| Tag |
Content |
| WERAM ID |
WERAM-Art-0001 |
| Ensembl Protein ID |
AT1G02580.1 |
| Uniprot Accession |
O65312; MEDEA_ARATH
|
| Genbank Protein ID |
NP_563658.1
|
| Protein Name |
Histone-lysine N-methyltransferase MEDEA |
| Genbank Nucleotide ID |
NM_100139.3
|
| Gene Name |
MEA |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HMT |
EZ |
SET |
H3K27 |
K |
20703330
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
EZ |
3.10e-60 |
202.2 |
286 |
659 |
| HMT |
SET1 |
1.40e-29 |
103.4 |
544 |
658 |
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. Required to prevent the proliferation of the central cell of the female gametophyte by repressing target genes before fertilization. After fertilization, it probably also regulates the embryo and endosperm proliferation and anteroposterior organization during seed development. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Interacts with the promoter and repress the transcription of genes such as PHE1 and PHE2, that are paternally active and maternally silenced genes. |
Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. Required to prevent the proliferation of the central cell of the female gametophyte by repressing target genes before fertilization. After fertilization, it probably also regulates the embryo and endosperm proliferation and anteroposterior organization during seed development. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Interacts with the promoter and repress the transcription of genes such as PHE1 and PHE2, that are paternally active and maternally silenced genes.
|
| Domain Profile |
HMT EZ
EZ.txt 65 dakrkGnklk.fanhsakp...ncyakvllva 92
+++ +k f + + +p cy kv v+
AT1G02580.1 286 ESRSSEDKSSlFEDEDRQPcseHCYLKVRSVT 317
44444444431444444442225787776665 PP
EZ.txt 1 krillgksdvaGwGlflkesvekneylgeytGelisddeadkrGkiydrakssflfnlndqlvidakrkGnklkfanhsakpncyakvllvaGdhriG 98
k+il+gksdv+GwG+f+++s++kneylgeytGeli++dea++rG+i+dr+ ss+lf+lndql+ida+rkGn++kf+nhsa+pncyak+++v+Gd+riG
AT1G02580.1 544 KKILIGKSDVHGWGAFTWDSLKKNEYLGEYTGELITHDEANERGRIEDRIGSSYLFTLNDQLEIDARRKGNEFKFLNHSARPNCYAKLMIVRGDQRIG 641
79************************************************************************************************ PP
EZ.txt 99 lfakrrieaseelffdyr 116
lfa+r+ie++eelffdy+
AT1G02580.1 642 LFAERAIEEGEELFFDYC 659
*****************7 PP
HMT SET1
SET1.txt 1 kelevakskikglglvakkeiekeelviEYvGevirsevadkrekeyekkeig.vylfrldedaevvvdatkkgniarfinhscepNceakvvavdge 97
k++ + ks+++g+g ++ ++++k+e + EY+Ge+i +++a++r + +++ g +ylf l+++ + +da++kgn+ +f nhs +pNc+ak + v g+
AT1G02580.1 544 KKILIGKSDVHGWGAFTWDSLKKNEYLGEYTGELITHDEANERGRIEDRI--GsSYLFTLNDQ--LEIDARRKGNEFKFLNHSARPNCYAKLMIVRGD 637
578899**************************************984444..548********..99******************************* PP
SET1.txt 98 kkiviyakraIekgeeltydY 118
++i+++a+raIe+geel++dY
AT1G02580.1 638 QRIGLFAERAIEEGEELFFDY 658
********************* PP
|
Protein Sequence
(Fasta) | MEKENHEDDG EGLPPELNQI KEQIEKERFL HIKRKFELRY IPSVATHASH HQSFDLNQPA 60
AEDDNGGDNK SLLSRMQNPL RHFSASSDYN SYEDQGYVLD EDQDYALEED VPLFLDEDVP 120
LLPSVKLPIV EKLPRSITWV FTKSSQLMAE SDSVIGKRQI YYLNGEALEL SSEEDEEDEE 180
EDEEEIKKEK CEFSEDVDRF IWTVGQDYGL DDLVVRRALA KYLEVDVSDI LERYNELKLK 240
NDGTAGEASD LTSKTITTAF QDFADRRHCR RCMIFDCHMH EKYEPESRSS EDKSSLFEDE 300
DRQPCSEHCY LKVRSVTEAD HVMDNDNSIS NKIVVSDPNN TMWTPVEKDL YLKGIEIFGR 360
NSCDVALNIL RGLKTCLEIY NYMREQDQCT MSLDLNKTTQ RHNQVTKKVS RKSSRSVRKK 420
SRLRKYARYP PALKKTTSGE AKFYKHYTPC TCKSKCGQQC PCLTHENCCE KYCGCSKDCN 480
NRFGGCNCAI GQCTNRQCPC FAANRECDPD LCRSCPLSCG DGTLGETPVQ IQCKNMQFLL 540
QTNKKILIGK SDVHGWGAFT WDSLKKNEYL GEYTGELITH DEANERGRIE DRIGSSYLFT 600
LNDQLEIDAR RKGNEFKFLN HSARPNCYAK LMIVRGDQRI GLFAERAIEE GEELFFDYCY 660
GPEHADWSRG REPRKTGASK RSKEARPAR 689Protein Fasta Sequence
>AT1G02580.1|MEA|Arabidopsis thaliana
MEKENHEDDGEGLPPELNQIKEQIEKERFLHIKRKFELRYIPSVATHASHHQSFDLNQPAAEDDNGGDNKSLLSRMQNPLRHFSASSDYNSYEDQGYVLDEDQDYALEEDVPLFLDEDVPLLPSVKLPIVEKLPRSITWVFTKSSQLMAESDSVIGKRQIYYLNGEALELSSEEDEEDEEEDEEEIKKEKCEFSEDVDRFIWTVGQDYGLDDLVVRRALAKYLEVDVSDILERYNELKLKNDGTAGEASDLTSKTITTAFQDFADRRHCRRCMIFDCHMHEKYEPESRSSEDKSSLFEDEDRQPCSEHCYLKVRSVTEADHVMDNDNSISNKIVVSDPNNTMWTPVEKDLYLKGIEIFGRNSCDVALNILRGLKTCLEIYNYMREQDQCTMSLDLNKTTQRHNQVTKKVSRKSSRSVRKKSRLRKYARYPPALKKTTSGEAKFYKHYTPCTCKSKCGQQCPCLTHENCCEKYCGCSKDCNNRFGGCNCAIGQCTNRQCPCFAANRECDPDLCRSCPLSCGDGTLGETPVQIQCKNMQFLLQTNKKILIGKSDVHGWGAFTWDSLKKNEYLGEYTGELITHDEANERGRIEDRIGSSYLFTLNDQLEIDARRKGNEFKFLNHSARPNCYAKLMIVRGDQRIGLFAERAIEEGEELFFDYCYGPEHADWSRGREPRKTGASKRSKEARPAR |
Nucleotide Sequence
(Fasta) | AGGCGAGTGG TTAATGGAGA AGGAAAACCA TGAGGACGAT GGTGAGGGTT TGCCACCCGA 60
ACTAAATCAG ATAAAAGAGC AAATCGAAAA GGAGAGATTT CTGCATATCA AGAGAAAATT 120
CGAGCTGAGA TACATTCCAA GTGTGGCTAC TCATGCTTCA CACCATCAAT CGTTTGACTT 180
AAACCAGCCC GCTGCAGAGG ATGATAATGG AGGAGACAAC AAATCACTTT TGTCGAGAAT 240
GCAAAACCCA CTTCGTCATT TCAGTGCCTC ATCTGATTAT AATTCTTACG AAGATCAAGG 300
TTATGTTCTT GATGAGGATC AAGATTATGC TCTTGAAGAA GATGTACCAT TATTTCTTGA 360
TGAAGATGTA CCATTATTAC CAAGTGTCAA GCTTCCAATT GTTGAGAAGC TACCACGATC 420
CATTACATGG GTCTTCACCA AAAGTAGCCA GCTGATGGCT GAAAGTGATT CTGTGATTGG 480
TAAGAGACAA ATCTATTATT TGAATGGTGA GGCACTAGAA TTGAGCAGTG AAGAAGATGA 540
GGAAGATGAA GAAGAAGATG AGGAAGAAAT CAAGAAAGAA AAATGCGAAT TTTCTGAAGA 600
TGTAGACCGA TTTATATGGA CGGTTGGGCA GGACTATGGT TTGGATGATC TGGTCGTGCG 660
GCGTGCTCTC GCCAAGTACC TCGAAGTGGA TGTTTCGGAC ATATTGGAAA GATACAATGA 720
ACTCAAGCTT AAGAATGATG GAACTGCTGG TGAGGCTTCT GATTTGACAT CCAAGACAAT 780
AACTACTGCT TTCCAGGATT TTGCTGATAG ACGTCATTGC CGTCGTTGCA TGATATTCGA 840
TTGTCATATG CATGAGAAGT ATGAGCCCGA GTCTAGATCC AGCGAAGACA AATCTAGTTT 900
GTTTGAGGAT GAAGATAGAC AACCATGCAG TGAGCATTGT TACCTCAAGG TGAGGAGTGT 960
GACAGAAGCT GATCATGTGA TGGATAATGA TAACTCTATA TCAAACAAGA TTGTGGTCTC 1020
AGATCCAAAC AACACTATGT GGACGCCTGT AGAGAAGGAT CTTTACTTGA AAGGAATTGA 1080
GATATTTGGG AGAAACAGTT GTGATGTTGC ATTAAACATA CTTCGGGGGC TTAAGACGTG 1140
CCTAGAGATT TACAATTACA TGCGCGAACA AGATCAATGT ACTATGTCAT TAGACCTTAA 1200
CAAAACTACA CAAAGACACA ATCAGGTTAC CAAAAAAGTA TCTCGAAAAA GTAGTAGGTC 1260
GGTCCGCAAA AAATCGAGAC TCCGAAAATA TGCTCGTTAT CCGCCTGCTT TAAAGAAAAC 1320
AACTAGTGGA GAAGCTAAGT TTTATAAGCA CTACACACCA TGCACTTGCA AGTCAAAATG 1380
TGGACAGCAA TGCCCTTGTT TAACTCACGA AAATTGCTGC GAGAAATATT GCGGGTGCTC 1440
AAAGGATTGC AACAATCGCT TTGGAGGATG TAATTGTGCA ATTGGCCAAT GCACAAATCG 1500
ACAATGTCCT TGTTTTGCTG CTAATCGTGA ATGCGATCCA GATCTTTGTC GGAGTTGTCC 1560
TCTTAGCTGT GGAGATGGCA CTCTTGGTGA GACACCAGTG CAAATCCAAT GCAAGAACAT 1620
GCAATTCCTC CTTCAAACCA ATAAAAAGAT TCTCATTGGA AAGTCTGATG TTCATGGATG 1680
GGGTGCATTT ACATGGGACT CTCTTAAAAA GAATGAGTAT CTCGGAGAAT ATACTGGAGA 1740
ACTGATCACT CATGATGAAG CTAATGAGCG TGGGAGAATA GAAGATCGGA TTGGTTCTTC 1800
CTACCTCTTT ACCTTGAATG ATCAGCTCGA AATCGATGCT CGCCGTAAAG GAAACGAGTT 1860
CAAATTTCTC AATCACTCAG CAAGACCTAA CTGCTACGCC AAGTTGATGA TTGTGAGAGG 1920
AGATCAGAGG ATTGGTCTAT TTGCGGAGAG AGCAATCGAA GAAGGTGAGG AGCTTTTCTT 1980
CGACTACTGC TATGGACCAG AACATGCGGA TTGGTCGCGT GGTCGAGAAC CTAGAAAGAC 2040
TGGTGCTTCT AAAAGGTCTA AGGAAGCCCG TCCAGCTCGT TAGTTTTTGA TCTGAGGAGA 2100
AGCAGCAATT CAAGCAGTCC TTTTTTTATG TTATGGTATA TCAATTAATA ATGTAATGCT 2160
ATTTTGTGTT ACTAAACCAA AACTTAAGTT TCTGTTTTAT TTGTTTTAGG GTGTTTTGTT 2220
TGTATCATAT GTGTCTTAAC TTTCAAAGTT TTCTTTTTGT ATTTCAATTT AAAAACAATG 2280
TTTATGTTGT T
2292Nucleotide Fasta Sequence
>AT1G02580.1|SET1|Arabidopsis thaliana
AGGCGAGTGGTTAATGGAGAAGGAAAACCATGAGGACGATGGTGAGGGTTTGCCACCCGAACTAAATCAGATAAAAGAGCAAATCGAAAAGGAGAGATTTCTGCATATCAAGAGAAAATTCGAGCTGAGATACATTCCAAGTGTGGCTACTCATGCTTCACACCATCAATCGTTTGACTTAAACCAGCCCGCTGCAGAGGATGATAATGGAGGAGACAACAAATCACTTTTGTCGAGAATGCAAAACCCACTTCGTCATTTCAGTGCCTCATCTGATTATAATTCTTACGAAGATCAAGGTTATGTTCTTGATGAGGATCAAGATTATGCTCTTGAAGAAGATGTACCATTATTTCTTGATGAAGATGTACCATTATTACCAAGTGTCAAGCTTCCAATTGTTGAGAAGCTACCACGATCCATTACATGGGTCTTCACCAAAAGTAGCCAGCTGATGGCTGAAAGTGATTCTGTGATTGGTAAGAGACAAATCTATTATTTGAATGGTGAGGCACTAGAATTGAGCAGTGAAGAAGATGAGGAAGATGAAGAAGAAGATGAGGAAGAAATCAAGAAAGAAAAATGCGAATTTTCTGAAGATGTAGACCGATTTATATGGACGGTTGGGCAGGACTATGGTTTGGATGATCTGGTCGTGCGGCGTGCTCTCGCCAAGTACCTCGAAGTGGATGTTTCGGACATATTGGAAAGATACAATGAACTCAAGCTTAAGAATGATGGAACTGCTGGTGAGGCTTCTGATTTGACATCCAAGACAATAACTACTGCTTTCCAGGATTTTGCTGATAGACGTCATTGCCGTCGTTGCATGATATTCGATTGTCATATGCATGAGAAGTATGAGCCCGAGTCTAGATCCAGCGAAGACAAATCTAGTTTGTTTGAGGATGAAGATAGACAACCATGCAGTGAGCATTGTTACCTCAAGGTGAGGAGTGTGACAGAAGCTGATCATGTGATGGATAATGATAACTCTATATCAAACAAGATTGTGGTCTCAGATCCAAACAACACTATGTGGACGCCTGTAGAGAAGGATCTTTACTTGAAAGGAATTGAGATATTTGGGAGAAACAGTTGTGATGTTGCATTAAACATACTTCGGGGGCTTAAGACGTGCCTAGAGATTTACAATTACATGCGCGAACAAGATCAATGTACTATGTCATTAGACCTTAACAAAACTACACAAAGACACAATCAGGTTACCAAAAAAGTATCTCGAAAAAGTAGTAGGTCGGTCCGCAAAAAATCGAGACTCCGAAAATATGCTCGTTATCCGCCTGCTTTAAAGAAAACAACTAGTGGAGAAGCTAAGTTTTATAAGCACTACACACCATGCACTTGCAAGTCAAAATGTGGACAGCAATGCCCTTGTTTAACTCACGAAAATTGCTGCGAGAAATATTGCGGGTGCTCAAAGGATTGCAACAATCGCTTTGGAGGATGTAATTGTGCAATTGGCCAATGCACAAATCGACAATGTCCTTGTTTTGCTGCTAATCGTGAATGCGATCCAGATCTTTGTCGGAGTTGTCCTCTTAGCTGTGGAGATGGCACTCTTGGTGAGACACCAGTGCAAATCCAATGCAAGAACATGCAATTCCTCCTTCAAACCAATAAAAAGATTCTCATTGGAAAGTCTGATGTTCATGGATGGGGTGCATTTACATGGGACTCTCTTAAAAAGAATGAGTATCTCGGAGAATATACTGGAGAACTGATCACTCATGATGAAGCTAATGAGCGTGGGAGAATAGAAGATCGGATTGGTTCTTCCTACCTCTTTACCTTGAATGATCAGCTCGAAATCGATGCTCGCCGTAAAGGAAACGAGTTCAAATTTCTCAATCACTCAGCAAGACCTAACTGCTACGCCAAGTTGATGATTGTGAGAGGAGATCAGAGGATTGGTCTATTTGCGGAGAGAGCAATCGAAGAAGGTGAGGAGCTTTTCTTCGACTACTGCTATGGACCAGAACATGCGGATTGGTCGCGTGGTCGAGAACCTAGAAAGACTGGTGCTTCTAAAAGGTCTAAGGAAGCCCGTCCAGCTCGTTAGTTTTTGATCTGAGGAGAAGCAGCAATTCAAGCAGTCCTTTTTTTATGTTATGGTATATCAATTAATAATGTAATGCTATTTTGTGTTACTAAACCAAAACTTAAGTTTCTGTTTTATTTGTTTTAGGGTGTTTTGTTTGTATCATATGTGTCTTAACTTTCAAAGTTTTCTTTTTGTATTTCAATTTAAAAACAATGTTTATGTTGTT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR026489--CXC_dom
IPR025778--Hist-Lys_N-MeTrfase_EZ
IPR001214--SET_dom
IPR033467--Tesmin/TSO1-like_CXC
|
| PROSITE |
PS51633--CXC
PS51576--SAM_MT43_EZ
PS50280--SET
|
| Pfam |
PF00856--SET
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:2000014--P:regulation of endosperm development
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0009646--P:response to absence of light
GO:0048317--P:seed morphogenesis
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
