Tag |
Content |
WERAM ID |
WERAM-Mum-0158 |
Ensembl Protein ID |
ENSMUSP00000090441.5 |
Uniprot Accession |
Q5SVQ0; KAT7_MOUSE; Q5SVQ1; Q5SVQ2; Q5SVQ3; Q5SVQ7; Q6PGC6; Q80Y65 |
Genbank Protein ID |
NP_001181933.1; NP_808287.1; XP_006533076.1; XP_006533077.1 |
Protein Name |
Histone acetyltransferase KAT7 |
Genbank Nucleotide ID |
NM_001195004.1; NM_177619.3; XM_006533013.2; XM_006533014.2 |
Gene Name |
KAT7;Hbo1;Myst2 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HAT |
MYST |
MYST-type HAT |
H3K14; H4K5; H4K8; H4K12 |
K |
25519988; 25743411; 23159946 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HAT |
MYST |
2.30e-130 |
435.3 |
337 |
609 |
|
Organism |
Mus musculus |
NCBI Taxa ID |
10090 |
Functional Description (View)Functional Description
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. |
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.
|
Domain Profile |
HAT MYST
MYST.txt 4 kniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnlCl 92 ++i++i++g+ye++twy+sp+pee+++l ly+cefclky+ks+++l+rh++kC +++pPg+eiyrk+++svfevdGkk+k+ycqnlCl ENSMUSP00000090441.5 337 NMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCL 425 689************************************************************************************** PP MYST.txt 93 laklfldhktlyydvepflFYvltetdekgahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekPLs 181 laklfldhktlyydvepflFYv+te+d++g+hl+GyFskek+s +yn++Cil++P+y+r+GyGk+Li+fsY+ls++e+k+gsPe+PLs ENSMUSP00000090441.5 426 LAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLS 514 ***************************************************************************************** PP MYST.txt 182 dlgllsYrsyWkevllellkekeekkkitikelskatgiaveDivstleslnlikekkgqyillksekiveel.lklakskkkklkvde 269 dlgl+sYrsyWkevll++l ++ + k+i+ike+s++t++++ Divstl++l+++k++kg++ +lk++++++e+ +k+ak++++++++d+ ENSMUSP00000090441.5 515 DLGLISYRSYWKEVLLRYL-HNFQGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWiAKEAKRSNSNKTMDP 602 *******************.999*************************************************95566777888999*** PP MYST.txt 270 eklkwkp 276 ++lkw+p ENSMUSP00000090441.5 603 SCLKWTP 609 *****97 PP
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Protein Sequence (Fasta) | MAIGVVKRNA GSSSDGTEDS DFSTDLEHTD SSESDGTSRR SARVTRSSAR LSQSSQDSSP 60 VRNLPSFGTE EPAYSTRRVT RSQQQPTPVT PKKYPLRQTR SSGSETEQVV DFSDRETKNT 120 ADHDESPPRT PTGNAPSSES DIDISSPNVS HDESIAKDMS LKDSGSDLSH RPKRRRFHES 180 YNFNMKCPTP GCNSLGHLTG KHERHFSISG CPLYHNLSAD ECKVRAQSRD KQIEERMLSH 240 RQDDNNRHAT RHQAPTERQL RYKEKVAELR KKRNSGLSKE QKEKYMEHRQ TYGNTREPLL 300 ENLTSEYDLD LFRRAQARAS EDLEKLRLQG QITEGSNMIK TIAFGRYELD TWYHSPYPEE 360 YARLGRLYMC EFCLKYMKSQ TILRRHMAKC VWKHPPGDEI YRKGSISVFE VDGKKNKIYC 420 QNLCLLAKLF LDHKTLYYDV EPFLFYVMTE ADNTGCHLIG YFSKEKNSFL NYNVSCILTM 480 PQYMRQGYGK MLIDFSYLLS KVEEKVGSPE RPLSDLGLIS YRSYWKEVLL RYLHNFQGKE 540 ISIKEISQET AVNPVDIVST LQALQMLKYW KGKHLVLKRQ DLIDEWIAKE AKRSNSNKTM 600 DPSCLKWTPP KGT 613Protein Fasta Sequence
>ENSMUSP00000090441.5|KAT7;Hbo1;Myst2|Mus musculus MAIGVVKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVRNLPSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKGT
|
Nucleotide Sequence (Fasta) | AAGGCCTGGA TTGGGGCGAC CAACGCCCCG CCCTTCCGGA TAGAGATGGC GATAGGTGTT 60 GTAAAGAGAA ATGCAGGCAG TAGTTCAGAT GGAACCGAAG ATTCCGATTT TTCTACAGAT 120 CTCGAGCATA CAGACAGTTC AGAGAGTGAT GGCACCTCGC GCCGATCTGC CCGAGTCACC 180 CGCTCCTCAG CCAGGCTAAG CCAGAGTTCC CAAGATTCCA GCCCTGTTCG AAATTTGCCG 240 TCTTTCGGCA CTGAGGAGCC TGCCTATTCT ACCAGAAGGG TGACCCGTAG TCAGCAGCAG 300 CCCACGCCAG TGACTCCAAA AAAGTACCCT CTTCGACAGA CTCGCTCATC TGGCTCTGAA 360 ACGGAGCAGG TGGTGGACTT TTCAGATAGA GAAACTAAAA ATACAGCTGA TCATGATGAG 420 TCACCACCTC GAACTCCAAC CGGAAATGCA CCTTCTTCTG AGTCTGACAT AGACATCTCC 480 AGCCCCAACG TGTCTCATGA TGAGAGCATT GCCAAGGACA TGTCCCTGAA GGACTCAGGC 540 AGTGATCTCT CTCACCGTCC CAAGCGACGT CGATTTCACG AAAGCTACAA TTTCAACATG 600 AAGTGTCCTA CGCCGGGCTG CAACTCTCTA GGACATCTTA CAGGAAAGCA CGAGAGACAT 660 TTCTCCATCT CAGGATGCCC GCTGTATCAT AACCTCTCAG CTGACGAATG CAAGGTGAGA 720 GCACAGAGCC GGGATAAGCA GATAGAAGAA AGGATGCTGT CCCACAGGCA AGATGACAAC 780 AACAGGCATG CAACCAGGCA CCAGGCACCA ACAGAGAGAC AGCTGCGGTA TAAGGAAAAG 840 GTGGCTGAAC TCAGGAAGAA AAGAAATTCT GGACTGAGCA AAGAGCAGAA GGAGAAATAC 900 ATGGAACACA GACAGACCTA TGGGAACACT CGGGAGCCTC TCTTGGAAAA CCTGACAAGT 960 GAATATGACT TAGATCTTTT CCGAAGAGCA CAAGCCCGGG CTTCTGAGGA TTTGGAGAAG 1020 TTAAGGCTTC AAGGCCAAAT CACAGAGGGA AGCAACATGA TTAAAACAAT TGCTTTTGGC 1080 CGCTATGAAC TGGACACTTG GTACCACTCT CCCTATCCTG AGGAATATGC GAGGCTGGGA 1140 CGTCTCTACA TGTGTGAATT CTGCTTAAAG TACATGAAGA GCCAGACAAT CCTCCGCCGA 1200 CACATGGCCA AGTGTGTGTG GAAACACCCC CCTGGTGATG AGATTTATCG CAAAGGCTCC 1260 ATCTCTGTGT TTGAAGTAGA CGGCAAGAAG AACAAGATCT ACTGCCAAAA CCTCTGCCTT 1320 TTGGCAAAGC TTTTTCTGGA CCATAAGACG CTATACTATG ATGTAGAACC TTTCCTGTTC 1380 TACGTTATGA CAGAAGCGGA CAATACTGGC TGTCATCTGA TTGGATATTT TTCTAAGGAG 1440 AAGAATTCAT TTCTCAACTA TAATGTCTCG TGCATCCTCA CCATGCCTCA GTACATGCGA 1500 CAGGGCTACG GGAAGATGCT GATCGATTTC AGTTATTTAC TTTCCAAAGT AGAAGAGAAA 1560 GTCGGCTCTC CAGAGCGCCC ACTGTCAGAC CTGGGGCTCA TAAGCTACCG CAGCTACTGG 1620 AAGGAGGTAC TGCTCCGATA CCTGCACAAC TTCCAGGGCA AGGAGATCTC CATCAAAGAA 1680 ATTAGCCAGG AAACAGCTGT GAATCCCGTG GACATTGTCA GCACTCTGCA AGCCCTTCAG 1740 ATGCTCAAGT ATTGGAAAGG CAAGCACCTA GTTTTAAAGA GACAGGACCT GATAGATGAG 1800 TGGATAGCCA AAGAGGCCAA AAGGTCCAAC TCCAACAAAA CCATGGATCC AAGCTGCTTA 1860 AAATGGACCC CTCCCAAGGG CACTTAAAGT GACCTATCAT TCCGAGCCAG CGAGCCCCAG 1920 CAGTAGGAAT CCGTACCCTA GGGATCTGTC TGTCATTTCT GTTGCTCTTG TGATTGGCAA 1980 GTACAGTATC CTTTGGGAAG GCCACCCCCT CAGCACTGTT CTGGCTCCAG CCTTCGTGTA 2040 CACTGCAGAC ACTAGTTCTG AGGAACTGTT GTTTCGGCCT CAGTGAGGTT GCCTGGACGG 2100 ATCTGTATGA GGCTCGAGTA CAGATCCCTC ATAGCACTGA CCCAAGGAGT TGTGTTATGG 2160 TACTGTACCT GTCCAGTCAC TGGTTCCCAC CTCATGCTTT TTAACTCCGA GGTTTGTTGT 2220 GTCCTGACCT TTGTGCTAGT GCTTTTTCCT GCCTGGATAG CAGACCTCCA AACATGGTTG 2280 CCACCAAAGG GCCCTTTCCA GTTACTTCTA ACACATTCTT CATGAAGGGG TGGGCAAGAG 2340 GCAGCGCCTG TGCGTGTCTG CTGGGAGGGT CCGCTCACCA TGGGTTTCAT CTCGCAGTCA 2400 CTCATTTTTC TCCCTTTTTG TCAAAAGACT TACTACCTTT GATCAGGATC AGGCTGCCCA 2460 GAGCTAGGAA CGCCTGGCAT TTCCCAGGGG TTCACAGGCC TGGTCCATCT GCGTGAGATG 2520 GTGAAGCCTA AGAGGTGGTC CCATGCTTTC CTTTGTATTT ACTTGTGGAC ACTGGGGCAG 2580 CATTGTGTAG AAGGAAATGA GGAATTCTTT GCCACAGCAG AAAATGCCCC CACTTTTTTT 2640 TCTGCCCCCT TTTATGTTGG TAGTTGCCAA AATATTTTAA CAGTCTTTTT TCATACATTA 2700 AATGACCACC CTGTGGATCT TTCCACACCT GCCTCTGCCA GTCTGGTGTA GGGCAGCTCT 2760 ACTTTCCACA CAAGTTGCAC TGATCTTGTC CAGAGCTTCC TGGGAGAAGT GGAAACTGGT 2820 TGAAATGCTT GTGTTTCTCA GCCCATGACT CAGCAAGACA GGGTGGCCAC TCTGCTACGG 2880 TTTGCTTCGC TCTCAACAGT GCCTCCCTCC CCCAGCAGAC TGAAGTGCTT CTGTCTAAGA 2940 ACTAAGTCCA TTCCCTTTCG GGACTTGCCA CCATCATCCT GTTCTCTGGG TTCCTATTTT 3000 TGGTGGTGTT AAGTGAAGGA AGAAGTGTTC CCTCTAATTT CTCCCTGTCC CAGTATATAA 3060 CCTGCTATCT TGGGGCAGCT TTTGATGTCT GACATGTCAC CCTTCCCAAG TTGGTCTCTT 3120 CCAACACTGC TGTCTTCACG TGGCACCCTC TTACCACAAC CCTAACTCTG GTCATTTGTG 3180 CCTTTCTCTT GTCATCTCTG TACACTACTA ATATTCACTG TGGGTTGGGG AGCTGATTTT 3240 AAGCATGTTC AGTGGCTCCC CTCCAGTTTC AGTGTAACTG TTAAAATGTA TCCAAAAGCC 3300 ACTTCACTGG GGGTTTTCTT AAGGGGTAAA GGCCTTTTAC AGATGCTGAG CCCTCCCCAC 3360 ATGTGGCAGA ATGTGCTCTT CTGTATCTAC TCAATAAAGC ATGTTCTCTG CTCA
3415Nucleotide Fasta Sequence
>ENSMUSP00000090441.5|MYST|Mus musculus AAGGCCTGGATTGGGGCGACCAACGCCCCGCCCTTCCGGATAGAGATGGCGATAGGTGTTGTAAAGAGAAATGCAGGCAGTAGTTCAGATGGAACCGAAGATTCCGATTTTTCTACAGATCTCGAGCATACAGACAGTTCAGAGAGTGATGGCACCTCGCGCCGATCTGCCCGAGTCACCCGCTCCTCAGCCAGGCTAAGCCAGAGTTCCCAAGATTCCAGCCCTGTTCGAAATTTGCCGTCTTTCGGCACTGAGGAGCCTGCCTATTCTACCAGAAGGGTGACCCGTAGTCAGCAGCAGCCCACGCCAGTGACTCCAAAAAAGTACCCTCTTCGACAGACTCGCTCATCTGGCTCTGAAACGGAGCAGGTGGTGGACTTTTCAGATAGAGAAACTAAAAATACAGCTGATCATGATGAGTCACCACCTCGAACTCCAACCGGAAATGCACCTTCTTCTGAGTCTGACATAGACATCTCCAGCCCCAACGTGTCTCATGATGAGAGCATTGCCAAGGACATGTCCCTGAAGGACTCAGGCAGTGATCTCTCTCACCGTCCCAAGCGACGTCGATTTCACGAAAGCTACAATTTCAACATGAAGTGTCCTACGCCGGGCTGCAACTCTCTAGGACATCTTACAGGAAAGCACGAGAGACATTTCTCCATCTCAGGATGCCCGCTGTATCATAACCTCTCAGCTGACGAATGCAAGGTGAGAGCACAGAGCCGGGATAAGCAGATAGAAGAAAGGATGCTGTCCCACAGGCAAGATGACAACAACAGGCATGCAACCAGGCACCAGGCACCAACAGAGAGACAGCTGCGGTATAAGGAAAAGGTGGCTGAACTCAGGAAGAAAAGAAATTCTGGACTGAGCAAAGAGCAGAAGGAGAAATACATGGAACACAGACAGACCTATGGGAACACTCGGGAGCCTCTCTTGGAAAACCTGACAAGTGAATATGACTTAGATCTTTTCCGAAGAGCACAAGCCCGGGCTTCTGAGGATTTGGAGAAGTTAAGGCTTCAAGGCCAAATCACAGAGGGAAGCAACATGATTAAAACAATTGCTTTTGGCCGCTATGAACTGGACACTTGGTACCACTCTCCCTATCCTGAGGAATATGCGAGGCTGGGACGTCTCTACATGTGTGAATTCTGCTTAAAGTACATGAAGAGCCAGACAATCCTCCGCCGACACATGGCCAAGTGTGTGTGGAAACACCCCCCTGGTGATGAGATTTATCGCAAAGGCTCCATCTCTGTGTTTGAAGTAGACGGCAAGAAGAACAAGATCTACTGCCAAAACCTCTGCCTTTTGGCAAAGCTTTTTCTGGACCATAAGACGCTATACTATGATGTAGAACCTTTCCTGTTCTACGTTATGACAGAAGCGGACAATACTGGCTGTCATCTGATTGGATATTTTTCTAAGGAGAAGAATTCATTTCTCAACTATAATGTCTCGTGCATCCTCACCATGCCTCAGTACATGCGACAGGGCTACGGGAAGATGCTGATCGATTTCAGTTATTTACTTTCCAAAGTAGAAGAGAAAGTCGGCTCTCCAGAGCGCCCACTGTCAGACCTGGGGCTCATAAGCTACCGCAGCTACTGGAAGGAGGTACTGCTCCGATACCTGCACAACTTCCAGGGCAAGGAGATCTCCATCAAAGAAATTAGCCAGGAAACAGCTGTGAATCCCGTGGACATTGTCAGCACTCTGCAAGCCCTTCAGATGCTCAAGTATTGGAAAGGCAAGCACCTAGTTTTAAAGAGACAGGACCTGATAGATGAGTGGATAGCCAAAGAGGCCAAAAGGTCCAACTCCAACAAAACCATGGATCCAAGCTGCTTAAAATGGACCCCTCCCAAGGGCACTTAAAGTGACCTATCATTCCGAGCCAGCGAGCCCCAGCAGTAGGAATCCGTACCCTAGGGATCTGTCTGTCATTTCTGTTGCTCTTGTGATTGGCAAGTACAGTATCCTTTGGGAAGGCCACCCCCTCAGCACTGTTCTGGCTCCAGCCTTCGTGTACACTGCAGACACTAGTTCTGAGGAACTGTTGTTTCGGCCTCAGTGAGGTTGCCTGGACGGATCTGTATGAGGCTCGAGTACAGATCCCTCATAGCACTGACCCAAGGAGTTGTGTTATGGTACTGTACCTGTCCAGTCACTGGTTCCCACCTCATGCTTTTTAACTCCGAGGTTTGTTGTGTCCTGACCTTTGTGCTAGTGCTTTTTCCTGCCTGGATAGCAGACCTCCAAACATGGTTGCCACCAAAGGGCCCTTTCCAGTTACTTCTAACACATTCTTCATGAAGGGGTGGGCAAGAGGCAGCGCCTGTGCGTGTCTGCTGGGAGGGTCCGCTCACCATGGGTTTCATCTCGCAGTCACTCATTTTTCTCCCTTTTTGTCAAAAGACTTACTACCTTTGATCAGGATCAGGCTGCCCAGAGCTAGGAACGCCTGGCATTTCCCAGGGGTTCACAGGCCTGGTCCATCTGCGTGAGATGGTGAAGCCTAAGAGGTGGTCCCATGCTTTCCTTTGTATTTACTTGTGGACACTGGGGCAGCATTGTGTAGAAGGAAATGAGGAATTCTTTGCCACAGCAGAAAATGCCCCCACTTTTTTTTCTGCCCCCTTTTATGTTGGTAGTTGCCAAAATATTTTAACAGTCTTTTTTCATACATTAAATGACCACCCTGTGGATCTTTCCACACCTGCCTCTGCCAGTCTGGTGTAGGGCAGCTCTACTTTCCACACAAGTTGCACTGATCTTGTCCAGAGCTTCCTGGGAGAAGTGGAAACTGGTTGAAATGCTTGTGTTTCTCAGCCCATGACTCAGCAAGACAGGGTGGCCACTCTGCTACGGTTTGCTTCGCTCTCAACAGTGCCTCCCTCCCCCAGCAGACTGAAGTGCTTCTGTCTAAGAACTAAGTCCATTCCCTTTCGGGACTTGCCACCATCATCCTGTTCTCTGGGTTCCTATTTTTGGTGGTGTTAAGTGAAGGAAGAAGTGTTCCCTCTAATTTCTCCCTGTCCCAGTATATAACCTGCTATCTTGGGGCAGCTTTTGATGTCTGACATGTCACCCTTCCCAAGTTGGTCTCTTCCAACACTGCTGTCTTCACGTGGCACCCTCTTACCACAACCCTAACTCTGGTCATTTGTGCCTTTCTCTTGTCATCTCTGTACACTACTAATATTCACTGTGGGTTGGGGAGCTGATTTTAAGCATGTTCAGTGGCTCCCCTCCAGTTTCAGTGTAACTGTTAAAATGTATCCAAAAGCCACTTCACTGGGGGTTTTCTTAAGGGGTAAAGGCCTTTTACAGATGCTGAGCCCTCCCCACATGTGGCAGAATGTGCTCTTCTGTATCTACTCAATAAAGCATGTTCTCTGCTCA
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Sequence Source |
Ensembl |
Keyword |
KW-0007--Acetylation KW-0012--Acyltransferase KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0235--DNA replication KW-0479--Metal-binding KW-0539--Nucleus KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0804--Transcription KW-0805--Transcription regulation KW-0808--Transferase KW-0862--Zinc KW-0863--Zinc-finger --
|
Interpro |
IPR016181--Acyl_CoA_acyltransferase IPR002717--HAT_MYST-type IPR002515--Znf_C2HC
|
PROSITE |
PS51726--MYST_HAT
|
Pfam |
PF01853--MOZ_SAS PF01530--zf-C2HC
|
Gene Ontology |
GO:0005737--C:cytoplasm GO:0000123--C:histone acetyltransferase complex GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0004402--F:histone acetyltransferase activity GO:0003700--F:transcription factor activity, sequence-specific DNA binding GO:0008270--F:zinc ion binding GO:0006260--P:DNA replication GO:0043966--P:histone H3 acetylation GO:0043983--P:histone H4-K12 acetylation GO:0043981--P:histone H4-K5 acetylation GO:0043982--P:histone H4-K8 acetylation GO:1900182--P:positive regulation of protein localization to nucleus GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |