| Tag |
Content |
| WERAM ID |
WERAM-Cae-0014 |
| Ensembl Protein ID |
R06A4.7 |
| Uniprot Accession |
O17514; MES2_CAEEL; O62335
|
| Genbank Protein ID |
NP_496992.3
|
| Protein Name |
Histone-lysine N-methyltransferase mes-2 |
| Genbank Nucleotide ID |
NM_064591.5
|
| Gene Name |
MES2 |
| Ensembl Information |
|
| Details |
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
EZ |
1.40e-57 |
193.4 |
301 |
737 |
|
| Organism |
Caenorhabditis elegans |
| NCBI Taxa ID |
6239 |
Functional Description
(View)Functional Description
Polycomb group (PcG) protein. Catalytic subunit of a the mes-2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells. |
Polycomb group (PcG) protein. Catalytic subunit of a the mes-2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells.
|
| Domain Profile |
HMT EZ
EZ.txt 76 anhsakpncyakv 88
a+ +p+cya +
R06A4.7 301 AQNLRNPTCYACL 313
455568****965 PP
EZ.txt 1 krillgksdvaGwGlflkesvekneylgeytGelisddeadkrGkiydrakssflfnlndqlvidakrkGnklkfanhsak.pncyakvllvaGdhriGlfa 101
kr+++g+s++aG+Glfl+e++ek+e+++eytGe+isddea++rG+iydr+++s++fn++++ +id++++Gn ++fanh++k p+cya++++vaG+hriG++a
R06A4.7 621 KRTYCGPSKIAGNGLFLLEPAEKDEFITEYTGERISDDEAERRGAIYDRYQCSYIFNIETGGAIDSYKIGNLARFANHDSKnPTCYARTMVVAGEHRIGFYA 722
79*****************************************************************************999******************** PP
EZ.txt 102 krrieaseelffdyr 116
krr+e+seel+fdy+
R06A4.7 723 KRRLEISEELTFDYS 737
**************6 PP
|
Protein Sequence
(Fasta) | MSNSEPSTST PSGKTKKRGK KCETSMGKSK KSKNLPRFVK IQPIFSSEKI KETVCEQGIE 60
ECKRMLKGHF NAIKDDYDIR VKDELDTDIK DWLKDASSSV NEYRRRLQEN LGEGRTIAKF 120
SFKNCEKYEE NDYKVSDSTV TWIKPDRTEE GDLMKKFRAP CSRIEVGDIS PPMIYWVPIE 180
QSVATPDQLR LTHMPYFGDG IDDGNIYEHL IDMFPDGIHG FSDNWSYVND WILYKLCRAA 240
LKDYQGSPDV FYYTLYRLWP NKSSQREFSS AFPVLCENFA EKGFDPSSLE PWKKTKIAEG 300
AQNLRNPTCY ACLAYTCAIH GFKAEIPIEF PNGEFYNAML PLPNNPENDG KMCSGNCWKS 360
VTMKEVSEVL VPDSEEILQK EVKIYFMKSR IAKMPIEDGA LIVNIYVFNT YIPFCEFVKK 420
YVDEDDEESK IRSCRDAYHL MMSMAENVSA RRLKMGQPSN RLSIKDRVNN FRRNQLSQEK 480
AKRKLRHDSL RIQALRDGLD AEKLIREDDM RDSQRNSEKV RMTAVTPITA CRHAGPCNAT 540
AENCACRENG VCSYMCKCDI NCSQRFPGCN CAAGQCYTKA CQCYRANWEC NPMTCNMCKC 600
DAIDSNIIKC RNFGMTRMIQ KRTYCGPSKI AGNGLFLLEP AEKDEFITEY TGERISDDEA 660
ERRGAIYDRY QCSYIFNIET GGAIDSYKIG NLARFANHDS KNPTCYARTM VVAGEHRIGF 720
YAKRRLEISE ELTFDYSYSG EHQIAFRMVQ TKERSEKPSR PKSQKLSKPM TSE 773Protein Fasta Sequence
>R06A4.7|MES2|Caenorhabditis elegans
MSNSEPSTSTPSGKTKKRGKKCETSMGKSKKSKNLPRFVKIQPIFSSEKIKETVCEQGIEECKRMLKGHFNAIKDDYDIRVKDELDTDIKDWLKDASSSVNEYRRRLQENLGEGRTIAKFSFKNCEKYEENDYKVSDSTVTWIKPDRTEEGDLMKKFRAPCSRIEVGDISPPMIYWVPIEQSVATPDQLRLTHMPYFGDGIDDGNIYEHLIDMFPDGIHGFSDNWSYVNDWILYKLCRAALKDYQGSPDVFYYTLYRLWPNKSSQREFSSAFPVLCENFAEKGFDPSSLEPWKKTKIAEGAQNLRNPTCYACLAYTCAIHGFKAEIPIEFPNGEFYNAMLPLPNNPENDGKMCSGNCWKSVTMKEVSEVLVPDSEEILQKEVKIYFMKSRIAKMPIEDGALIVNIYVFNTYIPFCEFVKKYVDEDDEESKIRSCRDAYHLMMSMAENVSARRLKMGQPSNRLSIKDRVNNFRRNQLSQEKAKRKLRHDSLRIQALRDGLDAEKLIREDDMRDSQRNSEKVRMTAVTPITACRHAGPCNATAENCACRENGVCSYMCKCDINCSQRFPGCNCAAGQCYTKACQCYRANWECNPMTCNMCKCDAIDSNIIKCRNFGMTRMIQKRTYCGPSKIAGNGLFLLEPAEKDEFITEYTGERISDDEAERRGAIYDRYQCSYIFNIETGGAIDSYKIGNLARFANHDSKNPTCYARTMVVAGEHRIGFYAKRRLEISEELTFDYSYSGEHQIAFRMVQTKERSEKPSRPKSQKLSKPMTSE |
Nucleotide Sequence
(Fasta) | ATGAGCAACT CAGAGCCCAG CACATCAACT CCCTCAGGAA AAACAAAGAA GCGCGGGAAA 60
AAGTGCGAAA CTTCTATGGG AAAATCGAAG AAATCGAAAA ATTTGCCTCG CTTTGTGAAA 120
ATTCAGCCAA TTTTTTCATC TGAAAAAATC AAGGAGACCG TGTGCGAACA AGGAATTGAA 180
GAATGTAAAC GTATGCTTAA AGGCCACTTC AATGCTATCA AAGATGACTA TGACATTCGA 240
GTAAAAGACG AGCTGGACAC AGACATCAAA GATTGGTTGA AGGATGCGAG CAGCAGTGTT 300
AATGAATATC GCAGAAGGCT GCAAGAAAAT TTAGGAGAGG GCAGAACTAT CGCAAAATTT 360
TCATTCAAAA ACTGTGAAAA ATACGAAGAA AACGACTACA AAGTCTCCGA TTCCACAGTT 420
ACATGGATCA AACCGGATCG AACGGAGGAA GGAGATTTGA TGAAGAAGTT TCGTGCTCCG 480
TGTTCACGTA TCGAGGTTGG CGACATTTCC CCGCCAATGA TATACTGGGT TCCAATCGAG 540
CAAAGTGTGG CGACTCCGGA TCAGCTGCGG CTCACGCATA TGCCGTATTT TGGCGATGGT 600
ATTGACGATG GGAATATCTA TGAGCATTTG ATTGATATGT TCCCAGATGG AATTCATGGA 660
TTTTCGGACA ACTGGTCCTA TGTCAATGAT TGGATACTCT ACAAACTATG CCGTGCTGCG 720
CTCAAAGACT ACCAAGGCAG CCCAGACGTA TTCTACTACA CCCTCTACCG TCTATGGCCA 780
AACAAAAGTT CACAGAGAGA ATTTTCGTCG GCTTTTCCCG TTTTGTGCGA GAACTTTGCT 840
GAAAAAGGAT TCGATCCGTC GAGCCTCGAA CCATGGAAGA AGACAAAAAT CGCTGAAGGT 900
GCTCAAAATC TTCGAAATCC GACGTGTTAC GCGTGCCTCG CATATACATG TGCGATTCAC 960
GGATTCAAAG CCGAAATTCC AATCGAGTTT CCGAATGGTG AATTCTATAA TGCGATGCTT 1020
CCGCTGCCAA ATAACCCGGA AAATGATGGA AAGATGTGTT CTGGAAATTG CTGGAAATCG 1080
GTGACGATGA AAGAAGTTTC AGAAGTTCTT GTGCCGGATT CTGAAGAAAT TCTGCAGAAA 1140
GAAGTGAAGA TTTATTTCAT GAAATCAAGA ATTGCAAAGA TGCCGATTGA AGATGGAGCG 1200
CTCATTGTGA ACATTTACGT GTTCAATACA TATATTCCAT TCTGCGAGTT TGTCAAAAAA 1260
TATGTCGACG AAGACGACGA GGAAAGCAAA ATTCGTTCAT GTCGTGACGC ATATCATCTA 1320
ATGATGTCGA TGGCAGAAAA TGTGAGCGCC CGACGACTTA AAATGGGACA ACCGTCGAAT 1380
AGATTAAGTA TCAAGGATCG AGTCAACAAC TTCCGTCGTA ATCAGTTGAG TCAGGAGAAG 1440
GCGAAGCGTA AGCTGCGTCA CGACAGTCTG CGTATTCAAG CATTGAGAGA TGGTCTGGAT 1500
GCGGAAAAAT TGATTCGAGA AGATGATATG CGTGATTCTC AGCGAAATAG CGAGAAAGTT 1560
CGCATGACCG CGGTGACGCC AATCACAGCG TGTCGACATG CGGGCCCATG CAACGCGACA 1620
GCCGAAAATT GTGCATGTCG TGAAAACGGA GTGTGCTCGT ACATGTGCAA ATGCGATATA 1680
AACTGTTCTC AGCGATTCCC GGGATGCAAT TGCGCCGCCG GTCAGTGCTA CACGAAGGCT 1740
TGCCAGTGCT ATCGAGCCAA TTGGGAATGT AATCCGATGA CGTGTAATAT GTGCAAATGC 1800
GACGCCATCG ACTCGAACAT AATAAAATGC CGCAATTTTG GAATGACTAG AATGATCCAA 1860
AAACGAACGT ATTGCGGGCC ATCGAAAATA GCAGGCAATG GACTTTTCTT GTTGGAACCC 1920
GCCGAAAAAG ACGAGTTCAT TACGGAATAC ACTGGTGAAC GAATTTCCGA TGATGAAGCC 1980
GAACGACGCG GTGCGATATA TGATCGATAT CAGTGCAGCT ACATTTTTAA CATTGAAACC 2040
GGGGGTGCGA TCGATTCGTA CAAAATTGGA AACTTGGCAC GATTTGCCAA TCATGACAGC 2100
AAGAATCCGA CGTGCTACGC GAGAACGATG GTTGTCGCCG GAGAGCACCG AATTGGGTTC 2160
TATGCGAAGA GACGGCTTGA GATTAGTGAA GAGCTCACAT TTGACTACAG TTATTCTGGA 2220
GAACATCAGA TAGCGTTCAG GATGGTCCAA ACCAAGGAGA GATCCGAGAA GCCCAGCAGG 2280
CCCAAAAGCC AGAAACTCTC CAAACCAATG ACTTCTGAAT AATCTTTTTT CTTGACTTTT 2340
TTTCTTAAAT TTTTCCCGTT GATATCACTT TCAAATCTCA AGATCTACTT GTTTAACTGT 2400
TATTTCCCTA GAATCTCATG TTTCTGAATA CATTTTCCTT CCTTCAAATT TCTGAAAACC 2460
ATAAATATAA TCGAATCAAA ATTCCTCCTA TAAAATCGCC CGACACAGCA CAA
2514Nucleotide Fasta Sequence
>R06A4.7|EZ|Caenorhabditis elegans
ATGAGCAACTCAGAGCCCAGCACATCAACTCCCTCAGGAAAAACAAAGAAGCGCGGGAAAAAGTGCGAAACTTCTATGGGAAAATCGAAGAAATCGAAAAATTTGCCTCGCTTTGTGAAAATTCAGCCAATTTTTTCATCTGAAAAAATCAAGGAGACCGTGTGCGAACAAGGAATTGAAGAATGTAAACGTATGCTTAAAGGCCACTTCAATGCTATCAAAGATGACTATGACATTCGAGTAAAAGACGAGCTGGACACAGACATCAAAGATTGGTTGAAGGATGCGAGCAGCAGTGTTAATGAATATCGCAGAAGGCTGCAAGAAAATTTAGGAGAGGGCAGAACTATCGCAAAATTTTCATTCAAAAACTGTGAAAAATACGAAGAAAACGACTACAAAGTCTCCGATTCCACAGTTACATGGATCAAACCGGATCGAACGGAGGAAGGAGATTTGATGAAGAAGTTTCGTGCTCCGTGTTCACGTATCGAGGTTGGCGACATTTCCCCGCCAATGATATACTGGGTTCCAATCGAGCAAAGTGTGGCGACTCCGGATCAGCTGCGGCTCACGCATATGCCGTATTTTGGCGATGGTATTGACGATGGGAATATCTATGAGCATTTGATTGATATGTTCCCAGATGGAATTCATGGATTTTCGGACAACTGGTCCTATGTCAATGATTGGATACTCTACAAACTATGCCGTGCTGCGCTCAAAGACTACCAAGGCAGCCCAGACGTATTCTACTACACCCTCTACCGTCTATGGCCAAACAAAAGTTCACAGAGAGAATTTTCGTCGGCTTTTCCCGTTTTGTGCGAGAACTTTGCTGAAAAAGGATTCGATCCGTCGAGCCTCGAACCATGGAAGAAGACAAAAATCGCTGAAGGTGCTCAAAATCTTCGAAATCCGACGTGTTACGCGTGCCTCGCATATACATGTGCGATTCACGGATTCAAAGCCGAAATTCCAATCGAGTTTCCGAATGGTGAATTCTATAATGCGATGCTTCCGCTGCCAAATAACCCGGAAAATGATGGAAAGATGTGTTCTGGAAATTGCTGGAAATCGGTGACGATGAAAGAAGTTTCAGAAGTTCTTGTGCCGGATTCTGAAGAAATTCTGCAGAAAGAAGTGAAGATTTATTTCATGAAATCAAGAATTGCAAAGATGCCGATTGAAGATGGAGCGCTCATTGTGAACATTTACGTGTTCAATACATATATTCCATTCTGCGAGTTTGTCAAAAAATATGTCGACGAAGACGACGAGGAAAGCAAAATTCGTTCATGTCGTGACGCATATCATCTAATGATGTCGATGGCAGAAAATGTGAGCGCCCGACGACTTAAAATGGGACAACCGTCGAATAGATTAAGTATCAAGGATCGAGTCAACAACTTCCGTCGTAATCAGTTGAGTCAGGAGAAGGCGAAGCGTAAGCTGCGTCACGACAGTCTGCGTATTCAAGCATTGAGAGATGGTCTGGATGCGGAAAAATTGATTCGAGAAGATGATATGCGTGATTCTCAGCGAAATAGCGAGAAAGTTCGCATGACCGCGGTGACGCCAATCACAGCGTGTCGACATGCGGGCCCATGCAACGCGACAGCCGAAAATTGTGCATGTCGTGAAAACGGAGTGTGCTCGTACATGTGCAAATGCGATATAAACTGTTCTCAGCGATTCCCGGGATGCAATTGCGCCGCCGGTCAGTGCTACACGAAGGCTTGCCAGTGCTATCGAGCCAATTGGGAATGTAATCCGATGACGTGTAATATGTGCAAATGCGACGCCATCGACTCGAACATAATAAAATGCCGCAATTTTGGAATGACTAGAATGATCCAAAAACGAACGTATTGCGGGCCATCGAAAATAGCAGGCAATGGACTTTTCTTGTTGGAACCCGCCGAAAAAGACGAGTTCATTACGGAATACACTGGTGAACGAATTTCCGATGATGAAGCCGAACGACGCGGTGCGATATATGATCGATATCAGTGCAGCTACATTTTTAACATTGAAACCGGGGGTGCGATCGATTCGTACAAAATTGGAAACTTGGCACGATTTGCCAATCATGACAGCAAGAATCCGACGTGCTACGCGAGAACGATGGTTGTCGCCGGAGAGCACCGAATTGGGTTCTATGCGAAGAGACGGCTTGAGATTAGTGAAGAGCTCACATTTGACTACAGTTATTCTGGAGAACATCAGATAGCGTTCAGGATGGTCCAAACCAAGGAGAGATCCGAGAAGCCCAGCAGGCCCAAAAGCCAGAAACTCTCCAAACCAATGACTTCTGAATAATCTTTTTTCTTGACTTTTTTTCTTAAATTTTTCCCGTTGATATCACTTTCAAATCTCAAGATCTACTTGTTTAACTGTTATTTCCCTAGAATCTCATGTTTCTGAATACATTTTCCTTCCTTCAAATTTCTGAAAACCATAAATATAATCGAATCAAAATTCCTCCTATAAAATCGCCCGACACAGCACAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR026489--CXC_dom
IPR001214--SET_dom
|
| PROSITE |
PS51633--CXC
PS50280--SET
|
| Pfam |
PF00856--SET
|
| Gene Ontology |
GO:0000786--C:nucleosome
GO:0031519--C:PcG protein complex
GO:0042054--F:histone methyltransferase activity
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0007276--P:gamete generation
GO:0007281--P:germ cell development
GO:0042078--P:germ-line stem cell division
GO:0070734--P:histone H3-K27 methylation
GO:0098532--P:histone H3-K27 trimethylation
GO:0016571--P:histone methylation
GO:0007275--P:multicellular organism development
GO:0040029--P:regulation of gene expression, epigenetic
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
