| Tag |
Content |
| WERAM ID |
WERAM-Mum-0113 |
| Ensembl Protein ID |
ENSMUSP00000033070.7 |
| Uniprot Accession |
Q9D1P2; KAT8_MOUSE; Q3UIY0; Q8BJ69; Q8BJ76; Q8CI73
|
| Genbank Protein ID |
NP_080646.1
|
| Protein Name |
Histone acetyltransferase KAT8 |
| Genbank Nucleotide ID |
NM_026370.1
|
| Gene Name |
KAT8;Mof;Myst1 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HAT |
MYST |
MYST-type HAT |
H4K16 |
K |
26550034
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HAT |
MYST |
4.00e-129 |
431.2 |
175 |
447 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'. |
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.
|
| Domain Profile |
HAT MYST
MYST.txt 2 kvkniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnl 90
kvk+++ki++g+yei++wy+spfpe++ k++kl++ce+clky+k ++s++ hl +C++r+pPg+eiyrk+++sv+evdGk++k+ycqnl
ENSMUSP00000033070.7 175 KVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKFEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNL 263
7899************************************************************************************* PP
MYST.txt 91 CllaklfldhktlyydvepflFYvltetdekgahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekP 179
Cllaklfldhktly+dvepf+FY+lte d++gah+vGyFskekes + +n+aCil+lPpyqr+GyGk+Li+fsYels+ e+++gsPekP
ENSMUSP00000033070.7 264 CLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKP 352
***************************************************************************************** PP
MYST.txt 180 LsdlgllsYrsyWkevllellkekeekkkitikelskatgiaveDivstleslnlikekkgqyillksekiveellklakskkkklkvd 268
Lsdlg+lsYrsyW++vlle+l ++ + +++ik+ls++t+i+++Di+stl+sln++k++kgq++++ + k+vee+lk+a+ kk+ ++vd
ENSMUSP00000033070.7 353 LSDLGKLSYRSYWSWVLLEIL--RDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVD 439
*********************..9999************************************************************** PP
MYST.txt 269 eeklkwkp 276
+ +lkw+p
ENSMUSP00000033070.7 440 SVCLKWAP 447
******87 PP
|
Protein Sequence
(Fasta) | MAAQGATAAV AATTSGTVGE GEPGPGENAA VEGPARSPGR VSPPTPARGE PEVTVEIGET 60
YLCRRPDSTW HSAEVIQSRV NDQEGREEFY VHYVGFNRRL DEWVDKNRLA LTKTVKDAVQ 120
KNSEKYLSEL AEQPERKITR NQKRKHDEIN HVQKTYAEMD PTTAALEKEH EAITKVKYVD 180
KIHIGNYEID AWYFSPFPED YGKQPKLWLC EYCLKYMKFE KSYRFHLGQC QWRQPPGKEI 240
YRKSNISVYE VDGKDHKIYC QNLCLLAKLF LDHKTLYFDV EPFVFYILTE VDRQGAHIVG 300
YFSKEKESPD GNNVACILTL PPYQRRGYGK FLIAFSYELS KLESTVGSPE KPLSDLGKLS 360
YRSYWSWVLL EILRDFRGTL SIKDLSQMTS ITQNDIISTL QSLNMVKYWK GQHVICVTPK 420
LVEEHLKSAQ YKKPPITVDS VCLKWAPPKH KQVKLSKK 458Protein Fasta Sequence
>ENSMUSP00000033070.7|KAT8;Mof;Myst1|Mus musculus
MAAQGATAAVAATTSGTVGEGEPGPGENAAVEGPARSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKFEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK |
Nucleotide Sequence
(Fasta) | CACTTCCGGC ACAGCAATGG CGGCACAGGG AGCTACAGCT GCAGTTGCTG CAACAACTTC 60
AGGAACTGTA GGGGAGGGAG AGCCCGGCCC GGGGGAAAAT GCAGCAGTCG AGGGGCCTGC 120
CCGGTCCCCG GGCCGGGTCT CTCCGCCGAC TCCGGCGCGT GGCGAACCAG AAGTCACCGT 180
GGAGATCGGA GAAACGTACC TGTGCCGGCG GCCGGATAGC ACCTGGCATT CAGCAGAAGT 240
GATCCAGTCT CGAGTGAATG ACCAGGAAGG CCGAGAAGAA TTCTATGTTC ACTATGTGGG 300
CTTTAACAGG CGACTGGACG AATGGGTGGA CAAGAACCGA CTCGCACTGA CCAAGACAGT 360
GAAGGATGCC GTGCAGAAGA ACTCTGAGAA ATACCTGAGT GAGCTGGCCG AGCAGCCAGA 420
GCGCAAGATC ACTCGAAACC AAAAGCGAAA GCATGATGAG ATCAACCATG TGCAGAAGAC 480
CTATGCAGAG ATGGACCCCA CCACAGCAGC CTTGGAAAAG GAACACGAGG CGATCACCAA 540
AGTGAAGTAT GTAGACAAGA TCCACATTGG GAACTATGAA ATCGATGCCT GGTATTTCTC 600
ACCTTTCCCA GAGGACTATG GGAAGCAGCC CAAGCTTTGG CTCTGCGAGT ACTGCCTCAA 660
ATACATGAAG TTCGAGAAGA GCTACCGCTT CCACCTGGGC CAGTGTCAGT GGCGGCAGCC 720
CCCAGGGAAG GAGATCTATC GAAAGAGCAA CATCTCTGTG TATGAAGTGG ATGGCAAAGA 780
CCACAAGATA TACTGTCAGA ACCTGTGTCT ACTGGCCAAG CTTTTCCTGG ACCACAAGAC 840
CTTGTATTTT GATGTGGAGC CCTTTGTCTT TTACATTCTG ACAGAAGTAG ATAGGCAAGG 900
GGCTCACATT GTTGGCTACT TTTCTAAGGA GAAGGAATCC CCAGATGGAA ACAACGTGGC 960
CTGCATCTTG ACCCTGCCTC CCTACCAGCG GCGTGGCTAT GGGAAGTTTC TCATCGCCTT 1020
CAGTTATGAG CTCTCTAAGC TCGAGAGTAC TGTAGGCTCC CCAGAGAAGC CACTGAGTGA 1080
CCTGGGCAAA CTCAGCTACA GAAGCTACTG GTCATGGGTC TTGCTGGAGA TCCTGCGAGA 1140
CTTCCGGGGC ACATTGTCTA TCAAAGATCT TAGCCAGATG ACCAGCATCA CCCAGAATGA 1200
CATCATCAGC ACCCTGCAGT CCCTCAACAT GGTCAAGTAC TGGAAGGGCC AGCATGTTAT 1260
CTGTGTCACA CCTAAGCTGG TAGAGGAACA CCTCAAAAGT GCCCAGTATA AGAAACCACC 1320
TATCACAGTG GACTCTGTCT GCCTCAAGTG GGCACCCCCG AAGCACAAAC AAGTCAAGCT 1380
TTCCAAGAAG TGAGTGGCCT GTGCCCTGCT TGGGATCTGG GTTTCCTGGC CTCTAACCTG 1440
TAAATATGTG TACAGACCTG TTTTGTGTCA TTTATTCATA AAGTAAAATC TGCTGGTGCA 1500
CTGGACTTTG GAGGTACGCA GAGATGCCAA AGGGTGGTAT TCTTCATTTC ATCTCACAGA 1560
CAGCCAGCTG TGTTAAAAA
Nucleotide Fasta Sequence
>ENSMUSP00000033070.7|MYST|Mus musculus
CACTTCCGGCACAGCAATGGCGGCACAGGGAGCTACAGCTGCAGTTGCTGCAACAACTTCAGGAACTGTAGGGGAGGGAGAGCCCGGCCCGGGGGAAAATGCAGCAGTCGAGGGGCCTGCCCGGTCCCCGGGCCGGGTCTCTCCGCCGACTCCGGCGCGTGGCGAACCAGAAGTCACCGTGGAGATCGGAGAAACGTACCTGTGCCGGCGGCCGGATAGCACCTGGCATTCAGCAGAAGTGATCCAGTCTCGAGTGAATGACCAGGAAGGCCGAGAAGAATTCTATGTTCACTATGTGGGCTTTAACAGGCGACTGGACGAATGGGTGGACAAGAACCGACTCGCACTGACCAAGACAGTGAAGGATGCCGTGCAGAAGAACTCTGAGAAATACCTGAGTGAGCTGGCCGAGCAGCCAGAGCGCAAGATCACTCGAAACCAAAAGCGAAAGCATGATGAGATCAACCATGTGCAGAAGACCTATGCAGAGATGGACCCCACCACAGCAGCCTTGGAAAAGGAACACGAGGCGATCACCAAAGTGAAGTATGTAGACAAGATCCACATTGGGAACTATGAAATCGATGCCTGGTATTTCTCACCTTTCCCAGAGGACTATGGGAAGCAGCCCAAGCTTTGGCTCTGCGAGTACTGCCTCAAATACATGAAGTTCGAGAAGAGCTACCGCTTCCACCTGGGCCAGTGTCAGTGGCGGCAGCCCCCAGGGAAGGAGATCTATCGAAAGAGCAACATCTCTGTGTATGAAGTGGATGGCAAAGACCACAAGATATACTGTCAGAACCTGTGTCTACTGGCCAAGCTTTTCCTGGACCACAAGACCTTGTATTTTGATGTGGAGCCCTTTGTCTTTTACATTCTGACAGAAGTAGATAGGCAAGGGGCTCACATTGTTGGCTACTTTTCTAAGGAGAAGGAATCCCCAGATGGAAACAACGTGGCCTGCATCTTGACCCTGCCTCCCTACCAGCGGCGTGGCTATGGGAAGTTTCTCATCGCCTTCAGTTATGAGCTCTCTAAGCTCGAGAGTACTGTAGGCTCCCCAGAGAAGCCACTGAGTGACCTGGGCAAACTCAGCTACAGAAGCTACTGGTCATGGGTCTTGCTGGAGATCCTGCGAGACTTCCGGGGCACATTGTCTATCAAAGATCTTAGCCAGATGACCAGCATCACCCAGAATGACATCATCAGCACCCTGCAGTCCCTCAACATGGTCAAGTACTGGAAGGGCCAGCATGTTATCTGTGTCACACCTAAGCTGGTAGAGGAACACCTCAAAAGTGCCCAGTATAAGAAACCACCTATCACAGTGGACTCTGTCTGCCTCAAGTGGGCACCCCCGAAGCACAAACAAGTCAAGCTTTCCAAGAAGTGAGTGGCCTGTGCCCTGCTTGGGATCTGGGTTTCCTGGCCTCTAACCTGTAAATATGTGTACAGACCTGTTTTGTGTCATTTATTCATAAAGTAAAATCTGCTGGTGCACTGGACTTTGGAGGTACGCAGAGATGCCAAAGGGTGGTATTCTTCATTTCATCTCACAGACAGCCAGCTGTGTTAAAAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR016181--Acyl_CoA_acyltransferase
IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR002717--HAT_MYST-type
IPR025995--Tudor-knot
|
| PROSITE |
PS51726--MYST_HAT
|
| Pfam |
PF01853--MOZ_SAS
PF11717--Tudor-knot
|
| Gene Ontology |
GO:0000123--C:histone acetyltransferase complex
GO:0000776--C:kinetochore
GO:0071339--C:MLL1 complex
GO:0072487--C:MSL complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016407--F:acetyltransferase activity
GO:0019899--F:enzyme binding
GO:0004402--F:histone acetyltransferase activity
GO:0046972--F:histone acetyltransferase activity (H4-K16 specific)
GO:0043995--F:histone acetyltransferase activity (H4-K5 specific)
GO:0043996--F:histone acetyltransferase activity (H4-K8 specific)
GO:0046872--F:metal ion binding
GO:0035064--F:methylated histone binding
GO:0008134--F:transcription factor binding
GO:0016573--P:histone acetylation
GO:0043984--P:histone H4-K16 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0030099--P:myeloid cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010506--P:regulation of autophagy
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
