| Tag |
Content |
| WERAM ID |
WERAM-Drm-0067 |
| Ensembl Protein ID |
FBpp0310647 |
| Uniprot Accession |
Q9I7I7; SIRT2_DROME
|
| Genbank Protein ID |
NP_001287422.1; NP_650880.2
|
| Protein Name |
NAD-dependent protein deacetylase Sirt2 |
| Genbank Nucleotide ID |
NM_001300493.1; NM_142623.4
|
| Gene Name |
SIRT2;CG5085 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
|
K |
25023514
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
7.40e-97 |
324.3 |
43 |
308 |
|
| Organism |
Drosophila melanogaster |
| NCBI Taxa ID |
7227 |
Functional Description
(View)Functional Description
NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span. |
NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span.
|
| Domain Profile |
HDAC SIR2
SIR2.txt 8 k..kskkivvltGAGiStsaGIPDFRs.seGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaelekkgkllrlytQN 102
+ +kiv+++GAGiStsaGIPDFRs ++Glys+lkk+elp+p+aifdld+f+k+p++f+alakelyp gs+ Pt++Hyf+++l++kg+l+r+ytQN
FBpp0310647 43 RvhGFRKIVTMVGAGISTSAGIPDFRSpGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFFALAKELYP-GSFIPTPAHYFIRLLNDKGLLQRHYTQN 139
444789***************************************************************.**************************** PP
SIR2.txt 103 iDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCekCkgvlkpdivffgenlpeefleeveedlkeadlllvlGtSlkve 200
iD+L+r +gl+edk++e+HGs++t++C+kC+ke++++++k++++a+ ++pkC+kC+gv+kpdivffgenlp++f+++ eed++++dll+++GtSl+v+
FBpp0310647 140 IDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEYDMDWMKAEIFAD-RLPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQ 236
**********************************************.9************************************************** PP
SIR2.txt 201 pvaslvkkavkkkvpvllvnleevk...................adkladlkllgdcdevveellkllgleee 254
p+aslv++ ++++ +ll+n++ v+ ++++d+++lgdcd v++l+k+lg+++e
FBpp0310647 237 PFASLVWRPGPRCI-RLLINRDAVGqascvlfmdpntrsllfdkPNNTRDVAFLGDCDAGVMALAKALGWDQE 308
***********999.89**************************9999***********************975 PP
|
Protein Sequence
(Fasta) | MDKVRRFFAN TLHLGGSSDA KEEVKVEKVI PDLSFDGFAE HWRVHGFRKI VTMVGAGIST 60
SAGIPDFRSP GSGLYSNLKK YELPHPTAIF DLDYFEKNPA PFFALAKELY PGSFIPTPAH 120
YFIRLLNDKG LLQRHYTQNI DTLDRLTGLP EDKIIEAHGS FHTNHCIKCR KEYDMDWMKA 180
EIFADRLPKC QKCQGVVKPD IVFFGENLPK RFYSSPEEDF QDCDLLIIMG TSLEVQPFAS 240
LVWRPGPRCI RLLINRDAVG QASCVLFMDP NTRSLLFDKP NNTRDVAFLG DCDAGVMALA 300
KALGWDQELQ QLITSERKKL SGSQNSEELQ QGKEKPQSDP DKMTSGDRDK KDASL 355Protein Fasta Sequence
>FBpp0310647|SIRT2;CG5085|Drosophila melanogaster
MDKVRRFFANTLHLGGSSDAKEEVKVEKVIPDLSFDGFAEHWRVHGFRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFFALAKELYPGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADRLPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASLVWRPGPRCIRLLINRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMALAKALGWDQELQQLITSERKKLSGSQNSEELQQGKEKPQSDPDKMTSGDRDKKDASL |
Nucleotide Sequence
(Fasta) | TCGATAGTTG TCAGAACTTG TTTTGCTTTT TACGTTAAAA CAAAACGCAA CATAAACAAT 60
TGGGAGAATT CATCACACTA TCCTCAGATT TACATACTTT CACCGGAAGG TGAATCTGTT 120
TACCATGGGC GACATCGAAG TAAAGAAGGA GGAACAACCG ACGACGCCCT CCAATTCCTC 180
GTCCAGTGAC GACGACGAGG AGGCCCCAGA CGACACAATG GATAAGGTTC GACGCTTCTT 240
TGCAAACACT CTACATCTCG GCGGCTCCTC GGACGCAAAG GAGGAAGTTA AAGTAGAGAA 300
GGTTATTCCA GATTTGAGTT TTGACGGCTT TGCCGAACAT TGGCGTGTGC ATGGTTTCCG 360
CAAGATTGTG ACCATGGTGG GAGCCGGCAT ATCTACATCT GCTGGCATTC CGGATTTCAG 420
ATCCCCAGGT TCCGGGTTAT ACAGCAATCT GAAGAAGTAC GAGCTGCCAC ATCCTACGGC 480
CATATTCGAT CTGGACTACT TCGAAAAGAA TCCAGCGCCG TTTTTTGCAC TGGCCAAGGA 540
ACTTTACCCT GGATCCTTCA TTCCCACGCC GGCCCACTAC TTTATCCGTT TGCTTAACGA 600
CAAGGGACTA CTGCAGCGCC ACTACACCCA GAACATAGAC ACGCTAGACC GGCTTACTGG 660
CCTGCCCGAG GACAAGATCA TTGAGGCCCA TGGCAGCTTC CACACCAACC ACTGCATTAA 720
GTGCCGCAAG GAGTACGACA TGGACTGGAT GAAGGCGGAG ATCTTCGCCG ATCGTCTGCC 780
CAAATGCCAA AAGTGCCAAG GCGTTGTTAA ACCAGACATT GTTTTCTTTG GCGAAAACTT 840
GCCAAAGAGA TTTTACTCCA GTCCTGAAGA GGATTTCCAG GATTGCGATC TGCTGATCAT 900
CATGGGCACA TCGTTGGAAG TGCAACCGTT TGCTTCACTG GTGTGGAGAC CAGGACCACG 960
TTGCATTCGC CTCTTGATCA ATCGCGATGC AGTGGGTCAG GCCAGCTGTG TGCTCTTTAT 1020
GGATCCCAAC ACGCGATCGC TACTCTTCGA TAAGCCCAAT AACACTAGGG ATGTGGCCTT 1080
TCTGGGCGAC TGTGATGCTG GCGTAATGGC TCTGGCCAAA GCCTTGGGCT GGGACCAAGA 1140
GCTGCAGCAG CTAATTACAA GTGAAAGGAA GAAACTGAGC GGCAGCCAGA ATAGTGAGGA 1200
GCTGCAACAA GGCAAAGAGA AACCGCAATC GGACCCGGAT AAGATGACTT CGGGCGATAG 1260
GGACAAGAAG GATGCTTCGC TTTAGACCCT AAGATTAGTT AGTAACATCC GTAGTTAATT 1320
TGTAGTTGAA TTGTGCAATT TGTTTACATG TGGATTACGT GTATAAAGCG GACAATGCCA 1380
AGCGCAGGCA TTGCTGGCTA ATACCGCGAG CTTTCTTTCT CCTCCGTTTC CGGCATTCAA 1440
TTATTCAAGT GCCATTTGTG AGCCATTAGC GTGTCCCTTT TGGCCGGGCC ACCATAAACC 1500
GCAAAAACTG ATTGAGTTGC TCTGCCGTTT CCGGCGCACA AAAAGCAGCA AACCGCCAAC 1560
AAAGGTTAAC TCTCGACATG TTTCTGTTTC GTTTTCTGCT CTGATCCGGG CTTGGCTATG 1620
GATTTCGATG CTGGTGTTGG TGTTGGTGCT GATGCTGATT TCGATTCAGT TACAGCTGCC 1680
CAGCCCCTCG ACATGGCTCG ACCGCTGCTG TGGGCGTGGC ATGTGGCATT CTAACTGCCT 1740
GTTTGTGTGG CTTACACGGA TGCTGCTCCT GCTCCTGCTC CTCCTCCTGC TGCTGCTGCT 1800
ACTGCTGCAT CAACTTAATG ACTCGCAATC TGTCCTGCAG AAGCACACAC GCACAAAGCG 1860
AAAGAGACAC ACACGGTAGA CCGGTAATGA AGCTTCTGCG GTGAATTGGC CAATAGAAAA 1920
TACGTACGGG CAGGACTAAT TAAAACCAAG CTCGCAATCG GGCCAGCGGA TAGCTACTGC 1980
CGGGGTACAC AACCGGATAT TGTTAATCGT TGACAGGGGC GACGGTTCGG AGGTGGATGC 2040
ATGGTATGAT GGGAGGCATC CCAGCCTGTC AACTTCGGGA CATGAATGGC TGCAGATGCA 2100
TTAGGAAATC AAATGCAGCC ACGGAAATAT TGATAGCCAC GCAATTTGTT GCAGTTTCAG 2160
CTGCCACTGC TGTTGCCATT GGAATTGCAC TTGCTTTTGG CCCAAAACTT TTGCAATTAA 2220
AGCTAATGGC CTAAGATCTT GTCTATGTGC AATTTTCCCG AGTCTTGCCT TCTCAGCGAA 2280
TGTTT
2286Nucleotide Fasta Sequence
>FBpp0310647|SIR2|Drosophila melanogaster
TCGATAGTTGTCAGAACTTGTTTTGCTTTTTACGTTAAAACAAAACGCAACATAAACAATTGGGAGAATTCATCACACTATCCTCAGATTTACATACTTTCACCGGAAGGTGAATCTGTTTACCATGGGCGACATCGAAGTAAAGAAGGAGGAACAACCGACGACGCCCTCCAATTCCTCGTCCAGTGACGACGACGAGGAGGCCCCAGACGACACAATGGATAAGGTTCGACGCTTCTTTGCAAACACTCTACATCTCGGCGGCTCCTCGGACGCAAAGGAGGAAGTTAAAGTAGAGAAGGTTATTCCAGATTTGAGTTTTGACGGCTTTGCCGAACATTGGCGTGTGCATGGTTTCCGCAAGATTGTGACCATGGTGGGAGCCGGCATATCTACATCTGCTGGCATTCCGGATTTCAGATCCCCAGGTTCCGGGTTATACAGCAATCTGAAGAAGTACGAGCTGCCACATCCTACGGCCATATTCGATCTGGACTACTTCGAAAAGAATCCAGCGCCGTTTTTTGCACTGGCCAAGGAACTTTACCCTGGATCCTTCATTCCCACGCCGGCCCACTACTTTATCCGTTTGCTTAACGACAAGGGACTACTGCAGCGCCACTACACCCAGAACATAGACACGCTAGACCGGCTTACTGGCCTGCCCGAGGACAAGATCATTGAGGCCCATGGCAGCTTCCACACCAACCACTGCATTAAGTGCCGCAAGGAGTACGACATGGACTGGATGAAGGCGGAGATCTTCGCCGATCGTCTGCCCAAATGCCAAAAGTGCCAAGGCGTTGTTAAACCAGACATTGTTTTCTTTGGCGAAAACTTGCCAAAGAGATTTTACTCCAGTCCTGAAGAGGATTTCCAGGATTGCGATCTGCTGATCATCATGGGCACATCGTTGGAAGTGCAACCGTTTGCTTCACTGGTGTGGAGACCAGGACCACGTTGCATTCGCCTCTTGATCAATCGCGATGCAGTGGGTCAGGCCAGCTGTGTGCTCTTTATGGATCCCAACACGCGATCGCTACTCTTCGATAAGCCCAATAACACTAGGGATGTGGCCTTTCTGGGCGACTGTGATGCTGGCGTAATGGCTCTGGCCAAAGCCTTGGGCTGGGACCAAGAGCTGCAGCAGCTAATTACAAGTGAAAGGAAGAAACTGAGCGGCAGCCAGAATAGTGAGGAGCTGCAACAAGGCAAAGAGAAACCGCAATCGGACCCGGATAAGATGACTTCGGGCGATAGGGACAAGAAGGATGCTTCGCTTTAGACCCTAAGATTAGTTAGTAACATCCGTAGTTAATTTGTAGTTGAATTGTGCAATTTGTTTACATGTGGATTACGTGTATAAAGCGGACAATGCCAAGCGCAGGCATTGCTGGCTAATACCGCGAGCTTTCTTTCTCCTCCGTTTCCGGCATTCAATTATTCAAGTGCCATTTGTGAGCCATTAGCGTGTCCCTTTTGGCCGGGCCACCATAAACCGCAAAAACTGATTGAGTTGCTCTGCCGTTTCCGGCGCACAAAAAGCAGCAAACCGCCAACAAAGGTTAACTCTCGACATGTTTCTGTTTCGTTTTCTGCTCTGATCCGGGCTTGGCTATGGATTTCGATGCTGGTGTTGGTGTTGGTGCTGATGCTGATTTCGATTCAGTTACAGCTGCCCAGCCCCTCGACATGGCTCGACCGCTGCTGTGGGCGTGGCATGTGGCATTCTAACTGCCTGTTTGTGTGGCTTACACGGATGCTGCTCCTGCTCCTGCTCCTCCTCCTGCTGCTGCTGCTACTGCTGCATCAACTTAATGACTCGCAATCTGTCCTGCAGAAGCACACACGCACAAAGCGAAAGAGACACACACGGTAGACCGGTAATGAAGCTTCTGCGGTGAATTGGCCAATAGAAAATACGTACGGGCAGGACTAATTAAAACCAAGCTCGCAATCGGGCCAGCGGATAGCTACTGCCGGGGTACACAACCGGATATTGTTAATCGTTGACAGGGGCGACGGTTCGGAGGTGGATGCATGGTATGATGGGAGGCATCCCAGCCTGTCAACTTCGGGACATGAATGGCTGCAGATGCATTAGGAAATCAAATGCAGCCACGGAAATATTGATAGCCACGCAATTTGTTGCAGTTTCAGCTGCCACTGCTGTTGCCATTGGAATTGCACTTGCTTTTGGCCCAAAACTTTTGCAATTAAAGCTAATGGCCTAAGATCTTGTCTATGTGCAATTTTCCCGAGTCTTGCCTTCTCAGCGAATGTTT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-1185--Reference proteome
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR017328--Sirtuin_class_I
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004407--F:histone deacetylase activity
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0008270--F:zinc ion binding
GO:0048813--P:dendrite morphogenesis
GO:0008340--P:determination of adult lifespan
GO:0016575--P:histone deacetylation
GO:0006476--P:protein deacetylation
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
