Tag |
Content |
WERAM ID |
WERAM-Hos-0087 |
Ensembl Protein ID |
ENSP00000323659.5 |
Uniprot Accession |
Q9Y4C1; KDM3A_HUMAN; D6W5M3; Q53S72; Q68D47; Q68UT9; Q6N050; Q8IY08 |
Genbank Protein ID |
NP_001140160.1; NP_060903.2 |
Protein Name |
Lysine-specific demethylase 3A |
Genbank Nucleotide ID |
NM_001146688.1; NM_018433.5 |
Gene Name |
KDM3A;JHDM2A;JMJD1A |
Ensembl Information |
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Details |
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Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDM |
JHDM2 |
5.20e-108 |
361.8 |
1073 |
1281 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. |
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
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Domain Profile |
HDM JHDM2
JHDM2.txt 1 eYckrdgklNLasklpknfvrpdlgPklynAyGlateedrklgttnlhldvsdavnilvyvgilkkkwaeedlkellksieeeeldevtr 90 eY++rdgklNLas+lp++fvrpdlgPk+ynAyGl+t edrk+gttnlhldvsda+n++vyvgi+k+++++e+ e+lk+i+++++de+t+ ENSP00000323659.5 1073 EYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEE--EVLKTIQDGDSDELTI 1160 7***********************************************************************..**************** PP JHDM2.txt 91 krvqdpkekpgalWhifaakdaekirellekvskeqgaevppdhdpihdqswyldrklrkrLfeeyGvegwtlvQklgdavlipagapHq 180 kr+ ++kekpgalWhi+aakd+ekire+l+kvs+eqg+e+p+dhdpihdqswyldr+lrkrL++eyGv+gw++vQ+lgd+v+ipagapHq ENSP00000323659.5 1161 KRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQENPADHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQ 1250 ****************************************************************************************** PP JHDM2.txt 181 vqnlkscvkvaedFvsPEnvkecfrltkeyr 211 v+nl+sc+kvaedFvsPE+vk+cf+lt+e+r ENSP00000323659.5 1251 VHNLYSCIKVAEDFVSPEHVKHCFWLTQEFR 1281 *****************************98 PP
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Protein Sequence (Fasta) | MVLTLGESWP VLVGRRFLSL SAADGSDGSH DSWDVERVAE WPWLSGTIRA VSHTDVTKKD 60 LKVCVEFDGE SWRKRRWIEV YSLLRRAFLV EHNLVLAERK SPEISERIVQ WPAITYKPLL 120 DKAGLGSITS VRFLGDQQRV FLSKDLLKPI QDVNSLRLSL TDNQIVSKEF QALIVKHLDE 180 SHLLKGDKNL VGSEVKIYSL DPSTQWFSAT VINGNPASKT LQVNCEEIPA LKIVDPSLIH 240 VEVVHDNLVT CGNSARIGAV KRKSSENNGT LVSKQAKSCS EASPSMCPVQ SVPTTVFKEI 300 LLGCTAATPP SKDPRQQSTP QAANSPPNLG AKIPQGCHKQ SLPEEISSCL NTKSEALRTK 360 PDVCKAGLLS KSSQIGTGDL KILTEPKGSC TQPKTNTDQE NRLESVPQAL TGLPKECLPT 420 KASSKAELEI ANPPELQKHL EHAPSPSDVS NAPEVKAGVN SDSPNNCSGK KVEPSALACR 480 SQNLKESSVK VDNESCCSRS NNKIQNAPSR KSVLTDPAKL KKLQQSGEAF VQDDSCVNIV 540 AQLPKCRECR LDSLRKDKEQ QKDSPVFCRF FHFRRLQFNK HGVLRVEGFL TPNKYDNEAI 600 GLWLPLTKNV VGIDLDTAKY ILANIGDHFC QMVISEKEAM STIEPHRQVA WKRAVKGVRE 660 MCDVCDTTIF NLHWVCPRCG FGVCVDCYRM KRKNCQQGAA YKTFSWLKCV KSQIHEPENL 720 MPTQIIPGKA LYDVGDIVHS VRAKWGIKAN CPCSNRQFKL FSKPASKEDL KQTSLAGEKP 780 TLGAVLQQNP SVLEPAAVGG EAASKPAGSM KPACPASTSP LNWLADLTSG NVNKENKEKQ 840 PTMPILKNEI KCLPPLPPLS KSSTVLHTFN STILTPVSNN NSGFLRNLLN SSTGKTENGL 900 KNTPKILDDI FASLVQNKTT SDLSKRPQGL TIKPSILGFD TPHYWLCDNR LLCLQDPNNK 960 SNWNVFRECW KQGQPVMVSG VHHKLNSELW KPESFRKEFG EQEVDLVNCR TNEIITGATV 1020 GDFWDGFEDV PNRLKNEKEP MVLKLKDWPP GEDFRDMMPS RFDDLMANIP LPEYTRRDGK 1080 LNLASRLPNY FVRPDLGPKM YNAYGLITPE DRKYGTTNLH LDVSDAANVM VYVGIPKGQC 1140 EQEEEVLKTI QDGDSDELTI KRFIEGKEKP GALWHIYAAK DTEKIREFLK KVSEEQGQEN 1200 PADHDPIHDQ SWYLDRSLRK RLHQEYGVQG WAIVQFLGDV VFIPAGAPHQ VHNLYSCIKV 1260 AEDFVSPEHV KHCFWLTQEF RYLSQTHTNH EDKLQVKNVI YHAVKDAVAM LKASESSFGK 1320 P 1321Protein Fasta Sequence
>ENSP00000323659.5|KDM3A;JHDM2A;JMJD1A|Homo sapiens MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLVEHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDESHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGTLVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQSLPEEISSCLNTKSEALRTKPDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQPKTNTDQENRLESVPQALTGLPKECLPTKASSKAELEIANPPELQKHLEHAPSPSDVSNAPEVKAGVNSDSPNNCSGKKVEPSALACRSQNLKESSVKVDNESCCSRSNNKIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDNEAIGLWLPLTKNVVGIDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWLKCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDLKQTSLAGEKPTLGAVLQQNPSVLEPAAVGGEAASKPAGSMKPACPASTSPLNWLADLTSGNVNKENKEKQPTMPILKNEIKCLPPLPPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGLKNTPKILDDIFASLVQNKTTSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNSELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEVLKTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQENPADHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSFGKP
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Nucleotide Sequence (Fasta) | TAATGGGGGT CGCCCGGGAG TCGGAAGGGG GAGGGGAAAG GGAGGAGGCA GCCAAGGAAT 60 TGTTTTTTTC TCTGGCCCCG CCCTCGCCCG GGGGGCCAAT GGTGATGATC TGTTTCCCCC 120 GGAGCCTCGC CCAGCTCCTG TGTTTCAGCC AATGAGCGGC GGAAGCGGCT CCGAGGGGGG 180 CGGGTCCGGG AGGCTGTGCG TGTCTTGTGA GAGCTCTTGA ACCAAGTCAG CGCTGGAGTC 240 GGCTAGGCGG CTGGAAACGG CGGCTGCCGC CGGTGACTCA GGGAGGCGGG AGGCGGGGGA 300 GGAGCTCTTC CTGCAGGCGT GGAAACCATG GTGCTCACGC TCGGAGAAAG TTGGCCGGTA 360 TTGGTGGGGA GGAGGTTTCT CAGTCTGTCC GCAGCCGACG GCAGCGATGG CAGCCACGAC 420 AGCTGGGACG TGGAGCGCGT CGCCGAGTGG CCCTGGCTCT CCGGGACCAT TCGAGCTGTT 480 TCCCACACCG ACGTTACCAA GAAGGATCTG AAGGTGTGTG TGGAATTTGA TGGGGAATCT 540 TGGAGGAAAA GAAGATGGAT AGAAGTCTAC AGCCTTCTAA GGAGAGCATT TTTAGTAGAA 600 CATAATTTGG TTTTAGCTGA ACGAAAGTCA CCTGAAATTT CTGAACGAAT TGTACAGTGG 660 CCTGCAATAA CGTACAAACC TCTGTTGGAC AAAGCTGGTT TGGGATCCAT AACTTCTGTT 720 CGCTTTCTGG GAGATCAACA AAGAGTATTT CTTTCTAAAG ACCTTTTGAA GCCTATACAG 780 GATGTAAACA GTCTTCGACT TTCTCTTACG GATAATCAGA TTGTCAGTAA AGAATTTCAA 840 GCTTTGATTG TGAAGCATTT AGATGAAAGC CATCTTTTAA AAGGTGACAA AAACTTAGTT 900 GGTTCAGAAG TAAAAATTTA TAGCTTGGAC CCATCTACTC AGTGGTTTTC AGCAACCGTT 960 ATAAATGGAA ACCCAGCATC AAAAACTCTT CAAGTCAACT GTGAGGAGAT TCCAGCACTG 1020 AAAATTGTTG ATCCGTCACT GATTCATGTT GAAGTTGTAC ACGATAACCT TGTGACATGT 1080 GGTAATTCTG CAAGAATTGG AGCTGTAAAA CGCAAGTCTT CTGAGAATAA TGGAACCCTG 1140 GTTTCCAAAC AAGCAAAATC TTGCTCTGAG GCCTCTCCCA GTATGTGTCC TGTGCAGTCT 1200 GTACCTACAA CAGTTTTTAA GGAGATACTG CTTGGCTGTA CTGCGGCAAC TCCACCTAGT 1260 AAGGACCCAA GACAGCAAAG TACTCCCCAG GCTGCCAACT CTCCACCTAA CCTTGGAGCA 1320 AAAATTCCTC AAGGATGTCA TAAACAAAGT TTACCAGAGG AAATTTCTTC CTGTCTAAAT 1380 ACAAAGTCTG AAGCTCTGAG AACAAAACCA GATGTCTGCA AAGCAGGGTT GCTCTCAAAG 1440 TCCTCTCAGA TTGGAACTGG AGACTTGAAA ATTCTGACTG AGCCAAAAGG CAGCTGTACT 1500 CAGCCTAAGA CAAACACTGA TCAGGAAAAC AGATTGGAGT CTGTTCCACA AGCATTGACT 1560 GGCCTTCCTA AGGAGTGCTT ACCTACAAAG GCTTCTTCTA AGGCAGAATT GGAAATTGCC 1620 AATCCTCCTG AACTGCAGAA GCACCTAGAA CATGCACCTT CCCCATCGGA TGTTTCAAAT 1680 GCACCAGAAG TGAAAGCAGG TGTCAATAGT GATAGCCCTA ATAACTGTTC AGGAAAAAAG 1740 GTAGAACCTT CAGCTTTAGC TTGCCGATCA CAGAATTTAA AGGAATCTTC AGTAAAAGTA 1800 GATAATGAAA GCTGTTGTTC AAGAAGCAAC AATAAAATCC AGAATGCCCC ATCCAGGAAG 1860 TCGGTTTTGA CAGACCCAGC TAAACTCAAA AAGCTGCAAC AGAGTGGCGA GGCCTTCGTA 1920 CAGGATGATT CTTGTGTGAA CATCGTGGCA CAGTTGCCTA AATGCCGAGA GTGTCGCTTG 1980 GACAGTCTCC GCAAGGATAA GGAGCAACAG AAGGACTCAC CTGTGTTTTG CCGCTTCTTT 2040 CACTTCAGGA GGTTACAATT CAACAAACAT GGTGTGTTGC GGGTAGAAGG CTTCTTAACA 2100 CCAAACAAGT ATGACAATGA AGCAATTGGC TTGTGGTTAC CTTTAACCAA AAACGTTGTG 2160 GGGATTGATT TGGACACAGC AAAGTACATC TTGGCCAACA TTGGAGACCA CTTCTGTCAA 2220 ATGGTGATTT CTGAAAAGGA AGCTATGTCA ACTATTGAGC CACACAGACA GGTTGCTTGG 2280 AAGCGAGCTG TCAAAGGTGT TCGAGAAATG TGTGATGTGT GCGACACCAC CATCTTCAAC 2340 CTGCACTGGG TGTGTCCTCG GTGTGGGTTT GGAGTATGTG TGGACTGCTA CCGGATGAAG 2400 AGAAAGAATT GCCAACAGGG TGCTGCTTAC AAGACTTTCT CTTGGCTAAA ATGTGTGAAG 2460 AGTCAGATAC ATGAACCAGA GAACTTAATG CCCACACAGA TCATTCCTGG AAAAGCACTC 2520 TATGATGTTG GAGACATTGT TCATTCTGTA AGAGCGAAAT GGGGAATAAA GGCAAACTGC 2580 CCTTGTTCAA ACAGGCAATT CAAACTCTTT TCAAAGCCAG CCTCAAAGGA AGACCTAAAA 2640 CAGACTTCTT TAGCTGGAGA AAAACCGACT CTTGGTGCAG TGCTCCAGCA GAATCCCTCA 2700 GTGTTGGAGC CAGCAGCTGT GGGTGGGGAA GCAGCCTCCA AGCCAGCCGG CAGCATGAAG 2760 CCTGCCTGTC CAGCCAGCAC ATCTCCTCTA AACTGGCTGG CCGACCTAAC CAGCGGGAAT 2820 GTCAACAAGG AAAACAAGGA AAAACAACCA ACAATGCCAA TTTTAAAGAA TGAAATCAAA 2880 TGCCTTCCAC CCCTCCCACC TTTAAGCAAA TCCAGCACAG TCCTCCATAC GTTTAACAGC 2940 ACAATTTTGA CACCCGTAAG CAACAACAAT TCTGGTTTCC TCCGGAATCT CTTGAATTCT 3000 TCTACAGGAA AGACAGAAAA TGGACTCAAG AATACACCAA AAATCCTTGA TGACATCTTT 3060 GCCTCTTTGG TGCAAAATAA GACGACTTCT GATTTATCTA AGAGGCCTCA AGGACTAACC 3120 ATCAAGCCCA GCATTCTGGG CTTTGACACT CCTCACTATT GGCTTTGTGA TAATCGCTTG 3180 CTGTGCTTGC AAGACCCCAA CAATAAGAGC AACTGGAATG TGTTTAGGGA GTGCTGGAAA 3240 CAAGGGCAGC CAGTGATGGT GTCTGGAGTG CATCATAAAT TGAACTCTGA ACTTTGGAAA 3300 CCTGAATCCT TCAGGAAAGA GTTTGGTGAG CAGGAAGTAG ACCTAGTTAA TTGTAGGACC 3360 AATGAAATCA TCACAGGAGC CACAGTAGGA GACTTCTGGG ATGGATTTGA AGATGTTCCA 3420 AATCGTTTGA AAAATGAAAA AGAACCAATG GTGTTGAAAC TTAAGGACTG GCCACCAGGA 3480 GAAGATTTTA GAGATATGAT GCCTTCCAGG TTTGATGATC TGATGGCCAA CATTCCACTG 3540 CCCGAGTACA CAAGGCGAGA TGGCAAACTG AATTTGGCCT CTAGGCTGCC AAACTACTTT 3600 GTTCGGCCAG ATCTGGGCCC CAAGATGTAT AATGCTTATG GATTAATCAC TCCTGAAGAT 3660 CGGAAATATG GAACAACAAA TCTTCACTTA GATGTATCTG ATGCAGCTAA TGTCATGGTC 3720 TATGTGGGAA TTCCCAAAGG ACAGTGTGAG CAAGAAGAAG AAGTCCTTAA GACCATCCAA 3780 GATGGAGATT CTGACGAACT CACAATAAAG CGATTTATTG AAGGAAAAGA GAAGCCAGGA 3840 GCACTGTGGC ACATATATGC TGCAAAGGAC ACGGAGAAGA TAAGGGAATT TCTTAAAAAG 3900 GTATCAGAAG AGCAAGGTCA AGAAAACCCA GCAGACCACG ATCCTATTCA TGATCAAAGC 3960 TGGTATTTAG ACCGATCATT AAGAAAACGT CTTCATCAAG AGTATGGAGT TCAAGGCTGG 4020 GCTATTGTAC AGTTTCTTGG GGATGTGGTG TTTATCCCGG CAGGAGCTCC ACATCAGGTT 4080 CATAACTTAT ATAGCTGCAT CAAAGTGGCT GAAGATTTTG TTTCTCCAGA GCATGTTAAA 4140 CACTGCTTCT GGCTTACTCA GGAATTCCGA TATCTGTCAC AGACTCATAC CAATCACGAA 4200 GATAAATTAC AGGTGAAGAA TGTTATCTAC CATGCAGTGA AAGATGCAGT TGCTATGCTG 4260 AAAGCCAGTG AATCCAGTTT TGGCAAACCT TAATCTCCCT GCACATTGGA AATGAATTAC 4320 AGGCAGCTGT TCAAACTCTT CAGGCAGGAT TCCTGTGGAC TTTGAGATTC ATGTTACCTC 4380 ATCTTCTTTT TTAAACTGTA CCCAACTTGT GAGGGTACTC TGTCTAATGT ATATTTCTAG 4440 TGTTTACAGA CAGTAAATGT GTATATGTAG TAACTATTTA CAGAACATGC ATCCTTAAAC 4500 TGTGACTTCT CACCTAGTGC AGAACTTTTA CCAGGCTGTA AAAGCAAAAC CTCGTATCAG 4560 CTCTGGAACA ATACCTGCAG TTATTCTTCA GCTGTTTGGA CAACTTAGAT TGGGTTTATA 4620 ACTATTAGGA ATCACTGCAC AGTTTATTTG GGTTGTGTTT TGTGTCTGAG TCCCCTCCCT 4680 CATCCCTTAG GGTCCAGAAG AGCAATGGAG GAAGTGACAG CTAATGTTGC AGTTCTTATT 4740 GTATGGCATA GGACTGGCAT TATATAGCAG AAATCAACTA CTGTACAATT TCTTGGGGTT 4800 AACCATCTTT AGTTAAATGG AATTTTAATT TAAATGACGC TTTGCTAATT TTAAGTGTTA 4860 AGCATTTTGC ATTAAAATAT TCATAT
4887Nucleotide Fasta Sequence
>ENSP00000323659.5|JHDM2|Homo sapiens TAATGGGGGTCGCCCGGGAGTCGGAAGGGGGAGGGGAAAGGGAGGAGGCAGCCAAGGAATTGTTTTTTTCTCTGGCCCCGCCCTCGCCCGGGGGGCCAATGGTGATGATCTGTTTCCCCCGGAGCCTCGCCCAGCTCCTGTGTTTCAGCCAATGAGCGGCGGAAGCGGCTCCGAGGGGGGCGGGTCCGGGAGGCTGTGCGTGTCTTGTGAGAGCTCTTGAACCAAGTCAGCGCTGGAGTCGGCTAGGCGGCTGGAAACGGCGGCTGCCGCCGGTGACTCAGGGAGGCGGGAGGCGGGGGAGGAGCTCTTCCTGCAGGCGTGGAAACCATGGTGCTCACGCTCGGAGAAAGTTGGCCGGTATTGGTGGGGAGGAGGTTTCTCAGTCTGTCCGCAGCCGACGGCAGCGATGGCAGCCACGACAGCTGGGACGTGGAGCGCGTCGCCGAGTGGCCCTGGCTCTCCGGGACCATTCGAGCTGTTTCCCACACCGACGTTACCAAGAAGGATCTGAAGGTGTGTGTGGAATTTGATGGGGAATCTTGGAGGAAAAGAAGATGGATAGAAGTCTACAGCCTTCTAAGGAGAGCATTTTTAGTAGAACATAATTTGGTTTTAGCTGAACGAAAGTCACCTGAAATTTCTGAACGAATTGTACAGTGGCCTGCAATAACGTACAAACCTCTGTTGGACAAAGCTGGTTTGGGATCCATAACTTCTGTTCGCTTTCTGGGAGATCAACAAAGAGTATTTCTTTCTAAAGACCTTTTGAAGCCTATACAGGATGTAAACAGTCTTCGACTTTCTCTTACGGATAATCAGATTGTCAGTAAAGAATTTCAAGCTTTGATTGTGAAGCATTTAGATGAAAGCCATCTTTTAAAAGGTGACAAAAACTTAGTTGGTTCAGAAGTAAAAATTTATAGCTTGGACCCATCTACTCAGTGGTTTTCAGCAACCGTTATAAATGGAAACCCAGCATCAAAAACTCTTCAAGTCAACTGTGAGGAGATTCCAGCACTGAAAATTGTTGATCCGTCACTGATTCATGTTGAAGTTGTACACGATAACCTTGTGACATGTGGTAATTCTGCAAGAATTGGAGCTGTAAAACGCAAGTCTTCTGAGAATAATGGAACCCTGGTTTCCAAACAAGCAAAATCTTGCTCTGAGGCCTCTCCCAGTATGTGTCCTGTGCAGTCTGTACCTACAACAGTTTTTAAGGAGATACTGCTTGGCTGTACTGCGGCAACTCCACCTAGTAAGGACCCAAGACAGCAAAGTACTCCCCAGGCTGCCAACTCTCCACCTAACCTTGGAGCAAAAATTCCTCAAGGATGTCATAAACAAAGTTTACCAGAGGAAATTTCTTCCTGTCTAAATACAAAGTCTGAAGCTCTGAGAACAAAACCAGATGTCTGCAAAGCAGGGTTGCTCTCAAAGTCCTCTCAGATTGGAACTGGAGACTTGAAAATTCTGACTGAGCCAAAAGGCAGCTGTACTCAGCCTAAGACAAACACTGATCAGGAAAACAGATTGGAGTCTGTTCCACAAGCATTGACTGGCCTTCCTAAGGAGTGCTTACCTACAAAGGCTTCTTCTAAGGCAGAATTGGAAATTGCCAATCCTCCTGAACTGCAGAAGCACCTAGAACATGCACCTTCCCCATCGGATGTTTCAAATGCACCAGAAGTGAAAGCAGGTGTCAATAGTGATAGCCCTAATAACTGTTCAGGAAAAAAGGTAGAACCTTCAGCTTTAGCTTGCCGATCACAGAATTTAAAGGAATCTTCAGTAAAAGTAGATAATGAAAGCTGTTGTTCAAGAAGCAACAATAAAATCCAGAATGCCCCATCCAGGAAGTCGGTTTTGACAGACCCAGCTAAACTCAAAAAGCTGCAACAGAGTGGCGAGGCCTTCGTACAGGATGATTCTTGTGTGAACATCGTGGCACAGTTGCCTAAATGCCGAGAGTGTCGCTTGGACAGTCTCCGCAAGGATAAGGAGCAACAGAAGGACTCACCTGTGTTTTGCCGCTTCTTTCACTTCAGGAGGTTACAATTCAACAAACATGGTGTGTTGCGGGTAGAAGGCTTCTTAACACCAAACAAGTATGACAATGAAGCAATTGGCTTGTGGTTACCTTTAACCAAAAACGTTGTGGGGATTGATTTGGACACAGCAAAGTACATCTTGGCCAACATTGGAGACCACTTCTGTCAAATGGTGATTTCTGAAAAGGAAGCTATGTCAACTATTGAGCCACACAGACAGGTTGCTTGGAAGCGAGCTGTCAAAGGTGTTCGAGAAATGTGTGATGTGTGCGACACCACCATCTTCAACCTGCACTGGGTGTGTCCTCGGTGTGGGTTTGGAGTATGTGTGGACTGCTACCGGATGAAGAGAAAGAATTGCCAACAGGGTGCTGCTTACAAGACTTTCTCTTGGCTAAAATGTGTGAAGAGTCAGATACATGAACCAGAGAACTTAATGCCCACACAGATCATTCCTGGAAAAGCACTCTATGATGTTGGAGACATTGTTCATTCTGTAAGAGCGAAATGGGGAATAAAGGCAAACTGCCCTTGTTCAAACAGGCAATTCAAACTCTTTTCAAAGCCAGCCTCAAAGGAAGACCTAAAACAGACTTCTTTAGCTGGAGAAAAACCGACTCTTGGTGCAGTGCTCCAGCAGAATCCCTCAGTGTTGGAGCCAGCAGCTGTGGGTGGGGAAGCAGCCTCCAAGCCAGCCGGCAGCATGAAGCCTGCCTGTCCAGCCAGCACATCTCCTCTAAACTGGCTGGCCGACCTAACCAGCGGGAATGTCAACAAGGAAAACAAGGAAAAACAACCAACAATGCCAATTTTAAAGAATGAAATCAAATGCCTTCCACCCCTCCCACCTTTAAGCAAATCCAGCACAGTCCTCCATACGTTTAACAGCACAATTTTGACACCCGTAAGCAACAACAATTCTGGTTTCCTCCGGAATCTCTTGAATTCTTCTACAGGAAAGACAGAAAATGGACTCAAGAATACACCAAAAATCCTTGATGACATCTTTGCCTCTTTGGTGCAAAATAAGACGACTTCTGATTTATCTAAGAGGCCTCAAGGACTAACCATCAAGCCCAGCATTCTGGGCTTTGACACTCCTCACTATTGGCTTTGTGATAATCGCTTGCTGTGCTTGCAAGACCCCAACAATAAGAGCAACTGGAATGTGTTTAGGGAGTGCTGGAAACAAGGGCAGCCAGTGATGGTGTCTGGAGTGCATCATAAATTGAACTCTGAACTTTGGAAACCTGAATCCTTCAGGAAAGAGTTTGGTGAGCAGGAAGTAGACCTAGTTAATTGTAGGACCAATGAAATCATCACAGGAGCCACAGTAGGAGACTTCTGGGATGGATTTGAAGATGTTCCAAATCGTTTGAAAAATGAAAAAGAACCAATGGTGTTGAAACTTAAGGACTGGCCACCAGGAGAAGATTTTAGAGATATGATGCCTTCCAGGTTTGATGATCTGATGGCCAACATTCCACTGCCCGAGTACACAAGGCGAGATGGCAAACTGAATTTGGCCTCTAGGCTGCCAAACTACTTTGTTCGGCCAGATCTGGGCCCCAAGATGTATAATGCTTATGGATTAATCACTCCTGAAGATCGGAAATATGGAACAACAAATCTTCACTTAGATGTATCTGATGCAGCTAATGTCATGGTCTATGTGGGAATTCCCAAAGGACAGTGTGAGCAAGAAGAAGAAGTCCTTAAGACCATCCAAGATGGAGATTCTGACGAACTCACAATAAAGCGATTTATTGAAGGAAAAGAGAAGCCAGGAGCACTGTGGCACATATATGCTGCAAAGGACACGGAGAAGATAAGGGAATTTCTTAAAAAGGTATCAGAAGAGCAAGGTCAAGAAAACCCAGCAGACCACGATCCTATTCATGATCAAAGCTGGTATTTAGACCGATCATTAAGAAAACGTCTTCATCAAGAGTATGGAGTTCAAGGCTGGGCTATTGTACAGTTTCTTGGGGATGTGGTGTTTATCCCGGCAGGAGCTCCACATCAGGTTCATAACTTATATAGCTGCATCAAAGTGGCTGAAGATTTTGTTTCTCCAGAGCATGTTAAACACTGCTTCTGGCTTACTCAGGAATTCCGATATCTGTCACAGACTCATACCAATCACGAAGATAAATTACAGGTGAAGAATGTTATCTACCATGCAGTGAAAGATGCAGTTGCTATGCTGAAAGCCAGTGAATCCAGTTTTGGCAAACCTTAATCTCCCTGCACATTGGAAATGAATTACAGGCAGCTGTTCAAACTCTTCAGGCAGGATTCCTGTGGACTTTGAGATTCATGTTACCTCATCTTCTTTTTTAAACTGTACCCAACTTGTGAGGGTACTCTGTCTAATGTATATTTCTAGTGTTTACAGACAGTAAATGTGTATATGTAGTAACTATTTACAGAACATGCATCCTTAAACTGTGACTTCTCACCTAGTGCAGAACTTTTACCAGGCTGTAAAAGCAAAACCTCGTATCAGCTCTGGAACAATACCTGCAGTTATTCTTCAGCTGTTTGGACAACTTAGATTGGGTTTATAACTATTAGGAATCACTGCACAGTTTATTTGGGTTGTGTTTTGTGTCTGAGTCCCCTCCCTCATCCCTTAGGGTCCAGAAGAGCAATGGAGGAAGTGACAGCTAATGTTGCAGTTCTTATTGTATGGCATAGGACTGGCATTATATAGCAGAAATCAACTACTGTACAATTTCTTGGGGTTAACCATCTTTAGTTAAATGGAATTTTAATTTAAATGACGCTTTGCTAATTTTAAGTGTTAAGCATTTTGCATTAAAATATTCATAT
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Sequence Source |
Ensembl |
Keyword |
KW-0007--Acetylation KW-0010--Activator KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0963--Cytoplasm KW-0221--Differentiation KW-0223--Dioxygenase KW-0408--Iron KW-0479--Metal-binding KW-0539--Nucleus KW-0560--Oxidoreductase KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0744--Spermatogenesis KW-0804--Transcription KW-0805--Transcription regulation KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR003347--JmjC_dom
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PROSITE |
PS51184--JMJC
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Pfam |
PF02373--JmjC
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0016020--C:membrane GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0050681--F:androgen receptor binding GO:0001047--F:core promoter binding GO:0051213--F:dioxygenase activity GO:0032452--F:histone demethylase activity GO:0005506--F:iron ion binding GO:0003700--F:transcription factor activity, sequence-specific DNA binding GO:0000976--F:transcription regulatory region sequence-specific DNA binding GO:0030521--P:androgen receptor signaling pathway GO:0046293--P:formaldehyde biosynthetic process GO:0033169--P:histone H3-K9 demethylation GO:0036123--P:histone H3-K9 dimethylation GO:0009755--P:hormone-mediated signaling pathway GO:0008584--P:male gonad development GO:0051573--P:negative regulation of histone H3-K9 methylation GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0045893--P:positive regulation of transcription, DNA-templated GO:2000036--P:regulation of stem cell population maintenance GO:0001666--P:response to hypoxia GO:0007290--P:spermatid nucleus elongation GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |