Tag |
Content |
WERAM ID |
WERAM-Drm-0017 |
Ensembl Protein ID |
FBpp0070794 |
Uniprot Accession |
O02193; MOF_DROME; A8B845; A8B850; A8B854; A8B859; A8B879; A8B889; A8B895; A8B8A1; A8ILB7; A8ILC1; A8ILC8; A8ILD1; A8ILD6; A8ILE1; A8ILE5; Q9W463 |
Genbank Protein ID |
NP_511051.1 |
Protein Name |
Males-absent on the first protein |
Genbank Nucleotide ID |
NM_078496.3 |
Gene Name |
MOF;CG3025 |
Ensembl Information |
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Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HAT |
MYST |
MYST-type HAT |
H4K16 |
K |
24788516 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HAT |
MYST |
4.10e-125 |
417.1 |
539 |
813 |
|
Organism |
Drosophila melanogaster |
NCBI Taxa ID |
7227 |
Functional Description (View)Functional Description
Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the MSL complex. Dosage compensation insures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes. May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex. As part of the NSL complex may associate with promoters of X chromosomal as well as autosomal genes and positively regulate their transcription through chromatin modification. |
Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the MSL complex. Dosage compensation insures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes. May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex. As part of the NSL complex may associate with promoters of X chromosomal as well as autosomal genes and positively regulate their transcription through chromatin modification.
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Domain Profile |
HAT MYST
MYST.txt 2 kvkniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnlCllaklfld 99 k+k+i+k+++g+yei+twy+spfpee+ k+++ly+ce+clky++ ++s+ +hl++C+ r+pPg+eiyrk+++s++ev+Gk+++lycq lCl+aklfld FBpp0070794 539 KIKYIDKLQFGNYEIDTWYFSPFPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLD 636 7899********************************************************************************************** PP MYST.txt 100 hktlyydvepflFYvltetdekgahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekPLsdlgllsYrsyWkevll 197 hk ly+d++pflFY+l+etd++g h+vGyFskek+s e+yn+aCilvlPp+qrkG+GklLi+fsYelsrkeg+igsPekPLsdlg+lsYrsyW+ +ll FBpp0070794 637 HKVLYFDMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRSYWAYTLL 734 ************************************************************************************************** PP MYST.txt 198 ellkekeekkkitikelskatgiaveDivstleslnlikekkgqyillksekiveellklakskkkklkvdeeklkwkp 276 el+k++ ++itikels+++gi+++Di+ tl+s+++ik++kgq +++ ++k+++++l+l + k++kl++d+++l w+p FBpp0070794 735 ELMKTRCAPEQITIKELSEMSGITHDDIIYTLQSMKMIKYWKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYLVWSP 813 *****************************************************************************87 PP
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Protein Sequence (Fasta) | MSEAELEQTP SAGHVQEQPI EEEHEPEQEP TDAYTIGGPP RTPVEDAAAE LSASLDVSGS 60 DQSAEQSLDL SGVQAEAAAE SEPPAKRQHR DISPISEDST PASSTSTSST RSSSSSRYDD 120 VSEAEEAPPE PEPEQPQQQQ QEEKKEDGQD QVKSPGPVEL EAQEPAQPQK QKEVVDQEIE 180 TEDEPSSDTV ICVADINPYG SGSNIDDFVM DPDAPPNAII TEVVTIPAPL HLKGTQQLGL 240 PLAAPPPPPP PPAAEQVPET PASPTDDGEE PPAVYLSPYI RSRYMQESTP GLPTRLAPRD 300 PRQRNMPPPA VVLPIQTVLS ANVEAISDDS SETSSSDDDE EEEEDEDDAL TMEHDNTSRE 360 TVITTGDPLM QKIDISENPD KIYFIRREDG TVHRGQVLQS RTTENAAAPD EYYVHYVGLN 420 RRLDGWVGRH RISDNADDLG GITVLPAPPL APDQPSTSRE MLAQQAAAAA AASSERQKRA 480 ANKDYYLSYC ENSRYDYSDR KMTRYQKRRY DEINHVQKSH AELTATQAAL EKEHESITKI 540 KYIDKLQFGN YEIDTWYFSP FPEEYGKART LYVCEYCLKY MRFRSSYAYH LHECDRRRPP 600 GREIYRKGNI SIYEVNGKEE SLYCQLLCLM AKLFLDHKVL YFDMDPFLFY ILCETDKEGS 660 HIVGYFSKEK KSLENYNVAC ILVLPPHQRK GFGKLLIAFS YELSRKEGVI GSPEKPLSDL 720 GRLSYRSYWA YTLLELMKTR CAPEQITIKE LSEMSGITHD DIIYTLQSMK MIKYWKGQNV 780 ICVTSKTIQD HLQLPQFKQP KLTIDTDYLV WSPQTAAAVV RAPGNSG 827Protein Fasta Sequence
>FBpp0070794|MOF;CG3025|Drosophila melanogaster MSEAELEQTPSAGHVQEQPIEEEHEPEQEPTDAYTIGGPPRTPVEDAAAELSASLDVSGSDQSAEQSLDLSGVQAEAAAESEPPAKRQHRDISPISEDSTPASSTSTSSTRSSSSSRYDDVSEAEEAPPEPEPEQPQQQQQEEKKEDGQDQVKSPGPVELEAQEPAQPQKQKEVVDQEIETEDEPSSDTVICVADINPYGSGSNIDDFVMDPDAPPNAIITEVVTIPAPLHLKGTQQLGLPLAAPPPPPPPPAAEQVPETPASPTDDGEEPPAVYLSPYIRSRYMQESTPGLPTRLAPRDPRQRNMPPPAVVLPIQTVLSANVEAISDDSSETSSSDDDEEEEEDEDDALTMEHDNTSRETVITTGDPLMQKIDISENPDKIYFIRREDGTVHRGQVLQSRTTENAAAPDEYYVHYVGLNRRLDGWVGRHRISDNADDLGGITVLPAPPLAPDQPSTSREMLAQQAAAAAAASSERQKRAANKDYYLSYCENSRYDYSDRKMTRYQKRRYDEINHVQKSHAELTATQAALEKEHESITKIKYIDKLQFGNYEIDTWYFSPFPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLDHKVLYFDMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRSYWAYTLLELMKTRCAPEQITIKELSEMSGITHDDIIYTLQSMKMIKYWKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYLVWSPQTAAAVVRAPGNSG
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Nucleotide Sequence (Fasta) | ACATGTTGTG ATAAATCAGG GTTGCATTTC ACGCCGTATT TCGTTTCATT TCCCTAAAGA 60 GTGAACAAAA ATACGCAATT GGACAAATCT AGTGGCTAAG AATGTCTGAA GCGGAGCTGG 120 AACAGACACC CAGCGCGGGC CACGTGCAGG AGCAGCCGAT TGAGGAGGAG CATGAGCCGG 180 AACAGGAGCC AACCGATGCG TACACAATTG GCGGTCCGCC GAGGACGCCG GTTGAAGATG 240 CGGCGGCCGA ATTGAGCGCC AGTCTAGACG TCAGCGGCTC GGATCAGTCG GCGGAGCAGT 300 CGCTCGACCT CAGCGGTGTC CAAGCGGAGG CCGCGGCGGA GTCAGAGCCA CCGGCGAAGC 360 GCCAGCATCG CGACATCAGT CCCATTTCGG AGGACAGCAC GCCGGCGAGC AGCACATCGA 420 CTAGTTCCAC CAGGTCGTCC AGCTCCTCCC GCTACGACGA TGTTAGCGAG GCGGAGGAGG 480 CACCACCGGA GCCCGAGCCG GAGCAACCAC AGCAGCAGCA GCAGGAGGAA AAGAAGGAGG 540 ACGGTCAGGA TCAGGTGAAG TCACCAGGTC CAGTTGAATT GGAGGCACAG GAGCCCGCGC 600 AGCCGCAGAA GCAGAAAGAG GTGGTGGACC AGGAAATTGA AACCGAGGAT GAGCCCTCCT 660 CCGATACGGT AATCTGCGTG GCCGACATCA ACCCCTACGG CAGTGGTTCC AACATTGACG 720 ACTTCGTTAT GGATCCCGAT GCTCCTCCCA ATGCAATAAT CACCGAGGTG GTTACCATTC 780 CAGCTCCTCT TCATCTCAAA GGGACACAAC AACTGGGGCT GCCATTGGCT GCCCCACCGC 840 CACCACCACC TCCTCCAGCA GCGGAACAAG TCCCCGAGAC TCCCGCCTCG CCCACAGATG 900 ACGGCGAGGA ACCACCAGCA GTATATTTAT CCCCCTACAT ACGCTCTCGC TACATGCAGG 960 AATCGACACC TGGCCTGCCC ACCCGCCTGG CGCCGCGTGA TCCTCGCCAG CGCAACATGC 1020 CGCCGCCAGC CGTAGTTCTG CCCATTCAAA CCGTACTTAG CGCCAACGTT GAGGCCATTT 1080 CTGACGACAG CAGCGAAACT AGCAGCAGCG ATGACGATGA AGAGGAAGAG GAGGACGAAG 1140 ATGATGCCTT GACCATGGAG CACGACAACA CTTCCAGGGA GACGGTCATC ACAACAGGTG 1200 ACCCTCTGAT GCAAAAGATC GATATAAGCG AAAATCCCGA CAAGATCTAT TTTATTCGGC 1260 GCGAGGATGG CACCGTGCAC CGTGGCCAGG TGCTTCAGTC TCGCACCACT GAGAATGCGG 1320 CCGCTCCCGA TGAGTACTAC GTCCACTATG TTGGTCTCAA TCGCCGCCTG GACGGATGGG 1380 TGGGCAGGCA TAGGATCTCG GACAATGCGG ATGACTTGGG CGGTATTACC GTGCTGCCAG 1440 CGCCACCATT AGCCCCCGAT CAGCCAAGTA CTAGCAGGGA AATGCTCGCC CAACAGGCCG 1500 CCGCGGCGGC AGCTGCCTCA TCCGAACGGC AGAAGCGTGC GGCCAACAAG GATTACTATC 1560 TGTCCTATTG CGAGAACAGT CGCTATGACT ACAGCGACCG CAAGATGACA CGCTACCAGA 1620 AGCGGCGCTA CGATGAGATC AACCACGTGC AGAAGAGCCA CGCTGAGCTG ACCGCCACGC 1680 AGGCGGCGCT GGAGAAGGAG CACGAGTCCA TTACGAAGAT CAAGTACATT GATAAGCTGC 1740 AGTTTGGCAA CTACGAGATC GACACCTGGT ACTTTAGTCC CTTCCCCGAA GAATATGGCA 1800 AGGCACGTAC GTTATATGTT TGCGAGTACT GCCTAAAGTA CATGCGCTTC AGGTCGAGCT 1860 ATGCCTATCA TCTGCACGAA TGCGACCGCA GGCGTCCGCC CGGAAGAGAG ATCTACCGCA 1920 AGGGCAATAT ATCCATTTAC GAGGTGAACG GCAAGGAGGA GTCACTATAC TGCCAACTTT 1980 TGTGTCTGAT GGCCAAGCTC TTTTTGGACC ACAAGGTTCT ATACTTCGAC ATGGACCCGT 2040 TTCTCTTTTA CATCCTTTGC GAGACGGACA AGGAGGGCAG TCACATTGTG GGCTATTTCT 2100 CCAAGGAAAA GAAGTCGCTG GAAAACTACA ACGTGGCCTG CATTCTGGTA TTGCCGCCGC 2160 ATCAGCGTAA GGGATTTGGA AAGCTACTAA TAGCCTTTAG CTATGAGCTG TCGCGCAAGG 2220 AGGGCGTAAT CGGTAGTCCG GAGAAACCGC TCTCGGATCT GGGTAGGCTG AGCTATCGCA 2280 GCTATTGGGC ATACACGCTG CTGGAGCTGA TGAAAACCCG CTGCGCTCCA GAGCAGATCA 2340 CAATCAAGGA GCTGAGCGAA ATGAGTGGCA TCACCCACGA CGACATTATC TACACGCTGC 2400 AGTCCATGAA GATGATCAAG TATTGGAAGG GCCAGAATGT CATTTGCGTT ACGTCCAAGA 2460 CCATTCAAGA CCACCTCCAG CTGCCGCAGT TCAAGCAGCC CAAGCTGACC ATCGACACCG 2520 ATTACCTCGT CTGGAGTCCG CAAACTGCAG CGGCAGTGGT CAGAGCTCCG GGAAATTCCG 2580 GCTAGCATAC GGAACCTGGA GACCCCGTTC TGCTATCATC GCATATAATT GTTATTGACG 2640 ATGACGATTA GGTTTTTTTT TTTTATTTTT TTTTAAAGAA AGCGTAGGAA TAAGCTATTC 2700 TATTGCACCC CTCCAAACGA AAAATGTATA GTCATATATC TAAATGGAAC CATCAGAAGG 2760 TTCAATGTAA TACTTAACAT TTGGTTTACA ATTTTTTTTT TTTATAGTTA AGGAGTTTTA 2820 CGGATAGGCT GTTGTAACTC TTAATGATAG AACCAAATGT CTAATTCGTT TGGCTAATGT 2880 TTTTGGAGAG GGAATTTGGA ACAACCATTT AAAAATTTTA AAAACTTCTG TGTTCTTGAA 2940 ATATATATCT TTAACTACTT TATCTCGAAA AACTCTGGAC TTGTTAAAAA CCAAATAAAC 3000 TTCCACAGCA GCCG
3015Nucleotide Fasta Sequence
>FBpp0070794|MYST|Drosophila melanogaster ACATGTTGTGATAAATCAGGGTTGCATTTCACGCCGTATTTCGTTTCATTTCCCTAAAGAGTGAACAAAAATACGCAATTGGACAAATCTAGTGGCTAAGAATGTCTGAAGCGGAGCTGGAACAGACACCCAGCGCGGGCCACGTGCAGGAGCAGCCGATTGAGGAGGAGCATGAGCCGGAACAGGAGCCAACCGATGCGTACACAATTGGCGGTCCGCCGAGGACGCCGGTTGAAGATGCGGCGGCCGAATTGAGCGCCAGTCTAGACGTCAGCGGCTCGGATCAGTCGGCGGAGCAGTCGCTCGACCTCAGCGGTGTCCAAGCGGAGGCCGCGGCGGAGTCAGAGCCACCGGCGAAGCGCCAGCATCGCGACATCAGTCCCATTTCGGAGGACAGCACGCCGGCGAGCAGCACATCGACTAGTTCCACCAGGTCGTCCAGCTCCTCCCGCTACGACGATGTTAGCGAGGCGGAGGAGGCACCACCGGAGCCCGAGCCGGAGCAACCACAGCAGCAGCAGCAGGAGGAAAAGAAGGAGGACGGTCAGGATCAGGTGAAGTCACCAGGTCCAGTTGAATTGGAGGCACAGGAGCCCGCGCAGCCGCAGAAGCAGAAAGAGGTGGTGGACCAGGAAATTGAAACCGAGGATGAGCCCTCCTCCGATACGGTAATCTGCGTGGCCGACATCAACCCCTACGGCAGTGGTTCCAACATTGACGACTTCGTTATGGATCCCGATGCTCCTCCCAATGCAATAATCACCGAGGTGGTTACCATTCCAGCTCCTCTTCATCTCAAAGGGACACAACAACTGGGGCTGCCATTGGCTGCCCCACCGCCACCACCACCTCCTCCAGCAGCGGAACAAGTCCCCGAGACTCCCGCCTCGCCCACAGATGACGGCGAGGAACCACCAGCAGTATATTTATCCCCCTACATACGCTCTCGCTACATGCAGGAATCGACACCTGGCCTGCCCACCCGCCTGGCGCCGCGTGATCCTCGCCAGCGCAACATGCCGCCGCCAGCCGTAGTTCTGCCCATTCAAACCGTACTTAGCGCCAACGTTGAGGCCATTTCTGACGACAGCAGCGAAACTAGCAGCAGCGATGACGATGAAGAGGAAGAGGAGGACGAAGATGATGCCTTGACCATGGAGCACGACAACACTTCCAGGGAGACGGTCATCACAACAGGTGACCCTCTGATGCAAAAGATCGATATAAGCGAAAATCCCGACAAGATCTATTTTATTCGGCGCGAGGATGGCACCGTGCACCGTGGCCAGGTGCTTCAGTCTCGCACCACTGAGAATGCGGCCGCTCCCGATGAGTACTACGTCCACTATGTTGGTCTCAATCGCCGCCTGGACGGATGGGTGGGCAGGCATAGGATCTCGGACAATGCGGATGACTTGGGCGGTATTACCGTGCTGCCAGCGCCACCATTAGCCCCCGATCAGCCAAGTACTAGCAGGGAAATGCTCGCCCAACAGGCCGCCGCGGCGGCAGCTGCCTCATCCGAACGGCAGAAGCGTGCGGCCAACAAGGATTACTATCTGTCCTATTGCGAGAACAGTCGCTATGACTACAGCGACCGCAAGATGACACGCTACCAGAAGCGGCGCTACGATGAGATCAACCACGTGCAGAAGAGCCACGCTGAGCTGACCGCCACGCAGGCGGCGCTGGAGAAGGAGCACGAGTCCATTACGAAGATCAAGTACATTGATAAGCTGCAGTTTGGCAACTACGAGATCGACACCTGGTACTTTAGTCCCTTCCCCGAAGAATATGGCAAGGCACGTACGTTATATGTTTGCGAGTACTGCCTAAAGTACATGCGCTTCAGGTCGAGCTATGCCTATCATCTGCACGAATGCGACCGCAGGCGTCCGCCCGGAAGAGAGATCTACCGCAAGGGCAATATATCCATTTACGAGGTGAACGGCAAGGAGGAGTCACTATACTGCCAACTTTTGTGTCTGATGGCCAAGCTCTTTTTGGACCACAAGGTTCTATACTTCGACATGGACCCGTTTCTCTTTTACATCCTTTGCGAGACGGACAAGGAGGGCAGTCACATTGTGGGCTATTTCTCCAAGGAAAAGAAGTCGCTGGAAAACTACAACGTGGCCTGCATTCTGGTATTGCCGCCGCATCAGCGTAAGGGATTTGGAAAGCTACTAATAGCCTTTAGCTATGAGCTGTCGCGCAAGGAGGGCGTAATCGGTAGTCCGGAGAAACCGCTCTCGGATCTGGGTAGGCTGAGCTATCGCAGCTATTGGGCATACACGCTGCTGGAGCTGATGAAAACCCGCTGCGCTCCAGAGCAGATCACAATCAAGGAGCTGAGCGAAATGAGTGGCATCACCCACGACGACATTATCTACACGCTGCAGTCCATGAAGATGATCAAGTATTGGAAGGGCCAGAATGTCATTTGCGTTACGTCCAAGACCATTCAAGACCACCTCCAGCTGCCGCAGTTCAAGCAGCCCAAGCTGACCATCGACACCGATTACCTCGTCTGGAGTCCGCAAACTGCAGCGGCAGTGGTCAGAGCTCCGGGAAATTCCGGCTAGCATACGGAACCTGGAGACCCCGTTCTGCTATCATCGCATATAATTGTTATTGACGATGACGATTAGGTTTTTTTTTTTTATTTTTTTTTAAAGAAAGCGTAGGAATAAGCTATTCTATTGCACCCCTCCAAACGAAAAATGTATAGTCATATATCTAAATGGAACCATCAGAAGGTTCAATGTAATACTTAACATTTGGTTTACAATTTTTTTTTTTTATAGTTAAGGAGTTTTACGGATAGGCTGTTGTAACTCTTAATGATAGAACCAAATGTCTAATTCGTTTGGCTAATGTTTTTGGAGAGGGAATTTGGAACAACCATTTAAAAATTTTAAAAACTTCTGTGTTCTTGAAATATATATCTTTAACTACTTTATCTCGAAAAACTCTGGACTTGTTAAAAACCAAATAAACTTCCACAGCAGCCG
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0007--Acetylation KW-0012--Acyltransferase KW-0156--Chromatin regulator KW-0158--Chromosome KW-0181--Complete proteome KW-0479--Metal-binding KW-0539--Nucleus KW-0621--Polymorphism KW-1185--Reference proteome KW-0808--Transferase KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR016181--Acyl_CoA_acyltransferase IPR016197--Chromodomain-like IPR002717--HAT_MYST-type IPR025995--Tudor-knot
|
PROSITE |
PS51726--MYST_HAT
|
Pfam |
PF01853--MOZ_SAS PF11717--Tudor-knot
|
Gene Ontology |
GO:0072487--C:MSL complex GO:0044545--C:NSL complex GO:0000228--C:nuclear chromosome GO:0005634--C:nucleus GO:0005705--C:polytene chromosome interband GO:0005667--C:transcription factor complex GO:0000805--C:X chromosome GO:0016456--C:X chromosome located dosage compensation complex, transcription activating GO:0003682--F:chromatin binding GO:0004402--F:histone acetyltransferase activity GO:0046972--F:histone acetyltransferase activity (H4-K16 specific) GO:0004468--F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor GO:0046872--F:metal ion binding GO:0003729--F:mRNA binding GO:0071479--P:cellular response to ionizing radiation GO:0000077--P:DNA damage checkpoint GO:0030330--P:DNA damage response, signal transduction by p53 class mediator GO:0006281--P:DNA repair GO:0007549--P:dosage compensation GO:0009047--P:dosage compensation by hyperactivation of X chromosome GO:0016573--P:histone acetylation GO:0043984--P:histone H4-K16 acetylation GO:0043066--P:negative regulation of apoptotic process GO:0018394--P:peptidyl-lysine acetylation GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity GO:2000873--P:regulation of histone H4 acetylation involved in response to DNA damage stimulus GO:0010212--P:response to ionizing radiation
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Orthology |
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Created Date |
25-Jun-2016 |