WERAM Information

Tag Content
WERAM ID WERAM-Drm-0031
Ensembl Protein ID FBpp0304793
Uniprot Accession Q9VM15; Q9VM15_DROME
Genbank Protein ID NP_001260192.1; NP_609117.4
Protein Name Histone acetyltransferase
Genbank Nucleotide ID NM_001273263.1; NM_135273.5
Gene Name CHM;CG5229;Dmel_CG5229
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0028387 FBtr0332523 FBpp0304793
FBgn0028387 FBtr0079443 FBpp0079071
Details
Type Family Domain Substrates AA References (PMIDs)
HAT MYST MYST-type HAT H4K5; H4K12; H4K18 K 12466527; 18022374
Status Reviewed
Classification
Type Family E-value Score Start End
HAT MYST 9.90e-123 409.3 526 801
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)
Domain Profile
  HAT MYST
     MYST.txt   4 kniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnlCllaklfldhk 101
                  k i++i++gky++k wy+sp+p+++++l+k+yicefcl+y+ks++ +krh++kC +r+pPg+eiyrk+kl+v++vdGk++k+ycq+lCllak+fldhk
  FBpp0304793 526 KGIKYISMGKYKMKVWYQSPYPDDAARLPKMYICEFCLRYQKSETGIKRHAEKCVWRHPPGDEIYRKGKLQVWQVDGKRYKQYCQHLCLLAKFFLDHK 623
                  6799********************************************************************************************** PP
     MYST.txt 102 tlyydvepflFYvltetdekgahlvGyFske....kesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekPLsdlgllsYrsyWkev 195
                  tlyydvepflFY++t +d +g+h+vGyFsk+    +e+++ yn++Cil+lPpyqrkGyG+lLi+fsY+l+r+egkigsPekPLsdlgl+sYrsyWk+v
  FBpp0304793 624 TLYYDVEPFLFYIMTLADVDGCHIVGYFSKHipflQEKNSFYNVSCILTLPPYQRKGYGRLLIDFSYLLTRVEGKIGSPEKPLSDLGLISYRSYWKDV 721
                  ******************************98887889999********************************************************* PP
     MYST.txt 196 llellkekeekkkitikelskatgiaveDivstleslnlikekkgqyillksekiveellklakskkkklkvdeeklkwkp 276
                  ll++l  +++ ++i+ik++s++t+i + Divstl++l ++k++kg++i+lk++++++e++++ k++ +  k+d+++l+w+p
  FBpp0304793 722 LLDYL-CNRSGNTIAIKDVSQETAIYSYDIVSTLQALGMMKYWKGKHIVLKKQDVLDEYEERVKRRGTFPKIDDSCLRWQP 801
                  *****.999**********************************************************************97 PP
Protein Sequence
(Fasta)		MALESGSSSS ESGSSSTSGS TSSETGSSSD TDSSSATPEE KPSTNSSAKS QTQTQQQTNS 60
GNAQRRKPVP AASEDKPKPS VAPSSKKVNN PPKSKLSSDD DEYEDSAPPA KKNSRAMGSS 120
TVTAAAAASA ARRKPPASVN KPSNPANKPS NPTQRSANNN TNRSLENGEG KRPSLSSSSN 180
STDDSMKIVK NGRKVPLKMA STVRPKQIRG KLPPAKKNGG GPVISSDGSS GSESGSNSGD 240
ESSSGSESEG SDSSNSYSSQ PVKGGAKGKR SGPTKIQNSD SEEERKDKAN PMRKLTRSLS 300
MRRTKQQPKQ ETDSESDGDL EDDKIMISKS PAKKPAPSNL NASKSKVKRE PIGISSGVLS 360
SIKSRPVSPI TQTEKKCPIE GCDSSGHLSG NLDKHFLPEA CPIYHNMSAS ECKERANERK 420
LRNEQRLKMP VNIVTAPGNQ NTNLKTLSPE QREFLAKIRE SRANFKPANN NFLDSKVKLE 480
KDVTDEDREP NLAGLVPDYD LQLFREAQAQ ASERIEDELK DLPVGKGIKY ISMGKYKMKV 540
WYQSPYPDDA ARLPKMYICE FCLRYQKSET GIKRHAEKCV WRHPPGDEIY RKGKLQVWQV 600
DGKRYKQYCQ HLCLLAKFFL DHKTLYYDVE PFLFYIMTLA DVDGCHIVGY FSKHIPFLQE 660
KNSFYNVSCI LTLPPYQRKG YGRLLIDFSY LLTRVEGKIG SPEKPLSDLG LISYRSYWKD 720
VLLDYLCNRS GNTIAIKDVS QETAIYSYDI VSTLQALGMM KYWKGKHIVL KKQDVLDEYE 780
ERVKRRGTFP KIDDSCLRWQ PFINIQPSSS P 811
Nucleotide Sequence
(Fasta)		CATCCACCTC TGGCCACTCT AATCAAAACA ATACAGGAAA ACAGGCATTT TTGTGTACAA 60
ATATTAAAAA AAACATTCTG CGCTACAAAA ATGGCCTTGG AGTCCGGCAG CAGCAGCTCG 120
GAGTCGGGCA GCTCATCCAC AAGCGGATCC ACCAGTTCGG AAACGGGCAG CAGCTCGGAC 180
ACGGATTCCA GCAGTGCGAC GCCGGAGGAG AAGCCATCCA CGAATTCCTC CGCCAAATCC 240
CAGACGCAAA CACAACAACA AACTAATTCC GGAAATGCAC AGAGAAGAAA GCCTGTTCCT 300
GCGGCGTCGG AGGATAAACC CAAGCCGAGC GTAGCGCCAT CTAGCAAAAA AGTAAACAAT 360
CCTCCCAAAA GTAAACTCTC CAGCGATGAC GACGAATATG AGGACTCGGC GCCGCCGGCC 420
AAAAAGAACT CACGTGCAAT GGGCAGTTCC ACTGTAACAG CGGCAGCTGC CGCCTCAGCA 480
GCCAGGAGAA AACCACCCGC GTCCGTCAAC AAGCCAAGCA ATCCCGCTAA CAAACCGAGC 540
AATCCTACCC AGCGATCGGC CAACAACAAC ACAAATCGAT CACTGGAGAA CGGCGAGGGC 600
AAGCGACCCT CGCTCTCCTC CTCGTCCAAT AGCACAGATG ACTCTATGAA GATCGTTAAA 660
AACGGGCGGA AGGTTCCCCT CAAAATGGCC AGCACGGTGA GGCCCAAACA AATCCGAGGA 720
AAATTGCCGC CGGCAAAGAA AAACGGCGGG GGACCGGTGA TCAGCAGTGA CGGAAGTTCG 780
GGCTCCGAGA GTGGCTCCAA CTCGGGCGAC GAATCAAGTT CAGGAAGCGA GTCTGAGGGA 840
AGTGATTCCA GCAACTCCTA CAGCTCGCAG CCAGTAAAAG GAGGAGCTAA AGGTAAGAGA 900
AGCGGACCAA CAAAAATCCA AAACTCCGAC AGCGAAGAAG AGCGAAAAGA CAAGGCCAAT 960
CCCATGAGGA AACTGACGCG ATCACTCAGC ATGCGAAGGA CAAAACAGCA ACCCAAACAG 1020
GAAACCGATT CTGAATCCGA TGGAGACCTA GAAGATGACA AAATTATGAT CTCCAAAAGT 1080
CCCGCCAAAA AGCCAGCGCC CTCGAATTTG AACGCCAGCA AAAGCAAAGT GAAAAGGGAA 1140
CCAATCGGAA TCAGCAGTGG CGTGCTGAGC TCCATTAAAT CCCGACCCGT GTCACCGATT 1200
ACCCAGACTG AGAAGAAGTG TCCCATCGAG GGCTGCGATT CATCCGGACA TCTGAGTGGC 1260
AATTTGGATA AGCACTTTTT GCCGGAGGCC TGTCCTATCT ATCACAACAT GTCCGCCTCG 1320
GAGTGCAAAG AGCGTGCCAA TGAGAGAAAA CTGAGGAATG AACAGCGACT AAAGATGCCG 1380
GTTAACATTG TGACGGCGCC GGGTAACCAA AACACCAATC TCAAGACGCT CTCGCCTGAG 1440
CAGCGCGAGT TTCTGGCCAA GATTCGCGAG TCAAGGGCTA ACTTTAAGCC GGCGAATAAC 1500
AATTTTTTAG ACTCGAAGGT AAAGCTGGAA AAAGACGTAA CGGACGAGGA CCGGGAACCA 1560
AATCTGGCAG GCCTGGTGCC TGACTATGAT TTGCAATTGT TCCGGGAAGC GCAAGCTCAA 1620
GCATCCGAAA GGATCGAAGA CGAACTCAAG GACCTGCCCG TGGGAAAGGG AATAAAATAT 1680
ATCAGCATGG GCAAGTACAA GATGAAGGTC TGGTATCAAT CCCCTTATCC GGACGATGCT 1740
GCCCGCCTGC CCAAAATGTA TATCTGCGAA TTCTGCCTGC GCTACCAAAA ATCAGAGACG 1800
GGCATCAAGC GGCATGCCGA GAAATGCGTC TGGCGGCATC CGCCGGGCGA TGAGATATAC 1860
CGCAAGGGCA AACTACAGGT GTGGCAGGTG GACGGGAAAC GTTATAAGCA ATACTGTCAG 1920
CATCTGTGCC TGCTAGCAAA ATTCTTTCTG GATCACAAAA CCCTCTACTA CGATGTGGAG 1980
CCCTTCCTTT TCTACATTAT GACGCTGGCC GATGTGGATG GATGTCATAT TGTTGGTTAT 2040
TTTAGCAAGC ATATTCCTTT CCTGCAGGAG AAGAACTCGT TTTACAATGT TTCCTGTATT 2100
TTAACATTGC CGCCATATCA GCGAAAGGGT TACGGAAGAT TACTCATCGA TTTCAGCTAT 2160
CTGCTGACCC GCGTGGAGGG AAAAATCGGA TCGCCGGAGA AACCTCTATC CGATCTGGGC 2220
CTGATCTCGT ACCGCTCGTA CTGGAAGGAT GTGCTCCTGG ACTACCTGTG CAATCGATCG 2280
GGAAACACGA TCGCCATCAA GGATGTATCG CAGGAAACTG CGATTTACTC ATACGACATT 2340
GTGAGCACCC TTCAAGCTCT CGGAATGATG AAGTACTGGA AGGGCAAGCA CATAGTGCTC 2400
AAAAAGCAAG ACGTACTGGA TGAGTACGAG GAGAGGGTGA AGCGAAGGGG AACCTTCCCC 2460
AAGATCGACG ACTCCTGCTT AAGATGGCAG CCCTTCATCA ATATCCAGCC GAGCTCATCT 2520
CCATAACCAC GTGGTTGGAA GCATGCCAGG GCATGCTTTG CAGACGCCGA CGACGATGAC 2580
GAATTCTTGG CTCCGAATTC TTGATTTCAA CGATTTTATT TTTGGGTAGA CATCTGAAGA 2640
ACCACATCTC CAGTCCTTCC TTTGCATTTA TCCTAGCGGA TATATGCATT AATGTAGAAT 2700
ATGTTTTGTA ACCACTTTCA TAAACATGAT ACAATTGGAG AATGGTTTTT AGGGAGCTTG 2760
TAACTCAATT TTTTAATATT TGTTGGTAGA TCTTAAGGCC AGCCTATTGT AAACATATGT 2820
ACGTGTGTGT GTCTGTACTT GTTATTAGCG AAGAATTGTA GTAATTAGAG TCTTAAGATA 2880
CATAGTGAAA TTCTCAAAAC GAAAAAAAGC TTAAAAAGAT AAGAGAAATA TACTCGGTTT 2940
ACGATCAAAG ACTTGACTTG CCTTGAGATT TAGATGAATC ATGGAGAAAC CGAAGGCCCG 3000
TGGTAGAAGA GGAAGAGGAA AGGAAGAGAG GTGAGTCAAG GAGTGGACTG TGTGTGCGAG 3060
TGTGTGGCAA CGCAAAAAGT GCACACACAC CAAGAAGCCC AGTCAGTCGG CGGCAGGGAG 3120
GCGAGCGCAT TGACATTGTC GCTTCGCTGG GAGAGACAGG TGAGAGGAGG GGCAGAGAGG 3180
TGTGCAGACC AGACGGGTTG GTTTTGGGCG CGGGTTTAGC GGGGTGTGCC CAAAAAGCAT 3240
ACACATGCAC CGGGAACAGC GCTGCAAAGC GTGGAGCAGA GAGCAGCAGC CAGAGAGTGA 3300
GA 3303
Sequence Source Ensembl
Keyword

KW-0012--Acyltransferase
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR002717--HAT_MYST-type
IPR002515--Znf_C2HC
PROSITE

PS51726--MYST_HAT
Pfam

PF01853--MOZ_SAS
PF01530--zf-C2HC
Gene Ontology

GO:0005634--C:nucleus
GO:0010484--F:H3 histone acetyltransferase activity
GO:0010485--F:H4 histone acetyltransferase activity
GO:0004402--F:histone acetyltransferase activity
GO:0003713--F:transcription coactivator activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0008270--F:zinc ion binding
GO:0022416--P:chaeta development
GO:0048813--P:dendrite morphogenesis
GO:0016458--P:gene silencing
GO:0016573--P:histone acetylation
GO:0043966--P:histone H3 acetylation
GO:0043967--P:histone H4 acetylation
GO:0046529--P:imaginal disc fusion, thorax closure
GO:0009996--P:negative regulation of cell fate specification
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0048666--P:neuron development
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010906--P:regulation of glucose metabolic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0016360--P:sensory organ precursor cell fate determination
GO:0048190--P:wing disc dorsal/ventral pattern formation
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Dan-0041 ENSDNOP00000004227.2 Dasypus novemcinctus 54 2e-136 483
WERAM-Orn-0076 ENSONIP00000008231.1 Oreochromis niloticus 54 3e-136 483
WERAM-Mod-0099 ENSMODP00000015208.2 Monodelphis domestica 54 1e-135 481
WERAM-Sah-0111 ENSSHAP00000011807.1 Sarcophilus harrisii 54 1e-135 481
WERAM-Pes-0018 ENSPSIP00000004151.1 Pelodiscus sinensis 54 1e-135 481
WERAM-Fia-0073 ENSFALP00000005432.1 Ficedula albicollis 54 1e-135 481
WERAM-Cap-0016 ENSCPOP00000001650.2 Cavia porcellus 54 2e-135 481
WERAM-Ova-0056 ENSOARP00000006067.1 Ovis aries 54 2e-135 481
WERAM-Bot-0165 ENSBTAP00000024887.5 Bos taurus 54 2e-135 481
WERAM-Gaga-0100 ENSGALP00000016147.4 Gallus gallus 54 2e-135 481
WERAM-Meg-0019 ENSMGAP00000001561.1 Meleagris gallopavo 54 2e-135 481
WERAM-Orc-0005 ENSOCUP00000000581.3 Oryctolagus cuniculus 54 2e-135 480
WERAM-Ict-0154 ENSSTOP00000015280.1 Ictidomys tridecemlineatus 54 2e-135 480
WERAM-Poa-0075 ENSPPYP00000010014.1 Pongo abelii 54 2e-135 480
WERAM-Pat-0076 ENSPTRP00000015934.4 Pan troglodytes 54 2e-135 480
WERAM-Hos-0130 ENSP00000259021.4 Homo sapiens 54 2e-135 480
WERAM-Gog-0085 ENSGGOP00000007314.2 Gorilla gorilla 54 2e-135 480
WERAM-Eqc-0063 ENSECAP00000008441.1 Equus caballus 54 2e-135 480
WERAM-Aim-0136 ENSAMEP00000012925.1 Ailuropoda melanoleuca 54 2e-135 480
WERAM-Anp-0058 ENSAPLP00000006419.1 Anas platyrhynchos 54 2e-135 480
WERAM-Tut-0008 ENSTTRP00000000444.1 Tursiops truncatus 54 2e-135 480
WERAM-Sus-0134 ENSSSCP00000018601.2 Sus scrofa 54 2e-135 480
WERAM-Fec-0034 ENSFCAP00000002433.3 Felis catus 54 3e-135 480
WERAM-Mum-0158 ENSMUSP00000090441.5 Mus musculus 54 3e-135 480
WERAM-Chs-0057 ENSCSAP00000001508.1 Chlorocebus sabaeus 54 3e-135 480
WERAM-Mim-0145 ENSMICP00000015020.1 Microcebus murinus 54 3e-135 480
WERAM-Myl-0126 ENSMLUP00000010098.2 Myotis lucifugus 55 5e-135 479
WERAM-Loa-0037 ENSLAFP00000002342.3 Loxodonta africana 54 5e-135 479
WERAM-Paa-0175 ENSPANP00000020135.1 Papio anubis 54 5e-135 479
WERAM-Otg-0020 ENSOGAP00000000937.2 Otolemur garnettii 54 7e-135 478
WERAM-Pof-0033 ENSPFOP00000002754.2 Poecilia formosa 53 7e-135 478
WERAM-Dar-0070 ENSDARP00000021648.8 Danio rerio 53 1e-134 478
WERAM-Tar-0174 ENSTRUP00000036778.1 Takifugu rubripes 53 1e-134 478
WERAM-Leo-0131 ENSLOCP00000016384.1 Lepisosteus oculatus 54 2e-134 478
WERAM-Nol-0032 ENSNLEP00000003949.1 Nomascus leucogenys 54 2e-134 477
WERAM-Caf-0180 ENSCAFP00000024952.2 Canis familiaris 54 2e-134 477
WERAM-Gam-0139 ENSGMOP00000014177.1 Gadus morhua 53 8e-134 475
WERAM-Tag-0027 ENSTGUP00000001933.1 Taeniopygia guttata 54 9e-134 475
WERAM-Lac-0093 ENSLACP00000011978.1 Latimeria chalumnae 54 1e-133 474
WERAM-Orla-0042 ENSORLP00000005128.1 Oryzias latipes 52 2e-133 474
WERAM-Ocp-0075 ENSOPRP00000006602.1 Ochotona princeps 53 2e-132 471
WERAM-Ten-0155 ENSTNIP00000015833.1 Tetraodon nigroviridis 53 3e-132 470
WERAM-Cii-0017 ENSCINP00000006517.3 Ciona intestinalis 51 3e-132 470
WERAM-Xet-0138 ENSXETP00000047416.3 Xenopus tropicalis 54 5e-132 469
WERAM-Gaa-0100 ENSGACP00000013042.1 Gasterosteus aculeatus 53 6e-132 469
WERAM-Xim-0096 ENSXMAP00000008646.1 Xiphophorus maculatus 52 1e-131 468
WERAM-Pem-0064 ENSPMAP00000007030.1 Petromyzon marinus 54 1e-131 468
WERAM-Cis-0023 ENSCSAVP00000005035.1 Ciona savignyi 52 5e-131 466
WERAM-Mup-0176 ENSMPUP00000015299.1 Mustela putorius furo 55 4e-129 459
WERAM-Anc-0047 ENSACAP00000004991.2 Anolis carolinensis 53 4e-128 456
WERAM-Asm-0232 ENSAMXP00000025043.1 Astyanax mexicanus 51 2e-120 431
WERAM-Mae-0040 ENSMEUP00000003756.1 Macropus eugenii 63 3e-120 430
WERAM-Caj-0080 ENSCJAP00000013077.2 Callithrix jacchus 63 3e-117 420
WERAM-Ran-0147 ENSRNOP00000029608.6 Rattus norvegicus 65 9e-109 392
WERAM-Mam-0215 ENSMMUP00000030925.2 Macaca mulatta 44 7e-95 346
WERAM-Tas-0059 ENSTSYP00000005370.1 Tarsius syrichta 47 2e-94 344
WERAM-Tub-0087 ENSTBEP00000010059.1 Tupaia belangeri 47 4e-94 343
WERAM-Ora-0060 ENSOANP00000009404.2 Ornithorhynchus anatinus 44 1e-93 342
WERAM-Dio-0052 ENSDORP00000005019.1 Dipodomys ordii 46 1e-93 341
WERAM-Prc-0040 ENSPCAP00000003620.1 Procavia capensis 46 5e-93 340
WERAM-Chh-0033 ENSCHOP00000003799.1 Choloepus hoffmanni 68 9e-93 338
WERAM-Ptv-0164 ENSPVAP00000013957.1 Pteropus vampyrus 50 5e-92 336
WERAM-Ect-0123 ENSETEP00000014407.1 Echinops telfairi 50 6e-92 336
WERAM-Ere-0057 ENSEEUP00000004856.1 Erinaceus europaeus 51 1e-91 335
Created Date 25-Jun-2016