Homo sapiens      Me_Reader      Chromodomain

※ Chromodomain family introduction

    Chromodomain: The chromodomain is the smallest member, consisting of four curved β-strands and an α-helix. The chromodomains of HP1 and Polycomb were found to recognize histone H3 trimethylated at K9 (H3K9me3) and H3K27me3, respectively, and these proteins were the first examples of readers specific for methyllysine. Chromodomains generally prefer trimethylated lysine, though some have been shown to bind dimethylated species. The aromatic cage of the chromodomain of mouse and fly HP1 contains an aspartate or glutamate residue, accounting for its ability to interact well with H3K9me3 and dimethylated H3K9 (H3K9me2). (1)

Reference
1. Musselman CA, Lalonde ME, Cote J, Kutateladze TG.Perceiving the epigenetic landscape through histone readers. Nat Struct Mol Biol.2012;19(12):1218-27. PMID: 23211769.



There are 13 genes.  Reviewed (7 or Unreviewed (6

No.StatusWERAM IDGene/Alias Name
1
WERAM-Hos-0054
CBX7
2
WERAM-Hos-0062
SUV39H1; MG44; KMT1A; H3-K9-HMTase1
3
WERAM-Hos-0137
CBX4
4
WERAM-Hos-0161
CDYL; CDYL1
5
WERAM-Hos-0184
CDYL2; 2010cell
6
WERAM-Hos-0215
CBX6
7
WERAM-Hos-0226
MPP8; MPHOSPH8
8
WERAM-Hos-0117
CDY2B
9
WERAM-Hos-0136
CBX8
10
WERAM-Hos-0201
CDY1
11
WERAM-Hos-0202
CDY1B
12
WERAM-Hos-0207
CBX2
13
WERAM-Hos-0213
CDY2A