| Tag |
Content |
| WERAM ID |
WERAM-Hos-0084 |
| Ensembl Protein ID |
ENSP00000363640.3 |
| Uniprot Accession |
O43189; PHF1_HUMAN; B1AZX2; B1AZX3; O60929; Q5SU07; Q5SU08; Q96KM7
|
| Genbank Protein ID |
NP_002627.1; NP_077084.1; XP_011512964.1; XP_011512969.1; XP_011512970.1; XP_011546744.1; XP_011546749.1; XP_011546750.1
|
| Protein Name |
PHD finger protein 1 |
| Genbank Nucleotide ID |
NM_002636.4; NM_024165.2; XM_011514662.1; XM_011514667.1; XM_011514668.1; XM_011548442.1; XM_011548447.1; XM_011548448.1
|
| Gene Name |
PHF1;PCL1 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
PHD |
PHD1,2 |
H3K36me3 |
K |
24352064
|
| Me_Reader |
Tudor |
Tudor |
H3K36me3 |
K |
24352064
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
PHD |
1.40e-13 |
53 |
89 |
238 |
| Me_Reader |
Tudor |
5.10e-13 |
51.3 |
31 |
85 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. |
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
|
| Domain Profile |
Me_Reader PHD
PHD.txt 3 iClvCg..kddegekemvqCdeCddwfHlkCvklplsslp.eg..kswyCpsCk 51
+C+vC+ ++ g++ +v C++C++++H++C+ + ++p eg +sw+C++C+
ENSP00000363640.3 89 LCCVCRseTVVPGNR-LVSCEKCRHAYHQDCHVPR-APAPgEGegTSWVCRQCV 140
5778*6445566666.****************999.77776667789******7 PP
PHD.txt 2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpeg...kswyCpsCk 51
+C+ Cg ++e + +m+qC +C +wfH C+++ ++l +g ++ C C+
ENSP00000363640.3 187 SYCY-CGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGdrfYEFECCVCR 238
69*9.*766555567*******************88888995555666*9998 PP
Me_Reader Tudor
Tudor.txt 2 skvGlrVvakwssdGyfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlreqyg 63
+++G++V+a+w+ dG+ Y g+i ++v+s++e++++++ed++++ + L+k+++++++ g
ENSP00000363640.3 31 LWEGQDVLARWT-DGLLYLGTI----KKVDSAREVCLVQFEDDSQFLV--LWKDISPAALPG 85
689*********.*********....********************77..9****9998765 PP
|
Protein Sequence
(Fasta) | MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV 60
CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV 120
PRAPAPGEGE GTSWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH 180
LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG 240
PEKVRRLQLR WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE 300
RSSRLLSALN SHKDRFISGR EIKKRKCLFG LHARMPPPVE PPTGDGALTS FPSGQGPGGG 360
VSRPLGKRRR PEPEPLRRRQ KGKVEELGPP SAVRNQPEPQ EQRERAHLQR ALQASVSPPS 420
PSPNQSYQGS SGYNFRPTDA RCLPSSPIRM FASFHPSAST AGTSGDSGPP DRSPLELHIG 480
FPTDIPKSAP HSMTASSSSV SSPSPGLPRR SAPPSPLCRS LSPGTGGGVR GGVGYLSRGD 540
PVRVLARRVR PDGSVQYLVE WGGGGIF 567Protein Fasta Sequence
>ENSP00000363640.3|PHF1;PCL1|Homo sapiens
MAQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSRLLSALNSHKDRFISGREIKKRKCLFGLHARMPPPVEPPTGDGALTSFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKVEELGPPSAVRNQPEPQEQRERAHLQRALQASVSPPSPSPNQSYQGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDSGPPDRSPLELHIGFPTDIPKSAPHSMTASSSSVSSPSPGLPRRSAPPSPLCRSLSPGTGGGVRGGVGYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF |
Nucleotide Sequence
(Fasta) | CACCCTCCCC CCCAACCGGT CCGTCCCTCC CCTCCCTCCC TCCCCCCCGC CGCCTCCTCC 60
TCCTGCCGCT GCCGCTGCTT TGGCTGCTGC GTCATACGCC CCAGAGCCGC CGGGACGGAG 120
GGGCTGGGCC TGGGGACCCC CCGGCCTCCG CCTGCACGCC CCCCCACGCC CGGACGTGCC 180
CTCTCCGCGC GGGGGACTCG CCTAGGTCTC CTACGTCTGC CCCTGCCCGG CTCCCGGCGG 240
CCCCAGCTGT CACCGGCCCC CCCAGGATGC AATGGCGCAG CCCCCCCGGC TGAGCCGCTC 300
TGGTGCCTCC TCACTTTGGG ACCCAGCTTC TCCTGCTCCC ACCTCTGGCC CCAGGCCTCG 360
GCTTTGGGAG GGTCAAGATG TGCTGGCCAG ATGGACTGAT GGGCTGCTAT ACTTGGGTAC 420
CATCAAAAAG GTGGACAGTG CTAGGGAGGT GTGTCTGGTC CAGTTTGAGG ATGATTCGCA 480
GTTTCTGGTT CTATGGAAAG ACATTAGCCC TGCTGCCCTC CCTGGAGAGG AACTCCTCTG 540
TTGTGTCTGT CGCTCTGAGA CTGTGGTCCC TGGGAACCGG CTGGTCAGCT GTGAGAAGTG 600
TCGCCATGCT TATCACCAGG ACTGCCATGT TCCCAGGGCT CCAGCCCCTG GAGAGGGAGA 660
GGGCACATCC TGGGTATGCC GCCAGTGTGT CTTTGCGATC GCCACCAAGA GGGGAGGTGC 720
CCTGAAGAAG GGCCCCTATG CCCGGGCCAT GCTGGGTATG AAGCTTTCTC TGCCATATGG 780
ACTGAAGGGG CTGGACTGGG ATGCTGGACA TCTGAGCAAC CGACAGCAGA GTTACTGTTA 840
CTGTGGTGGC CCTGGGGAGT GGAACCTGAA AATGCTGCAG TGCCGGAGCT GCCTGCAGTG 900
GTTCCATGAG GCCTGCACCC AGTGTCTGAG CAAGCCCCTC CTCTATGGGG ACAGGTTCTA 960
TGAATTTGAA TGCTGTGTGT GTCGCGGGGG CCCTGAGAAA GTCCGGAGAC TACAGCTTCG 1020
CTGGGTGGAT GTGGCCCATC TTGTCCTGTA TCACCTCAGT GTTTGCTGTA AGAAGAAATA 1080
CTTTGATTTT GATCGTGAGA TCCTCCCCTT CACTTCTGAG AATTGGGACA GTTTGCTCCT 1140
GGGGGAGCTT TCAGACACCC CCAAAGGAGA ACGTTCTTCC AGGCTCCTCT CTGCTCTTAA 1200
CAGCCACAAG GACCGTTTCA TTTCAGGGAG AGAGATTAAG AAGAGGAAAT GTTTGTTTGG 1260
TCTCCATGCT CGGATGCCTC CCCCTGTGGA GCCCCCTACT GGAGATGGAG CACTCACCAG 1320
CTTCCCTTCA GGGCAGGGCC CTGGGGGAGG GGTCTCACGT CCCCTGGGGA AGCGCCGGAG 1380
GCCGGAGCCA GAGCCCCTGA GGAGGAGGCA GAAGGGGAAA GTGGAGGAGC TGGGGCCACC 1440
CTCAGCAGTG CGCAATCAGC CCGAGCCCCA GGAGCAGAGG GAGCGGGCTC ATCTGCAGAG 1500
GGCACTGCAG GCCTCAGTGT CTCCACCATC CCCCAGCCCT AACCAGAGTT ACCAGGGCAG 1560
CAGCGGCTAC AACTTCCGGC CCACAGATGC CCGCTGCCTG CCCAGCAGCC CCATCCGGAT 1620
GTTTGCTTCC TTCCACCCTT CTGCCAGCAC CGCAGGGACC TCTGGGGACA GTGGACCCCC 1680
AGACAGGTCA CCCCTGGAAC TTCACATTGG TTTCCCCACA GACATCCCTA AAAGTGCCCC 1740
CCACTCGATG ACTGCCTCAT CTTCCTCAGT TTCATCCCCA TCCCCAGGTC TTCCTAGACG 1800
CTCAGCACCC CCTTCTCCCC TGTGCCGTAG TTTGTCTCCT GGGACTGGGG GAGGAGTCCG 1860
AGGTGGGGTT GGTTACCTGT CCCGAGGGGA CCCTGTCCGG GTCCTTGCTC GGAGAGTACG 1920
GCCTGATGGC TCTGTGCAGT ACCTGGTTGA GTGGGGAGGA GGGGGCATCT TCTGAACAGC 1980
CTGCCTCTGC CCAGCTCCCC ATTCACACAC ACCGGCACTT TCATACCCTG ACCTCTGACC 2040
TCACCTACAG CTGGGATGTA CCTGGAGAGA TAGGGGGTAG TTCTCCCTAC TGCCCAGGCT 2100
GGAATCCAAG AGTGGGGAGT GGGGAAGAGG CCCTCTTCTC TACCCTCCTT CATGATTCCT 2160
GACCCCTCCC ATCCTTCCCA TTTCCTTTGA TGTTATTTTG TTACAGCTTT TTAAATATTT 2220
TTTAAAATTA TTTAACCCCT GGGGGCAGAG ACTGAGGAGG GAGGATGATA AGGGATCCCG 2280
GACTCTGTAT GATTGAAATA AAGAGAAATA AACAAATCTA GCAGCTCTGA
2331Nucleotide Fasta Sequence
>ENSP00000363640.3|Tudor|Homo sapiens
CACCCTCCCCCCCAACCGGTCCGTCCCTCCCCTCCCTCCCTCCCCCCCGCCGCCTCCTCCTCCTGCCGCTGCCGCTGCTTTGGCTGCTGCGTCATACGCCCCAGAGCCGCCGGGACGGAGGGGCTGGGCCTGGGGACCCCCCGGCCTCCGCCTGCACGCCCCCCCACGCCCGGACGTGCCCTCTCCGCGCGGGGGACTCGCCTAGGTCTCCTACGTCTGCCCCTGCCCGGCTCCCGGCGGCCCCAGCTGTCACCGGCCCCCCCAGGATGCAATGGCGCAGCCCCCCCGGCTGAGCCGCTCTGGTGCCTCCTCACTTTGGGACCCAGCTTCTCCTGCTCCCACCTCTGGCCCCAGGCCTCGGCTTTGGGAGGGTCAAGATGTGCTGGCCAGATGGACTGATGGGCTGCTATACTTGGGTACCATCAAAAAGGTGGACAGTGCTAGGGAGGTGTGTCTGGTCCAGTTTGAGGATGATTCGCAGTTTCTGGTTCTATGGAAAGACATTAGCCCTGCTGCCCTCCCTGGAGAGGAACTCCTCTGTTGTGTCTGTCGCTCTGAGACTGTGGTCCCTGGGAACCGGCTGGTCAGCTGTGAGAAGTGTCGCCATGCTTATCACCAGGACTGCCATGTTCCCAGGGCTCCAGCCCCTGGAGAGGGAGAGGGCACATCCTGGGTATGCCGCCAGTGTGTCTTTGCGATCGCCACCAAGAGGGGAGGTGCCCTGAAGAAGGGCCCCTATGCCCGGGCCATGCTGGGTATGAAGCTTTCTCTGCCATATGGACTGAAGGGGCTGGACTGGGATGCTGGACATCTGAGCAACCGACAGCAGAGTTACTGTTACTGTGGTGGCCCTGGGGAGTGGAACCTGAAAATGCTGCAGTGCCGGAGCTGCCTGCAGTGGTTCCATGAGGCCTGCACCCAGTGTCTGAGCAAGCCCCTCCTCTATGGGGACAGGTTCTATGAATTTGAATGCTGTGTGTGTCGCGGGGGCCCTGAGAAAGTCCGGAGACTACAGCTTCGCTGGGTGGATGTGGCCCATCTTGTCCTGTATCACCTCAGTGTTTGCTGTAAGAAGAAATACTTTGATTTTGATCGTGAGATCCTCCCCTTCACTTCTGAGAATTGGGACAGTTTGCTCCTGGGGGAGCTTTCAGACACCCCCAAAGGAGAACGTTCTTCCAGGCTCCTCTCTGCTCTTAACAGCCACAAGGACCGTTTCATTTCAGGGAGAGAGATTAAGAAGAGGAAATGTTTGTTTGGTCTCCATGCTCGGATGCCTCCCCCTGTGGAGCCCCCTACTGGAGATGGAGCACTCACCAGCTTCCCTTCAGGGCAGGGCCCTGGGGGAGGGGTCTCACGTCCCCTGGGGAAGCGCCGGAGGCCGGAGCCAGAGCCCCTGAGGAGGAGGCAGAAGGGGAAAGTGGAGGAGCTGGGGCCACCCTCAGCAGTGCGCAATCAGCCCGAGCCCCAGGAGCAGAGGGAGCGGGCTCATCTGCAGAGGGCACTGCAGGCCTCAGTGTCTCCACCATCCCCCAGCCCTAACCAGAGTTACCAGGGCAGCAGCGGCTACAACTTCCGGCCCACAGATGCCCGCTGCCTGCCCAGCAGCCCCATCCGGATGTTTGCTTCCTTCCACCCTTCTGCCAGCACCGCAGGGACCTCTGGGGACAGTGGACCCCCAGACAGGTCACCCCTGGAACTTCACATTGGTTTCCCCACAGACATCCCTAAAAGTGCCCCCCACTCGATGACTGCCTCATCTTCCTCAGTTTCATCCCCATCCCCAGGTCTTCCTAGACGCTCAGCACCCCCTTCTCCCCTGTGCCGTAGTTTGTCTCCTGGGACTGGGGGAGGAGTCCGAGGTGGGGTTGGTTACCTGTCCCGAGGGGACCCTGTCCGGGTCCTTGCTCGGAGAGTACGGCCTGATGGCTCTGTGCAGTACCTGGTTGAGTGGGGAGGAGGGGGCATCTTCTGAACAGCCTGCCTCTGCCCAGCTCCCCATTCACACACACCGGCACTTTCATACCCTGACCTCTGACCTCACCTACAGCTGGGATGTACCTGGAGAGATAGGGGGTAGTTCTCCCTACTGCCCAGGCTGGAATCCAAGAGTGGGGAGTGGGGAAGAGGCCCTCTTCTCTACCCTCCTTCATGATTCCTGACCCCTCCCATCCTTCCCATTTCCTTTGATGTTATTTTGTTACAGCTTTTTAAATATTTTTTAAAATTATTTAACCCCTGGGGGCAGAGACTGAGGAGGGAGGATGATAAGGGATCCCGGACTCTGTATGATTGAAATAAAGAGAAATAAACAAATCTAGCAGCTCTGA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR025894--Mtf2_C_dom
IPR031202--PHF1
IPR002999--Tudor
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
|
| PROSITE |
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
|
| Pfam |
PF14061--Mtf2_C
PF00628--PHD
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005815--C:microtubule organizing center
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0035064--F:methylated histone binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016568--P:chromatin modification
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0061086--P:negative regulation of histone H3-K27 methylation
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
