| Tag |
Content |
| WERAM ID |
WERAM-Hos-0074 |
| Ensembl Protein ID |
ENSP00000466924.1 |
| Uniprot Accession |
Q92800; EZH1_HUMAN; A6NCH6; B4DIJ1; B4DIZ7; B4DSS2; B4E3R7; O43287; Q14459; Q53XP3
|
| Genbank Protein ID |
NP_001982.2
|
| Protein Name |
Histone-lysine N-methyltransferase EZH1 |
| Genbank Nucleotide ID |
NM_001991.4
|
| Gene Name |
EZH1;KMT6B |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HMT |
SET1 |
SET |
H3K27 |
K |
25537518; 26807165
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
EZ |
2.10e-61 |
207.4 |
613 |
728 |
| HMT |
SET1 |
2.10e-41 |
143.1 |
613 |
728 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. |
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
|
| Domain Profile |
HMT EZ
EZ.txt 1 krillgksdvaGwGlflkesvekneylgeytGelisddeadkrGkiydrakssflfnlndqlvidakrkGnklkfanhsakpncyakvllva 92
k++ll++sdvaGwG f+kesv+kne+++ey+Gelis+dead+rGk+yd+++ssflfnln+++v+da+rkGnk++fanhs +pncyakv++v+
ENSP00000466924.1 613 KHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVN 704
789***************************************************************************************** PP
EZ.txt 93 GdhriGlfakrrieaseelffdyr 116
GdhriG+fakr+i+a+eelffdyr
ENSP00000466924.1 705 GDHRIGIFAKRAIQAGEELFFDYR 728
***********************7 PP
HMT SET1
SET1.txt 1 kelevakskikglglvakkeiekeelviEYvGevirsevadkrekeyekkeigvylfrldedaevvvdatkkgniarfinhscepNceakvv 92
k+l +a s+++g+g ++k++++k+e++ EY+Ge+i++++ad+r k y+k+ ++++lf+l++d +vvdat+kgn++rf nhs++pNc+akvv
ENSP00000466924.1 613 KHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKY-MSSFLFNLNND--FVVDATRKGNKIRFANHSVNPNCYAKVV 701
678999*******************************************9.778********..**************************** PP
SET1.txt 93 avdgekkiviyakraIekgeeltydYk 119
+v+g+++i+i+akraI++geel++dY+
ENSP00000466924.1 702 MVNGDHRIGIFAKRAIQAGEELFFDYR 728
**************************6 PP
|
Protein Sequence
(Fasta) | MEIPNPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ EKTQILNEEW 60
KKLRVQPVQS MKPVSGHPFL KKCTIESIFP GFASQHMLMR SLNTVALVPI MYSWSPLQQN 120
FMVEDETVLC NIPYMGDEVK EEDETFIEEL INNYDGKVHG EEEMIPGSVL ISDAVFLELV 180
DALNQYSDEE EEGHNDTSDG KQDDSKEDLP VTRKRKRHAI EGNKKSSKKQ FPNDMIFSAI 240
ASMFPENGVP DDMKERYREL TEMSDPNALP PQCTPNIDGP NAKSVQREQS LHSFHTLFCR 300
RCFKYDCFLH PFHATPNVYK RKNKEIKIEP EPCGTDCFLL LEGAKEYAML HNPRSKCSGR 360
RRRRHHIVSA SCSNASASAV AETKEGDSDR DTGNDWASSS SEANSRCQTP TKQKASPAPP 420
QLCVVEAPSE PVEWTGAEES LFRVFHGTYF NNFCSIARLL GTKTCKQVFQ FAVKESLILK 480
LPTDELMNPS QKKKRKHRLW AAHCRKIQLK KDNSSTQVYN YQPCDHPDRP CDSTCPCIMT 540
QNFCEKFCQC NPDCQNRFPG CRCKTQCNTK QCPCYLAVRE CDPDLCLTCG ASEHWDCKVV 600
SCKNCSIQRG LKKHLLLAPS DVAGWGTFIK ESVQKNEFIS EYCGELISQD EADRRGKVYD 660
KYMSSFLFNL NNDFVVDATR KGNKIRFANH SVNPNCYAKV VMVNGDHRIG IFAKRAIQAG 720
EELFFDYRYS QADALKYVGI ERETDVL 747Protein Fasta Sequence
>ENSP00000466924.1|EZH1;KMT6B|Homo sapiens
MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQNFMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVDALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILKLPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL |
Nucleotide Sequence
(Fasta) | ATGCGTCCTA GCAGCGGGAC CCGCGGCTCG GGATGGAGGA TTACAGCAAG ATGGAAATAC 60
CAAATCCCCC TACCTCCAAA TGTATCACTT ACTGGAAAAG AAAAGTGAAA TCTGAATACA 120
TGCGACTTCG ACAACTTAAA CGGCTTCAGG CAAATATGGG TGCAAAGGCT TTGTATGTGG 180
CAAATTTTGC AAAGGTTCAA GAAAAAACCC AGATCCTCAA TGAAGAATGG AAGAAGCTTC 240
GTGTCCAACC TGTTCAGTCA ATGAAGCCTG TGAGTGGACA CCCTTTTCTC AAAAAGTGTA 300
CCATAGAGAG CATTTTCCCG GGATTTGCAA GCCAACATAT GTTAATGAGG TCACTGAACA 360
CAGTTGCATT GGTTCCCATC ATGTATTCCT GGTCCCCTCT CCAACAGAAC TTTATGGTAG 420
AAGATGAGAC GGTTTTGTGC AATATTCCCT ACATGGGAGA TGAAGTGAAA GAAGAAGATG 480
AGACTTTTAT TGAGGAGCTG ATCAATAACT ATGATGGGAA AGTCCATGGT GAAGAAGAGA 540
TGATCCCTGG ATCCGTTCTG ATTAGTGATG CTGTTTTTCT GGAGTTGGTC GATGCCCTGA 600
ATCAGTACTC AGATGAGGAG GAGGAAGGGC ACAATGACAC CTCAGATGGA AAGCAGGATG 660
ACAGCAAAGA AGATCTGCCA GTAACAAGAA AGAGAAAGCG ACATGCTATT GAAGGCAACA 720
AAAAGAGTTC CAAGAAACAG TTCCCAAATG ACATGATCTT CAGTGCAATT GCCTCAATGT 780
TCCCTGAGAA TGGTGTCCCA GATGACATGA AGGAGAGGTA TCGAGAACTA ACAGAGATGT 840
CAGACCCCAA TGCACTTCCC CCTCAGTGCA CACCCAACAT CGATGGCCCC AATGCCAAGT 900
CTGTGCAGCG GGAGCAATCT CTGCACTCCT TCCACACACT TTTTTGCCGG CGCTGCTTTA 960
AATACGACTG CTTCCTTCAC CCTTTTCATG CCACCCCTAA TGTATATAAA CGCAAGAATA 1020
AAGAAATCAA GATTGAACCA GAACCATGTG GCACAGACTG CTTCCTTTTG CTGGAAGGAG 1080
CAAAGGAGTA TGCCATGCTC CACAACCCCC GCTCCAAGTG CTCTGGTCGT CGCCGGAGAA 1140
GGCACCACAT AGTCAGTGCT TCCTGCTCCA ATGCCTCAGC CTCTGCTGTG GCTGAGACTA 1200
AAGAAGGAGA CAGTGACAGG GACACAGGCA ATGACTGGGC CTCCAGTTCT TCAGAGGCTA 1260
ACTCTCGCTG TCAGACTCCC ACAAAACAGA AGGCTAGTCC AGCCCCACCT CAACTCTGCG 1320
TAGTGGAAGC ACCCTCGGAG CCTGTGGAAT GGACTGGGGC TGAAGAATCT CTTTTTCGAG 1380
TCTTCCATGG CACCTACTTC AACAACTTCT GTTCAATAGC CAGGCTTCTG GGGACCAAGA 1440
CGTGCAAGCA GGTCTTTCAG TTTGCAGTCA AAGAATCACT TATCCTGAAG CTGCCAACAG 1500
ATGAGCTCAT GAACCCCTCA CAGAAGAAGA AAAGAAAGCA CAGATTGTGG GCTGCACACT 1560
GCAGGAAGAT TCAGCTGAAG AAAGATAACT CTTCCACACA AGTGTACAAC TACCAACCCT 1620
GCGACCACCC AGACCGCCCC TGTGACAGCA CCTGCCCCTG CATCATGACT CAGAATTTCT 1680
GTGAGAAGTT CTGCCAGTGC AACCCAGACT GTCAGAATCG TTTCCCTGGC TGTCGCTGTA 1740
AGACCCAGTG CAATACCAAG CAATGTCCTT GCTATCTGGC AGTGCGAGAA TGTGACCCTG 1800
ACCTGTGTCT CACCTGTGGG GCCTCAGAGC ACTGGGACTG CAAGGTGGTT TCCTGTAAAA 1860
ACTGCAGCAT CCAGCGTGGA CTTAAGAAGC ACCTGCTGCT GGCCCCCTCT GATGTGGCCG 1920
GATGGGGCAC CTTCATAAAG GAGTCTGTGC AGAAGAACGA ATTCATTTCT GAATACTGTG 1980
GTGAGCTCAT CTCTCAGGAT GAGGCTGATC GACGCGGAAA GGTCTATGAC AAATACATGT 2040
CCAGCTTCCT CTTCAACCTC AATAATGATT TTGTAGTGGA TGCTACTCGG AAAGGAAACA 2100
AAATTCGATT TGCAAATCAT TCAGTGAATC CCAACTGTTA TGCCAAAGTG GTCATGGTGA 2160
ATGGAGACCA TCGGATTGGG ATCTTTGCCA AGAGGGCAAT TCAAGCTGGC GAAGAGCTCT 2220
TCTTTGATTA CAGGTACAGC CAAGCTGATG CTCTCAAGTA CGTGGGGATC GAGAGGGAGA 2280
CCGACGTCCT TTAGCCCTCC CAGGCCCCAC GGCAGCACTT ATGGTAGCGG CACTGTCTTG 2340
GCTTTCGTGC TCACACCACT GCTGCTCGAG TCTCCTGCAC TGTGTCTCCC ACACTGAGAA 2400
ACCCCCCAAC CCACTCCCTC TGTAGTGAGG CCTCTGCCAT GTCCAGAGGG CACAAAACTG 2460
TCTCAATGAG AGGGGAGACA GAGGCAGCTA GGGCTTGGTC T
2502Nucleotide Fasta Sequence
>ENSP00000466924.1|SET1|Homo sapiens
ATGCGTCCTAGCAGCGGGACCCGCGGCTCGGGATGGAGGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGAAATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTCTCAAAAAGTGTACCATAGAGAGCATTTTCCCGGGATTTGCAAGCCAACATATGTTAATGAGGTCACTGAACACAGTTGCATTGGTTCCCATCATGTATTCCTGGTCCCCTCTCCAACAGAACTTTATGGTAGAAGATGAGACGGTTTTGTGCAATATTCCCTACATGGGAGATGAAGTGAAAGAAGAAGATGAGACTTTTATTGAGGAGCTGATCAATAACTATGATGGGAAAGTCCATGGTGAAGAAGAGATGATCCCTGGATCCGTTCTGATTAGTGATGCTGTTTTTCTGGAGTTGGTCGATGCCCTGAATCAGTACTCAGATGAGGAGGAGGAAGGGCACAATGACACCTCAGATGGAAAGCAGGATGACAGCAAAGAAGATCTGCCAGTAACAAGAAAGAGAAAGCGACATGCTATTGAAGGCAACAAAAAGAGTTCCAAGAAACAGTTCCCAAATGACATGATCTTCAGTGCAATTGCCTCAATGTTCCCTGAGAATGGTGTCCCAGATGACATGAAGGAGAGGTATCGAGAACTAACAGAGATGTCAGACCCCAATGCACTTCCCCCTCAGTGCACACCCAACATCGATGGCCCCAATGCCAAGTCTGTGCAGCGGGAGCAATCTCTGCACTCCTTCCACACACTTTTTTGCCGGCGCTGCTTTAAATACGACTGCTTCCTTCACCCTTTTCATGCCACCCCTAATGTATATAAACGCAAGAATAAAGAAATCAAGATTGAACCAGAACCATGTGGCACAGACTGCTTCCTTTTGCTGGAAGGAGCAAAGGAGTATGCCATGCTCCACAACCCCCGCTCCAAGTGCTCTGGTCGTCGCCGGAGAAGGCACCACATAGTCAGTGCTTCCTGCTCCAATGCCTCAGCCTCTGCTGTGGCTGAGACTAAAGAAGGAGACAGTGACAGGGACACAGGCAATGACTGGGCCTCCAGTTCTTCAGAGGCTAACTCTCGCTGTCAGACTCCCACAAAACAGAAGGCTAGTCCAGCCCCACCTCAACTCTGCGTAGTGGAAGCACCCTCGGAGCCTGTGGAATGGACTGGGGCTGAAGAATCTCTTTTTCGAGTCTTCCATGGCACCTACTTCAACAACTTCTGTTCAATAGCCAGGCTTCTGGGGACCAAGACGTGCAAGCAGGTCTTTCAGTTTGCAGTCAAAGAATCACTTATCCTGAAGCTGCCAACAGATGAGCTCATGAACCCCTCACAGAAGAAGAAAAGAAAGCACAGATTGTGGGCTGCACACTGCAGGAAGATTCAGCTGAAGAAAGATAACTCTTCCACACAAGTGTACAACTACCAACCCTGCGACCACCCAGACCGCCCCTGTGACAGCACCTGCCCCTGCATCATGACTCAGAATTTCTGTGAGAAGTTCTGCCAGTGCAACCCAGACTGTCAGAATCGTTTCCCTGGCTGTCGCTGTAAGACCCAGTGCAATACCAAGCAATGTCCTTGCTATCTGGCAGTGCGAGAATGTGACCCTGACCTGTGTCTCACCTGTGGGGCCTCAGAGCACTGGGACTGCAAGGTGGTTTCCTGTAAAAACTGCAGCATCCAGCGTGGACTTAAGAAGCACCTGCTGCTGGCCCCCTCTGATGTGGCCGGATGGGGCACCTTCATAAAGGAGTCTGTGCAGAAGAACGAATTCATTTCTGAATACTGTGGTGAGCTCATCTCTCAGGATGAGGCTGATCGACGCGGAAAGGTCTATGACAAATACATGTCCAGCTTCCTCTTCAACCTCAATAATGATTTTGTAGTGGATGCTACTCGGAAAGGAAACAAAATTCGATTTGCAAATCATTCAGTGAATCCCAACTGTTATGCCAAAGTGGTCATGGTGAATGGAGACCATCGGATTGGGATCTTTGCCAAGAGGGCAATTCAAGCTGGCGAAGAGCTCTTCTTTGATTACAGGTACAGCCAAGCTGATGCTCTCAAGTACGTGGGGATCGAGAGGGAGACCGACGTCCTTTAGCCCTCCCAGGCCCCACGGCAGCACTTATGGTAGCGGCACTGTCTTGGCTTTCGTGCTCACACCACTGCTGCTCGAGTCTCCTGCACTGTGTCTCCCACACTGAGAAACCCCCCAACCCACTCCCTCTGTAGTGAGGCCTCTGCCATGTCCAGAGGGCACAAAACTGTCTCAATGAGAGGGGAGACAGAGGCAGCTAGGGCTTGGTCT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR026489--CXC_dom
IPR032926--EZH1
IPR021654--EZH1/EZH2
IPR001005--SANT/Myb
IPR001214--SET_dom
IPR033467--Tesmin/TSO1-like_CXC
|
| PROSITE |
PS51633--CXC
PS50280--SET
|
| Pfam |
PF11616--EZH2_WD-Binding
PF00856--SET
|
| Gene Ontology |
GO:0035098--C:ESC/E(Z) complex
GO:0005654--C:nucleoplasm
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0009653--P:anatomical structure morphogenesis
GO:0021766--P:hippocampus development
GO:0070734--P:histone H3-K27 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
