WERAM Information

Tag Content
WERAM ID WERAM-Hos-0028
Ensembl Protein ID ENSP00000380750.4
Uniprot Accession Q6NYC1; JMJD6_HUMAN; B3KMN8; B4DGX1; Q86VY0; Q8IUM5; Q9Y4E2
Genbank Protein ID NP_001074930.1; NP_055982.2
Protein Name Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Genbank Nucleotide ID NM_001081461.1; NM_015167.2
Gene Name JMJD6;PTDSR
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000070495.14 ENST00000397625.8 ENSP00000380750.4
ENSG00000070495.14 ENST00000303996.10 ENSP00000302916.6
ENSG00000070495.14 ENST00000445478.6 ENSP00000394085.2
ENSG00000070495.14 ENST00000542934.5 ENSP00000442362.1
ENSG00000070495.14 ENST00000585429.1 ENSP00000465330.1
ENSG00000070495.14 ENST00000617192.4 ENSP00000483941.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JmjC_only Jmjc H3R2; H4R3; H1.4K25 R,K 20889125
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JmjC_only 9.90e-55 186.6 147 301
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.
Domain Profile
  HDM JmjC_only
      JmjC_only.txt   2 ledylvpktfsdqlwqlkeelsepfyclvgsnwfltGpassgfplHvddi..eaflvqveGrkrwrlyepsepaellklasdeqvkqedlll 91 
                        ledy+vpk+f+d+l+q+++e+++p+y+     wf++Gp++sg+++H+d++  +a++++v+G+krw+l+++s+p+el+k+++de+++q+d+++
  ENSP00000380750.4 147 LEDYKVPKFFTDDLFQYAGEKRRPPYR-----WFVMGPPRSGTGIHIDPLgtSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAI 233
                        689************************.....************************************************************ PP
      JmjC_only.txt  92 tkftliaprplletvle..........pgellyiprgtwHqalsldvtlsvsqnfssetflenvvlka 149
                        t+f++i+pr++l+t+++          pge++++p+g+wH++l+ld+t++++qnf+s+t++++v++k+
  ENSP00000380750.4 234 TWFNVIYPRTQLPTWPPefkpleilqkPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKT 301
                        ******************************************************************96 PP
Protein Sequence
(Fasta)		MNHKSKKRIR EAKRSARPEL KDSLDWTRHN YYESFSLSPA AVADNVERAD ALQLSVEEFV 60
ERYERPYKPV VLLNAQEGWS AQEKWTLERL KRKYRNQKFK CGEDNDGYSV KMKMKYYIEY 120
MESTRDDSPL YIFDSSYGEH PKRRKLLEDY KVPKFFTDDL FQYAGEKRRP PYRWFVMGPP 180
RSGTGIHIDP LGTSAWNALV QGHKRWCLFP TSTPRELIKV TRDEGGNQQD EAITWFNVIY 240
PRTQLPTWPP EFKPLEILQK PGETVFVPGG WWHVVLNLDT TIAITQNFAS STNFPVVWHK 300
TVRGRPKLSR KWYRILKQEH PELAVLADSV DLQESTGIAS DSSSDSSSSS SSSSSDSDSE 360
CESGSEGDGT VHRRKKRRTC SMVGNGDTTS QDDCVSKERS SSR 403
Nucleotide Sequence
(Fasta)		AGCGAAGGGC GTTTGGGTAC TGCCGTCGCC GCCGCCCAGG CCGGGGAGGG GTGCGTTAGT 60
GTCAGGAAGC GGGCTGCGCC GAGGTCGTAG CGGAACCAGC TGGCGACCCC GCAGAATGAA 120
CCACAAGAGC AAGAAGCGCA TCCGCGAGGC CAAGCGGAGT GCGCGGCCGG AGCTCAAGGA 180
CTCGCTGGAT TGGACCCGGC ACAACTACTA CGAGAGCTTC TCGCTGAGCC CGGCGGCCGT 240
GGCGGATAAC GTGGAAAGGG CAGATGCTTT ACAGCTGTCT GTGGAAGAAT TTGTGGAGCG 300
GTATGAAAGA CCTTACAAGC CCGTGGTTTT GTTGAATGCG CAAGAGGGCT GGTCTGCGCA 360
GGAGAAATGG ACTCTGGAGC GCCTAAAAAG GAAATATCGG AACCAGAAGT TCAAGTGTGG 420
TGAGGATAAC GATGGCTACT CAGTGAAGAT GAAGATGAAA TACTACATCG AGTACATGGA 480
GAGCACTCGA GATGATAGTC CCCTTTACAT CTTTGACAGC AGCTATGGTG AACACCCTAA 540
AAGAAGGAAA CTTTTGGAAG ACTACAAGGT GCCAAAGTTT TTCACTGATG ACCTTTTCCA 600
GTATGCTGGG GAGAAGCGCA GGCCCCCTTA CAGGTGGTTT GTGATGGGGC CACCACGCTC 660
CGGAACTGGG ATTCACATCG ACCCTCTGGG AACCAGTGCC TGGAATGCCT TAGTTCAGGG 720
CCACAAGCGC TGGTGCCTGT TTCCTACCAG CACTCCCAGG GAACTCATCA AAGTGACCCG 780
AGACGAAGGA GGGAACCAGC AAGACGAAGC TATTACCTGG TTTAATGTTA TTTATCCCCG 840
GACACAGCTT CCAACCTGGC CACCTGAATT CAAACCCCTG GAAATCTTAC AAAAACCAGG 900
AGAGACTGTC TTTGTACCAG GAGGCTGGTG GCATGTTGTC CTCAATCTCG ACACTACTAT 960
CGCCATCACC CAAAATTTTG CCAGCAGCAC CAACTTCCCT GTGGTATGGC ACAAGACGGT 1020
AAGAGGGAGA CCAAAGTTAT CAAGGAAATG GTATAGGATT TTGAAGCAAG AGCACCCCGA 1080
GTTGGCAGTC CTCGCAGACT CGGTTGACCT TCAGGAGTCC ACAGGGATAG CTTCCGACAG 1140
CTCCAGCGAC TCTTCCAGCT CCTCCAGCTC CAGTTCGTCA GACTCCGACT CAGAGTGCGA 1200
GTCTGGATCC GAGGGCGATG GGACAGTGCA CCGCAGGAAG AAGAGGAGGA CGTGCAGCAT 1260
GGTGGGAAAC GGGGACACCA CCTCCCAGGA CGACTGTGTC AGCAAAGAGC GCAGCTCCTC 1320
CAGGTGACCC AGCAAGGCTG TTGTCTGTAT GGAAGGACAC GCTCGCGGCA AGGGCAGGGC 1380
CTGGGGAGGG TGGCCTGTCC AGTCCTGCAG ACAAGGGGAG GCCTGACAGA GCCCAAGAAT 1440
GAGGACACCC TCGGCACGGG AACCCATTCA CTTAGCGTTT GCTCCAGTAG CTTTCCCTCT 1500
GCTACCAATG CAGATAAACG CGGCTTGTTT TACTCAGGCA AGAGAATGTG AATAGTGCCA 1560
AGAAAATCCT TTACATTATT TAATAAAAAT TGAATCCATT TTC 1604
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR003347--JmjC_dom
PROSITE

PS51184--JMJC
Pfam

PF02373--JmjC
Gene Ontology

GO:0005829--C:cytosol
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0032452--F:histone demethylase activity
GO:0033746--F:histone demethylase activity (H3-R2 specific)
GO:0033749--F:histone demethylase activity (H4-R3 specific)
GO:0042802--F:identical protein binding
GO:0005506--F:iron ion binding
GO:0070815--F:peptidyl-lysine 5-dioxygenase activity
GO:0004872--F:receptor activity
GO:0003723--F:RNA binding
GO:0003727--F:single-stranded RNA binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0048821--P:erythrocyte development
GO:0007507--P:heart development
GO:0070078--P:histone H3-R2 demethylation
GO:0070079--P:histone H4-R3 demethylation
GO:0001822--P:kidney development
GO:0030324--P:lung development
GO:0042116--P:macrophage activation
GO:0006397--P:mRNA processing
GO:0018395--P:peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
GO:0043654--P:recognition of apoptotic cell
GO:0048024--P:regulation of mRNA splicing, via spliceosome
GO:0006355--P:regulation of transcription, DNA-templated
GO:0060041--P:retina development in camera-type eye
GO:0008380--P:RNA splicing
GO:0002040--P:sprouting angiogenesis
GO:0033077--P:T cell differentiation in thymus
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0079 ENSPTRP00000016473.5 Pan troglodytes 100 0.0 766
WERAM-Gog-0158 ENSGGOP00000014007.2 Gorilla gorilla 100 0.0 766
WERAM-Paa-0141 ENSPANP00000016217.1 Papio anubis 100 0.0 765
WERAM-Chs-0054 ENSCSAP00000001424.1 Chlorocebus sabaeus 100 0.0 764
WERAM-Otg-0222 ENSOGAP00000019826.1 Otolemur garnettii 99 0.0 761
WERAM-Ict-0020 ENSSTOP00000001294.2 Ictidomys tridecemlineatus 99 0.0 760
WERAM-Cap-0046 ENSCPOP00000003815.2 Cavia porcellus 98 0.0 758
WERAM-Tub-0106 ENSTBEP00000012083.1 Tupaia belangeri 98 0.0 758
WERAM-Mae-0146 ENSMEUP00000015287.1 Macropus eugenii 98 0.0 758
WERAM-Bot-0168 ENSBTAP00000025492.2 Bos taurus 98 0.0 757
WERAM-Caf-0062 ENSCAFP00000007665.3 Canis familiaris 98 0.0 757
WERAM-Aim-0155 ENSAMEP00000014340.1 Ailuropoda melanoleuca 98 0.0 756
WERAM-Fec-0199 ENSFCAP00000017315.1 Felis catus 98 0.0 756
WERAM-Mup-0155 ENSMPUP00000013325.1 Mustela putorius furo 98 0.0 753
WERAM-Dio-0147 ENSDORP00000013595.1 Dipodomys ordii 98 0.0 753
WERAM-Ran-0002 ENSRNOP00000062806.2 Rattus norvegicus 98 0.0 753
WERAM-Tut-0019 ENSTTRP00000001611.1 Tursiops truncatus 98 0.0 752
WERAM-Myl-0109 ENSMLUP00000008847.2 Myotis lucifugus 98 0.0 752
WERAM-Mum-0201 ENSMUSP00000047570.3 Mus musculus 98 0.0 751
WERAM-Dan-0135 ENSDNOP00000033761.1 Dasypus novemcinctus 98 0.0 751
WERAM-Sah-0060 ENSSHAP00000006947.1 Sarcophilus harrisii 97 0.0 749
WERAM-Sus-0155 ENSSSCP00000019843.1 Sus scrofa 98 0.0 746
WERAM-Gaga-0019 ENSGALP00000002781.3 Gallus gallus 95 0.0 739
WERAM-Fia-0009 ENSFALP00000000934.1 Ficedula albicollis 95 0.0 736
WERAM-Tag-0108 ENSTGUP00000008044.1 Taeniopygia guttata 93 0.0 724
WERAM-Anc-0089 ENSACAP00000008327.2 Anolis carolinensis 92 0.0 718
WERAM-Ova-0063 ENSOARP00000007146.1 Ovis aries 94 0.0 712
WERAM-Caj-0138 ENSCJAP00000024741.2 Callithrix jacchus 99 0.0 708
WERAM-Eqc-0170 ENSECAP00000018718.1 Equus caballus 93 0.0 704
WERAM-Orc-0189 ENSOCUP00000016193.1 Oryctolagus cuniculus 96 0.0 699
WERAM-Lac-0130 ENSLACP00000015343.2 Latimeria chalumnae 88 0.0 693
WERAM-Leo-0105 ENSLOCP00000013846.1 Lepisosteus oculatus 88 0.0 685
WERAM-Loa-0203 ENSLAFP00000018854.1 Loxodonta africana 98 0.0 684
WERAM-Orn-0113 ENSONIP00000011746.1 Oreochromis niloticus 84 0.0 680
WERAM-Xet-0121 ENSXETP00000042228.2 Xenopus tropicalis 85 0.0 676
WERAM-Mim-0148 ENSMICP00000015443.1 Microcebus murinus 99 0.0 675
WERAM-Tar-0008 ENSTRUP00000002033.1 Takifugu rubripes 86 0.0 671
WERAM-Pof-0111 ENSPFOP00000009393.2 Poecilia formosa 85 0.0 671
WERAM-Orla-0200 ENSORLP00000023114.1 Oryzias latipes 84 0.0 665
WERAM-Dar-0223 ENSDARP00000139813.1 Danio rerio 85 0.0 664
WERAM-Meg-0041 ENSMGAP00000003880.2 Meleagris gallopavo 95 0.0 664
WERAM-Ora-0097 ENSOANP00000018329.1 Ornithorhynchus anatinus 97 0.0 663
WERAM-Anp-0031 ENSAPLP00000003577.1 Anas platyrhynchos 95 0.0 662
WERAM-Ten-0076 ENSTNIP00000009269.1 Tetraodon nigroviridis 83 0.0 658
WERAM-Pes-0011 ENSPSIP00000002948.1 Pelodiscus sinensis 95 0.0 654
WERAM-Prc-0013 ENSPCAP00000000938.1 Procavia capensis 98 0.0 649
WERAM-Ocp-0066 ENSOPRP00000005803.1 Ochotona princeps 95 0.0 645
WERAM-Gam-0076 ENSGMOP00000008186.1 Gadus morhua 80 0.0 642
WERAM-Gaa-0152 ENSGACP00000019814.1 Gasterosteus aculeatus 80 0.0 637
WERAM-Asm-0055 ENSAMXP00000006811.1 Astyanax mexicanus 87 1e-166 583
WERAM-Ect-0080 ENSETEP00000008689.1 Echinops telfairi 84 2e-166 582
WERAM-Pem-0032 ENSPMAP00000004415.1 Petromyzon marinus 78 3e-163 571
WERAM-Mam-0203 ENSMMUP00000029497.2 Macaca mulatta 100 3e-160 562
WERAM-Mod-0018 ENSMODP00000032069.1 Monodelphis domestica 99 1e-152 536
WERAM-Cii-0038 ENSCINP00000014659.3 Ciona intestinalis 72 6e-148 521
WERAM-Cis-0078 ENSCSAVP00000016921.1 Ciona savignyi 72 2e-146 516
WERAM-Drm-0068 FBpp0083632 Drosophila melanogaster 71 6e-146 514
WERAM-Vip-0045 ENSVPAP00000004119.1 Vicugna pacos 98 3e-136 482
WERAM-Nol-0028 ENSNLEP00000003064.2 Nomascus leucogenys 100 8e-114 407
WERAM-Cae-0017 F29B9.4a Caenorhabditis elegans 56 2e-108 390
WERAM-Met-0103 KEH30262 Medicago truncatula 23 3e-07 53.9
WERAM-Sei-0115 Si029989m Setaria italica 24 7e-07 52.8
Created Date 25-Jun-2016