WERAM Information

Tag Content
WERAM ID WERAM-Mum-0022
Ensembl Protein ID ENSMUSP00000072732.4
Uniprot Accession Q8VDQ8; SIR2_MOUSE; E9PXF5; Q9CXS5; Q9EQ18; Q9ERJ9; U5TP50
Genbank Protein ID NP_001116237.1; NP_001116238.1; NP_071877.3
Protein Name NAD-dependent protein deacetylase sirtuin-2
Genbank Nucleotide ID NM_001122765.1; NM_001122766.1; NM_022432.4
Gene Name SIRT2;Sir2l2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000015149.14 ENSMUST00000072965.4 ENSMUSP00000072732.4
ENSMUSG00000015149.14 ENSMUST00000170068.8 ENSMUSP00000132783.1
ENSMUSG00000015149.14 ENSMUST00000155327.7 ENSMUSP00000146462.1
ENSMUSG00000015149.14 ENSMUST00000122915.7 ENSMUSP00000147217.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type H3K9; H3K14; H3K56; H4K16 K 26620281; 17447894
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 6.90e-96 322 67 339
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates with both chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression. Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response. Deacetylates also histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition. During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells. Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellular metabolic pathways. Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity. Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells. Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy. Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation. Deacetylates HIF1A, and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia. Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300. Deacetylates also EIF5A. Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor.
Domain Profile
  HDAC SIR2
              SIR2.txt   3 lakllk..kskkivvltGAGiStsaGIPDFRs.seGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflae 88 
                           ++++++  +++k+++l+GAGiStsaGIPDFRs s+Gly++l+k++lp+peaif++++f+k+p++f+alakelyp g++kPt +Hyf+++
  ENSMUSP00000072732.4  67 VTRYMQseRCRKVICLVGAGISTSAGIPDFRSpSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYP-GQFKPTICHYFIRL 154
                           5666666699****************************************************************.************** PP
              SIR2.txt  89 lekkgkllrlytQNiDgLerkaglkedklvelHGslatasCtk..CkkefpreeikeklkakekvpkCekCkgvlkpdivffgenlpee 175
                           l++kg+llr+ytQNiD+Ler agl+ ++lve+HG+++t++C++  C+ke+++ ++kek++++  +p+Ce+C++v+kpdivffgenlp++
  ENSMUSP00000072732.4 155 LKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNtsCRKEYTMGWMKEKIFSE-ATPRCEQCQSVVKPDIVFFGENLPSR 242
                           *****************************************7666****************9.9************************* PP
              SIR2.txt 176 fleeveedlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevk....................adkladlkllgdcdevvee 244
                           f++++++d++++dll+++GtSl+v+p+asl+ ++++  +p+ll+n+e+++                    +++++d+++lgdcd+ + +
  ENSMUSP00000072732.4 243 FFSCMQSDFSKVDLLIIMGTSLQVQPFASLI-SKAPLATPRLLINKEKTGqtdpflgmmmglgggmdfdsKKAYRDVAWLGDCDQGCLA 330
                           *******************************.99***********************************99****************** PP
              SIR2.txt 245 llkllglee 253
                           l++llg+++
  ENSMUSP00000072732.4 331 LADLLGWKK 339
                           *******97 PP
Protein Sequence
(Fasta)		MAEPDPSDPL ETQAGKVQEA QDSDSDTEGG ATGGEAEMDF LRNLFTQTLG LGSQKERLLD 60
ELTLEGVTRY MQSERCRKVI CLVGAGISTS AGIPDFRSPS TGLYANLEKY HLPYPEAIFE 120
ISYFKKHPEP FFALAKELYP GQFKPTICHY FIRLLKEKGL LLRCYTQNID TLERVAGLEP 180
QDLVEAHGTF YTSHCVNTSC RKEYTMGWMK EKIFSEATPR CEQCQSVVKP DIVFFGENLP 240
SRFFSCMQSD FSKVDLLIIM GTSLQVQPFA SLISKAPLAT PRLLINKEKT GQTDPFLGMM 300
MGLGGGMDFD SKKAYRDVAW LGDCDQGCLA LADLLGWKKE LEDLVRREHA NIDAQSGSQA 360
PNPSTTISPG KSPPPAKEAA RTKEKEEQQ 389
Nucleotide Sequence
(Fasta)		ATCCTATCTC GGCCTCTTCT TGTTTCCGCT GCCGTCACGG GACAGAGCAG TCGGTGACAG 60
TCCCGAGGGC CCCCACCCCG TTCCCATGGC CGAGCCGGAC CCCTCTGACC CTCTGGAGAC 120
CCAGGCAGGG AAGGTGCAGG AGGCTCAGGA TTCAGACTCG GACACTGAGG GAGGAGCCAC 180
TGGTGGAGAG GCAGAGATGG ACTTCCTGAG GAATTTATTC ACCCAGACCC TGGGCCTGGG 240
TTCCCAAAAG GAGCGTCTTC TAGACGAGCT GACCCTCGAA GGAGTGACAC GCTACATGCA 300
GAGCGAGCGC TGCCGCAAGG TCATCTGTTT GGTGGGAGCC GGAATCTCCA CGTCCGCGGG 360
TATCCCTGAC TTCCGCTCCC CGTCCACTGG CCTCTATGCA AACCTGGAGA AGTACCACCT 420
TCCTTACCCA GAGGCCATCT TTGAGATCAG CTACTTCAAG AAACATCCGG AACCCTTCTT 480
TGCCCTTGCC AAGGAGCTCT ATCCCGGGCA GTTCAAGCCA ACCATCTGCC ACTACTTCAT 540
CCGCCTGCTG AAGGAGAAGG GGCTGCTGCT GCGCTGCTAC ACGCAGAACA TAGACACGCT 600
GGAACGAGTG GCGGGGCTGG AGCCCCAGGA CCTGGTGGAG GCCCACGGCA CCTTCTACAC 660
ATCACACTGT GTCAACACCT CCTGCAGAAA AGAATACACG ATGGGCTGGA TGAAAGAGAA 720
GATCTTCTCA GAAGCAACTC CCAGGTGTGA GCAGTGTCAG AGTGTGGTAA AGCCTGATAT 780
CGTGTTTTTC GGTGAGAACC TTCCATCGCG CTTCTTCTCC TGCATGCAGT CAGACTTCTC 840
CAAGGTGGAC CTCCTCATCA TCATGGGCAC CTCCCTGCAG GTGCAGCCCT TCGCCTCCCT 900
CATCAGCAAG GCACCACTAG CCACCCCACG GCTGCTCATT AACAAGGAAA AGACAGGCCA 960
GACGGACCCC TTCCTGGGCA TGATGATGGG CCTGGGAGGT GGCATGGATT TTGACTCCAA 1020
GAAGGCTTAC AGGGACGTGG CCTGGCTGGG TGACTGTGAT CAAGGCTGCC TGGCTCTCGC 1080
TGACCTCCTC GGATGGAAGA AGGAACTGGA AGACCTTGTC CGGAGGGAGC ATGCCAACAT 1140
AGATGCCCAG TCAGGGTCAC AGGCCCCCAA CCCCAGCACT ACCATCTCCC CTGGAAAGTC 1200
CCCACCGCCT GCCAAGGAGG CGGCCAGGAC CAAAGAGAAA GAGGAACAGC AGTAACAGTA 1260
ACCATGACCT CCCGCAGGAC AGCGGAGCCC GGCCAGCACT GGGCCCTCTT AACATGCAGC 1320
TTGTGTGAGC TCAAAGACCC TTCGTTCTTT AACCACGTTC TTGAAATCAG GGTCCCCAAC 1380
TCAATCCCAG AAAAGCCTAA TATACCTAGG GGCTGAGGCC TGTGCAGTCT GTAGCTGGGG 1440
CCTCTAACCA CCATAGCCTC TAACCACCAT AGCCTCTAAC CACCATAGCC TCTAACCACC 1500
CAGGCAAGAA GCAGCCTTCC CTAACTTCTA ATTATTCCCA GACAACAGGC TACCCCAAAA 1560
CCCCTAACAG TGCCAGAATA AGGCATTTCT CTATTGTTTT CAGGGGGCCT ATGGCTAAAT 1620
CAAATTAACC TACCCCGCAT AGGGGCTGGA CTCTACAAAT AGAACTTCAC CCAAGGGGGT 1680
GGGGCCTTGT GGGATCTCTG AGCCTGAAGG CCTGCCAACT CTCTGCCTCC AACAAAGTGG 1740
GTACTAGGCT CCCTTTCCTG GGGACCCACT TGCCAGCTGT TGGTGGATGA GCAAGAGACC 1800
TTGCTTATTA GAAACAAATT AAAAAACAAA ACAAAGCAAC TAA 1844
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0131--Cell cycle
KW-0132--Cell division
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0221--Differentiation
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0469--Meiosis
KW-0472--Membrane
KW-0479--Metal-binding
KW-0493--Microtubule
KW-0498--Mitosis
KW-0520--NAD
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
--
Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR017328--Sirtuin_class_I
IPR026590--Ssirtuin_cat_dom
PROSITE

PS50305--SIRTUIN
Pfam

PF02146--SIR2
Gene Ontology

GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0097386--C:glial cell projection
GO:0030426--C:growth cone
GO:0044224--C:juxtaparanode region of axon
GO:0043219--C:lateral loop
GO:0072687--C:meiotic spindle
GO:0005874--C:microtubule
GO:0030496--C:midbody
GO:0072686--C:mitotic spindle
GO:0043209--C:myelin sheath
GO:0035748--C:myelin sheath abaxonal region
GO:0005720--C:nuclear heterochromatin
GO:0005634--C:nucleus
GO:0033010--C:paranodal junction
GO:0033270--C:paranode region of axon
GO:0043204--C:perikaryon
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043220--C:Schmidt-Lanterman incisure
GO:0005819--C:spindle
GO:0097456--C:terminal loop
GO:0048487--F:beta-tubulin binding
GO:0003682--F:chromatin binding
GO:0035035--F:histone acetyltransferase binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0046970--F:NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0034979--F:NAD-dependent protein deacetylase activity
GO:0033558--F:protein deacetylase activity
GO:0008134--F:transcription factor binding
GO:0042903--F:tubulin deacetylase activity
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051301--P:cell division
GO:0044242--P:cellular lipid catabolic process
GO:0061433--P:cellular response to caloric restriction
GO:0071872--P:cellular response to epinephrine stimulus
GO:0035729--P:cellular response to hepatocyte growth factor stimulus
GO:0071456--P:cellular response to hypoxia
GO:0071219--P:cellular response to molecule of bacterial origin
GO:0034599--P:cellular response to oxidative stress
GO:0048012--P:hepatocyte growth factor receptor signaling pathway
GO:0016575--P:histone deacetylation
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0051321--P:meiotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0022011--P:myelination in peripheral nervous system
GO:0043066--P:negative regulation of apoptotic process
GO:0010507--P:negative regulation of autophagy
GO:0008285--P:negative regulation of cell proliferation
GO:1900425--P:negative regulation of defense response to bacterium
GO:0045599--P:negative regulation of fat cell differentiation
GO:1900226--P:negative regulation of NLRP3 inflammasome complex assembly
GO:0048715--P:negative regulation of oligodendrocyte differentiation
GO:0070446--P:negative regulation of oligodendrocyte progenitor proliferation
GO:0010801--P:negative regulation of peptidyl-threonine phosphorylation
GO:0042177--P:negative regulation of protein catabolic process
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045843--P:negative regulation of striated muscle tissue development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061428--P:negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0034983--P:peptidyl-lysine deacetylation
GO:0014065--P:phosphatidylinositol 3-kinase signaling
GO:0051987--P:positive regulation of attachment of spindle microtubules to kinetochore
GO:0051781--P:positive regulation of cell division
GO:0043388--P:positive regulation of DNA binding
GO:1900119--P:positive regulation of execution phase of apoptosis
GO:0045836--P:positive regulation of meiotic nuclear division
GO:1900195--P:positive regulation of oocyte maturation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:2000777--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006476--P:protein deacetylation
GO:0043491--P:protein kinase B signaling
GO:0051726--P:regulation of cell cycle
GO:0045598--P:regulation of fat cell differentiation
GO:0031641--P:regulation of myelination
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0021762--P:substantia nigra development
GO:0006351--P:transcription, DNA-templated
GO:0090042--P:tubulin deacetylation
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ict-0150 ENSSTOP00000021109.1 Ictidomys tridecemlineatus 90 0.0 652
WERAM-Bot-0020 ENSBTAP00000002327.5 Bos taurus 90 0.0 652
WERAM-Chs-0045 ENSCSAP00000000306.1 Chlorocebus sabaeus 89 0.0 648
WERAM-Paa-0135 ENSPANP00000006205.1 Papio anubis 89 0.0 647
WERAM-Fec-0038 ENSFCAP00000002933.3 Felis catus 90 0.0 646
WERAM-Ran-0132 ENSRNOP00000059450.1 Rattus norvegicus 96 0.0 645
WERAM-Myl-0011 ENSMLUP00000000900.2 Myotis lucifugus 90 0.0 644
WERAM-Hos-0274 ENSP00000489602.1 Homo sapiens 89 0.0 642
WERAM-Orc-0210 ENSOCUP00000021500.1 Oryctolagus cuniculus 89 0.0 642
WERAM-Aim-0098 ENSAMEP00000009297.1 Ailuropoda melanoleuca 89 0.0 640
WERAM-Nol-0162 ENSNLEP00000017842.2 Nomascus leucogenys 89 0.0 639
WERAM-Otg-0090 ENSOGAP00000007418.2 Otolemur garnettii 87 0.0 637
WERAM-Loa-0172 ENSLAFP00000017245.2 Loxodonta africana 87 0.0 634
WERAM-Pat-0091 ENSPTRP00000018763.5 Pan troglodytes 88 0.0 630
WERAM-Gog-0026 ENSGGOP00000002451.2 Gorilla gorilla 88 0.0 630
WERAM-Ova-0058 ENSOARP00000006315.1 Ovis aries 88 3e-180 628
WERAM-Cap-0128 ENSCPOP00000010177.2 Cavia porcellus 87 6e-176 614
WERAM-Mup-0205 ENSMPUP00000017641.1 Mustela putorius furo 89 1e-175 613
WERAM-Poa-0087 ENSPPYP00000011137.1 Pongo abelii 90 2e-175 612
WERAM-Mam-0216 ENSMMUP00000031121.2 Macaca mulatta 86 1e-174 609
WERAM-Eqc-0193 ENSECAP00000020926.1 Equus caballus 88 4e-172 601
WERAM-Caj-0143 ENSCJAP00000025706.2 Callithrix jacchus 89 2e-166 582
WERAM-Dio-0012 ENSDORP00000001437.1 Dipodomys ordii 84 1e-157 553
WERAM-Ptv-0123 ENSPVAP00000010931.1 Pteropus vampyrus 91 2e-155 545
WERAM-Caf-0068 ENSCAFP00000008416.3 Canis familiaris 91 8e-154 540
WERAM-Pes-0004 ENSPSIP00000002368.1 Pelodiscus sinensis 77 4e-152 535
WERAM-Anc-0100 ENSACAP00000009519.3 Anolis carolinensis 75 7e-151 530
WERAM-Ect-0047 ENSETEP00000005080.1 Echinops telfairi 77 6e-149 524
WERAM-Tut-0138 ENSTTRP00000011179.1 Tursiops truncatus 80 6e-148 521
WERAM-Leo-0146 ENSLOCP00000017602.1 Lepisosteus oculatus 76 6e-142 501
WERAM-Pof-0038 ENSPFOP00000003166.2 Poecilia formosa 72 2e-140 496
WERAM-Xet-0018 ENSXETP00000005130.2 Xenopus tropicalis 75 3e-139 492
WERAM-Tar-0064 ENSTRUP00000012981.1 Takifugu rubripes 73 3e-138 489
WERAM-Dan-0004 ENSDNOP00000000434.2 Dasypus novemcinctus 73 3e-138 488
WERAM-Asm-0153 ENSAMXP00000015326.1 Astyanax mexicanus 75 4e-138 488
WERAM-Ocp-0048 ENSOPRP00000004238.2 Ochotona princeps 89 2e-137 486
WERAM-Dar-0028 ENSDARP00000003412.6 Danio rerio 69 5e-136 481
WERAM-Xim-0026 ENSXMAP00000002581.1 Xiphophorus maculatus 70 8e-136 480
WERAM-Orn-0200 ENSONIP00000020932.1 Oreochromis niloticus 72 2e-133 472
WERAM-Gaa-0062 ENSGACP00000007590.1 Gasterosteus aculeatus 68 3e-128 455
WERAM-Pem-0066 ENSPMAP00000007192.1 Petromyzon marinus 67 9e-127 450
WERAM-Gam-0155 ENSGMOP00000015228.1 Gadus morhua 69 2e-123 439
WERAM-Sus-0185 ENSSSCP00000020261.1 Sus scrofa 73 3e-119 426
WERAM-Cis-0075 ENSCSAVP00000016120.1 Ciona savignyi 62 3e-114 409
WERAM-Cii-0054 ENSCINP00000012226.3 Ciona intestinalis 60 4e-114 408
WERAM-Gaga-0175 ENSGALP00000041842.1 Gallus gallus 61 1e-113 407
WERAM-Orla-0088 ENSORLP00000010757.1 Oryzias latipes 57 2e-110 396
WERAM-Mim-0081 ENSMICP00000007830.1 Microcebus murinus 75 9e-108 387
WERAM-Sah-0002 ENSSHAP00000000118.1 Sarcophilus harrisii 82 6e-107 384
WERAM-Drm-0067 FBpp0310647 Drosophila melanogaster 54 1e-98 357
WERAM-Mae-0115 ENSMEUP00000010974.1 Macropus eugenii 86 1e-91 334
WERAM-Anp-0145 ENSAPLP00000015403.1 Anas platyrhynchos 49 5e-82 302
WERAM-Meg-0026 ENSMGAP00000002050.2 Meleagris gallopavo 48 2e-81 300
WERAM-Mod-0192 ENSMODP00000026476.2 Monodelphis domestica 51 2e-80 296
WERAM-Miv-0009 MVLG_01362T0 Microbotryum violaceum 49 3e-79 292
WERAM-Ast-0036 CADATEAP00009630 Aspergillus terreus 47 1e-78 290
WERAM-Fia-0142 ENSFALP00000011956.1 Ficedula albicollis 52 2e-77 286
WERAM-Usm-0036 UM05892P0 Ustilago maydis 50 3e-77 286
WERAM-Soa-0118 ENSSARP00000011447.1 Sorex araneus 48 5e-77 285
WERAM-Fuo-0021 FOXG_06023P0 Fusarium oxysporum 49 5e-77 285
WERAM-Asc-0030 CADACLAP00006830 Aspergillus clavatus 46 3e-76 283
WERAM-Lac-0044 ENSLACP00000006675.2 Latimeria chalumnae 46 3e-76 283
WERAM-Trv-0012 EHK19002 Trichoderma virens 49 1e-75 281
WERAM-Tag-0102 ENSTGUP00000007081.1 Taeniopygia guttata 51 1e-75 280
WERAM-Mao-0040 MGG_17827T0 Magnaporthe oryzae 48 4e-75 279
WERAM-Pyt-0039 EFQ86136 Pyrenophora teres 50 1e-74 277
WERAM-Gag-0013 GGTG_03219T0 Gaeumannomyces graminis 47 1e-74 277
WERAM-Scj-0005 EEB06048 Schizosaccharomyces japonicus 47 1e-74 277
WERAM-Zyt-0001 Mycgr3P100618 Zymoseptoria tritici 50 2e-74 276
WERAM-Tub-0067 ENSTBEP00000008310.1 Tupaia belangeri 47 3e-74 276
WERAM-Asn-0005 CADANIAP00000554 Aspergillus nidulans 48 3e-74 276
WERAM-Ten-0144 ENSTNIP00000015099.1 Tetraodon nigroviridis 47 3e-74 276
WERAM-Coi-0005 EAS35645 Coccidioides immitis 49 4e-74 275
WERAM-Osl-0012 ABO98065 Ostreococcus lucimarinus 46 5e-74 275
WERAM-Mel-0010 EGG12163 Melampsora laricipopulina 53 5e-74 275
WERAM-Pug-0030 EFP89251 Puccinia graminis 52 9e-74 274
WERAM-Trr-0018 EGR46788 Trichoderma reesei 49 3e-73 272
WERAM-Asni-0009 CADANGAP00002892 Aspergillus niger 50 4e-73 272
WERAM-Aso-0005 CADAORAP00000633 Aspergillus oryzae 47 8e-73 271
WERAM-Asf-0024 CADAFLAP00010064 Aspergillus flavus 47 8e-73 271
WERAM-Spr-0042 CBQ70931 Sporisorium reilianum 49 9e-73 271
WERAM-Crn-0031 AAW44797 Cryptococcus neoformans 47 2e-72 270
WERAM-Scp-0042 SPCC132.02.1:pep Schizosaccharomyces pombe 46 3e-72 269
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 49 3e-72 269
WERAM-Nec-0006 EFNCRP00000000764 Neurospora crassa 48 9e-72 268
WERAM-Asfu-0013 CADAFUAP00003392 Aspergillus fumigatus 47 1e-71 267
WERAM-Lab-0008 EDR12994 Laccaria bicolor 42 2e-71 266
WERAM-Lem-0007 CBY02082 Leptosphaeria maculans 49 3e-71 266
WERAM-Pytr-0009 EDU41553 Pyrenophora triticirepentis 51 2e-70 263
WERAM-Caa-0033 KGT64755 Candida albicans 47 4e-67 252
WERAM-Kop-0007 CAY68156 Komagataella pastoris 47 2e-65 246
WERAM-Asg-0028 AAS54472 Ashbya gossypii 44 8e-64 241
WERAM-Kll-0027 CAG98291 Kluyveromyces lactis 42 1e-61 234
WERAM-Cag-0026 CAG62123 Candida glabrata 43 2e-61 233
WERAM-Tas-0108 ENSTSYP00000011158.1 Tarsius syrichta 41 1e-58 224
WERAM-Sac-0046 YPL015C Saccharomyces cerevisiae 41 6e-58 222
WERAM-Ere-0116 ENSEEUP00000012184.1 Erinaceus europaeus 41 1e-57 221
WERAM-Ved-0011 EGY21147 Verticillium dahliae 49 8e-56 214
WERAM-Chg-0025 EAQ89546 Chaetomium globosum 42 1e-55 214
WERAM-Cym-0017 CML119CT Cyanidioschyzon merolae 39 1e-52 204
WERAM-Vip-0121 ENSVPAP00000010985.1 Vicugna pacos 43 8e-52 201
WERAM-Cae-0022 R11A8.4a Caenorhabditis elegans 43 4e-49 192
WERAM-Yal-0031 CAG78100 Yarrowia lipolytica 38 6e-46 182
WERAM-Phn-0017 SNOT_06735 Phaeosphaeria nodorum 33 2e-40 163
Created Date 25-Jun-2016