WERAM Information

Tag Content
WERAM ID WERAM-Mum-0201
Ensembl Protein ID ENSMUSP00000047570.3
Uniprot Accession Q9ERI5; JMJD6_MOUSE; A2AA26; A8Y5I2; Q80TX1
Genbank Protein ID NP_203971.2
Protein Name Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Genbank Nucleotide ID NM_033398.2
Gene Name JMJD6;PTDSR
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000056962.11 ENSMUST00000047616.9 ENSMUSP00000047570.3
ENSMUSG00000056962.11 ENSMUST00000140513.1 ENSMUSP00000115086.1
ENSMUSG00000056962.11 ENSMUST00000142495.7 ENSMUSP00000117922.1
ENSMUSG00000056962.11 ENSMUST00000140349.7 ENSMUSP00000120850.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JmjC_only Jmjc H3R2; H4R3; H1.4K25 R,K 20889125
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JmjC_only 1.10e-54 185.6 147 301
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses (By similarity).
Domain Profile
  HDM JmjC_only
         JmjC_only.txt   2 ledylvpktfsdqlwqlkeelsepfyclvgsnwfltGpassgfplHvddi..eaflvqveGrkrwrlyepsepaellklasdeqvkqed 88 
                           ledy+vpk+f+d+l+q+++e+++p+y+     wf++Gp++sg+++H+d++  +a++++v+G+krw+l+++++p+el+k++++e+++q+d
  ENSMUSP00000047570.3 147 LEDYKVPKFFTDDLFQYAGEKRRPPYR-----WFVMGPPRSGTGIHIDPLgtSAWNALVQGHKRWCLFPTNTPRELIKVTREEGGNQQD 230
                           689************************.....********************************************************* PP
         JmjC_only.txt  89 llltkftliaprplletvle..........pgellyiprgtwHqalsldvtlsvsqnfssetflenvvlka 149
                           +++t+f++i+pr++l+t+++          pge++++p+g+wH++l+ld+t++++qnf+s+t++++v++k+
  ENSMUSP00000047570.3 231 EAITWFNVIYPRTQLPTWPPefkpleilqkPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKT 301
                           *********************************************************************96 PP
Protein Sequence
(Fasta)		MNHKSKKRIR EAKRSARPEL KDSLDWTRHN YYESYPLNPA AVPDNVERAD ALQLSVKEFV 60
ERYERPYKPV VLLNAQEGWS AQEKWTLERL KRKYRNQKFK CGEDNDGYSV KMKMKYYIEY 120
MESTRDDSPL YIFDSSYGEH PKRRKLLEDY KVPKFFTDDL FQYAGEKRRP PYRWFVMGPP 180
RSGTGIHIDP LGTSAWNALV QGHKRWCLFP TNTPRELIKV TREEGGNQQD EAITWFNVIY 240
PRTQLPTWPP EFKPLEILQK PGETVFVPGG WWHVVLNLDT TIAITQNFAS STNFPVVWHK 300
TVRGRPKLSR KWYRILKQEH PELAVLADAV DLQESTGIAS DSSSDSSSSS SSSSSDSDSE 360
CESGSEGDGT THRRKKRRTC SMVGNGDTTS QDDCVSKERS SSR 403
Nucleotide Sequence
(Fasta)		GGCGGGTCTG GCAGGTCGCT GAGGCCAATG GCGGACCGCA TGAGGCGGTG GGGCGGGGAG 60
GAAGGCCGCT GTTCGCCCAA CCCAAAGCTC CGGTGGCGGC TGAGGAGTGA ATCTTCTGGA 120
AGGCGACTTT AAAGGCGCCG GGCCGGAGCG AAGGGCGTCT CGGGGCCGCG CCAGCCAGGG 180
AGGGAGGGCG CGTTTGGTGG CAGGAAACGC GAGCCGCGTC GGGGTCGGGG CGGAACCGGA 240
CGGCGAGCGG CTCACGATGA ACCACAAGAG CAAGAAGCGC ATCCGCGAGG CCAAGCGAAG 300
TGCGCGGCCG GAGCTCAAGG ACTCGCTCGA CTGGACCCGG CACAACTACT ACGAGAGCTA 360
CCCGCTGAAC CCCGCGGCCG TGCCGGATAA CGTGGAGAGA GCTGATGCCT TACAGCTGTC 420
GGTGAAAGAG TTCGTGGAGC GCTACGAGAG GCCTTACAAG CCCGTGGTTC TGCTCAATGC 480
ACAAGAGGGC TGGTCCGCAC AGGAGAAATG GACTCTGGAG CGCCTCAAAA GGAAATACCG 540
GAACCAGAAG TTCAAGTGCG GCGAGGATAA TGACGGCTAC TCGGTTAAGA TGAAGATGAA 600
GTACTACATC GAGTACATGG AGAGCACCCG CGATGACAGT CCCCTTTACA TCTTCGATAG 660
CAGCTATGGC GAACACCCCA AAAGAAGGAA ACTTTTGGAA GACTACAAGG TGCCCAAGTT 720
TTTCACAGAT GATCTTTTCC AATACGCGGG GGAGAAACGC AGACCCCCTT ACAGGTGGTT 780
TGTGATGGGG CCACCGCGTT CTGGAACTGG GATTCACATC GACCCTCTGG GGACCAGTGC 840
CTGGAATGCC TTAGTTCAGG GTCACAAGCG GTGGTGCCTC TTCCCAACAA ACACACCCAG 900
AGAACTCATC AAGGTGACCC GAGAAGAAGG AGGGAACCAA CAGGATGAAG CAATTACCTG 960
GTTTAATGTC ATCTATCCCC GGACACAGCT TCCAACCTGG CCACCTGAAT TCAAACCCCT 1020
GGAGATATTA CAGAAACCAG GAGAAACTGT CTTTGTACCA GGGGGCTGGT GGCATGTTGT 1080
CCTCAACCTT GACACCACCA TTGCCATCAC CCAGAACTTT GCCAGCAGCA CCAACTTCCC 1140
TGTTGTGTGG CACAAGACGG TAAGAGGGAG ACCAAAGTTA TCAAGGAAGT GGTATAGGAT 1200
CTTGAAACAG GAGCACCCTG AGCTGGCAGT CCTGGCCGAC GCAGTTGACC TCCAGGAGTC 1260
CACAGGCATT GCCTCTGACA GCTCCAGCGA CTCTTCTAGC TCCTCTAGTT CCAGCTCGTC 1320
AGACTCGGAC TCAGAGTGTG AATCTGGGTC AGAAGGTGAT GGGACGACAC ACCGCAGGAA 1380
GAAGAGGAGA ACCTGCAGCA TGGTGGGAAA TGGGGACACT ACCTCCCAGG ATGACTGTGT 1440
GAGCAAAGAG CGCAGCTCCT CCAGGTGACC ACATGTGGCC GCTGTCTGTG CCAGGATATG 1500
CTCGCAGCCA GGCTTGGGGG GCTGACACCC AGAGAACAAG GACACTCAGA TGGGAGTTGG 1560
TAGTACGTGG TACAGTGGCT TTTCTCTGTG GTCATGTCTT AGGGGCAAAG GCGTGTGGAT 1620
GGTGCCAATG AAACCCTTTA CCTATTTAAT AAAAACGGAT ACATTTTA 1669
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR003347--JmjC_dom
PROSITE

PS51184--JMJC
Pfam

PF02373--JmjC
Gene Ontology

GO:0005829--C:cytosol
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0033746--F:histone demethylase activity (H3-R2 specific)
GO:0033749--F:histone demethylase activity (H4-R3 specific)
GO:0042802--F:identical protein binding
GO:0005506--F:iron ion binding
GO:0070815--F:peptidyl-lysine 5-dioxygenase activity
GO:0042803--F:protein homodimerization activity
GO:0004872--F:receptor activity
GO:0003723--F:RNA binding
GO:0003727--F:single-stranded RNA binding
GO:0043277--P:apoptotic cell clearance
GO:0001568--P:blood vessel development
GO:0007166--P:cell surface receptor signaling pathway
GO:0048821--P:erythrocyte development
GO:0007507--P:heart development
GO:0070078--P:histone H3-R2 demethylation
GO:0070079--P:histone H4-R3 demethylation
GO:0001822--P:kidney development
GO:0030324--P:lung development
GO:0042116--P:macrophage activation
GO:0006397--P:mRNA processing
GO:0018395--P:peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
GO:0043654--P:recognition of apoptotic cell
GO:0048024--P:regulation of mRNA splicing, via spliceosome
GO:0006355--P:regulation of transcription, DNA-templated
GO:0060041--P:retina development in camera-type eye
GO:0008380--P:RNA splicing
GO:0002040--P:sprouting angiogenesis
GO:0033077--P:T cell differentiation in thymus
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0002 ENSRNOP00000062806.2 Rattus norvegicus 100 0.0 765
WERAM-Cap-0046 ENSCPOP00000003815.2 Cavia porcellus 98 0.0 757
WERAM-Otg-0222 ENSOGAP00000019826.1 Otolemur garnettii 98 0.0 754
WERAM-Paa-0141 ENSPANP00000016217.1 Papio anubis 98 0.0 754
WERAM-Bot-0168 ENSBTAP00000025492.2 Bos taurus 98 0.0 753
WERAM-Chs-0054 ENSCSAP00000001424.1 Chlorocebus sabaeus 98 0.0 753
WERAM-Hos-0028 ENSP00000380750.4 Homo sapiens 98 0.0 751
WERAM-Pat-0079 ENSPTRP00000016473.5 Pan troglodytes 98 0.0 751
WERAM-Gog-0158 ENSGGOP00000014007.2 Gorilla gorilla 98 0.0 751
WERAM-Fec-0199 ENSFCAP00000017315.1 Felis catus 98 0.0 751
WERAM-Dio-0147 ENSDORP00000013595.1 Dipodomys ordii 97 0.0 751
WERAM-Ict-0020 ENSSTOP00000001294.2 Ictidomys tridecemlineatus 98 0.0 751
WERAM-Tub-0106 ENSTBEP00000012083.1 Tupaia belangeri 97 0.0 750
WERAM-Caf-0062 ENSCAFP00000007665.3 Canis familiaris 97 0.0 749
WERAM-Aim-0155 ENSAMEP00000014340.1 Ailuropoda melanoleuca 97 0.0 749
WERAM-Mup-0155 ENSMPUP00000013325.1 Mustela putorius furo 97 0.0 746
WERAM-Mae-0146 ENSMEUP00000015287.1 Macropus eugenii 97 0.0 746
WERAM-Tut-0019 ENSTTRP00000001611.1 Tursiops truncatus 97 0.0 746
WERAM-Sus-0155 ENSSSCP00000019843.1 Sus scrofa 97 0.0 745
WERAM-Dan-0135 ENSDNOP00000033761.1 Dasypus novemcinctus 97 0.0 743
WERAM-Myl-0109 ENSMLUP00000008847.2 Myotis lucifugus 97 0.0 741
WERAM-Sah-0060 ENSSHAP00000006947.1 Sarcophilus harrisii 95 0.0 737
WERAM-Gaga-0019 ENSGALP00000002781.3 Gallus gallus 94 0.0 734
WERAM-Fia-0009 ENSFALP00000000934.1 Ficedula albicollis 94 0.0 731
WERAM-Tag-0108 ENSTGUP00000008044.1 Taeniopygia guttata 93 0.0 719
WERAM-Anc-0089 ENSACAP00000008327.2 Anolis carolinensis 91 0.0 714
WERAM-Ova-0063 ENSOARP00000007146.1 Ovis aries 93 0.0 704
WERAM-Eqc-0170 ENSECAP00000018718.1 Equus caballus 93 0.0 701
WERAM-Orc-0189 ENSOCUP00000016193.1 Oryctolagus cuniculus 95 0.0 695
WERAM-Caj-0138 ENSCJAP00000024741.2 Callithrix jacchus 98 0.0 694
WERAM-Lac-0130 ENSLACP00000015343.2 Latimeria chalumnae 87 0.0 689
WERAM-Orn-0113 ENSONIP00000011746.1 Oreochromis niloticus 84 0.0 679
WERAM-Leo-0105 ENSLOCP00000013846.1 Lepisosteus oculatus 87 0.0 678
WERAM-Loa-0203 ENSLAFP00000018854.1 Loxodonta africana 97 0.0 678
WERAM-Xet-0121 ENSXETP00000042228.2 Xenopus tropicalis 85 0.0 676
WERAM-Mim-0148 ENSMICP00000015443.1 Microcebus murinus 99 0.0 671
WERAM-Tar-0008 ENSTRUP00000002033.1 Takifugu rubripes 85 0.0 669
WERAM-Pof-0111 ENSPFOP00000009393.2 Poecilia formosa 85 0.0 669
WERAM-Orla-0200 ENSORLP00000023114.1 Oryzias latipes 84 0.0 665
WERAM-Meg-0041 ENSMGAP00000003880.2 Meleagris gallopavo 95 0.0 659
WERAM-Dar-0223 ENSDARP00000139813.1 Danio rerio 84 0.0 659
WERAM-Anp-0031 ENSAPLP00000003577.1 Anas platyrhynchos 95 0.0 658
WERAM-Ora-0097 ENSOANP00000018329.1 Ornithorhynchus anatinus 96 0.0 657
WERAM-Ten-0076 ENSTNIP00000009269.1 Tetraodon nigroviridis 83 0.0 656
WERAM-Pes-0011 ENSPSIP00000002948.1 Pelodiscus sinensis 95 0.0 653
WERAM-Prc-0013 ENSPCAP00000000938.1 Procavia capensis 97 0.0 645
WERAM-Ocp-0066 ENSOPRP00000005803.1 Ochotona princeps 95 0.0 642
WERAM-Gam-0076 ENSGMOP00000008186.1 Gadus morhua 79 0.0 639
WERAM-Gaa-0152 ENSGACP00000019814.1 Gasterosteus aculeatus 80 0.0 637
WERAM-Asm-0055 ENSAMXP00000006811.1 Astyanax mexicanus 85 1e-164 577
WERAM-Ect-0080 ENSETEP00000008689.1 Echinops telfairi 83 2e-164 575
WERAM-Pem-0032 ENSPMAP00000004415.1 Petromyzon marinus 78 7e-163 570
WERAM-Mam-0203 ENSMMUP00000029497.2 Macaca mulatta 98 3e-157 552
WERAM-Mod-0018 ENSMODP00000032069.1 Monodelphis domestica 97 1e-150 530
WERAM-Cii-0038 ENSCINP00000014659.3 Ciona intestinalis 71 2e-146 516
WERAM-Cis-0078 ENSCSAVP00000016921.1 Ciona savignyi 72 3e-145 512
WERAM-Drm-0068 FBpp0083632 Drosophila melanogaster 70 4e-145 511
WERAM-Vip-0045 ENSVPAP00000004119.1 Vicugna pacos 97 4e-135 478
WERAM-Nol-0028 ENSNLEP00000003064.2 Nomascus leucogenys 99 6e-113 404
WERAM-Cae-0017 F29B9.4a Caenorhabditis elegans 56 1e-106 383
WERAM-Met-0103 KEH30262 Medicago truncatula 22 2e-06 51.2
WERAM-Sei-0115 Si029989m Setaria italica 23 5e-06 49.7
Created Date 25-Jun-2016