| Tag |
Content |
| WERAM ID |
WERAM-Sac-0008 |
| Ensembl Protein ID |
YDR191W |
| Uniprot Accession |
P53688; HST4_YEAST; D6VSH4
|
| Genbank Protein ID |
NP_010477.3
|
| Protein Name |
NAD-dependent histone deacetylase HST4 |
| Genbank Nucleotide ID |
NM_001180499.3
|
| Gene Name |
HST4;YDR191W;YD9346.03 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
H3K56 |
K |
16818235
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
4.80e-63 |
211.3 |
86 |
369 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
NAD-dependent histone deacetylase, which contributes together with HST3 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance. |
NAD-dependent histone deacetylase, which contributes together with HST3 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance.
|
| Domain Profile |
HDAC SIR2
SIR2.txt 4 akllkkskkivvltGAGiStsaGIPDFRsseGlysklkkeelpspeaifdld.ffrkdpkv..fyalakelyp.lgsakPtktHyflaelekkgkllrlyt 100
+ +l+ sk++vv++GAGiS++aGIPDFRsseG++s+++ + s++++fd++ ++ +++++ f +l+ +l++ +++++Ptk+H++l+e++++g+llrlyt
YDR191W 86 SYALNYSKRMVVVSGAGISVAAGIPDFRSSEGIFSTVNGG---SGKDLFDYNrVYGDESMSlkFNQLMVSLFRlSKNCQPTKFHEMLNEFARDGRLLRLYT 183
567899**********************************...9******9955555555589************************************** PP
SIR2.txt 101 QNiDgL.....erkaglked....klvelHGslatasCtkCk..kefpreeikeklkak...ekvpkCekC................kgvlkpdivffgen 171
QNiDgL +++++++ + ++v+lHGs+++++C+kC k f++e +k++ k + e +p+C++C g+l+p++++++e
YDR191W 184 QNIDGLdtqlpHLSTNVPLAkpipSTVQLHGSIKHMECNKCLniKPFDPELFKCDDKFDsrtEIIPSCPQCeeyetvrkmaglrstgVGKLRPRVILYNEV 284
******88888788888877888899***************98899999*999998888788899********************999************* PP
SIR2.txt 172 lpe.efleeveed..lkeadlllvlGtSlkvepvaslvkkavkkkvp....vllvnleevk.....adkladlkllgdcdevvee 244
+pe +f+ e++++ +k++d+l+++GtSlk+ +v+++++++++k + vl++n+++ + + k +dl++lgdc++v++
YDR191W 285 HPEgDFIGEIANNdlKKRIDCLIIVGTSLKIPGVKNICRQFAAKVHAnrgiVLYLNTSMPPknvldSLKFVDLVVLGDCQHVTSL 369
***99****999989999*********************8888877777879999**999999999999************9875 PP
|
Protein Sequence
(Fasta) | MKQKFVLPIT PPSTAEKKPQ TENRCNENLK PRRLLPQLKK SVRNRKPRLS YRPELNSVFD 60
LDAYVDSTHL SKSQRHHMDR DAGFISYALN YSKRMVVVSG AGISVAAGIP DFRSSEGIFS 120
TVNGGSGKDL FDYNRVYGDE SMSLKFNQLM VSLFRLSKNC QPTKFHEMLN EFARDGRLLR 180
LYTQNIDGLD TQLPHLSTNV PLAKPIPSTV QLHGSIKHME CNKCLNIKPF DPELFKCDDK 240
FDSRTEIIPS CPQCEEYETV RKMAGLRSTG VGKLRPRVIL YNEVHPEGDF IGEIANNDLK 300
KRIDCLIIVG TSLKIPGVKN ICRQFAAKVH ANRGIVLYLN TSMPPKNVLD SLKFVDLVVL 360
GDCQHVTSLL Protein Fasta Sequence
>YDR191W|HST4;YDR191W;YD9346.03|Saccharomyces cerevisiae
MKQKFVLPITPPSTAEKKPQTENRCNENLKPRRLLPQLKKSVRNRKPRLSYRPELNSVFDLDAYVDSTHLSKSQRHHMDRDAGFISYALNYSKRMVVVSGAGISVAAGIPDFRSSEGIFSTVNGGSGKDLFDYNRVYGDESMSLKFNQLMVSLFRLSKNCQPTKFHEMLNEFARDGRLLRLYTQNIDGLDTQLPHLSTNVPLAKPIPSTVQLHGSIKHMECNKCLNIKPFDPELFKCDDKFDSRTEIIPSCPQCEEYETVRKMAGLRSTGVGKLRPRVILYNEVHPEGDFIGEIANNDLKKRIDCLIIVGTSLKIPGVKNICRQFAAKVHANRGIVLYLNTSMPPKNVLDSLKFVDLVVLGDCQHVTSLL |
Nucleotide Sequence
(Fasta) | ATGAAGCAAA AATTTGTACT ACCGATCACC CCACCAAGTA CGGCGGAAAA GAAGCCTCAA 60
ACAGAAAACC GTTGCAATGA GAATTTGAAG CCTAGAAGAT TGCTACCGCA ATTGAAAAAA 120
AGTGTCCGTA ACAGGAAACC TAGACTGTCA TATAGGCCTG AGTTAAACTC TGTGTTTGAT 180
CTGGATGCGT ACGTGGATTC GACACACTTG TCCAAATCCC AACGCCATCA TATGGACCGC 240
GACGCCGGTT TTATTAGCTA TGCTCTGAAT TATAGCAAAA GAATGGTTGT AGTCAGCGGG 300
GCAGGTATAT CTGTTGCCGC TGGTATACCG GATTTTAGAT CCAGTGAAGG GATTTTCTCT 360
ACTGTGAACG GCGGCTCTGG GAAAGATTTG TTTGACTACA ATCGTGTGTA TGGCGACGAA 420
TCAATGAGTT TGAAATTTAA TCAGTTAATG GTGTCATTGT TCAGATTATC CAAGAATTGC 480
CAACCTACAA AATTTCATGA AATGCTCAAT GAGTTTGCTA GGGATGGCAG GCTATTGAGA 540
CTGTACACGC AGAATATTGA CGGTTTAGAT ACACAATTAC CTCATTTATC AACTAATGTG 600
CCTCTGGCGA AGCCAATACC CAGTACAGTA CAATTACACG GAAGCATAAA ACACATGGAA 660
TGCAATAAAT GTCTGAATAT CAAACCTTTT GACCCTGAAC TGTTCAAATG CGACGACAAA 720
TTTGATTCTC GGACTGAAAT CATACCGTCA TGTCCACAAT GTGAAGAATA TGAAACAGTT 780
AGAAAAATGG CAGGCTTAAG ATCTACTGGT GTGGGCAAGT TGCGTCCAAG AGTAATTTTA 840
TACAATGAGG TCCACCCTGA AGGTGATTTT ATCGGTGAAA TTGCCAATAA TGACTTAAAG 900
AAAAGAATTG ATTGTTTGAT TATTGTTGGA ACGAGTTTGA AGATTCCCGG AGTGAAAAAT 960
ATTTGCAGGC AGTTTGCGGC CAAAGTCCAT GCAAACAGGG GTATTGTGTT ATATTTAAAC 1020
ACCAGTATGC CGCCTAAGAA TGTGCTAGAC TCTTTGAAAT TTGTAGACCT AGTTGTACTG 1080
GGAGATTGTC AGCATGTTAC CTCATTATTA TAG
1114Nucleotide Fasta Sequence
>YDR191W|SIR2|Saccharomyces cerevisiae
ATGAAGCAAAAATTTGTACTACCGATCACCCCACCAAGTACGGCGGAAAAGAAGCCTCAAACAGAAAACCGTTGCAATGAGAATTTGAAGCCTAGAAGATTGCTACCGCAATTGAAAAAAAGTGTCCGTAACAGGAAACCTAGACTGTCATATAGGCCTGAGTTAAACTCTGTGTTTGATCTGGATGCGTACGTGGATTCGACACACTTGTCCAAATCCCAACGCCATCATATGGACCGCGACGCCGGTTTTATTAGCTATGCTCTGAATTATAGCAAAAGAATGGTTGTAGTCAGCGGGGCAGGTATATCTGTTGCCGCTGGTATACCGGATTTTAGATCCAGTGAAGGGATTTTCTCTACTGTGAACGGCGGCTCTGGGAAAGATTTGTTTGACTACAATCGTGTGTATGGCGACGAATCAATGAGTTTGAAATTTAATCAGTTAATGGTGTCATTGTTCAGATTATCCAAGAATTGCCAACCTACAAAATTTCATGAAATGCTCAATGAGTTTGCTAGGGATGGCAGGCTATTGAGACTGTACACGCAGAATATTGACGGTTTAGATACACAATTACCTCATTTATCAACTAATGTGCCTCTGGCGAAGCCAATACCCAGTACAGTACAATTACACGGAAGCATAAAACACATGGAATGCAATAAATGTCTGAATATCAAACCTTTTGACCCTGAACTGTTCAAATGCGACGACAAATTTGATTCTCGGACTGAAATCATACCGTCATGTCCACAATGTGAAGAATATGAAACAGTTAGAAAAATGGCAGGCTTAAGATCTACTGGTGTGGGCAAGTTGCGTCCAAGAGTAATTTTATACAATGAGGTCCACCCTGAAGGTGATTTTATCGGTGAAATTGCCAATAATGACTTAAAGAAAAGAATTGATTGTTTGATTATTGTTGGAACGAGTTTGAAGATTCCCGGAGTGAAAAATATTTGCAGGCAGTTTGCGGCCAAAGTCCATGCAAACAGGGGTATTGTGTTATATTTAAACACCAGTATGCCGCCTAAGAATGTGCTAGACTCTTTGAAATTTGTAGACCTAGTTGTACTGGGAGATTGTCAGCATGTTACCTCATTATTATAG
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:1990383--P:cellular response to biotin starvation
GO:0006348--P:chromatin silencing at telomere
GO:0016575--P:histone deacetylation
GO:0046459--P:short-chain fatty acid metabolic process
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
