WERAM Information

Tag Content
WERAM ID WERAM-Hos-0043
Ensembl Protein ID ENSP00000360621.1
Uniprot Accession Q13415; ORC1_HUMAN; D3DQ34; Q13471; Q5T0F5
Genbank Protein ID NP_001177747.1; NP_001177748.1; NP_004144.2
Protein Name Origin recognition complex subunit 1
Genbank Nucleotide ID NM_001190818.1; NM_001190819.1; NM_004153.3
Gene Name ORC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000085840.12 ENST00000371566.1 ENSP00000360621.1
ENSG00000085840.12 ENST00000371568.7 ENSP00000360623.3
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader BAH BAH H4K20me2 K 22398447
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader BAH 6.50e-47 161.1 45 170
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Domain Profile
  Me_Reader BAH
            BAH.txt   1 lllkkgdsvllqdderktpdvyiikiieLfeneneveikkfarvrwffRpseikesksrllykkkfanevfkselydtdseinleevigvvq 92 
                        +++++g++vl+++d++++p  y++k++eLfe+++++++kk+arv+wf+R++e++++k++ll++k++a+e+f+++++++ds+in+e++ig+v+
  ENSP00000360621.1  45 IHIQIGQFVLIEGDDDENP--YVAKLLELFEDDSDPPPKKRARVQWFVRFCEVPACKRHLLGRKPGAQEIFWYDYPACDSNINAETIIGLVR 134
                        79*****************..*********************************************************************** PP
            BAH.txt  93 vlplaeynkesipktekeddvflvdlslekkaekflki 130
                        v+pla+  k+++p++ k++++++v+ls+++k++++l++
  ENSP00000360621.1 135 VIPLAP--KDVVPTNLKNEKTLFVKLSWNEKKFRPLSS 170
                        ******..***************************987 PP
Protein Sequence
(Fasta)		MAHYPTRLKT RKTYSWVGRP LLDRKLHYQT YREMCVKTEG CSTEIHIQIG QFVLIEGDDD 60
ENPYVAKLLE LFEDDSDPPP KKRARVQWFV RFCEVPACKR HLLGRKPGAQ EIFWYDYPAC 120
DSNINAETII GLVRVIPLAP KDVVPTNLKN EKTLFVKLSW NEKKFRPLSS ELFAELNKPQ 180
ESAAKCQKPV RAKSKSAESP SWTPAEHVAK RIESRHSASK SRQTPTHPLT PRARKRLELG 240
NLGNPQMSQQ TSCASLDSPG RIKRKVAFSE ITSPSKRSQP DKLQTLSPAL KAPEKTRETG 300
LSYTEDDKKA SPEHRIILRT RIAASKTIDI REERTLTPIS GGQRSSVVPS VILKPENIKK 360
RDAKEAKAQN EATSTPHRIR RKSSVLTMNR IRQQLRFLGN SKSDQEEKEI LPAAEISDSS 420
SDEEEASTPP LPRRAPRTVS RNLRSSLKSS LHTLTKVPKK SLKPRTPRCA APQIRSRSLA 480
AQEPASVLEE ARLRLHVSAV PESLPCREQE FQDIYNFVES KLLDHTGGCM YISGVPGTGK 540
TATVHEVIRC LQQAAQANDV PPFQYIEVNG MKLTEPHQVY VQILQKLTGQ KATANHAAEL 600
LAKQFCTRGS PQETTVLLVD ELDLLWTHKQ DIMYNLFDWP THKEARLVVL AIANTMDLPE 660
RIMMNRVSSR LGLTRMCFQP YTYSQLQQIL RSRLKHLKAF EDDAIQLVAR KVAALSGDAR 720
RCLDICRRAT EICEFSQQKP DSPGLVTIAH SMEAVDEMFS SSYITAIKNS SVLEQSFLRA 780
ILAEFRRSGL EEATFQQIYS QHVALCRMEG LPYPTMSETM AVCSHLGSCR LLLVEPSRND 840
LLLRVRLNVS QDDVLYALKD E 861
Nucleotide Sequence
(Fasta)		CTTTGGTCCT GGCTTTCGGC CCGTAGTTGT AGAAGGAGCC CTGCTGGTGC AGGTTAGAGG 60
TGCCGCATCC CCCGGAGCTC TCGAAGTGGA GGCGGTAGGA AACGGAGGGC TTGCGGCTAG 120
CCGGAGGAAG CTTTGGAGCC GGCCATGGCA CACTACCCCA CAAGGCTGAA GACCAGAAAA 180
ACTTATTCAT GGGTTGGCAG GCCCTTGTTG GATCGAAAAC TGCACTACCA AACCTATAGA 240
GAAATGTGTG TGAAAACAGA AGGTTGTTCC ACCGAGATTC ACATCCAGAT TGGACAGTTT 300
GTGTTGATTG AAGGGGATGA TGATGAAAAC CCGTATGTTG CTAAATTGCT TGAGTTGTTC 360
GAAGATGACT CTGATCCTCC TCCTAAGAAA CGTGCTCGAG TACAGTGGTT TGTCCGATTC 420
TGTGAAGTCC CTGCCTGTAA ACGGCATTTG TTGGGCCGGA AGCCTGGTGC ACAGGAAATA 480
TTCTGGTATG ATTACCCGGC CTGTGACAGC AACATTAATG CGGAGACCAT CATTGGCCTT 540
GTTCGGGTGA TACCTTTAGC CCCAAAGGAT GTGGTACCGA CGAATCTGAA AAATGAGAAG 600
ACACTCTTTG TGAAACTATC CTGGAATGAG AAGAAATTCA GGCCACTTTC CTCAGAACTA 660
TTTGCGGAGT TGAATAAACC ACAAGAGAGT GCAGCCAAGT GCCAGAAACC CGTGAGAGCC 720
AAGAGTAAGA GTGCAGAGAG CCCTTCTTGG ACCCCAGCAG AACATGTGGC CAAAAGGATT 780
GAATCAAGGC ACTCCGCCTC CAAATCTCGC CAAACTCCTA CCCATCCTCT TACCCCAAGA 840
GCCAGAAAGA GGCTGGAGCT TGGCAACTTA GGTAACCCTC AGATGTCCCA GCAGACTTCA 900
TGTGCCTCCT TGGATTCTCC AGGAAGAATA AAACGGAAAG TGGCCTTCTC GGAGATCACC 960
TCACCTTCTA AGAGATCTCA GCCTGATAAA CTTCAAACCT TGTCTCCAGC TCTGAAAGCC 1020
CCAGAGAAAA CCAGAGAGAC TGGACTCTCT TATACTGAGG ATGACAAGAA GGCTTCACCT 1080
GAACATCGCA TAATCCTGAG AACCCGAATT GCAGCTTCGA AAACCATAGA CATTAGAGAG 1140
GAGAGAACAC TTACCCCTAT CAGTGGGGGA CAGAGATCTT CAGTGGTGCC ATCCGTGATT 1200
CTGAAACCAG AAAACATCAA AAAGAGGGAT GCAAAAGAAG CAAAAGCCCA GAATGAAGCG 1260
ACCTCTACTC CCCATCGTAT CCGCAGAAAG AGTTCTGTCT TGACTATGAA TCGGATTAGG 1320
CAGCAGCTTC GGTTTCTAGG TAATAGTAAA AGTGACCAAG AAGAGAAAGA GATTCTGCCA 1380
GCAGCAGAGA TTTCAGACTC TAGCAGTGAC GAAGAAGAGG CTTCCACACC GCCCCTTCCA 1440
AGGAGAGCAC CCAGAACTGT GTCCAGGAAC CTGCGATCTT CCTTGAAGTC ATCCTTACAT 1500
ACCCTCACGA AGGTGCCAAA GAAGAGTCTC AAGCCTAGAA CGCCACGTTG TGCCGCTCCT 1560
CAGATCCGTA GTCGAAGCCT GGCTGCCCAG GAGCCAGCCA GTGTGCTGGA GGAAGCCCGA 1620
CTGAGGCTGC ATGTTTCTGC TGTACCTGAG TCTCTTCCCT GTCGGGAACA GGAATTCCAA 1680
GACATCTACA ATTTTGTGGA AAGCAAACTC CTTGACCATA CCGGAGGGTG CATGTACATC 1740
TCCGGTGTCC CTGGGACAGG GAAGACTGCC ACTGTTCATG AAGTGATACG CTGCCTGCAG 1800
CAGGCAGCCC AAGCCAATGA TGTTCCTCCC TTTCAATACA TTGAGGTCAA TGGCATGAAG 1860
CTGACGGAGC CCCACCAAGT CTATGTGCAA ATCTTGCAGA AGCTAACAGG CCAAAAAGCA 1920
ACAGCCAACC ATGCGGCAGA ACTGCTGGCA AAGCAATTCT GCACCCGAGG GTCACCTCAG 1980
GAAACCACCG TCCTGCTTGT GGATGAGCTC GACCTTCTGT GGACTCACAA ACAAGACATA 2040
ATGTACAATC TCTTTGACTG GCCCACTCAT AAGGAGGCCC GGCTTGTGGT CCTGGCAATT 2100
GCCAACACAA TGGACCTGCC AGAGCGAATC ATGATGAACC GGGTGTCCAG CCGACTGGGT 2160
CTTACCAGGA TGTGCTTCCA GCCCTATACA TATAGCCAGC TGCAGCAGAT CCTAAGGTCC 2220
CGGCTCAAGC ATCTAAAGGC CTTTGAAGAT GATGCCATCC AGCTGGTAGC CAGGAAGGTA 2280
GCAGCACTGT CTGGAGATGC ACGACGGTGC CTGGACATCT GCAGGCGTGC CACAGAGATC 2340
TGTGAGTTCT CCCAGCAGAA GCCTGACTCC CCTGGCCTGG TCACCATAGC CCACTCAATG 2400
GAAGCTGTGG ATGAGATGTT TTCATCATCA TACATCACGG CCATCAAAAA TTCCTCTGTT 2460
CTGGAACAGA GCTTCCTGAG AGCCATCCTC GCAGAGTTCC GTCGATCAGG ACTGGAGGAA 2520
GCCACGTTTC AACAGATATA TAGTCAACAT GTGGCACTGT GCAGAATGGA GGGACTGCCG 2580
TACCCCACCA TGTCAGAGAC CATGGCCGTG TGTTCTCACC TGGGCTCCTG TCGCCTCCTG 2640
CTTGTGGAGC CCAGCAGGAA CGATCTGCTC CTTCGGGTGC GGCTCAACGT CAGCCAGGAT 2700
GATGTGCTGT ATGCGCTGAA AGACGAGTAA AGGGGCTTCA CAAGTTAAAA GACTGGGGTC 2760
TTGCTGGGTT TTGTTTTTTG AGACAGGGTC TTGCTCTGTC GCCCAGGCTG GAGTGCAGTG 2820
GCACGATCAT GGCTCACTGC AGCCTTGACT TCTCAGGCTT AGGTGACCCC CCAACCTCAT 2880
CCTCCCAGGT GGCTGAAACT ACAGGCACAT GCCACCATGC CCAGCTGATT TTTTGTAGAG 2940
ACAGGGCTTC ACCATGTTGC CAAGCTAGTC TACAAAGCAT CTGATTTTGG AAGTACATGG 3000
AATTGTTGTA ACAAAGTATA TTGAATGGAA ATGGCTCTCA TGTATTTTGG AATTTTCCAT 3060
TAAATAATTT GCTTTTTCCT 3081
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0235--DNA replication
KW-0238--DNA-binding
KW-0242--Dwarfism
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
--
Interpro

IPR003593--AAA+_ATPase
IPR003959--ATPase_AAA_core
IPR001025--BAH_dom
IPR015163--Cdc6_C
IPR027417--P-loop_NTPase
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS51038--BAH
Pfam

PF00004--AAA
PF01426--BAH
PF09079--Cdc6_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005664--C:nuclear origin of replication recognition complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000808--C:origin recognition complex
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0006260--P:DNA replication
GO:0006270--P:DNA replication initiation
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0070318--P:positive regulation of G0 to G1 transition
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Gog-0040 ENSGGOP00000003862.2 Gorilla gorilla 99 0.0 1632
WERAM-Pat-0006 ENSPTRP00000001270.2 Pan troglodytes 99 0.0 1623
WERAM-Poa-0010 ENSPPYP00000001568.1 Pongo abelii 97 0.0 1598
WERAM-Mam-0129 ENSMMUP00000018823.2 Macaca mulatta 95 0.0 1546
WERAM-Chs-0014 ENSCSAP00000016740.1 Chlorocebus sabaeus 95 0.0 1541
WERAM-Paa-0148 ENSPANP00000000718.1 Papio anubis 94 0.0 1535
WERAM-Caj-0225 ENSCJAP00000040193.2 Callithrix jacchus 87 0.0 1403
WERAM-Fec-0027 ENSFCAP00000002316.3 Felis catus 82 0.0 1335
WERAM-Aim-0101 ENSAMEP00000009770.1 Ailuropoda melanoleuca 80 0.0 1315
WERAM-Caf-0044 ENSCAFP00000005581.3 Canis familiaris 81 0.0 1307
WERAM-Bot-0032 ENSBTAP00000003523.5 Bos taurus 80 0.0 1303
WERAM-Tut-0183 ENSTTRP00000015290.1 Tursiops truncatus 81 0.0 1288
WERAM-Orc-0009 ENSOCUP00000000831.2 Oryctolagus cuniculus 78 0.0 1281
WERAM-Mup-0074 ENSMPUP00000006849.1 Mustela putorius furo 79 0.0 1278
WERAM-Ova-0046 ENSOARP00000005671.1 Ovis aries 78 0.0 1274
WERAM-Loa-0046 ENSLAFP00000003139.3 Loxodonta africana 79 0.0 1270
WERAM-Eqc-0055 ENSECAP00000007647.1 Equus caballus 79 0.0 1268
WERAM-Ict-0135 ENSSTOP00000013960.2 Ictidomys tridecemlineatus 78 0.0 1253
WERAM-Sus-0025 ENSSSCP00000004177.1 Sus scrofa 78 0.0 1246
WERAM-Cap-0056 ENSCPOP00000004564.2 Cavia porcellus 76 0.0 1211
WERAM-Ran-0055 ENSRNOP00000012492.5 Rattus norvegicus 69 0.0 1079
WERAM-Mum-0092 ENSMUSP00000099805.3 Mus musculus 65 0.0 1011
WERAM-Tub-0063 ENSTBEP00000007929.1 Tupaia belangeri 81 0.0 717
WERAM-Ptv-0102 ENSPVAP00000009238.1 Pteropus vampyrus 65 2e-146 517
WERAM-Thc-0110 EOY32655 Theobroma cacao 41 5e-78 290
WERAM-Sol-0041 Solyc03g006420.2.1 Solanum lycopersicum 42 8e-77 286
WERAM-Glm-0175 GLYMA13G41490.1 Glycine max 40 8e-77 286
WERAM-Pot-0103 POPTR_0009s05910.1 Populus trichocarpa 40 6e-76 283
WERAM-Bro-0178 Bo9g078420.1 Brassica oleracea 41 1e-75 282
WERAM-Brr-0148 Bra029471.1-P Brassica rapa 41 1e-75 281
WERAM-Arl-0096 fgenesh2_kg.6__ 3199__ AT4G12620.1 Arabidopsis lyrata 40 1e-75 281
WERAM-Viv-0033 VIT_06s0004g02050.t01 Vitis vinifera 40 2e-75 281
WERAM-Art-0098 AT4G12620.1 Arabidopsis thaliana 40 6e-75 280
WERAM-Met-0185 KEH21251 Medicago truncatula 40 8e-75 279
WERAM-Sem-0121 EFJ25159 Selaginella moellendorffii 42 3e-74 277
WERAM-Prp-0096 EMJ14761 Prunus persica 41 1e-73 275
WERAM-Mua-0132 GSMUA_Achr8P31340_001 Musa acuminata 40 4e-73 273
WERAM-Php-0132 PP1S90_96V6.1 Physcomitrella patens 39 8e-72 269
WERAM-Brd-0023 BRADI1G47050.1 Brachypodium distachyon 40 1e-71 269
WERAM-Orbr-0070 OB06G15250.1 Oryza brachyantha 39 7e-71 266
WERAM-Org-0058 ORGLA06G0052100.1 Oryza glaberrima 39 1e-70 265
WERAM-Orm-0058 OMERI06G06700.1 Oryza meridionalis 39 2e-70 265
WERAM-Lep-0062 LPERR06G05260.1 Leersia perrieri 39 3e-70 264
WERAM-Sei-0023 Si005876m Setaria italica 39 5e-70 263
WERAM-Orgl-0060 OGLUM06G05860.1 Oryza glumaepatula 39 1e-69 261
WERAM-Zem-0141 GRMZM2G455243_P01 Zea mays 39 1e-69 261
WERAM-Sob-0130 Sb10g005910.1 Sorghum bicolor 39 1e-68 259
WERAM-Amt-0031 ERN11779 Amborella trichopoda 40 2e-68 258
WERAM-Orr-0061 ORUFI06G05830.1 Oryza rufipogon 39 4e-68 257
WERAM-Orp-0057 OPUNC06G05470.1 Oryza punctata 39 6e-68 256
WERAM-Orl-0031 KN538791.1_FGP002 Oryza longistaminata 39 8e-68 256
WERAM-Orb-0060 OBART06G05680.1 Oryza barthii 39 9e-68 256
WERAM-Osl-0008 ABO95923 Ostreococcus lucimarinus 36 6e-61 233
WERAM-Hov-0026 MLOC_18813.1 Hordeum vulgare 43 1e-59 228
WERAM-Sot-0106 PGSC0003DMT400033353 Solanum tuberosum 43 2e-59 228
WERAM-Orni-0060 ONIVA06G15290.1 Oryza nivara 36 6e-59 226
WERAM-Chr-0014 EDP07857 Chlamydomonas reinhardtii 40 3e-38 158
Created Date 25-Jun-2016