WERAM Information

Tag Content
WERAM ID WERAM-Drm-0068
Ensembl Protein ID FBpp0083632
Uniprot Accession Q9VD28; JMJD6_DROME
Genbank Protein ID NP_651026.1
Protein Name Bifunctional arginine demethylase and lysyl-hydroxylase PSR
Genbank Nucleotide ID NM_142769.4
Gene Name PSR;dPSR;BEST:LD22859;L0022859;CG5383;JMJD6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0038948 FBtr0084239 FBpp0083632
FBgn0038948 FBtr0330378 FBpp0303404
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JmjC_only Jmjc R 26207949
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JmjC_only 6.60e-55 185.4 2 306
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)		 Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase.
Domain Profile
  HDM JmjC_only
  JmjC_only.txt  2 ledylvpktfsdqlwqlkeel 22
                   +e+++ pk+++++++++k+++
    FBpp0083632  2 SEEFKLPKRSRKRTREVKRKA 22
                   678899999999999999876 PP
  JmjC_only.txt   2 ledylvpktfsdqlwqlkeelsepfyclvgsnwfltGpassgfplHvddi..eaflvqveGrkrwrlyepsepaellklasdeqvkqedllltkft 95 
                    l+dy+vpk+f+d+l+q+++e+++p+y+     wf++Gpa+sg+++H+d++  +a++++++G+krw+l+++++p+ellk++s +++kq+d+++t+f+
    FBpp0083632 152 LDDYVVPKYFRDDLFQYCGENRRPPYR-----WFVMGPARSGTGIHIDPLgtSAWNTLIRGHKRWCLFPTQTPKELLKVTSAMGGKQRDEAITWFS 242
                    689************************.....**************************************************************** PP
  JmjC_only.txt  96 liaprplletvle..........pgellyiprgtwHqalsldvtlsvsqnfssetflenvvlka 149
                    +i+pr++l++++e          +ge++++p+g+wH++l++d+t++++qnfss+t++++v++k+
    FBpp0083632 243 TIYPRTQLPSWPEqyrpievlqgAGETVFVPGGWWHVVLNMDDTIAITQNFSSQTNFPCVWHKT 306
                    **************************************************************96 PP
Protein Sequence
(Fasta)		MSEEFKLPKR SRKRTREVKR KARPELDGEN AWSAMRYCEK FEPFWDFTDN LERIEESQVP 60
ESEFIERFER PYKPVVIRGC TDGWLALEKW TLARLAKKYR NQKFKCGEDN EGYSVKMKMK 120
YYVEYMQSTR DDSPLYIFDS SFGEHHRRRK LLDDYVVPKY FRDDLFQYCG ENRRPPYRWF 180
VMGPARSGTG IHIDPLGTSA WNTLIRGHKR WCLFPTQTPK ELLKVTSAMG GKQRDEAITW 240
FSTIYPRTQL PSWPEQYRPI EVLQGAGETV FVPGGWWHVV LNMDDTIAIT QNFSSQTNFP 300
CVWHKTVRGR PKLSRKWLRV LRDQRPELAQ IADSINLNES TGFASDSSSN SSSSSSSSSS 360
SSEEEESDDG GDSNTDSGQE SLTAKKKKKR RMAGGGSGSG SMGGSSRS 408
Nucleotide Sequence
(Fasta)		CTGCGGCGTC TGGCCACACT GCACTCACGC TGCTTTAATT TCCAGGAGCT GTGGAAAATT 60
GGCCAATTTC AGCAGGATGA GCGAGGAATT CAAGCTGCCC AAGCGTTCCC GCAAGCGCAC 120
ACGTGAGGTG AAGCGCAAGG CTCGTCCGGA GCTGGACGGC GAGAATGCCT GGTCGGCCAT 180
GCGGTACTGT GAGAAGTTCG AGCCATTTTG GGATTTCACC GATAACCTGG AGCGGATCGA 240
GGAGTCGCAG GTGCCGGAGT CGGAGTTCAT CGAACGCTTC GAGCGACCCT ACAAGCCGGT 300
GGTCATTCGC GGCTGCACCG ATGGCTGGTT GGCGCTGGAA AAGTGGACAC TAGCCCGCCT 360
GGCCAAGAAG TATCGCAACC AGAAGTTCAA GTGCGGCGAG GACAACGAGG GCTATAGCGT 420
CAAGATGAAG ATGAAGTACT ACGTGGAGTA CATGCAGAGC ACGCGCGATG ACAGCCCGCT 480
GTACATCTTC GACAGCAGCT TCGGCGAACA CCATCGTCGG CGCAAGCTCC TGGATGACTA 540
TGTGGTGCCC AAGTATTTTC GCGACGACCT CTTCCAGTAC TGCGGCGAGA ATCGTCGTCC 600
GCCTTACCGC TGGTTTGTCA TGGGACCGGC TCGCTCCGGC ACCGGCATCC ACATTGATCC 660
ACTGGGCACT AGTGCCTGGA ACACGCTGAT CCGCGGCCAC AAGCGCTGGT GCCTGTTCCC 720
CACCCAAACG CCCAAGGAGC TGCTCAAGGT CACCAGTGCC ATGGGTGGCA AGCAGCGAGA 780
CGAGGCCATC ACCTGGTTCA GCACCATATA TCCGCGCACC CAGCTGCCTA GTTGGCCGGA 840
GCAATACCGC CCCATCGAAG TGCTGCAGGG AGCAGGCGAG ACTGTATTCG TGCCCGGCGG 900
CTGGTGGCAC GTGGTGCTCA ACATGGACGA CACCATTGCC ATCACCCAGA ACTTCAGTTC 960
GCAGACGAAC TTCCCCTGCG TCTGGCACAA GACTGTTCGC GGCCGGCCAA AGTTGTCACG 1020
CAAGTGGCTG CGCGTGCTGC GAGACCAGCG ACCGGAGCTG GCCCAGATCG CCGATAGTAT 1080
TAACCTGAAC GAGAGCACCG GCTTCGCATC GGACAGCTCC AGCAATTCAA GCTCCTCCTC 1140
GTCGAGCAGC TCCTCGTCTT CGGAGGAGGA GGAGAGCGAC GATGGCGGCG ATTCCAACAC 1200
GGACAGCGGC CAGGAGAGTC TGACGGCCAA GAAGAAAAAG AAGCGGCGCA TGGCTGGCGG 1260
CGGCTCCGGG TCCGGCTCCA TGGGCGGATC ATCGCGTTCC TGATCCAGGG AGCGGGCCAA 1320
GCGCAAGGGC TTGCTCATGC GCCTCTTTCA ACGCCAACTG ATGCTGCTGA GAGGACTGCC 1380
CCGCCGCTGC CGGCTCAGTT AGCACTGAGG TCGCGATCAT ACTCTGCAGA GTTTTGTGTA 1440
TTTTTCTACT TGGACCAGCA TGTTTGCAGC TCCTGGATCC CGTGCTCGCC CTCATCGAAT 1500
GCCTGCTCCC TGATTTCAAT AGATGCTCCG GACGTGACTC ATTAGCGTAA ACCCTAAATG 1560
CAAATAAATA AATGAATCCA ATATGTTTGT 1591
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR003347--JmjC_dom
PROSITE

PS51184--JMJC
Pfam

PF02373--JmjC
Gene Ontology

GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0070815--F:peptidyl-lysine 5-dioxygenase activity
GO:0035212--P:cell competition in a multicellular organism
GO:0016568--P:chromatin modification
GO:0043066--P:negative regulation of apoptotic process
GO:0046329--P:negative regulation of JNK cascade
GO:0018395--P:peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Mae-0146 ENSMEUP00000015287.1 Macropus eugenii 71 2e-146 515
WERAM-Paa-0141 ENSPANP00000016217.1 Papio anubis 71 3e-146 515
WERAM-Leo-0105 ENSLOCP00000013846.1 Lepisosteus oculatus 70 4e-146 514
WERAM-Hos-0028 ENSP00000380750.4 Homo sapiens 71 6e-146 514
WERAM-Otg-0222 ENSOGAP00000019826.1 Otolemur garnettii 71 1e-145 513
WERAM-Chs-0054 ENSCSAP00000001424.1 Chlorocebus sabaeus 71 1e-145 513
WERAM-Tut-0019 ENSTTRP00000001611.1 Tursiops truncatus 71 1e-145 513
WERAM-Bot-0168 ENSBTAP00000025492.2 Bos taurus 71 1e-145 513
WERAM-Pat-0079 ENSPTRP00000016473.5 Pan troglodytes 71 1e-145 513
WERAM-Gog-0158 ENSGGOP00000014007.2 Gorilla gorilla 71 1e-145 513
WERAM-Cap-0046 ENSCPOP00000003815.2 Cavia porcellus 71 2e-145 513
WERAM-Aim-0155 ENSAMEP00000014340.1 Ailuropoda melanoleuca 71 2e-145 513
WERAM-Caf-0062 ENSCAFP00000007665.3 Canis familiaris 71 2e-145 513
WERAM-Mup-0155 ENSMPUP00000013325.1 Mustela putorius furo 71 2e-145 512
WERAM-Sah-0060 ENSSHAP00000006947.1 Sarcophilus harrisii 71 2e-145 512
WERAM-Fec-0199 ENSFCAP00000017315.1 Felis catus 71 2e-145 512
WERAM-Orla-0200 ENSORLP00000023114.1 Oryzias latipes 69 2e-145 512
WERAM-Dio-0147 ENSDORP00000013595.1 Dipodomys ordii 70 2e-145 512
WERAM-Caj-0138 ENSCJAP00000024741.2 Callithrix jacchus 71 3e-145 512
WERAM-Tub-0106 ENSTBEP00000012083.1 Tupaia belangeri 71 4e-145 511
WERAM-Dan-0135 ENSDNOP00000033761.1 Dasypus novemcinctus 71 5e-145 511
WERAM-Dar-0223 ENSDARP00000139813.1 Danio rerio 69 5e-145 511
WERAM-Mum-0201 ENSMUSP00000047570.3 Mus musculus 70 6e-145 511
WERAM-Ran-0002 ENSRNOP00000062806.2 Rattus norvegicus 70 7e-145 511
WERAM-Gaga-0019 ENSGALP00000002781.3 Gallus gallus 70 7e-145 510
WERAM-Ict-0020 ENSSTOP00000001294.2 Ictidomys tridecemlineatus 70 8e-145 510
WERAM-Fia-0009 ENSFALP00000000934.1 Ficedula albicollis 71 9e-145 510
WERAM-Orn-0113 ENSONIP00000011746.1 Oreochromis niloticus 69 1e-144 510
WERAM-Xet-0121 ENSXETP00000042228.2 Xenopus tropicalis 69 5e-144 508
WERAM-Myl-0109 ENSMLUP00000008847.2 Myotis lucifugus 71 6e-144 507
WERAM-Anc-0089 ENSACAP00000008327.2 Anolis carolinensis 70 8e-144 507
WERAM-Sus-0155 ENSSSCP00000019843.1 Sus scrofa 70 1e-143 506
WERAM-Gam-0076 ENSGMOP00000008186.1 Gadus morhua 68 2e-143 506
WERAM-Lac-0130 ENSLACP00000015343.2 Latimeria chalumnae 68 3e-143 505
WERAM-Pof-0111 ENSPFOP00000009393.2 Poecilia formosa 69 5e-143 504
WERAM-Tar-0008 ENSTRUP00000002033.1 Takifugu rubripes 69 2e-142 503
WERAM-Gaa-0152 ENSGACP00000019814.1 Gasterosteus aculeatus 67 5e-142 501
WERAM-Ova-0063 ENSOARP00000007146.1 Ovis aries 70 1e-141 500
WERAM-Tag-0108 ENSTGUP00000008044.1 Taeniopygia guttata 69 1e-141 499
WERAM-Ten-0076 ENSTNIP00000009269.1 Tetraodon nigroviridis 68 4e-141 498
WERAM-Eqc-0170 ENSECAP00000018718.1 Equus caballus 68 2e-139 493
WERAM-Ora-0097 ENSOANP00000018329.1 Ornithorhynchus anatinus 76 4e-139 491
WERAM-Pem-0032 ENSPMAP00000004415.1 Petromyzon marinus 68 6e-139 491
WERAM-Orc-0189 ENSOCUP00000016193.1 Oryctolagus cuniculus 72 7e-139 491
WERAM-Loa-0203 ENSLAFP00000018854.1 Loxodonta africana 74 1e-138 490
WERAM-Mim-0148 ENSMICP00000015443.1 Microcebus murinus 75 2e-138 489
WERAM-Anp-0031 ENSAPLP00000003577.1 Anas platyrhynchos 74 1e-137 487
WERAM-Meg-0041 ENSMGAP00000003880.2 Meleagris gallopavo 74 4e-137 485
WERAM-Ocp-0066 ENSOPRP00000005803.1 Ochotona princeps 75 5e-136 481
WERAM-Asm-0055 ENSAMXP00000006811.1 Astyanax mexicanus 71 2e-135 479
WERAM-Pes-0011 ENSPSIP00000002948.1 Pelodiscus sinensis 73 2e-135 479
WERAM-Prc-0013 ENSPCAP00000000938.1 Procavia capensis 72 3e-135 478
WERAM-Cii-0038 ENSCINP00000014659.3 Ciona intestinalis 64 7e-133 471
WERAM-Cis-0078 ENSCSAVP00000016921.1 Ciona savignyi 61 8e-129 457
WERAM-Ect-0080 ENSETEP00000008689.1 Echinops telfairi 58 8e-113 404
WERAM-Mam-0203 ENSMMUP00000029497.2 Macaca mulatta 70 1e-110 397
WERAM-Mod-0018 ENSMODP00000032069.1 Monodelphis domestica 78 2e-110 396
WERAM-Cae-0017 F29B9.4a Caenorhabditis elegans 56 7e-108 387
WERAM-Vip-0045 ENSVPAP00000004119.1 Vicugna pacos 74 8e-103 371
WERAM-Nol-0028 ENSNLEP00000003064.2 Nomascus leucogenys 76 3e-76 283
WERAM-Xim-0128 ENSXMAP00000010848.1 Xiphophorus maculatus 28 7e-07 52.8
WERAM-Poa-0168 ENSPPYP00000020257.1 Pongo abelii 29 2e-06 51.2
Created Date 25-Jun-2016