WERAM Information

Tag Content
WERAM ID WERAM-Mum-0092
Ensembl Protein ID ENSMUSP00000099805.3
Uniprot Accession Q9Z1N2; ORC1_MOUSE; A2A8R3
Genbank Protein ID NP_035145.2
Protein Name Origin recognition complex subunit 1
Genbank Nucleotide ID NM_011015.2
Gene Name ORC1;Orc1l
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028587.18 ENSMUST00000102744.3 ENSMUSP00000099805.3
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader BAH BAH H4K20me2 K 22398447
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader BAH 3.00e-49 167.9 44 417
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
Domain Profile
  Me_Reader BAH
               BAH.txt   1 lllkkgdsvllqdderktpdvyiikiieLfeneneveikkfarvrwffRpseikesksrllykkkfanevfkselydtdseinleevig 89 
                           +++k+g++vl+q++++k+p  y++k+ieLf+n++ev++kk+arv+wf+R+ ei++sk++ll+++++a+e+f+++++d+d++in+e++ig
  ENSMUSP00000099805.3  44 IHIKVGQFVLIQGEDNKKP--YVAKLIELFQNGAEVPPKKCARVQWFVRFLEIPVSKRHLLGRSPPAQEIFWYDCSDWDNKINVETIIG 130
                           79*****************..******************************************************************** PP
               BAH.txt  90 vvqvlplaeynkesipktekeddvflvdlslekkaekflkie 131
                           +vqv++la+  +e+ip+++k++++++v+ls++kk++++l++e
  ENSMUSP00000099805.3 131 PVQVVALAP--EEVIPVDQKSEETLFVKLSWNKKDFAPLPPE 170
                           *********..***************************9975 PP
               BAH.txt  80 seinleevigvvqvlp...laeynkesipktekeddvflvd 117
                           s + l+ +  + ++l+     +  +es++ + +e+d f+  
  ENSMUSP00000099805.3 377 SLLTLKRIRQQLCLLDgddRDQEEEESVDSESEEEDEFISS 417
                           55667777777777752223456789999999999999866 PP
Protein Sequence
(Fasta)		MPSYLTRQKT RQTFSWVGRP LPNRKQFQQM YREICMKIND GSEIHIKVGQ FVLIQGEDNK 60
KPYVAKLIEL FQNGAEVPPK KCARVQWFVR FLEIPVSKRH LLGRSPPAQE IFWYDCSDWD 120
NKINVETIIG PVQVVALAPE EVIPVDQKSE ETLFVKLSWN KKDFAPLPPE VLAALREQED 180
SPEWQKPLKA KIKNVKSPAR NTTEQEVKGI KSNHSTSKFH QTPANIVIPN AKKSLELDGL 240
GFTRKPNTRW SKKSSCDSLD YQKTSKRRAA FSETTSPPKK PNKPREIKPS SALETRVKNG 300
QTQPFCAKSS VVLRARNPAM TTTKLGVDNT LSPIRNGLRS SVVPSGGLTP VYIRRKAKEQ 360
ETHKEPIRTS RVHRKSSLLT LKRIRQQLCL LDGDDRDQEE EESVDSESEE EDEFISSLPT 420
RNSLGQSRTR QTPSKSPQKN PKPRTPHRAT PQIRDRNLAV QEPASALEEA RLRLHVSAVP 480
DSLPCREQEF QDIYSFVESK LLDGTGGCMY ISGVPGTGKT ATVHEVIRCL QQAAETDDVP 540
PFQYVEVNGM KLTEPHQVYV QILKKLTGQK ATANHAAELL AKQFCGQGSQ KETTVLLVDE 600
LDLLWTHKQD VMYNLFDWPT HKGAHLIVLT IANTMDLPER IMMNRVSSRL GLTRMSFQPY 660
SHSQLKQILV SRLRNLRAFE DDAIQLVARK VAALSGDARR CLDICRRATE ICELSHLRGD 720
SLSLVTVAHL MEAIDEMFSS SYITAIKNSS VVEQSFLRAI IAEFRRSGLE EATFQQIYSQ 780
HVALCRMEGL PYPTMSETMA VCSRLGSCRL LLVEPSRNDL LLRVRLNVSQ NDVLFALKEE 840
Nucleotide Sequence
(Fasta)		AGTTCTTAGT CAGCTGAGAG CTGGGACTAC GTGTTGTAGC CGTGGTCTCC CGGAGGAGCC 60
AGACCTGGAC GAGCGAGCGT CCCCCAGCTA CTCCAGTGCC TGGACTGCAA AGCGTCGGCG 120
AGCCCATCAG ACCATGCCAT CCTACCTCAC AAGGCAGAAG ACCAGACAAA CTTTCTCATG 180
GGTTGGCAGG CCATTGCCGA ATCGAAAACA GTTCCAACAA ATGTACAGAG AAATTTGTAT 240
GAAAATCAAT GATGGTTCTG AGATTCACAT CAAGGTTGGA CAGTTTGTAT TGATTCAGGG 300
GGAAGATAAT AAAAAGCCCT ATGTGGCTAA ACTGATTGAA TTATTTCAAA ATGGAGCTGA 360
AGTTCCTCCC AAGAAATGTG CACGAGTACA GTGGTTTGTC AGATTCCTTG AGATTCCTGT 420
CTCTAAAAGG CACTTGTTAG GCCGCAGTCC TCCTGCACAG GAGATATTCT GGTATGACTG 480
TTCTGACTGG GATAACAAGA TTAATGTGGA GACCATCATT GGCCCTGTTC AGGTAGTGGC 540
ATTAGCCCCA GAAGAAGTGA TTCCTGTGGA TCAGAAAAGT GAGGAGACAC TGTTTGTGAA 600
GCTATCCTGG AATAAAAAGG ACTTTGCACC ACTGCCACCA GAAGTGCTTG CAGCATTAAG 660
GGAACAAGAA GATAGTCCTG AGTGGCAAAA ACCTTTAAAA GCCAAGATTA AGAATGTAAA 720
AAGCCCTGCC CGGAACACAA CAGAACAAGA GGTCAAAGGG ATCAAATCAA ATCATTCCAC 780
TTCCAAATTT CACCAGACTC CTGCTAATAT TGTCATCCCC AATGCAAAGA AGTCGCTGGA 840
ACTCGATGGC TTAGGTTTTA CCAGGAAGCC TAACACGAGG TGGTCAAAGA AGAGCTCGTG 900
TGACTCCTTG GATTATCAAA AAACATCTAA AAGAAGAGCA GCCTTCTCTG AGACCACCTC 960
GCCTCCTAAA AAGCCTAATA AACCTCGTGA AATCAAGCCC TCTTCAGCTT TGGAAACTCG 1020
AGTTAAAAAT GGACAAACTC AACCTTTTTG TGCCAAAAGT AGTGTGGTTC TGAGAGCCCG 1080
GAACCCAGCT ATGACGACCA CAAAGCTTGG TGTGGACAAC ACACTTAGCC CTATCAGGAA 1140
TGGGTTGAGA TCTTCAGTGG TGCCCTCTGG GGGTCTGACA CCAGTATACA TTAGGAGGAA 1200
GGCAAAAGAA CAAGAAACTC ACAAAGAACC CATCCGTACT TCTCGTGTCC ATAGAAAGAG 1260
TTCTCTCTTG ACTTTGAAGC GGATTAGGCA ACAGCTTTGT CTTCTAGATG GTGATGACAG 1320
GGACCAAGAA GAGGAAGAGT CCGTAGACTC TGAGAGTGAG GAGGAAGATG AGTTTATTTC 1380
CTCCCTCCCA ACAAGAAATT CCCTGGGGCA GTCCAGGACC CGGCAGACCC CCTCCAAGTC 1440
ACCACAGAAA AATCCTAAAC CTAGAACACC TCATCGTGCC ACTCCTCAGA TCCGAGACAG 1500
AAACCTGGCT GTCCAGGAGC CAGCTAGTGC GCTGGAAGAG GCACGGCTGA GGTTGCATGT 1560
TTCTGCTGTG CCTGACTCTC TCCCCTGTCG AGAGCAGGAA TTCCAAGACA TCTACAGCTT 1620
TGTGGAAAGT AAACTTCTTG ATGGGACTGG AGGGTGTATG TACATTTCTG GGGTCCCTGG 1680
GACAGGGAAG ACAGCCACTG TGCATGAGGT CATACGCTGT CTGCAGCAGG CAGCAGAAAC 1740
AGATGATGTT CCTCCCTTTC AATATGTTGA GGTTAATGGG ATGAAGCTGA CAGAACCCCA 1800
CCAAGTCTAT GTGCAGATTT TAAAGAAACT GACAGGCCAG AAGGCAACAG CCAATCATGC 1860
AGCAGAACTG CTGGCGAAGC AATTCTGTGG CCAAGGGTCC CAGAAGGAAA CCACTGTACT 1920
GCTCGTGGAT GAGCTTGACC TTCTTTGGAC TCACAAACAA GATGTAATGT ACAACCTCTT 1980
TGATTGGCCT ACTCACAAAG GGGCCCACTT GATAGTGCTG ACCATTGCCA ACACCATGGA 2040
CCTTCCCGAG AGGATCATGA TGAACCGTGT GTCTAGCCGA CTGGGCCTCA CCAGGATGTC 2100
TTTCCAGCCC TATTCTCACA GCCAGCTGAA ACAGATCTTA GTGTCTCGAC TGAGGAATTT 2160
AAGGGCCTTT GAGGACGATG CCATCCAGCT GGTGGCCAGG AAGGTAGCAG CCCTCTCTGG 2220
AGATGCCCGG CGCTGCCTGG ACATCTGCAG GCGTGCCACG GAGATCTGCG AGCTTTCCCA 2280
TCTACGCGGT GACTCTCTGA GCCTGGTGAC TGTGGCCCAC TTAATGGAAG CTATAGATGA 2340
AATGTTCTCC TCGTCATATA TTACTGCCAT CAAAAACTCT TCTGTCGTGG AACAGAGCTT 2400
CCTGAGAGCC ATTATTGCGG AATTCCGTCG GTCAGGACTA GAGGAAGCAA CCTTTCAACA 2460
GATATACAGT CAGCACGTGG CTCTGTGCCG AATGGAGGGA CTGCCATACC CAACCATGTC 2520
AGAGACCATG GCTGTGTGCT CACGTCTGGG TTCTTGCCGC CTCCTTCTGG TGGAGCCCAG 2580
TAGAAATGAC CTCCTCCTTC GAGTGAGACT CAATGTTAGC CAGAATGACG TGCTGTTTGC 2640
TCTCAAAGAA GAGTGAAGGA CTTCACAAAT TTCTGCTTTG TCTCAGAGCT TTATTTTATT 2700
TCTTCAGAAC ATGGAATTAC AGCAGAATAT ACAGGATGGA AATTGTTGTT ATAAATTTGT 2760
TATTTTCCAT TATTTATTTT GCTTTTTCCA AAGTGTTGGA GAAGTTACGG TAACATACTA 2820
TGTATATAAA GATATGTATA CAATATACTT GTATCTATAT AAAATAGTTC TGGGAGAATT 2880
TGTATGAAGT TAGGTATACT GGTTGCCTCT GAGAAATCCC TGGTGGGTTG GTCAGAGGTT 2940
AGAGGAAGAC TTGACTATAT GCTATGATGT ATTGGATTTT AAATGATACA AAGTAAAATT 3000
GATTTTATAG AAAA 3015
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0235--DNA replication
KW-0238--DNA-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
--
Interpro

IPR003593--AAA+_ATPase
IPR003959--ATPase_AAA_core
IPR001025--BAH_dom
IPR015163--Cdc6_C
IPR027417--P-loop_NTPase
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS51038--BAH
Pfam

PF00004--AAA
PF01426--BAH
PF09079--Cdc6_C
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0005664--C:nuclear origin of replication recognition complex
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0000808--C:origin recognition complex
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0006260--P:DNA replication
GO:0070318--P:positive regulation of G0 to G1 transition
GO:0048661--P:positive regulation of smooth muscle cell proliferation
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0055 ENSRNOP00000012492.5 Rattus norvegicus 82 0.0 1309
WERAM-Fec-0027 ENSFCAP00000002316.3 Felis catus 67 0.0 1054
WERAM-Bot-0032 ENSBTAP00000003523.5 Bos taurus 66 0.0 1039
WERAM-Caf-0044 ENSCAFP00000005581.3 Canis familiaris 67 0.0 1036
WERAM-Aim-0101 ENSAMEP00000009770.1 Ailuropoda melanoleuca 67 0.0 1035
WERAM-Eqc-0055 ENSECAP00000007647.1 Equus caballus 68 0.0 1034
WERAM-Orc-0009 ENSOCUP00000000831.2 Oryctolagus cuniculus 67 0.0 1031
WERAM-Poa-0010 ENSPPYP00000001568.1 Pongo abelii 66 0.0 1030
WERAM-Ict-0135 ENSSTOP00000013960.2 Ictidomys tridecemlineatus 67 0.0 1029
WERAM-Ova-0046 ENSOARP00000005671.1 Ovis aries 66 0.0 1029
WERAM-Loa-0046 ENSLAFP00000003139.3 Loxodonta africana 66 0.0 1023
WERAM-Pat-0006 ENSPTRP00000001270.2 Pan troglodytes 66 0.0 1023
WERAM-Mup-0074 ENSMPUP00000006849.1 Mustela putorius furo 66 0.0 1022
WERAM-Gog-0040 ENSGGOP00000003862.2 Gorilla gorilla 66 0.0 1020
WERAM-Hos-0043 ENSP00000360621.1 Homo sapiens 66 0.0 1015
WERAM-Chs-0014 ENSCSAP00000016740.1 Chlorocebus sabaeus 65 0.0 1004
WERAM-Cap-0056 ENSCPOP00000004564.2 Cavia porcellus 66 0.0 1004
WERAM-Paa-0148 ENSPANP00000000718.1 Papio anubis 65 0.0 1002
WERAM-Mam-0129 ENSMMUP00000018823.2 Macaca mulatta 65 0.0 1001
WERAM-Sus-0025 ENSSSCP00000004177.1 Sus scrofa 66 0.0 994
WERAM-Caj-0225 ENSCJAP00000040193.2 Callithrix jacchus 65 0.0 983
WERAM-Tut-0183 ENSTTRP00000015290.1 Tursiops truncatus 65 0.0 980
WERAM-Tub-0063 ENSTBEP00000007929.1 Tupaia belangeri 75 0.0 674
WERAM-Ptv-0102 ENSPVAP00000009238.1 Pteropus vampyrus 46 7e-81 299
WERAM-Sem-0121 EFJ25159 Selaginella moellendorffii 41 1e-77 288
WERAM-Php-0132 PP1S90_96V6.1 Physcomitrella patens 40 1e-74 278
WERAM-Art-0098 AT4G12620.1 Arabidopsis thaliana 39 9e-74 276
WERAM-Bro-0178 Bo9g078420.1 Brassica oleracea 39 2e-73 275
WERAM-Arl-0096 fgenesh2_kg.6__ 3199__ AT4G12620.1 Arabidopsis lyrata 39 2e-73 275
WERAM-Brr-0148 Bra029471.1-P Brassica rapa 39 2e-73 275
WERAM-Thc-0110 EOY32655 Theobroma cacao 41 2e-73 274
WERAM-Sol-0041 Solyc03g006420.2.1 Solanum lycopersicum 40 1e-71 268
WERAM-Viv-0033 VIT_06s0004g02050.t01 Vitis vinifera 39 1e-70 265
WERAM-Lep-0062 LPERR06G05260.1 Leersia perrieri 37 2e-70 265
WERAM-Glm-0175 GLYMA13G41490.1 Glycine max 39 3e-70 264
WERAM-Prp-0096 EMJ14761 Prunus persica 39 7e-70 263
WERAM-Org-0058 ORGLA06G0052100.1 Oryza glaberrima 39 9e-70 262
WERAM-Orm-0058 OMERI06G06700.1 Oryza meridionalis 39 2e-69 261
WERAM-Orbr-0070 OB06G15250.1 Oryza brachyantha 39 3e-69 261
WERAM-Pot-0103 POPTR_0009s05910.1 Populus trichocarpa 39 4e-69 260
WERAM-Met-0185 KEH21251 Medicago truncatula 38 6e-69 259
WERAM-Sei-0023 Si005876m Setaria italica 37 1e-68 259
WERAM-Orgl-0060 OGLUM06G05860.1 Oryza glumaepatula 39 2e-68 258
WERAM-Mua-0132 GSMUA_Achr8P31340_001 Musa acuminata 39 3e-68 258
WERAM-Brd-0023 BRADI1G47050.1 Brachypodium distachyon 37 4e-68 257
WERAM-Zem-0141 GRMZM2G455243_P01 Zea mays 38 5e-68 256
WERAM-Sob-0130 Sb10g005910.1 Sorghum bicolor 38 6e-67 253
WERAM-Orr-0061 ORUFI06G05830.1 Oryza rufipogon 39 6e-67 253
WERAM-Orp-0057 OPUNC06G05470.1 Oryza punctata 39 7e-67 253
WERAM-Orb-0060 OBART06G05680.1 Oryza barthii 39 1e-66 252
WERAM-Orl-0031 KN538791.1_FGP002 Oryza longistaminata 39 1e-66 252
WERAM-Amt-0031 ERN11779 Amborella trichopoda 39 1e-65 248
WERAM-Osl-0008 ABO95923 Ostreococcus lucimarinus 38 3e-62 237
WERAM-Orni-0060 ONIVA06G15290.1 Oryza nivara 36 1e-56 218
WERAM-Hov-0026 MLOC_18813.1 Hordeum vulgare 41 1e-55 216
WERAM-Sot-0106 PGSC0003DMT400033353 Solanum tuberosum 42 2e-55 214
WERAM-Chr-0014 EDP07857 Chlamydomonas reinhardtii 40 6e-38 157
Created Date 25-Jun-2016