| Tag |
Content |
| WERAM ID |
WERAM-Scp-0006 |
| Ensembl Protein ID |
SPAC1783.04c.1:pep |
| Uniprot Accession |
Q9UR39; HST4_SCHPO
|
| Genbank Protein ID |
NP_593659.1
|
| Protein Name |
NAD-dependent protein deacetylase hst4 |
| Genbank Nucleotide ID |
NM_001019091.2
|
| Gene Name |
HST4;SPAC1783.04c |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
H3K56; H4K12; H4K16 |
K |
12466527
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
1.70e-63 |
212.5 |
50 |
336 |
|
| Organism |
Schizosaccharomyces pombe |
| NCBI Taxa ID |
284812 |
Functional Description
(View)Functional Description
NAD-dependent histone deacetylase, which contributes to both telomeric and centromeric silencing, proper cell cycle progression, DNA damage control, recombination, and genomic maintenance. |
NAD-dependent histone deacetylase, which contributes to both telomeric and centromeric silencing, proper cell cycle progression, DNA damage control, recombination, and genomic maintenance.
|
| Domain Profile |
HDAC SIR2
SIR2.txt 3 lakllkkskkivvltGAGiStsaGIPDFRsseGlysklkke..elpspeaifdldffrkdpkv..fyalakelyp.lgsakPtktHyflae 88
l+++++k+k+ivv+tGAGiS++aGIPDFRsseGl+s+l++e ++s++++fd +++r+ ++v f+a+ ++l++ +++a+Pt +H fl++
SPAC1783.04c.1:pep 50 LVSAIRKAKRIVVVTGAGISCDAGIPDFRSSEGLFSSLRAEykLNCSGKELFDGSVYRDLKSVniFHAMIRKLHMlSNNARPTDFHLFLSQ 140
7889**********************************998767899************999999************************** PP
SIR2.txt 89 lekkgkllrlytQNiDgLerk.aglked..........klvelHGslatasCtkCk..kefpreeikeklkakekvpkCekC......... 157
l++++kllrlytQNiD Le++ gl++ +++ lHG+l+++sCt+C+ k+f+++ + ++ v++C++C
SPAC1783.04c.1:pep 141 LAQESKLLRLYTQNIDFLETRlEGLQTCiplpqsapwpTTIPLHGTLEVVSCTRCSflKKFNPDIFD-----RNGVTVCPDCktenevrri 226
******************7652566644777799*********************965666655555.....456889************* PP
SIR2.txt 158 .......kgvlkpdivffgenlpe.efleeveed..lkeadlllvlGtSlkvepvaslvkkavkkkvp....vllvnleevk..adkladl 232
+g+l+p+iv+++e +p+ e++ +v+++ +++ d+l+v GtS+k+ +v++++k++++ ++ v+++n++e + +l+dl
SPAC1783.04c.1:pep 227 agkrsviEGCLRPRIVLYNEIHPDsESIGSVCSQdlKSRPDCLIVAGTSCKIPGVKRIIKEMSNCVHKqkgnVIWLNYDEPTkdFLNLCDL 317
***********************97778888877677889*******************96554444444459*****9998556699*** PP
SIR2.txt 233 kllgdcdevveellkllgl 251
+++gd++ ++++l ll++
SPAC1783.04c.1:pep 318 VVQGDLQIAIRRLKPLLDA 336
************9988765 PP
|
Protein Sequence
(Fasta) | MKVEEHVPLI QESRKRKCQS SENASKRQQL LSKLPLRLHT GNENVDLSPL VSAIRKAKRI 60
VVVTGAGISC DAGIPDFRSS EGLFSSLRAE YKLNCSGKEL FDGSVYRDLK SVNIFHAMIR 120
KLHMLSNNAR PTDFHLFLSQ LAQESKLLRL YTQNIDFLET RLEGLQTCIP LPQSAPWPTT 180
IPLHGTLEVV SCTRCSFLKK FNPDIFDRNG VTVCPDCKTE NEVRRIAGKR SVIEGCLRPR 240
IVLYNEIHPD SESIGSVCSQ DLKSRPDCLI VAGTSCKIPG VKRIIKEMSN CVHKQKGNVI 300
WLNYDEPTKD FLNLCDLVVQ GDLQIAIRRL KPLLDAPSWK LKSHSAKRTS KQKSSEQTKI 360
TSSTKITKAI GLNTKSNDSS KKDNTSFQLH QVLNSIEIPK VEIKQEVEYA TPSPL 415Protein Fasta Sequence
>SPAC1783.04c.1:pep|HST4;SPAC1783.04c|Schizosaccharomyces pombe
MKVEEHVPLIQESRKRKCQSSENASKRQQLLSKLPLRLHTGNENVDLSPLVSAIRKAKRIVVVTGAGISCDAGIPDFRSSEGLFSSLRAEYKLNCSGKELFDGSVYRDLKSVNIFHAMIRKLHMLSNNARPTDFHLFLSQLAQESKLLRLYTQNIDFLETRLEGLQTCIPLPQSAPWPTTIPLHGTLEVVSCTRCSFLKKFNPDIFDRNGVTVCPDCKTENEVRRIAGKRSVIEGCLRPRIVLYNEIHPDSESIGSVCSQDLKSRPDCLIVAGTSCKIPGVKRIIKEMSNCVHKQKGNVIWLNYDEPTKDFLNLCDLVVQGDLQIAIRRLKPLLDAPSWKLKSHSAKRTSKQKSSEQTKITSSTKITKAIGLNTKSNDSSKKDNTSFQLHQVLNSIEIPKVEIKQEVEYATPSPL |
Nucleotide Sequence
(Fasta) | CCTTCAACGG CCTTTCGAAA CGTACGTAGA CACAACCGCC TAACCGTCAA TCACAACTTA 60
ATTCCTCAAC CATTCCATTT TAGGAAGAAG TCGAAGAGTT CAATGATTTT AATATATTTT 120
AATTAATGCA CTCAACTTTT TGGATTTAAA AAATTCCAAA TTTACGTAGC TTAGTATGAA 180
AGTGGAGGAG CACGTCCCTC TAATACAGGA GTCGAGGAAG AGAAAATGCC AATCTTCTGA 240
AAATGCTTCG AAAAGGCAGC AATTACTTTC CAAGCTTCCA CTTAGACTTC ATACAGGCAA 300
TGAAAATGTC GATTTATCTC CTTTAGTTTC TGCCATTCGC AAGGCAAAGC GCATAGTCGT 360
TGTTACTGGT GCTGGAATTT CTTGTGATGC TGGAATTCCT GATTTCCGTT CCTCTGAGGG 420
TCTTTTCTCC TCCCTTCGTG CGGAGTATAA ATTGAACTGC TCCGGGAAGG AATTGTTTGA 480
TGGATCTGTT TACAGAGATC TTAAGAGTGT TAACATCTTT CACGCAATGA TTAGAAAGCT 540
ACATATGCTT TCTAATAATG CACGCCCCAC TGATTTCCAT TTATTTTTAT CTCAACTAGC 600
CCAAGAATCT AAGCTGTTAC GTTTATACAC ACAAAATATT GATTTTTTAG AAACCAGACT 660
CGAGGGCCTT CAAACATGTA TTCCATTGCC GCAGTCTGCC CCTTGGCCTA CCACGATTCC 720
TCTTCACGGG ACACTGGAAG TTGTAAGTTG CACAAGGTGC AGCTTTTTGA AAAAATTTAA 780
TCCAGATATA TTTGATAGAA ATGGTGTTAC TGTTTGCCCT GACTGTAAAA CCGAGAACGA 840
GGTTCGTCGT ATAGCAGGAA AAAGATCAGT TATCGAGGGT TGCCTTCGTC CTCGGATTGT 900
TTTGTACAAT GAGATACATC CGGATTCCGA ATCTATTGGT TCGGTCTGTT CACAAGATTT 960
AAAGTCCCGC CCTGACTGTC TAATTGTTGC TGGTACTTCT TGTAAAATCC CTGGTGTCAA 1020
AAGAATTATC AAGGAAATGA GCAACTGTGT GCATAAACAG AAGGGAAATG TTATTTGGTT 1080
GAATTATGAC GAACCTACGA AAGATTTTTT GAACTTATGC GACCTGGTTG TACAAGGAGA 1140
CCTTCAAATT GCTATTAGAC GTCTGAAGCC TTTATTAGAT GCTCCAAGTT GGAAACTCAA 1200
GTCCCATTCT GCCAAAAGAA CTTCAAAACA AAAATCTTCC GAACAAACAA AGATTACTTC 1260
TTCCACTAAA ATTACGAAAG CTATTGGCTT GAACACGAAA AGCAATGATA GTTCTAAGAA 1320
AGATAACACT TCTTTTCAGT TGCACCAAGT GCTCAATAGT ATTGAAATAC CCAAGGTGGA 1380
AATTAAACAA GAAGTTGAAT ATGCAACCCC TTCTCCGCTT TAACATTTAG CTTCAATAAA 1440
CCATGTTAAA AATATCAATT TATCCTTCTT ACCCCAAATG AGGTTTAAAT AATGC
1496Nucleotide Fasta Sequence
>SPAC1783.04c.1:pep|SIR2|Schizosaccharomyces pombe
CCTTCAACGGCCTTTCGAAACGTACGTAGACACAACCGCCTAACCGTCAATCACAACTTAATTCCTCAACCATTCCATTTTAGGAAGAAGTCGAAGAGTTCAATGATTTTAATATATTTTAATTAATGCACTCAACTTTTTGGATTTAAAAAATTCCAAATTTACGTAGCTTAGTATGAAAGTGGAGGAGCACGTCCCTCTAATACAGGAGTCGAGGAAGAGAAAATGCCAATCTTCTGAAAATGCTTCGAAAAGGCAGCAATTACTTTCCAAGCTTCCACTTAGACTTCATACAGGCAATGAAAATGTCGATTTATCTCCTTTAGTTTCTGCCATTCGCAAGGCAAAGCGCATAGTCGTTGTTACTGGTGCTGGAATTTCTTGTGATGCTGGAATTCCTGATTTCCGTTCCTCTGAGGGTCTTTTCTCCTCCCTTCGTGCGGAGTATAAATTGAACTGCTCCGGGAAGGAATTGTTTGATGGATCTGTTTACAGAGATCTTAAGAGTGTTAACATCTTTCACGCAATGATTAGAAAGCTACATATGCTTTCTAATAATGCACGCCCCACTGATTTCCATTTATTTTTATCTCAACTAGCCCAAGAATCTAAGCTGTTACGTTTATACACACAAAATATTGATTTTTTAGAAACCAGACTCGAGGGCCTTCAAACATGTATTCCATTGCCGCAGTCTGCCCCTTGGCCTACCACGATTCCTCTTCACGGGACACTGGAAGTTGTAAGTTGCACAAGGTGCAGCTTTTTGAAAAAATTTAATCCAGATATATTTGATAGAAATGGTGTTACTGTTTGCCCTGACTGTAAAACCGAGAACGAGGTTCGTCGTATAGCAGGAAAAAGATCAGTTATCGAGGGTTGCCTTCGTCCTCGGATTGTTTTGTACAATGAGATACATCCGGATTCCGAATCTATTGGTTCGGTCTGTTCACAAGATTTAAAGTCCCGCCCTGACTGTCTAATTGTTGCTGGTACTTCTTGTAAAATCCCTGGTGTCAAAAGAATTATCAAGGAAATGAGCAACTGTGTGCATAAACAGAAGGGAAATGTTATTTGGTTGAATTATGACGAACCTACGAAAGATTTTTTGAACTTATGCGACCTGGTTGTACAAGGAGACCTTCAAATTGCTATTAGACGTCTGAAGCCTTTATTAGATGCTCCAAGTTGGAAACTCAAGTCCCATTCTGCCAAAAGAACTTCAAAACAAAAATCTTCCGAACAAACAAAGATTACTTCTTCCACTAAAATTACGAAAGCTATTGGCTTGAACACGAAAAGCAATGATAGTTCTAAGAAAGATAACACTTCTTTTCAGTTGCACCAAGTGCTCAATAGTATTGAAATACCCAAGGTGGAAATTAAACAAGAAGTTGAATATGCAACCCCTTCTCCGCTTTAACATTTAGCTTCAATAAACCATGTTAAAAATATCAATTTATCCTTCTTACCCCAAATGAGGTTTAAATAATGC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0000781--C:chromosome, telomeric region
GO:0031934--C:mating-type region heterochromatin
GO:0000790--C:nuclear chromatin
GO:0031618--C:nuclear pericentric heterochromatin
GO:1902377--C:nuclear rDNA heterochromatin
GO:1990707--C:nuclear subtelomeric heterochromatin
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0030702--P:chromatin silencing at centromere
GO:0006348--P:chromatin silencing at telomere
GO:0016575--P:histone deacetylation
GO:0071572--P:histone H3-K56 deacetylation
GO:1990679--P:histone H4-K12 deacetylation
GO:1990678--P:histone H4-K16 deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0031508--P:pericentric heterochromatin assembly
GO:0006282--P:regulation of DNA repair
GO:0060303--P:regulation of nucleosome density
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
