WERAM Information

Tag Content
WERAM ID WERAM-Hos-0160
Ensembl Protein ID ENSP00000339764.4
Uniprot Accession Q9NQV8; PRDM8_HUMAN; A8K7X2; Q6IQ36
Genbank Protein ID NP_001092873.1; NP_064611.3; XP_005263203.1
Protein Name PR domain zinc finger protein 8
Genbank Nucleotide ID NM_001099403.1; NM_020226.3; XM_005263146.3
Gene Name PRDM8;PFM5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000152784.15 ENST00000339711.8 ENSP00000339764.4
ENSG00000152784.15 ENST00000415738.2 ENSP00000406998.2
ENSG00000152784.15 ENST00000504452.5 ENSP00000423985.1
ENSG00000152784.15 ENST00000515013.5 ENSP00000425149.1
Details
Type Family Domain Substrates AA References (PMIDs)
HMT RIZ SET H3K9 K 25537518
Status Reviewed
Classification
Type Family E-value Score Start End
HMT RIZ 8.50e-32 112 17 131
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity).
Domain Profile
  HMT RIZ
            RIZ.txt   2 evelaessipkeglgvyakkkiekgekfGPfvGekkileeveenanekliweisedkgevkyi..vDasdeeksn....WlryvnvArskee 87 
                        +v+++ ++i+   ++vy++++i++++ fGP+v     l++++ ++++++i+++s+dk++v yi  vD+s+++ s+    Wlr+v++Ar+kee
  ENSP00000339764.4  17 AVQQCLTDIF---TSVYTTCDIPENAIFGPCV-----LSHTSLYDSIAFIALKSTDKRTVPYIfrVDTSAANGSSeglmWLRLVQSARDKEE 100
                        6889999998...9******************.....9*************************9**************************** PP
            RIZ.txt  88 qNLaalqineqifYktikdIepdeELLvwyk 118
                        qNL+a+++n q+fY+++++I++deELLvwy+
  ENSP00000339764.4 101 QNLEAYIKNGQLFYRSLRRIAKDEELLVWYG 131
                        ******************************6 PP
Protein Sequence
(Fasta)		MEDTGIQRGI WDGDAKAVQQ CLTDIFTSVY TTCDIPENAI FGPCVLSHTS LYDSIAFIAL 60
KSTDKRTVPY IFRVDTSAAN GSSEGLMWLR LVQSARDKEE QNLEAYIKNG QLFYRSLRRI 120
AKDEELLVWY GKELTELLLL CPSRSHNKMN GSSPYTCLEC SQRFQFEFPY VAHLRFRCPK 180
RLHSADISPQ DEQGGGVGTK DHGGGGGGGK DQQQQQQEAP LGPGPKFCKA GPLHHYPSPS 240
PESSNPSAAA GGSSAKPSTD FHNLARELEN SRGGSSCSPA QSLSSGSGSG GGGGHQEAEL 300
SPDGIATGGG KGKRKFPEEA AEGGGGAGLV GGRGRFVERP LPASKEDLVC TPQQYRASGS 360
YFGLEENGRL FAPPSPETGE AKRSAFVEVK KAARAASLQE EGTADGAGVA SEDQDAGGGG 420
GSSTPAAASP VGAEKLLAPR PGGPLPSRLE GGSPARGSAF TSVPQLGSAG STSGGGGTGA 480
GAAGGAGGGQ GAASDERKSA FSQPARSFSQ LSPLVLGQKL GALEPCHPAD GVGPTRLYPA 540
AADPLAVKLQ GAADLNGGCG SLPSGGGGLP KQSPFLYATA FWPKSSAAAA AAAAAAAAGP 600
LQLQLPSALT LLPPSFTSLC LPAQNWCAKC NASFRMTSDL VYHMRSHHKK EYAMEPLVKR 660
RREEKLKCPI CNESFRERHH LSRHMTSHN 689
Nucleotide Sequence
(Fasta)		AAAAGCAGCA TCAGACAAGA GCTTTATTAA TCCCTTACAC GAGCAAATGC GATCTCTGAC 60
CTACTAGACT TGTTTTCCTA CAATTTCACA AAAAGCCTCG CTAGAGGAAT GTGCAAGGAC 120
AGAAGGGAAA CTGAGGAGAC CCGCAACTCA TTAGCGAAAT AATAGGGTGC ACTTCAATAA 180
AAATGCGGTC CTGAAGTGGA GCAGACTCAC CGGCAAGGAG CCCGGAAAAT CGTCAGGGGC 240
GGCGGCAAAA TACTATCAAA TCAGCCTGGG AAGCATCTTT TCGCTCAGCA AGTTCAAGAG 300
AACAAATATG TTACAATCCT TGCCTATTCT TGCCTCCACT TCATAATGTC ATAAAAGCCA 360
CCTGGGGTGT CATTTATCAA CCTCTCTCCA GCCCACTCTT CCAAAATAAC ACTACAGTTT 420
CCTACATGTG TATTTTTGCC AGGACTCCAA AGAGCCTTGC TAAAGTGGAA CAAGCAAAAT 480
CCTCCCCTGG CCTCCTGGGA CTGCAGTCAC CAGGCTGTCA AAGCCTCAAT ACCCCACTGA 540
GTTCCAGAGA AGGGTCTCAA AGCTGGGAGA GGATCAAACT AACATGGAGT AGAGAATTGA 600
ACTGTGAAAA AGAAGCCCGA GATTCCCCAG CGACGTGGTG TTGCAGCCCC GTTGAAGGAG 660
TCAACTTGCA GGCTGTTAAA GACCTCAAGT CATTAGCATC AGCTGCTGCA CTAAAGGGGC 720
AAGTCAGCGC CTCTAAGTGG CTTAGCGCAC AAACGAGGCT CCCGAGACGG CCTCGGCAAC 780
TCCATCCCCT CCTCCACCAC CCGCTGGATG TGAAAAGCTT TCCGGAGCCC ATCTTGGGGG 840
AAGCTTGGTA GTGTTGGCGC TCCTGAAGAG AGACGACGCC CGTTTATCAC CCCCAGGCAA 900
CTAGCTGCGC AAATCAGCGG TGGCTCCAGG GCTAGAGAAT CCCTGGAGCT AACCGCACCC 960
CTCTCCCTTT CACGGAACGC GGACTCCGGG GAAATACGCA CGGGGTCCGC ACGCGCTGGG 1020
TGTCCAGCTC TCTGTCACAG CTTCTCCAAG TGCCTAGTGA AACGGGGAAA GGCCCTCTCC 1080
AATCATTTTG GAAGAGCCTA AAAGGCGGCA ACACCAACAC CTCTTGACAT GGAAATACAC 1140
TGATACAATA GGCAAAAGGA AACACTCGAT TGCATCTTCC CGGTTCCAGG TGGCCTTATT 1200
TGGGAGATTC TATACTGACC TTATTCCTGT GATGGAGGAT ACTGGCATCC AGCGAGGCAT 1260
CTGGGATGGA GATGCCAAGG CTGTCCAACA ATGTCTGACA GATATTTTTA CCAGCGTTTA 1320
CACCACCTGC GACATCCCTG AGAATGCTAT ATTTGGTCCC TGTGTCCTGA GCCATACTTC 1380
CCTATATGAC AGCATAGCTT TCATAGCTCT CAAGTCTACT GACAAGAGAA CAGTACCGTA 1440
TATCTTTCGG GTAGACACCT CAGCAGCAAA TGGTTCCTCA GAAGGTCTCA TGTGGCTGCG 1500
GTTGGTCCAA TCGGCCAGAG ATAAGGAAGA GCAGAACCTT GAAGCCTACA TAAAAAACGG 1560
ACAGCTGTTC TACCGCTCTC TCCGCAGGAT TGCCAAAGAC GAGGAGTTAC TAGTTTGGTA 1620
CGGGAAAGAA CTGACTGAGT TACTCTTGCT CTGCCCCTCT AGATCCCACA ACAAAATGAA 1680
TGGGTCGTCC CCTTACACAT GCCTGGAATG CAGCCAACGT TTCCAGTTTG AGTTCCCCTA 1740
TGTGGCGCAT CTGCGTTTCC GCTGCCCCAA GAGACTTCAC AGCGCTGATA TAAGTCCCCA 1800
AGACGAACAA GGCGGCGGCG TGGGCACCAA GGACCACGGG GGCGGCGGCG GCGGTGGCAA 1860
AGACCAGCAG CAGCAGCAGC AGGAGGCACC TTTAGGCCCG GGTCCCAAGT TTTGCAAAGC 1920
CGGCCCCCTC CACCACTACC CATCCCCCTC CCCGGAAAGC AGCAACCCAT CCGCTGCCGC 1980
CGGCGGCAGC AGCGCGAAGC CATCCACAGA CTTCCACAAC CTGGCCAGGG AGCTGGAAAA 2040
CTCCCGGGGA GGCAGCAGCT GCTCCCCAGC CCAGAGCCTC AGCAGCGGTA GCGGCAGCGG 2100
CGGCGGCGGC GGCCACCAGG AGGCGGAGCT GAGTCCCGAC GGCATCGCCA CGGGCGGCGG 2160
CAAAGGAAAG AGGAAATTCC CGGAGGAGGC GGCGGAGGGC GGCGGTGGCG CTGGTCTGGT 2220
AGGGGGCCGG GGCCGCTTCG TAGAGCGGCC CCTCCCGGCC TCCAAGGAGG ATCTGGTGTG 2280
CACACCGCAG CAGTACCGAG CCTCGGGCAG CTACTTCGGC CTGGAAGAGA ACGGCCGCCT 2340
CTTCGCGCCG CCAAGTCCCG AGACGGGCGA GGCGAAGCGC AGCGCCTTCG TGGAGGTGAA 2400
GAAGGCTGCC CGCGCGGCCA GCCTGCAGGA GGAGGGGACA GCCGACGGCG CGGGAGTCGC 2460
CTCCGAGGAC CAGGACGCTG GCGGCGGCGG CGGCTCCTCC ACGCCCGCGG CCGCGTCACC 2520
GGTGGGCGCC GAGAAGCTGC TGGCCCCGCG GCCTGGGGGC CCGCTGCCCA GCCGGCTCGA 2580
GGGCGGCAGT CCTGCGAGGG GCAGCGCCTT CACTTCGGTG CCGCAGCTGG GCAGCGCGGG 2640
CAGCACCAGC GGTGGGGGCG GAACGGGCGC CGGGGCCGCA GGCGGCGCGG GCGGGGGCCA 2700
GGGCGCCGCG TCGGACGAGC GCAAAAGCGC CTTCTCGCAG CCAGCACGCT CTTTCTCGCA 2760
GCTGTCCCCG CTGGTGCTGG GCCAGAAGCT GGGCGCGCTC GAGCCATGCC ACCCCGCCGA 2820
CGGCGTGGGC CCCACCAGAC TCTATCCCGC CGCCGCGGAC CCTCTAGCGG TGAAGCTCCA 2880
GGGGGCCGCG GACCTGAACG GAGGTTGCGG GTCCCTGCCG AGCGGCGGCG GCGGCCTGCC 2940
TAAGCAGAGC CCCTTCCTGT ACGCCACCGC CTTCTGGCCC AAGAGCTCCG CTGCCGCTGC 3000
AGCCGCGGCT GCGGCGGCGG CCGCGGGGCC CTTGCAGCTG CAGCTGCCCT CGGCGCTCAC 3060
GCTGCTGCCG CCCTCCTTCA CCTCGCTGTG TCTGCCCGCG CAGAACTGGT GCGCCAAGTG 3120
CAATGCCTCC TTCCGCATGA CCTCCGACCT GGTGTACCAT ATGAGGTCGC ACCACAAAAA 3180
GGAGTATGCG ATGGAGCCCT TGGTGAAGCG GCGGCGAGAG GAGAAACTCA AGTGCCCCAT 3240
CTGCAATGAG TCCTTCAGGG AGCGCCACCA CCTCTCCAGG CACATGACCT CGCATAATTG 3300
ACTCGGAAAG GACCCCAGCT TTCCACGCGC GCGCAAGCAC AGTTAAGCCA CCTGCAGGAA 3360
TAAACACGCG AGAACATCCA CCGCTTCCTT GCACCCCGAA ACCCTGCACA AAGACACATA 3420
CATTCACCGC CCCCCCGCCC CCCCAACGCG CACACACACG TCCTCTCCTC CCAGGAACCT 3480
CATTCAAATA TTTACCCGGG ACACACACCC CCCCCCACAC ACACACACAG ACACACTCAC 3540
ACACAAGAGC CAGGATGGTG GAGTTTTGAT TGGGTGGGTT GTTTGAGGGG GTTTTCTTTT 3600
GAATGCACGC ATTTTCACTT TCCCCAAAAC AAAGGTACAT TTTTTAAAAT GTCATATATT 3660
GCAACATATT GATGCATTTG TCATACGTTT CTACTTAAAT TATTAAGCAC TTACGATTTA 3720
GATGTAATAA TTATATGTAA GGGCAAAATT TATTTTAGAT ATAAAGTAAA GGAGGAGGGT 3780
GAGATGCTTT CTGCATTTCT TGATGACAGT TTGTGTTCCT ACAAAAATAA ACAAAATGAA 3840
TAAAAAGGGA TCACCATTCA ATTTGAGTTT CCAGGGGGAA GTGCATGTAT AATGAAATGA 3900
TAATGGACTT CAATGAAGAA TGTCATCAAT TATGTACATA TGTATTTTCT TTTAATACAA 3960
AGTGTAATTT TGTGCCAGTG AAATGGAGTC TGAATAGTTA TGTGTTTCTT TTATCCCTGG 4020
AAATATTTAT TAAACTTTAT AGTTTATCCG AGTATGTTGG ATGCTTTGAC AATAAATGAC 4080
TATTTTCTTC AAAGC 4096
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0887--Epilepsy
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001214--SET_dom
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
PROSITE

PS50280--SET
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam
Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0008168--F:methyltransferase activity
GO:0014003--P:oligodendrocyte development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Chs-0049 ENSCSAP00000000815.1 Chlorocebus sabaeus 96 0.0 974
WERAM-Gog-0086 ENSGGOP00000007338.2 Gorilla gorilla 95 0.0 949
WERAM-Caj-0155 ENSCJAP00000027757.2 Callithrix jacchus 87 0.0 934
WERAM-Ict-0136 ENSSTOP00000014046.2 Ictidomys tridecemlineatus 90 0.0 918
WERAM-Mae-0142 ENSMEUP00000014502.1 Macropus eugenii 76 0.0 770
WERAM-Pat-0131 ENSPTRP00000027850.5 Pan troglodytes 100 0.0 661
WERAM-Orc-0202 ENSOCUP00000022376.1 Oryctolagus cuniculus 84 8e-174 608
WERAM-Ptv-0068 ENSPVAP00000006559.1 Pteropus vampyrus 87 3e-165 579
WERAM-Dan-0090 ENSDNOP00000009037.3 Dasypus novemcinctus 84 3e-161 566
WERAM-Sus-0063 ENSSSCP00000009869.2 Sus scrofa 85 1e-157 554
WERAM-Tub-0043 ENSTBEP00000005317.1 Tupaia belangeri 87 3e-153 539
WERAM-Ect-0063 ENSETEP00000006689.1 Echinops telfairi 78 6e-151 531
WERAM-Nol-0086 ENSNLEP00000010355.1 Nomascus leucogenys 97 2e-139 494
WERAM-Fec-0177 ENSFCAP00000019355.1 Felis catus 87 5e-132 469
WERAM-Cap-0174 ENSCPOP00000016305.1 Cavia porcellus 76 5e-130 462
WERAM-Otg-0193 ENSOGAP00000019247.1 Otolemur garnettii 93 2e-125 447
WERAM-Mup-0071 ENSMPUP00000006502.1 Mustela putorius furo 82 4e-121 432
WERAM-Aim-0063 ENSAMEP00000005538.1 Ailuropoda melanoleuca 85 3e-119 426
WERAM-Ova-0205 ENSOARP00000020374.1 Ovis aries 90 1e-117 421
WERAM-Bot-0176 ENSBTAP00000046130.2 Bos taurus 91 3e-117 420
WERAM-Loa-0153 ENSLAFP00000013567.3 Loxodonta africana 87 2e-115 414
WERAM-Mam-0027 ENSMMUP00000004446.2 Macaca mulatta 100 2e-113 407
WERAM-Poa-0129 ENSPPYP00000016613.1 Pongo abelii 96 5e-108 389
WERAM-Pes-0172 ENSPSIP00000020061.1 Pelodiscus sinensis 92 5e-98 356
WERAM-Eqc-0139 ENSECAP00000015312.1 Equus caballus 96 2e-92 337
WERAM-Tag-0023 ENSTGUP00000001575.1 Taeniopygia guttata 94 4e-78 290
WERAM-Myl-0115 ENSMLUP00000009197.2 Myotis lucifugus 35 2e-11 68.2
WERAM-Pem-0083 ENSPMAP00000008984.1 Petromyzon marinus 33 2e-10 65.5
WERAM-Soa-0002 ENSSARP00000000218.1 Sorex araneus 37 1e-09 62.4
WERAM-Chh-0045 ENSCHOP00000005073.1 Choloepus hoffmanni 36 2e-09 61.6
WERAM-Paa-0092 ENSPANP00000006501.1 Papio anubis 36 4e-09 60.8
WERAM-Ocp-0132 ENSOPRP00000013913.2 Ochotona princeps 35 6e-09 60.5
WERAM-Ran-0144 ENSRNOP00000060531.1 Rattus norvegicus 35 1e-08 59.3
WERAM-Mum-0189 ENSMUSP00000131871.1 Mus musculus 35 2e-08 58.9
WERAM-Prc-0084 ENSPCAP00000007153.1 Procavia capensis 35 2e-08 58.5
WERAM-Lac-0137 ENSLACP00000015755.1 Latimeria chalumnae 38 2e-08 58.5
WERAM-Dio-0007 ENSDORP00000000987.1 Dipodomys ordii 36 2e-08 58.5
WERAM-Mim-0047 ENSMICP00000004601.1 Microcebus murinus 44 3e-08 58.2
WERAM-Orn-0176 ENSONIP00000017915.1 Oreochromis niloticus 30 9e-08 56.2
WERAM-Mod-0198 ENSMODP00000031611.2 Monodelphis domestica 53 2e-07 55.8
WERAM-Tar-0068 ENSTRUP00000013557.1 Takifugu rubripes 38 5e-07 53.9
WERAM-Dar-0018 ENSDARP00000015394.5 Danio rerio 25 8e-07 53.1
WERAM-Ten-0068 ENSTNIP00000008582.1 Tetraodon nigroviridis 35 9e-07 53.1
WERAM-Ora-0057 ENSOANP00000008625.2 Ornithorhynchus anatinus 47 2e-06 52.0
Created Date 25-Jun-2016