WERAM Information

Tag Content
WERAM ID WERAM-Hos-0274
Ensembl Protein ID ENSP00000489602.1
Uniprot Accession Q8IXJ6; SIR2_HUMAN; A8K3V1; B2RB45; O95889; Q924Y7; Q9P0G8; Q9UNT0; Q9Y6E9; U5TP13
Genbank Protein ID NP_001180215.1; NP_036369.2; NP_085096.1; XP_006723174.1; XP_011524956.1; XP_011524957.1
Protein Name NAD-dependent protein deacetylase sirtuin-2
Genbank Nucleotide ID NM_001193286.1; NM_012237.3; NM_030593.2; XM_006723111.1; XM_011526654.1; XM_011526655.1
Gene Name SIRT2;SIR2L;SIR2L2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000283100.1 ENST00000634533.1 ENSP00000489602.1
ENSG00000283100.1 ENST00000635478.1 ENSP00000488940.1
ENSG00000283100.1 ENST00000634707.1 ENSP00000488998.1
ENSG00000283100.1 ENST00000634328.1 ENSP00000489020.1
ENSG00000283100.1 ENST00000635078.1 ENSP00000489426.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type H3K9; H3K14; H3K56; H4K16 K 19698979; 17447894
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 1.60e-93 315 67 339
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression. Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response. Deacetylates also histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition. Upon bacterium Listeria monocytogenes infection, deacetylates 'Lys-18' of histone H3 in a receptor tyrosine kinase MET- and PI3K/Akt-dependent manner, thereby inhibiting transcriptional activity and promoting late stages of listeria infection. During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells. Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellular metabolic pathways. Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity. Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells. Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy. Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation. Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia. Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300. Deacetylates also EIF5A. Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor.
Domain Profile
  HDAC SIR2
           SIR2.txt   3 lakllk..kskkivvltGAGiStsaGIPDFRs.seGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaelek 91 
                        +a++++  +++++++l+GAGiStsaGIPDFRs s+Gly++l+k++lp+peaif++++f+k+p++f+alakelyp g++kPt +Hyf+++l++
  ENSP00000489602.1  67 VARYMQseRCRRVICLVGAGISTSAGIPDFRSpSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYP-GQFKPTICHYFMRLLKD 157
                        5666766699****************************************************************.***************** PP
           SIR2.txt  92 kgkllrlytQNiDgLerkaglkedklvelHGslatasCtk..CkkefpreeikeklkakekvpkCekCkgvlkpdivffgenlpeefleeve 181
                        kg+llr+ytQNiD+Ler agl++++lve+HG+++t++C++  C++e+p +++kek++++  +pkCe+C++++kpdivffge+lp++f+++++
  ENSP00000489602.1 158 KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSasCRHEYPLSWMKEKIFSE-VTPKCEDCQSLVKPDIVFFGESLPARFFSCMQ 248
                        **************************************9777****************9.9******************************* PP
           SIR2.txt 182 edlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevk....................adkladlkllgdcdevveellkllglee 253
                        +d+ ++dlllv+GtSl+v+p+asl+ ++++ ++p+ll+n+e+ +                    +++++d+++lg+cd+ + +l++llg+++
  ENSP00000489602.1 249 SDFLKVDLLLVMGTSLQVQPFASLI-SKAPLSTPRLLINKEKAGqsdpflgmimglgggmdfdsKKAYRDVAWLGECDQGCLALAELLGWKK 339
                        *************************.99***********************************99*************************97 PP
Protein Sequence
(Fasta)		MAEPDPSHPL ETQAGKVQEA QDSDSDSEGG AAGGEADMDF LRNLFSQTLS LGSQKERLLD 60
ELTLEGVARY MQSERCRRVI CLVGAGISTS AGIPDFRSPS TGLYDNLEKY HLPYPEAIFE 120
ISYFKKHPEP FFALAKELYP GQFKPTICHY FMRLLKDKGL LLRCYTQNID TLERIAGLEQ 180
EDLVEAHGTF YTSHCVSASC RHEYPLSWMK EKIFSEVTPK CEDCQSLVKP DIVFFGESLP 240
ARFFSCMQSD FLKVDLLLVM GTSLQVQPFA SLISKAPLST PRLLINKEKA GQSDPFLGMI 300
MGLGGGMDFD SKKAYRDVAW LGECDQGCLA LAELLGWKKE LEDLVRREHA SIDAQSGAGV 360
PNPSTSASPK KSPPPAKDEA RTTEREKPQ 389
Nucleotide Sequence
(Fasta)		CATTTTCCGG GCGCCCTTTA CCAACATGGC TGCTGACGCC ACGCCTTCTG GGACTCGTAG 60
TCCGGTCCTC GCGCGCTTTC TTACCTAACT GGGGCGCTCT GGGTGTTGTA CGAAAGCGCG 120
TCTGCGGCCG CAATGTCTGC TGAGAGTTGT AGTTCTGTGC CCTATCACGG CCACTCCCAT 180
TTCTGGTGCC GTCACGGGAC AGAGCAGTCG GTGACAGGAC AGAGCAGTCG GTGACGGGAC 240
ACAGTGGTTG GTGACGGGAC AGAGCGGTCG GTGACAGCCT CAAGGGCTTC AGCACCGCGC 300
CCATGGCAGA GCCAGACCCC TCTCACCCTC TGGAGACCCA GGCAGGGAAG GTGCAGGAGG 360
CTCAGGACTC AGATTCAGAC TCTGAGGGAG GAGCCGCTGG TGGAGAAGCA GACATGGACT 420
TCCTGCGGAA CTTATTCTCC CAGACGCTCA GCCTGGGCAG CCAGAAGGAG CGTCTGCTGG 480
ACGAGCTGAC CTTGGAAGGG GTGGCCCGGT ACATGCAGAG CGAACGCTGT CGCAGAGTCA 540
TCTGTTTGGT GGGAGCTGGA ATCTCCACAT CCGCAGGCAT CCCCGACTTT CGCTCTCCAT 600
CCACCGGCCT CTATGACAAC CTAGAGAAGT ACCATCTTCC CTACCCAGAG GCCATCTTTG 660
AGATCAGCTA TTTCAAGAAA CATCCGGAAC CCTTCTTCGC CCTCGCCAAG GAACTCTATC 720
CTGGGCAGTT CAAGCCAACC ATCTGTCACT ACTTCATGCG CCTGCTGAAG GACAAGGGGC 780
TACTCCTGCG CTGCTACACG CAGAACATAG ATACCCTGGA GCGAATAGCC GGGCTGGAAC 840
AGGAGGACTT GGTGGAGGCG CACGGCACCT TCTACACATC ACACTGCGTC AGCGCCAGCT 900
GCCGGCACGA ATACCCGCTA AGCTGGATGA AAGAGAAGAT CTTCTCTGAG GTGACGCCCA 960
AGTGTGAAGA CTGTCAGAGC CTGGTGAAGC CTGATATCGT CTTTTTTGGT GAGAGCCTCC 1020
CAGCGCGTTT CTTCTCCTGT ATGCAGTCAG ACTTCCTGAA GGTGGACCTC CTCCTGGTCA 1080
TGGGTACCTC CTTGCAGGTG CAGCCCTTTG CCTCCCTCAT CAGCAAGGCA CCCCTCTCCA 1140
CCCCTCGCCT GCTCATCAAC AAGGAGAAAG CTGGCCAGTC GGACCCTTTC CTGGGGATGA 1200
TTATGGGCCT CGGAGGAGGC ATGGACTTTG ACTCCAAGAA GGCCTACAGG GACGTGGCCT 1260
GGCTGGGTGA ATGCGACCAG GGCTGCCTGG CCCTTGCTGA GCTCCTTGGA TGGAAGAAGG 1320
AGCTGGAGGA CCTTGTCCGG AGGGAGCACG CCAGCATAGA TGCCCAGTCG GGGGCGGGGG 1380
TCCCCAACCC CAGCACTTCA GCTTCCCCCA AGAAGTCCCC GCCACCTGCC AAGGACGAGG 1440
CCAGGACAAC AGAGAGGGAG AAACCCCAGT GACAGCTGCA TCTCCCAGGC GGGATGCCGA 1500
GCTCCTCAGG GACAGCTGAG CCCCAACCGG GCCTGGCCCC CTCTTAACCA GCAGTTCTTG 1560
TCTGGGGAGC TCAGAACATC CCCCAATCTC TTACAGCTCC CTCCCCAAAA CTGGGGTCCC 1620
AGCAACCCTG GCCCCCAACC CCAGCAAATC TCTAACACCT CCTAGAGGCC AAGGCTTAAA 1680
CAGGCATCTC TACCAGCCCC ACTGTCTCTA ACCACTCCTG GGCTAAGGAG TAACCTCCCT 1740
CATCTCTAAC TGCCCCCACG GGGCCAGGGC TACCCCAGAA CTTTTAACTC TTCCAGGACA 1800
GGGAGCTTCG GGCCCCCACT CTGTCTCCTG CCCCCGGGGG CCTGTGGCTA AGTAAACCAT 1860
ACCTAACCTA CCCCAGTGTG GGTGTGGGCC TCTGAATATA ACCCACACCC AGCGTAGGGG 1920
GAGTCTGAGC CGGGAGGGCT CCCGAGTCTC TGCCTTCAGC TCCCAAAGTG GGTGGTGGGC 1980
CCCCTTCACG TGGGACCCAC TTCCCATGCT GGATGGGCAG AAGACATTGC TTATTGGAGA 2040
CAAATTAAAA ACAAAAACAA CTAACAATCC 2071
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0131--Cell cycle
KW-0132--Cell division
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0221--Differentiation
KW-0378--Hydrolase
KW-0391--Immunity
KW-0399--Innate immunity
KW-0469--Meiosis
KW-0472--Membrane
KW-0479--Metal-binding
KW-0493--Microtubule
KW-0498--Mitosis
KW-0520--NAD
KW-0523--Neurodegeneration
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
--
Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR017328--Sirtuin_class_I
IPR026590--Ssirtuin_cat_dom
PROSITE

PS50305--SIRTUIN
Pfam

PF02146--SIR2
Gene Ontology

GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0005677--C:chromatin silencing complex
GO:0005694--C:chromosome
GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0097386--C:glial cell projection
GO:0030426--C:growth cone
GO:0044224--C:juxtaparanode region of axon
GO:0043219--C:lateral loop
GO:0072687--C:meiotic spindle
GO:0005874--C:microtubule
GO:0030496--C:midbody
GO:0072686--C:mitotic spindle
GO:0043209--C:myelin sheath
GO:0035748--C:myelin sheath abaxonal region
GO:0005720--C:nuclear heterochromatin
GO:0005634--C:nucleus
GO:0033010--C:paranodal junction
GO:0033270--C:paranode region of axon
GO:0043204--C:perikaryon
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043220--C:Schmidt-Lanterman incisure
GO:0005819--C:spindle
GO:0097456--C:terminal loop
GO:0003682--F:chromatin binding
GO:0035035--F:histone acetyltransferase binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0046970--F:NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0034979--F:NAD-dependent protein deacetylase activity
GO:0033558--F:protein deacetylase activity
GO:0008134--F:transcription factor binding
GO:0042903--F:tubulin deacetylase activity
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051301--P:cell division
GO:0044242--P:cellular lipid catabolic process
GO:0061433--P:cellular response to caloric restriction
GO:0071872--P:cellular response to epinephrine stimulus
GO:0035729--P:cellular response to hepatocyte growth factor stimulus
GO:0071456--P:cellular response to hypoxia
GO:0071219--P:cellular response to molecule of bacterial origin
GO:0034599--P:cellular response to oxidative stress
GO:0006342--P:chromatin silencing
GO:0000183--P:chromatin silencing at rDNA
GO:0006348--P:chromatin silencing at telomere
GO:0016458--P:gene silencing
GO:0048012--P:hepatocyte growth factor receptor signaling pathway
GO:0016575--P:histone deacetylation
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0045087--P:innate immune response
GO:0051321--P:meiotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0022011--P:myelination in peripheral nervous system
GO:0043066--P:negative regulation of apoptotic process
GO:0010507--P:negative regulation of autophagy
GO:0008285--P:negative regulation of cell proliferation
GO:1900425--P:negative regulation of defense response to bacterium
GO:0045599--P:negative regulation of fat cell differentiation
GO:1900226--P:negative regulation of NLRP3 inflammasome complex assembly
GO:0048715--P:negative regulation of oligodendrocyte differentiation
GO:0070446--P:negative regulation of oligodendrocyte progenitor proliferation
GO:0010801--P:negative regulation of peptidyl-threonine phosphorylation
GO:0042177--P:negative regulation of protein catabolic process
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045843--P:negative regulation of striated muscle tissue development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061428--P:negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0034983--P:peptidyl-lysine deacetylation
GO:0014065--P:phosphatidylinositol 3-kinase signaling
GO:0051987--P:positive regulation of attachment of spindle microtubules to kinetochore
GO:0051781--P:positive regulation of cell division
GO:0043388--P:positive regulation of DNA binding
GO:1900119--P:positive regulation of execution phase of apoptosis
GO:0045836--P:positive regulation of meiotic nuclear division
GO:1900195--P:positive regulation of oocyte maturation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:2000777--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006471--P:protein ADP-ribosylation
GO:0006476--P:protein deacetylation
GO:0043491--P:protein kinase B signaling
GO:0051726--P:regulation of cell cycle
GO:0007096--P:regulation of exit from mitosis
GO:0031641--P:regulation of myelination
GO:0042325--P:regulation of phosphorylation
GO:0051775--P:response to redox state
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0021762--P:substantia nigra development
GO:0006351--P:transcription, DNA-templated
GO:0090042--P:tubulin deacetylation
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Chs-0045 ENSCSAP00000000306.1 Chlorocebus sabaeus 99 0.0 684
WERAM-Paa-0135 ENSPANP00000006205.1 Papio anubis 98 0.0 681
WERAM-Nol-0162 ENSNLEP00000017842.2 Nomascus leucogenys 99 0.0 677
WERAM-Pat-0091 ENSPTRP00000018763.5 Pan troglodytes 99 0.0 677
WERAM-Gog-0026 ENSGGOP00000002451.2 Gorilla gorilla 99 0.0 676
WERAM-Poa-0087 ENSPPYP00000011137.1 Pongo abelii 99 0.0 654
WERAM-Ict-0150 ENSSTOP00000021109.1 Ictidomys tridecemlineatus 88 2e-180 629
WERAM-Bot-0020 ENSBTAP00000002327.5 Bos taurus 86 8e-180 627
WERAM-Mam-0216 ENSMMUP00000031121.2 Macaca mulatta 95 1e-178 623
WERAM-Fec-0038 ENSFCAP00000002933.3 Felis catus 89 1e-178 622
WERAM-Myl-0011 ENSMLUP00000000900.2 Myotis lucifugus 89 2e-178 622
WERAM-Mum-0022 ENSMUSP00000072732.4 Mus musculus 88 3e-178 621
WERAM-Orc-0210 ENSOCUP00000021500.1 Oryctolagus cuniculus 88 6e-178 620
WERAM-Loa-0172 ENSLAFP00000017245.2 Loxodonta africana 87 1e-175 613
WERAM-Otg-0090 ENSOGAP00000007418.2 Otolemur garnettii 85 6e-174 607
WERAM-Aim-0098 ENSAMEP00000009297.1 Ailuropoda melanoleuca 87 8e-174 607
WERAM-Cap-0128 ENSCPOP00000010177.2 Cavia porcellus 86 7e-173 603
WERAM-Caj-0143 ENSCJAP00000025706.2 Callithrix jacchus 93 1e-171 599
WERAM-Ova-0058 ENSOARP00000006315.1 Ovis aries 84 2e-171 598
WERAM-Eqc-0193 ENSECAP00000020926.1 Equus caballus 87 5e-171 597
WERAM-Mup-0205 ENSMPUP00000017641.1 Mustela putorius furo 86 1e-170 596
WERAM-Ran-0132 ENSRNOP00000059450.1 Rattus norvegicus 87 1e-167 586
WERAM-Ptv-0123 ENSPVAP00000010931.1 Pteropus vampyrus 89 3e-152 535
WERAM-Caf-0068 ENSCAFP00000008416.3 Canis familiaris 89 7e-152 534
WERAM-Dio-0012 ENSDORP00000001437.1 Dipodomys ordii 80 4e-151 531
WERAM-Pes-0004 ENSPSIP00000002368.1 Pelodiscus sinensis 79 1e-150 530
WERAM-Anc-0100 ENSACAP00000009519.3 Anolis carolinensis 77 4e-149 525
WERAM-Tut-0138 ENSTTRP00000011179.1 Tursiops truncatus 80 2e-146 515
WERAM-Ect-0047 ENSETEP00000005080.1 Echinops telfairi 73 5e-140 494
WERAM-Leo-0146 ENSLOCP00000017602.1 Lepisosteus oculatus 75 2e-139 492
WERAM-Xet-0018 ENSXETP00000005130.2 Xenopus tropicalis 74 3e-137 485
WERAM-Pof-0038 ENSPFOP00000003166.2 Poecilia formosa 73 2e-136 483
WERAM-Asm-0153 ENSAMXP00000015326.1 Astyanax mexicanus 75 2e-136 482
WERAM-Tar-0064 ENSTRUP00000012981.1 Takifugu rubripes 73 6e-136 481
WERAM-Dar-0028 ENSDARP00000003412.6 Danio rerio 72 2e-134 476
WERAM-Ocp-0048 ENSOPRP00000004238.2 Ochotona princeps 87 6e-134 474
WERAM-Xim-0026 ENSXMAP00000002581.1 Xiphophorus maculatus 71 3e-133 472
WERAM-Orn-0200 ENSONIP00000020932.1 Oreochromis niloticus 74 4e-133 471
WERAM-Dan-0004 ENSDNOP00000000434.2 Dasypus novemcinctus 73 5e-133 471
WERAM-Gaa-0062 ENSGACP00000007590.1 Gasterosteus aculeatus 69 6e-129 457
WERAM-Pem-0066 ENSPMAP00000007192.1 Petromyzon marinus 68 7e-129 457
WERAM-Gam-0155 ENSGMOP00000015228.1 Gadus morhua 70 2e-124 443
WERAM-Cii-0054 ENSCINP00000012226.3 Ciona intestinalis 61 4e-115 412
WERAM-Sus-0185 ENSSSCP00000020261.1 Sus scrofa 73 9e-114 407
WERAM-Cis-0075 ENSCSAVP00000016120.1 Ciona savignyi 61 6e-113 404
WERAM-Gaga-0175 ENSGALP00000041842.1 Gallus gallus 63 3e-112 402
WERAM-Orla-0088 ENSORLP00000010757.1 Oryzias latipes 59 1e-109 394
WERAM-Mim-0081 ENSMICP00000007830.1 Microcebus murinus 75 1e-106 383
WERAM-Sah-0002 ENSSHAP00000000118.1 Sarcophilus harrisii 81 9e-104 374
WERAM-Drm-0067 FBpp0310647 Drosophila melanogaster 51 4e-96 348
WERAM-Mae-0115 ENSMEUP00000010974.1 Macropus eugenii 87 1e-90 330
WERAM-Anp-0145 ENSAPLP00000015403.1 Anas platyrhynchos 51 2e-82 303
WERAM-Meg-0026 ENSMGAP00000002050.2 Meleagris gallopavo 50 4e-81 298
WERAM-Mod-0192 ENSMODP00000026476.2 Monodelphis domestica 50 1e-79 294
WERAM-Miv-0009 MVLG_01362T0 Microbotryum violaceum 50 2e-79 293
WERAM-Usm-0036 UM05892P0 Ustilago maydis 50 5e-78 288
WERAM-Soa-0118 ENSSARP00000011447.1 Sorex araneus 48 3e-77 286
WERAM-Fuo-0021 FOXG_06023P0 Fusarium oxysporum 49 3e-77 286
WERAM-Asc-0030 CADACLAP00006830 Aspergillus clavatus 49 1e-76 284
WERAM-Trv-0012 EHK19002 Trichoderma virens 50 1e-76 284
WERAM-Fia-0142 ENSFALP00000011956.1 Ficedula albicollis 52 3e-76 282
WERAM-Ast-0036 CADATEAP00009630 Aspergillus terreus 47 1e-75 281
WERAM-Tub-0067 ENSTBEP00000008310.1 Tupaia belangeri 49 2e-75 280
WERAM-Lac-0044 ENSLACP00000006675.2 Latimeria chalumnae 47 2e-75 280
WERAM-Asn-0005 CADANIAP00000554 Aspergillus nidulans 49 4e-75 279
WERAM-Trr-0018 EGR46788 Trichoderma reesei 50 5e-75 278
WERAM-Zyt-0001 Mycgr3P100618 Zymoseptoria tritici 50 5e-75 278
WERAM-Coi-0005 EAS35645 Coccidioides immitis 48 6e-75 278
WERAM-Gag-0013 GGTG_03219T0 Gaeumannomyces graminis 48 8e-75 278
WERAM-Mao-0040 MGG_17827T0 Magnaporthe oryzae 49 9e-75 278
WERAM-Tag-0102 ENSTGUP00000007081.1 Taeniopygia guttata 51 1e-74 277
WERAM-Mel-0010 EGG12163 Melampsora laricipopulina 54 2e-74 276
WERAM-Spr-0042 CBQ70931 Sporisorium reilianum 50 2e-74 276
WERAM-Asni-0009 CADANGAP00002892 Aspergillus niger 49 3e-74 276
WERAM-Pyt-0039 EFQ86136 Pyrenophora teres 49 5e-74 275
WERAM-Scp-0042 SPCC132.02.1:pep Schizosaccharomyces pombe 48 7e-74 275
WERAM-Scj-0005 EEB06048 Schizosaccharomyces japonicus 47 1e-73 273
WERAM-Ten-0144 ENSTNIP00000015099.1 Tetraodon nigroviridis 49 3e-73 273
WERAM-Pug-0030 EFP89251 Puccinia graminis 52 8e-73 271
WERAM-Osl-0012 ABO98065 Ostreococcus lucimarinus 47 3e-72 269
WERAM-Lab-0008 EDR12994 Laccaria bicolor 43 6e-72 268
WERAM-Asfu-0013 CADAFUAP00003392 Aspergillus fumigatus 50 1e-71 267
WERAM-Aso-0005 CADAORAP00000633 Aspergillus oryzae 48 1e-71 267
WERAM-Asf-0024 CADAFLAP00010064 Aspergillus flavus 48 1e-71 267
WERAM-Lem-0007 CBY02082 Leptosphaeria maculans 48 4e-71 265
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 49 1e-70 264
WERAM-Pytr-0009 EDU41553 Pyrenophora triticirepentis 50 3e-70 263
WERAM-Nec-0006 EFNCRP00000000764 Neurospora crassa 47 3e-70 262
WERAM-Crn-0031 AAW44797 Cryptococcus neoformans 48 4e-70 262
WERAM-Asg-0028 AAS54472 Ashbya gossypii 45 1e-64 244
WERAM-Kop-0007 CAY68156 Komagataella pastoris 46 4e-64 242
WERAM-Caa-0033 KGT64755 Candida albicans 46 6e-64 241
WERAM-Kll-0027 CAG98291 Kluyveromyces lactis 43 2e-63 239
WERAM-Cag-0026 CAG62123 Candida glabrata 43 5e-62 235
WERAM-Sac-0046 YPL015C Saccharomyces cerevisiae 42 6e-60 228
WERAM-Ved-0011 EGY21147 Verticillium dahliae 43 1e-57 221
WERAM-Tas-0108 ENSTSYP00000011158.1 Tarsius syrichta 43 1e-55 214
WERAM-Chg-0025 EAQ89546 Chaetomium globosum 44 5e-55 212
WERAM-Ere-0116 ENSEEUP00000012184.1 Erinaceus europaeus 42 1e-54 211
WERAM-Cym-0017 CML119CT Cyanidioschyzon merolae 43 2e-51 200
WERAM-Vip-0121 ENSVPAP00000010985.1 Vicugna pacos 46 7e-49 192
WERAM-Yal-0031 CAG78100 Yarrowia lipolytica 39 4e-47 186
WERAM-Cae-0022 R11A8.4a Caenorhabditis elegans 43 2e-46 184
WERAM-Phn-0017 SNOT_06735 Phaeosphaeria nodorum 34 3e-40 163
Created Date 25-Jun-2016