Homo sapiens      HMT      SUV39

※ SUV39 family introduction

    SUV39: The Su(var)3-9 gene was originally identified in a genetic screen as a suppressor of position effect variegation in Drosophila. This was the first hint that the Su(var)3-9 protein might be involved in regulating chromatin structure. In mice, there are two highly related homologues of the Drosophila Su(var)3-9, Suv39h1 and Suv39h2. Following the identification of Suv39h1 as a lysine methyltransferase capable of methylating Lys9 of histone H3 (H3K9), confirmation that this protein can modulate chromatin architecture came with the finding that it creates a specific binding site for the heterochromatin protein HP1. As Suv39h1 and HP1 interact, it is thought that Suv39h1 methylating H3 K9, and then HP1 binding to the methylated H3, forms a positive feedback loop allowing HP1 and H3 K9 methylation to spread along chromatin, generating repressive heterochromatin in the process. (1)

Reference
1. Schneider R, Bannister AJ, Kouzarides T.Unsafe SETs: histone lysine methyltransferases and cancer. Trends Biochem Sci.2002;27(8):396-402. PMID: 12151224.



There are 13 genes.  Reviewed (7 or Unreviewed (6

No.StatusWERAM IDGene/Alias Name
1
WERAM-Hos-0062
SUV39H1; MG44; KMT1A; H3-K9-HMTase1
2
WERAM-Hos-0129
SETDB2; CLLD8; CLLL8; KMT1F; C13orf4
3
WERAM-Hos-0145
SETDB1; ESET; KG1T; KMT1E; TDRD21; H3-K9-HMTase4
4
WERAM-Hos-0159
SUV39h2; KMT1B
5
WERAM-Hos-0193
SETMAR; Mar1; HsMar1; METNASE
6
WERAM-Hos-0211
EHMT1; GLP; GLP1; KMT1D; FP13812; EUHMTASE1; Eu-HMTase1; bA188C12.1; KIAA1876
7
WERAM-Hos-0242
EHMT2; G9A; BAT8; GAT8; NG36; KMT1C; C6orf30
8
WERAM-Hos-0239
EHMT2
9
WERAM-Hos-0247
EHMT2
10
WERAM-Hos-0252
EHMT2
11
WERAM-Hos-0253
EHMT2
12
WERAM-Hos-0261
EHMT2
13
WERAM-Hos-0262
EHMT2