| Tag |
Content |
| WERAM ID |
WERAM-Mum-0056 |
| Ensembl Protein ID |
ENSMUSP00000073402.5 |
| Uniprot Accession |
Q9Z1B8; PHF1_MOUSE; O54808
|
| Genbank Protein ID |
NP_033369.2
|
| Protein Name |
PHD finger protein 1 |
| Genbank Nucleotide ID |
NM_009343.3
|
| Gene Name |
PHF1;Plc1;Tctex-3;Tctex3 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
PHD |
PHD1,2 |
H3K36me3 |
K |
26745824
|
| Me_Reader |
Tudor |
Tudor |
H3K36me3 |
K |
26745824
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
PHD |
6.40e-14 |
53.3 |
89 |
238 |
| Me_Reader |
Tudor |
2.80e-13 |
51.4 |
31 |
85 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18086877). According to other reports, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. |
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18086877). According to other reports, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
|
| Domain Profile |
Me_Reader PHD
PHD.txt 3 iClvCg..kddegekemvqCdeCddwfHlkCvklplsslp.eg..kswyCpsCk 51
+C+vC+ ++ g++ +v C++C++++H++C+ + ++p eg +sw+C++C+
ENSMUSP00000073402.5 89 LCCVCRseTVVPGNR-LVSCEKCRHAYHQDCHVPR-APAPgEGegASWVCRQCV 140
5778*6445566666.****************999.77776667799******7 PP
PHD.txt 2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpeg...kswyCpsCk 51
+C+ Cg ++e + +m+qC +C +wfH C+++ ++l +g ++ C C+
ENSMUSP00000073402.5 187 SYCY-CGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGdrfYEFECCVCR 238
69*9.*766555567*******************88888995555666*9998 PP
Me_Reader Tudor
Tudor.txt 2 skvGlrVvakwssdGyfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlreqyg 63
+++G++V+a+w+ dG+ Y g+i ++v+s++e++++++ed++++ + L+k+++++++ g
ENSMUSP00000073402.5 31 LWEGQDVLARWT-DGLLYLGTI----KKVDSAREVCLVQFEDDSQFLV--LWKDISPAALPG 85
689*********.*********....********************77..9****9998765 PP
|
Protein Sequence
(Fasta) | MAQLPRLSRL GAPSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV 60
CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV 120
PRAPAPGEGE GASWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH 180
LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG 240
PEKVRRLQLR WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE 300
RSSQLLSALN SHKDRFISGR EIKKRKCLFG LHARTPPPVE LLTGDGAPTS FPSGQGPGGG 360
VSRPLGKRWR SEPEPLRRRQ KGKVEELGPP TAAHSRHGSR EQRALQASVS PPPPSPNQSY 420
EGSSGYNFRP TDARCLPSSP IRMFASFHPS ASTAGTSGDS EPPDRSPLGL HIGFPTDTPK 480
SSPHSVTASS SSVPALTPGF SRHSPPSPLC RSLSPGTGGG VRGGVSYLSR GDPVRVLARR 540
VRPDGSVQYL VEWGGGGIF 559Protein Fasta Sequence
>ENSMUSP00000073402.5|PHF1;Plc1;Tctex-3;Tctex3|Mus musculus
MAQLPRLSRLGAPSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGASWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSQLLSALNSHKDRFISGREIKKRKCLFGLHARTPPPVELLTGDGAPTSFPSGQGPGGGVSRPLGKRWRSEPEPLRRRQKGKVEELGPPTAAHSRHGSREQRALQASVSPPPPSPNQSYEGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDSEPPDRSPLGLHIGFPTDTPKSSPHSVTASSSSVPALTPGFSRHSPPSPLCRSLSPGTGGGVRGGVSYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF |
Nucleotide Sequence
(Fasta) | AGAAGGTTAT TTCCTGCTGA CCCAGAGCAA GCCTCCCATC CGAAAAAGGG GCTGCAGGGA 60
TTTCCTCGAC CTCCGCGACC GGCCGCGCCC CCAACAGCGC AGCGCCCTCC GGGCCCGCTG 120
GAGGTGAGGG AGGTGCTGCC TGCCCGTCCC TCTGTCGTCT CCTCCCCCTG GTGCTCCCCA 180
CCCTCCACTC TCCTCCCTCC TTCTGTCGAC TCCTCCTGCC GCTGCTGCTG CTTTGGCTGC 240
TGCGTCATAC GCCCCAGAGC CGCCAGGACG GAGGGGCTGG GCCCGGGGAC CCCCTGGCCT 300
CCGCCTGCAC GCCCCCCGGC GCTCACACTC AGTCTTCCCG CACCGGAGAC TCATCCAGGT 360
CTCTTGAGTC TGACCCTACC TGGCTTCCAG CTGCCCCGGC TGTCACCGGC CCCCCCAGGA 420
TGCAATGGCG CAGCTCCCCC GGCTGAGCCG TTTGGGTGCC CCCTCTCTCT GGGATCCAGC 480
TTCCCCTGCT CCCACCTCAG GCCCCAGACC TCGGCTTTGG GAAGGCCAAG ATGTGCTGGC 540
CAGATGGACT GATGGGCTGC TGTACTTGGG TACCATCAAA AAGGTGGACA GTGCTCGAGA 600
GGTGTGTCTG GTCCAGTTTG AGGACGATTC CCAGTTTCTG GTTCTATGGA AGGATATCAG 660
CCCAGCTGCC CTCCCTGGGG AGGAGCTGCT CTGTTGTGTG TGTCGCTCTG AGACCGTGGT 720
ACCTGGGAAC CGGCTGGTCA GCTGTGAGAA GTGTCGCCAT GCTTATCACC AGGACTGTCA 780
CGTTCCCAGG GCCCCGGCCC CTGGAGAAGG AGAGGGCGCA TCCTGGGTAT GCCGCCAGTG 840
TGTCTTTGCA ATCGCCACTA AGAGGGGAGG CGCACTGAAG AAAGGTCCCT ATGCCCGGGC 900
CATGCTGGGC ATGAAGCTCT CCCTGCCATA CGGATTAAAA GGGCTGGACT GGGATGCTGG 960
ACATTTGAGC AACAGACAGC AGAGCTACTG CTACTGTGGA GGCCCTGGAG AGTGGAACCT 1020
GAAAATGCTG CAGTGCCGGA GCTGCCTCCA GTGGTTCCAT GAGGCCTGCA CCCAGTGTCT 1080
GAGCAAGCCC CTCCTCTACG GAGACAGATT CTATGAATTT GAGTGCTGTG TGTGCCGGGG 1140
CGGCCCTGAG AAGGTCCGGA GGTTACAGCT TCGCTGGGTG GATGTGGCCC ATCTTGTCCT 1200
CTACCACCTC AGCGTTTGCT GTAAGAAGAA ATATTTTGAT TTTGACCGAG AGATCCTCCC 1260
CTTCACCTCT GAGAATTGGG ACAGTCTGCT CCTGGGGGAG CTCTCAGATA CTCCCAAGGG 1320
AGAGCGCTCT TCCCAGCTCC TTTCTGCTCT TAACAGCCAC AAGGACCGTT TCATTTCAGG 1380
GAGGGAGATT AAAAAGCGAA AATGTCTTTT TGGTCTCCAT GCTCGGACCC CTCCTCCTGT 1440
GGAGCTTCTC ACTGGAGATG GAGCCCCCAC CAGCTTCCCT TCAGGGCAGG GCCCTGGGGG 1500
AGGGGTCTCA CGTCCCCTGG GGAAACGATG GAGGTCGGAG CCAGAACCCT TAAGGAGGAG 1560
GCAGAAGGGG AAAGTGGAGG AACTGGGGCC ACCCACGGCA GCACACAGTC GGCATGGGTC 1620
CCGGGAGCAG AGGGCCCTGC AGGCCTCGGT GTCTCCACCA CCCCCCAGCC CTAACCAGAG 1680
CTATGAGGGC AGCAGCGGCT ACAACTTCCG GCCCACAGAC GCCCGCTGTC TGCCCAGCAG 1740
CCCTATCCGG ATGTTCGCCT CCTTCCACCC TTCTGCCAGC ACTGCAGGGA CCTCTGGGGA 1800
CAGTGAACCC CCAGATAGGT CACCTCTGGG ACTTCACATT GGCTTCCCCA CAGACACCCC 1860
TAAAAGTTCA CCCCACTCAG TGACGGCCTC ATCTTCCTCG GTCCCAGCCC TGACCCCAGG 1920
CTTTTCCAGA CATTCACCCC CTTCTCCCTT GTGCCGTAGT CTGTCTCCGG GGACTGGGGG 1980
AGGAGTCCGA GGTGGGGTTA GCTACCTGTC CCGAGGGGAC CCTGTGAGGG TCCTTGCTCG 2040
AAGAGTGCGG CCTGACGGCT CTGTGCAGTA CCTAGTTGAG TGGGGAGGGG GGGGCATCTT 2100
CTGACAGCCT GCTTCTGCTC CCCTCCCCAT TCACACACTG GCACTTTCAT GCCCTGACCT 2160
CTGACCTCAC CTACAGCTGG GATGTACCTG GAGAGATGGG GAGTGGTTCT CCCTCCTGCC 2220
CAGGCTGGAA TCCAGGGGAG TGAAGAGGTC CTCTTCTCTG CCCCTTCATG ACTCCTAATG 2280
CCCCCCCTCA TTTCCTTTGA TGTTATTTTG TTACAGCTTT TGAGATAATT TTTTAAGACT 2340
ATTTAACCCC TGGGATTAGA GATTGGGGGG GGGGGTTTGG GTGGTCCAGG ATTCCAGACT 2400
GTATGACTGT AATAAAGATA AATAAACCT
Nucleotide Fasta Sequence
>ENSMUSP00000073402.5|Tudor|Mus musculus
AGAAGGTTATTTCCTGCTGACCCAGAGCAAGCCTCCCATCCGAAAAAGGGGCTGCAGGGATTTCCTCGACCTCCGCGACCGGCCGCGCCCCCAACAGCGCAGCGCCCTCCGGGCCCGCTGGAGGTGAGGGAGGTGCTGCCTGCCCGTCCCTCTGTCGTCTCCTCCCCCTGGTGCTCCCCACCCTCCACTCTCCTCCCTCCTTCTGTCGACTCCTCCTGCCGCTGCTGCTGCTTTGGCTGCTGCGTCATACGCCCCAGAGCCGCCAGGACGGAGGGGCTGGGCCCGGGGACCCCCTGGCCTCCGCCTGCACGCCCCCCGGCGCTCACACTCAGTCTTCCCGCACCGGAGACTCATCCAGGTCTCTTGAGTCTGACCCTACCTGGCTTCCAGCTGCCCCGGCTGTCACCGGCCCCCCCAGGATGCAATGGCGCAGCTCCCCCGGCTGAGCCGTTTGGGTGCCCCCTCTCTCTGGGATCCAGCTTCCCCTGCTCCCACCTCAGGCCCCAGACCTCGGCTTTGGGAAGGCCAAGATGTGCTGGCCAGATGGACTGATGGGCTGCTGTACTTGGGTACCATCAAAAAGGTGGACAGTGCTCGAGAGGTGTGTCTGGTCCAGTTTGAGGACGATTCCCAGTTTCTGGTTCTATGGAAGGATATCAGCCCAGCTGCCCTCCCTGGGGAGGAGCTGCTCTGTTGTGTGTGTCGCTCTGAGACCGTGGTACCTGGGAACCGGCTGGTCAGCTGTGAGAAGTGTCGCCATGCTTATCACCAGGACTGTCACGTTCCCAGGGCCCCGGCCCCTGGAGAAGGAGAGGGCGCATCCTGGGTATGCCGCCAGTGTGTCTTTGCAATCGCCACTAAGAGGGGAGGCGCACTGAAGAAAGGTCCCTATGCCCGGGCCATGCTGGGCATGAAGCTCTCCCTGCCATACGGATTAAAAGGGCTGGACTGGGATGCTGGACATTTGAGCAACAGACAGCAGAGCTACTGCTACTGTGGAGGCCCTGGAGAGTGGAACCTGAAAATGCTGCAGTGCCGGAGCTGCCTCCAGTGGTTCCATGAGGCCTGCACCCAGTGTCTGAGCAAGCCCCTCCTCTACGGAGACAGATTCTATGAATTTGAGTGCTGTGTGTGCCGGGGCGGCCCTGAGAAGGTCCGGAGGTTACAGCTTCGCTGGGTGGATGTGGCCCATCTTGTCCTCTACCACCTCAGCGTTTGCTGTAAGAAGAAATATTTTGATTTTGACCGAGAGATCCTCCCCTTCACCTCTGAGAATTGGGACAGTCTGCTCCTGGGGGAGCTCTCAGATACTCCCAAGGGAGAGCGCTCTTCCCAGCTCCTTTCTGCTCTTAACAGCCACAAGGACCGTTTCATTTCAGGGAGGGAGATTAAAAAGCGAAAATGTCTTTTTGGTCTCCATGCTCGGACCCCTCCTCCTGTGGAGCTTCTCACTGGAGATGGAGCCCCCACCAGCTTCCCTTCAGGGCAGGGCCCTGGGGGAGGGGTCTCACGTCCCCTGGGGAAACGATGGAGGTCGGAGCCAGAACCCTTAAGGAGGAGGCAGAAGGGGAAAGTGGAGGAACTGGGGCCACCCACGGCAGCACACAGTCGGCATGGGTCCCGGGAGCAGAGGGCCCTGCAGGCCTCGGTGTCTCCACCACCCCCCAGCCCTAACCAGAGCTATGAGGGCAGCAGCGGCTACAACTTCCGGCCCACAGACGCCCGCTGTCTGCCCAGCAGCCCTATCCGGATGTTCGCCTCCTTCCACCCTTCTGCCAGCACTGCAGGGACCTCTGGGGACAGTGAACCCCCAGATAGGTCACCTCTGGGACTTCACATTGGCTTCCCCACAGACACCCCTAAAAGTTCACCCCACTCAGTGACGGCCTCATCTTCCTCGGTCCCAGCCCTGACCCCAGGCTTTTCCAGACATTCACCCCCTTCTCCCTTGTGCCGTAGTCTGTCTCCGGGGACTGGGGGAGGAGTCCGAGGTGGGGTTAGCTACCTGTCCCGAGGGGACCCTGTGAGGGTCCTTGCTCGAAGAGTGCGGCCTGACGGCTCTGTGCAGTACCTAGTTGAGTGGGGAGGGGGGGGCATCTTCTGACAGCCTGCTTCTGCTCCCCTCCCCATTCACACACTGGCACTTTCATGCCCTGACCTCTGACCTCACCTACAGCTGGGATGTACCTGGAGAGATGGGGAGTGGTTCTCCCTCCTGCCCAGGCTGGAATCCAGGGGAGTGAAGAGGTCCTCTTCTCTGCCCCTTCATGACTCCTAATGCCCCCCCTCATTTCCTTTGATGTTATTTTGTTACAGCTTTTGAGATAATTTTTTAAGACTATTTAACCCCTGGGATTAGAGATTGGGGGGGGGGGTTTGGGTGGTCCAGGATTCCAGACTGTATGACTGTAATAAAGATAAATAAACCT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR025894--Mtf2_C_dom
IPR031202--PHF1
IPR002999--Tudor
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
|
| PROSITE |
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
|
| Pfam |
PF14061--Mtf2_C
PF00628--PHD
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0035098--C:ESC/E(Z) complex
GO:0005815--C:microtubule organizing center
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016568--P:chromatin modification
GO:0061086--P:negative regulation of histone H3-K27 methylation
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
