| Tag |
Content |
| WERAM ID |
WERAM-Drm-0004 |
| Ensembl Protein ID |
FBpp0076008 |
| Uniprot Accession |
P42124; EZ_DROME; B7Z0G2; Q9VTA3
|
| Genbank Protein ID |
NP_001137932.1; NP_524021.2
|
| Protein Name |
Histone-lysine N-methyltransferase E(z) |
| Genbank Nucleotide ID |
NM_001144460.3; NM_079297.3
|
| Gene Name |
EZ;KMT6;CG6502 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HMT |
EZ |
SET |
H3K9; H3K27 |
K |
12697833
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
EZ |
1.30e-63 |
212.9 |
626 |
741 |
| HMT |
SET1 |
1.90e-40 |
138.2 |
626 |
741 |
|
| Organism |
Drosophila melanogaster |
| NCBI Taxa ID |
7227 |
Functional Description
(View)Functional Description
Polycomb group (PcG) protein. Catalytic subunit of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required. |
Polycomb group (PcG) protein. Catalytic subunit of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.
|
| Domain Profile |
HMT EZ
EZ.txt 1 krillgksdvaGwGlflkesvekneylgeytGelisddeadkrGkiydrakssflfnlndqlvidakrkGnklkfanhsakpncyakvllvaGdhriG 98
k++l+++sd+aGwG+flke+++kne+++ey+Ge+is+dead+rGk+yd++++sflfnln+++v+da+rkGnk++fanhs++pncyakv++v+GdhriG
FBpp0076008 626 KHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIG 723
789*********************************************************************************************** PP
EZ.txt 99 lfakrrieaseelffdyr 116
+fakr+i+ +eelffdyr
FBpp0076008 724 IFAKRAIQPGEELFFDYR 741
*****************7 PP
HMT SET1
SET1.txt 1 kelevakskikglglvakkeiekeelviEYvGevirsevadkrekeyekkeigvylfrldedaevvvdatkkgniarfinhscepNceakvvavdgek 98
k+l +a s+i+g+g++ k+ +k+e++ EY+Ge+i++++ad+r k y+k+ + ++lf+l++d +vvdat+kgn++rf nhs +pNc+akv++v g++
FBpp0076008 626 KHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKY-MCSFLFNLNND--FVVDATRKGNKIRFANHSINPNCYAKVMMVTGDH 720
678999*******************************************9.456********..********************************** PP
SET1.txt 99 kiviyakraIekgeeltydYk 119
+i+i+akraI+ geel++dY+
FBpp0076008 721 RIGIFAKRAIQPGEELFFDYR 741
********************6 PP
|
Protein Sequence
(Fasta) | MNSTKVPPEW KRRVKSEYIK IRQQKRYKRA DEIKEAWIRN WDEHNHNVQD LYCESKVWQA 60
KPYDPPHVDC VKRAEVTSYN GIPSGPQKVP ICVINAVTPI PTMYTWAPTQ QNFMVEDETV 120
LHNIPYMGDE VLDKDGKFIE ELIKNYDGKV HGDKDPSFMD DAIFVELVHA LMRSYSKELE 180
EAAPGTATAI KTETLAKSKQ GEDDGVVDVD ADGESPMKLE KTDSKGDLTE VEKKETEEPL 240
ETEDADVKPD VEEVKDKLPF PAPIIFQAIS ANFPDKGTAQ ELKEKYIELT EHQDPERPQE 300
CTPNIDGIKA ESVSRERTMH SFHTLFCRRC FKYDCFLHRL QGHAGPNLQK RRYPELKPFA 360
EPCSNSCYML IDGMKEKLAA DSKTPPIDSC NEASSEDSND SNSQFSNKDF NHENSKDNGL 420
TVNSAAVAEI NSIMAGMMNI TSTQCVWTGA DQALYRVLHK VYLKNYCAIA HNMLTKTCRQ 480
VYEFAQKEDA EFSFEDLRQD FTPPRKKKKK QRLWSLHCRK IQLKKDSSSN HVYNYTPCDH 540
PGHPCDMNCS CIQTQNFCEK FCNCSSDCQN RFPGCRCKAQ CNTKQCPCYL AVRECDPDLC 600
QACGADQFKL TKITCKNVCV QRGLHKHLLM APSDIAGWGI FLKEGAQKNE FISEYCGEII 660
SQDEADRRGK VYDKYMCSFL FNLNNDFVVD ATRKGNKIRF ANHSINPNCY AKVMMVTGDH 720
RIGIFAKRAI QPGEELFFDY RYGPTEQLKF VGIEREMEIV Protein Fasta Sequence
>FBpp0076008|EZ;KMT6;CG6502|Drosophila melanogaster
MNSTKVPPEWKRRVKSEYIKIRQQKRYKRADEIKEAWIRNWDEHNHNVQDLYCESKVWQAKPYDPPHVDCVKRAEVTSYNGIPSGPQKVPICVINAVTPIPTMYTWAPTQQNFMVEDETVLHNIPYMGDEVLDKDGKFIEELIKNYDGKVHGDKDPSFMDDAIFVELVHALMRSYSKELEEAAPGTATAIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEEPLETEDADVKPDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEHQDPERPQECTPNIDGIKAESVSRERTMHSFHTLFCRRCFKYDCFLHRLQGHAGPNLQKRRYPELKPFAEPCSNSCYMLIDGMKEKLAADSKTPPIDSCNEASSEDSNDSNSQFSNKDFNHENSKDNGLTVNSAAVAEINSIMAGMMNITSTQCVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTCRQVYEFAQKEDAEFSFEDLRQDFTPPRKKKKKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDHPGHPCDMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQACGADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDYRYGPTEQLKFVGIEREMEIV |
Nucleotide Sequence
(Fasta) | CAACACTACA CAAAGCAGGG TCGTACCAAA GAGGGGCTCT TTGTTTATTT CCTACTTTCA 60
GTACAAAATG GTTGTATAGC TAATTTAAAT TTTTATTATA ATATAAATAT AATTAATGGC 120
TTACCGGACA AATTAAGTAC CCACTAAATG GTCTTCTACA TACACCCATG TGTCTAAGTT 180
ATTCTTCCTG CAGTACAACG GTCACACTGC GGCAGCTGTT GCAAAAAAAG GCGGATAATA 240
TTTGTAGCAA AATCAGTGTT TTTTATACGT AAAATCAACA AATATAAAGT CCCTCGAAGG 300
CATTATGAAT AGCACTAAAG TGCCGCCCGA GTGGAAGAGG CGTGTCAAGT CGGAGTACAT 360
CAAAATCAGG CAGCAGAAGC GCTACAAACG TGCCGACGAG ATCAAGGAGG CGTGGATAAG 420
AAACTGGGAC GAGCACAACC ACAATGTACA GGATCTGTAC TGCGAGTCGA AGGTTTGGCA 480
GGCTAAACCC TACGATCCGC CGCATGTGGA CTGTGTGAAG CGGGCGGAGG TGACTAGCTA 540
CAATGGCATT CCCAGCGGTC CGCAAAAGGT GCCCATTTGC GTGATCAACG CGGTCACTCC 600
CATACCCACC ATGTACACGT GGGCACCAAC ACAGCAGAAC TTCATGGTGG AGGATGAGAC 660
GGTGCTGCAC AATATACCCT ATATGGGCGA CGAGGTCCTC GATAAGGATG GCAAGTTCAT 720
AGAGGAACTG ATCAAAAACT ACGATGGCAA GGTTCACGGC GACAAGGATC CCTCGTTCAT 780
GGACGATGCC ATCTTCGTAG AACTGGTGCA CGCCCTTATG CGCTCCTACA GCAAGGAACT 840
GGAGGAAGCC GCTCCGGGTA CAGCGACTGC CATTAAAACA GAGACGTTGG CGAAATCAAA 900
ACAGGGCGAA GATGATGGGG TAGTTGATGT TGACGCAGAT GGTGAATCTC CCATGAAGCT 960
TGAGAAAACC GACAGCAAAG GGGATCTGAC TGAAGTTGAG AAGAAGGAAA CTGAAGAACC 1020
GCTGGAGACT GAAGATGCGG ATGTTAAGCC CGATGTGGAA GAAGTCAAGG ACAAGCTGCC 1080
CTTCCCTGCG CCCATTATTT TTCAGGCCAT CAGCGCTAAC TTTCCAGACA AGGGCACCGC 1140
GCAAGAGCTC AAAGAAAAGT ACATTGAGCT TACGGAGCAC CAGGATCCGG AGCGCCCACA 1200
GGAGTGCACA CCCAACATTG ACGGCATCAA GGCCGAGAGC GTTTCCCGGG AAAGGACTAT 1260
GCACTCCTTT CACACGCTCT TCTGTCGTCG TTGCTTCAAA TACGACTGCT TCCTGCACCG 1320
CTTGCAAGGA CATGCGGGTC CCAATCTCCA GAAGCGTCGC TATCCGGAAC TGAAGCCTTT 1380
CGCCGAACCT TGCAGCAACT CCTGCTACAT GTTGATCGAT GGCATGAAGG AAAAGCTGGC 1440
GGCCGATAGC AAGACACCTC CCATTGATTC CTGCAATGAG GCCAGCTCCG AGGACAGTAA 1500
TGACAGCAAC AGTCAGTTTA GCAACAAGGA CTTTAATCAT GAGAATAGCA AGGATAATGG 1560
CCTGACTGTA AATAGCGCCG CTGTGGCTGA GATCAACTCC ATTATGGCTG GCATGATGAA 1620
CATCACCAGT ACGCAGTGCG TTTGGACAGG CGCTGACCAA GCACTTTATC GGGTCTTGCA 1680
TAAAGTGTAT TTAAAGAACT ACTGCGCGAT TGCGCACAAC ATGCTGACCA AGACCTGTCG 1740
TCAGGTGTAC GAGTTTGCCC AGAAGGAGGA TGCTGAGTTT AGCTTCGAGG ATTTGCGACA 1800
GGACTTCACA CCTCCGCGCA AGAAGAAGAA GAAGCAACGT CTGTGGTCGC TGCACTGTCG 1860
TAAGATTCAG CTAAAGAAGG ACTCATCCTC GAATCACGTG TACAACTACA CGCCCTGCGA 1920
CCATCCCGGA CATCCATGCG ACATGAACTG CTCCTGCATT CAGACACAAA ACTTCTGCGA 1980
AAAGTTCTGC AACTGCAGCA GCGATTGCCA GAATCGTTTC CCCGGCTGTC GCTGCAAGGC 2040
TCAGTGCAAT ACGAAGCAGT GTCCTTGCTA TCTGGCAGTG CGCGAGTGTG ATCCCGATCT 2100
GTGCCAGGCC TGCGGAGCGG ATCAGTTTAA GCTGACCAAG ATCACGTGCA AGAACGTGTG 2160
CGTGCAGCGA GGACTGCACA AGCACCTGCT CATGGCTCCG TCTGACATCG CCGGCTGGGG 2220
CATCTTTCTT AAGGAGGGTG CGCAAAAGAA TGAGTTCATT TCGGAATATT GTGGCGAGAT 2280
CATATCCCAA GATGAAGCCG ATCGCCGTGG CAAGGTTTAC GACAAGTACA TGTGCTCATT 2340
TCTTTTCAAT CTGAACAACG ATTTTGTTGT GGATGCCACT CGGAAGGGCA ACAAGATTCG 2400
GTTTGCCAAT CATTCCATTA ATCCCAATTG CTATGCCAAG GTTATGATGG TCACCGGCGA 2460
TCATCGCATC GGCATCTTTG CCAAGCGGGC CATTCAGCCC GGCGAAGAGC TATTCTTTGA 2520
CTACAGATAC GGACCCACGG AGCAGCTGAA GTTCGTGGGC ATAGAGCGTG AAATGGAAAT 2580
TGTTTGATAA CGAGTCTACT TATGAAAATC GTATCATACA AATTGAATAA AACTATATTT 2640
TTGAAAACAC
2651Nucleotide Fasta Sequence
>FBpp0076008|SET1|Drosophila melanogaster
CAACACTACACAAAGCAGGGTCGTACCAAAGAGGGGCTCTTTGTTTATTTCCTACTTTCAGTACAAAATGGTTGTATAGCTAATTTAAATTTTTATTATAATATAAATATAATTAATGGCTTACCGGACAAATTAAGTACCCACTAAATGGTCTTCTACATACACCCATGTGTCTAAGTTATTCTTCCTGCAGTACAACGGTCACACTGCGGCAGCTGTTGCAAAAAAAGGCGGATAATATTTGTAGCAAAATCAGTGTTTTTTATACGTAAAATCAACAAATATAAAGTCCCTCGAAGGCATTATGAATAGCACTAAAGTGCCGCCCGAGTGGAAGAGGCGTGTCAAGTCGGAGTACATCAAAATCAGGCAGCAGAAGCGCTACAAACGTGCCGACGAGATCAAGGAGGCGTGGATAAGAAACTGGGACGAGCACAACCACAATGTACAGGATCTGTACTGCGAGTCGAAGGTTTGGCAGGCTAAACCCTACGATCCGCCGCATGTGGACTGTGTGAAGCGGGCGGAGGTGACTAGCTACAATGGCATTCCCAGCGGTCCGCAAAAGGTGCCCATTTGCGTGATCAACGCGGTCACTCCCATACCCACCATGTACACGTGGGCACCAACACAGCAGAACTTCATGGTGGAGGATGAGACGGTGCTGCACAATATACCCTATATGGGCGACGAGGTCCTCGATAAGGATGGCAAGTTCATAGAGGAACTGATCAAAAACTACGATGGCAAGGTTCACGGCGACAAGGATCCCTCGTTCATGGACGATGCCATCTTCGTAGAACTGGTGCACGCCCTTATGCGCTCCTACAGCAAGGAACTGGAGGAAGCCGCTCCGGGTACAGCGACTGCCATTAAAACAGAGACGTTGGCGAAATCAAAACAGGGCGAAGATGATGGGGTAGTTGATGTTGACGCAGATGGTGAATCTCCCATGAAGCTTGAGAAAACCGACAGCAAAGGGGATCTGACTGAAGTTGAGAAGAAGGAAACTGAAGAACCGCTGGAGACTGAAGATGCGGATGTTAAGCCCGATGTGGAAGAAGTCAAGGACAAGCTGCCCTTCCCTGCGCCCATTATTTTTCAGGCCATCAGCGCTAACTTTCCAGACAAGGGCACCGCGCAAGAGCTCAAAGAAAAGTACATTGAGCTTACGGAGCACCAGGATCCGGAGCGCCCACAGGAGTGCACACCCAACATTGACGGCATCAAGGCCGAGAGCGTTTCCCGGGAAAGGACTATGCACTCCTTTCACACGCTCTTCTGTCGTCGTTGCTTCAAATACGACTGCTTCCTGCACCGCTTGCAAGGACATGCGGGTCCCAATCTCCAGAAGCGTCGCTATCCGGAACTGAAGCCTTTCGCCGAACCTTGCAGCAACTCCTGCTACATGTTGATCGATGGCATGAAGGAAAAGCTGGCGGCCGATAGCAAGACACCTCCCATTGATTCCTGCAATGAGGCCAGCTCCGAGGACAGTAATGACAGCAACAGTCAGTTTAGCAACAAGGACTTTAATCATGAGAATAGCAAGGATAATGGCCTGACTGTAAATAGCGCCGCTGTGGCTGAGATCAACTCCATTATGGCTGGCATGATGAACATCACCAGTACGCAGTGCGTTTGGACAGGCGCTGACCAAGCACTTTATCGGGTCTTGCATAAAGTGTATTTAAAGAACTACTGCGCGATTGCGCACAACATGCTGACCAAGACCTGTCGTCAGGTGTACGAGTTTGCCCAGAAGGAGGATGCTGAGTTTAGCTTCGAGGATTTGCGACAGGACTTCACACCTCCGCGCAAGAAGAAGAAGAAGCAACGTCTGTGGTCGCTGCACTGTCGTAAGATTCAGCTAAAGAAGGACTCATCCTCGAATCACGTGTACAACTACACGCCCTGCGACCATCCCGGACATCCATGCGACATGAACTGCTCCTGCATTCAGACACAAAACTTCTGCGAAAAGTTCTGCAACTGCAGCAGCGATTGCCAGAATCGTTTCCCCGGCTGTCGCTGCAAGGCTCAGTGCAATACGAAGCAGTGTCCTTGCTATCTGGCAGTGCGCGAGTGTGATCCCGATCTGTGCCAGGCCTGCGGAGCGGATCAGTTTAAGCTGACCAAGATCACGTGCAAGAACGTGTGCGTGCAGCGAGGACTGCACAAGCACCTGCTCATGGCTCCGTCTGACATCGCCGGCTGGGGCATCTTTCTTAAGGAGGGTGCGCAAAAGAATGAGTTCATTTCGGAATATTGTGGCGAGATCATATCCCAAGATGAAGCCGATCGCCGTGGCAAGGTTTACGACAAGTACATGTGCTCATTTCTTTTCAATCTGAACAACGATTTTGTTGTGGATGCCACTCGGAAGGGCAACAAGATTCGGTTTGCCAATCATTCCATTAATCCCAATTGCTATGCCAAGGTTATGATGGTCACCGGCGATCATCGCATCGGCATCTTTGCCAAGCGGGCCATTCAGCCCGGCGAAGAGCTATTCTTTGACTACAGATACGGACCCACGGAGCAGCTGAAGTTCGTGGGCATAGAGCGTGAAATGGAAATTGTTTGATAACGAGTCTACTTATGAAAATCGTATCATACAAATTGAATAAAACTATATTTTTGAAAACAC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR026489--CXC_dom
IPR001005--SANT/Myb
IPR001214--SET_dom
IPR033467--Tesmin/TSO1-like_CXC
|
| PROSITE |
PS51633--CXC
PS50280--SET
|
| Pfam |
PF00856--SET
|
| Gene Ontology |
GO:0035098--C:ESC/E(Z) complex
GO:0035097--C:histone methyltransferase complex
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0042054--F:histone methyltransferase activity
GO:0046976--F:histone methyltransferase activity (H3-K27 specific)
GO:0046974--F:histone methyltransferase activity (H3-K9 specific)
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0007411--P:axon guidance
GO:0006342--P:chromatin silencing
GO:0006723--P:cuticle hydrocarbon biosynthetic process
GO:0048813--P:dendrite morphogenesis
GO:0016458--P:gene silencing
GO:0070734--P:histone H3-K27 methylation
GO:0051567--P:histone H3-K9 methylation
GO:0016571--P:histone methylation
GO:0007517--P:muscle organ development
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0022008--P:neurogenesis
GO:0042810--P:pheromone metabolic process
GO:0035186--P:syncytial blastoderm mitotic cell cycle
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
