Saccharomyces cerevisiae      Me_Reader      PHD

※ PHD family introduction

    PHD: Distinct from the Royal family is the PHD finger, a well-characterized reader of H3K4me3. It contains a C4HC3 motif that coordinates two zinc ions in a cross-brace manner. Such an arrangement produces a globular domain with a small β-sheet and an α-helix. PHD fingers make extensive contacts with H3K4me3, imparting a high degree of specificity. (1)

Reference
1. Musselman CA, Lalonde ME, Cote J, Kutateladze TG.Perceiving the epigenetic landscape through histone readers. Nat Struct Mol Biol.2012;19(12):1218-27. PMID: 23211769.



There are 12 genes.  Reviewed (10 or Unreviewed (2

No.StatusWERAM IDGene/Alias Name
1
WERAM-Sac-0012
JHD1; JHDM1; Jhd1; YER051W
2
WERAM-Sac-0020
Yng2; EAF4; NBN1; YHR090C
3
WERAM-Sac-0025
Bye1; YKL005C; YKL150
4
WERAM-Sac-0027
Set3; YKR029C
5
WERAM-Sac-0036
"Ecm5,YMR176W,YM8010.06"
6
WERAM-Sac-0038
Pho23; YNL097C; N2205
7
WERAM-Sac-0042
Yng1; YOR064C; YOR29-15
8
WERAM-Sac-0049
Spp1; CPS40; SAF41; YPL138C
9
WERAM-Sac-0050
Cti6; RXT1; YPL181W
10
WERAM-Sac-0052
Nto1; YPR031W
11
WERAM-Sac-0015
SNT2
12
WERAM-Sac-0034
RCO1