011700.1 Poecilia formosa 50 0.0 1017
WERAM-Pes-0153 ENSPSIP00000018112.1 Pelodiscus sinensis 83 0.0 805
WERAM-Lac-0182 ENSLACP00000020988.1 Latimeria chalumnae 57 0.0 748
WERAM-Poa-0047 ENSPPYP00000005754.2 Pongo abelii 59 0.0 747
WERAM-Dar-0126 ENSDARP00000121246.1 Danio rerio 58 0.0 744
WERAM-Gam-0153 ENSGMOP00000015244.1 Gadus morhua 59 0.0 744
WERAM-Leo-0042 ENSLOCP00000006157.1 Lepisosteus oculatus 60 0.0 732
WERAM-Orla-0116 ENSORLP00000013894.1 Oryzias latipes 58 0.0 723
WERAM-Mae-0022 ENSMEUP00000001662.1 Macropus eugenii 56 0.0 707
WERAM-Ten-0161 ENSTNIP00000016121.1 Tetraodon nigroviridis 55 0.0 706
WERAM-Sus-0150 ENSSSCP00000025010.1 Sus scrofa 99 0.0 670
WERAM-Ora-0061 ENSOANP00000009538.1 Ornithorhynchus anatinus 78 0.0 663
WERAM-Xet-0130 ENSXETP00000059375.1 Xenopus tropicalis 54 0.0 660
WERAM-Asm-0097 ENSAMXP00000010134.1 Astyanax mexicanus 50 2e-171 600
WERAM-Dio-0063 ENSDORP00000006291.1 Dipodomys ordii 74 6e-145 513
WERAM-Ict-0192 ENSSTOP00000017380.1 Ictidomys tridecemlineatus 60 1e-142 505
WERAM-Prc-0078 ENSPCAP00000006985.1 Procavia capensis 63 2e-128 457
WERAM-Drm-0062 FBpp0289915 Drosophila melanogaster 61 1e-116 419
WERAM-Cis-0003 ENSCSAVP00000000437.1 Ciona savignyi 58 2e-115 414
WERAM-Cii-0015 ENSCINP00000005646.3 Ciona intestinalis 59 3e-101 368
WERAM-Gog-0162 ENSGGOP00000014352.2 Gorilla gorilla 46 2e-74 278
WERAM-Tut-0006 ENSTTRP00000000351.1 Tursiops truncatus 46 9e-74 276
WERAM-Cae-0065 T26A5.5a Caenorhabditis elegans 45 9e-71 266
WERAM-Pem-0097 ENSPMAP00000010124.1 Petromyzon marinus 45 1e-69 263
Created Date 25-Jun-2016