WERAM Information

Tag Content
WERAM ID WERAM-Hos-0193
Ensembl Protein ID ENSP00000373354.3
Uniprot Accession Q53H47; SETMR_HUMAN; B4DY74; E7EN68; Q13579; Q1G668; Q96F41
Genbank Protein ID NP_001230652.1; NP_001263254.1; NP_001307606.1; NP_001307607.1; NP_006506.3
Protein Name Histone-lysine N-methyltransferase SETMAR
Genbank Nucleotide ID NM_001243723.1; NM_001276325.1; NM_001320677.1; NM_001320678.1; NM_006515.3
Gene Name SETMAR;Mar1;HsMar1;METNASE
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000170364.12 ENST00000358065.4 ENSP00000373354.3
ENSG00000170364.12 ENST00000430981.1 ENSP00000403000.1
Details
Type Family Domain Substrates AA References (PMIDs)
HMT SUV39 SET H3K36 K 25537518
Status Reviewed
Classification
Type Family E-value Score Start End
HMT SUV39 4.10e-34 120 140 262
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750).
Domain Profile
  HMT SUV39
          SUV39.txt   2 rLqvfktenkGwGvrclddiakgsFvciyaGeiltddeaekegl...eegdeyladldskesvenlkegyesdvplssdssntrqekdkees 90 
                        ++qvfkt++kGwG+r+l+ i+kg+Fvc+yaGe+l  +e++++ +   +++++y++++++                         + ++++  
  ENSP00000373354.3 140 HFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHlqtKSDSNYIIAIRE-------------------------HVYNGQVM 206
                        79**************************************9933344666667666665.........................45888999 PP
          SUV39.txt  91 eyiidakkegnvgrflnHscspNlfvqnvfvdthdlrfprvafFaskrikagtELtwdY 149
                        e ++d ++ gn+grflnHsc+pNl++ +v +   d+++p++a+Fa+k+i +++EL++dY
  ENSP00000373354.3 207 ETFVDPTYIGNIGRFLNHSCEPNLLMIPVRI---DSMVPKLALFAAKDIVPEEELSYDY 262
                        9****************************99...679********************** PP
Protein Sequence
(Fasta)		MFAEAAKTTR PCGMAEFKEK PEAPTEQLDV ACGQENLPVG AWPPGAAPAP FQYTPDHVVG 60
PGADIDPTQI TFPGCICVKT PCLPGTCSCL RHGENYDDNS CLRDIGSGGK YAEPVFECNV 120
LCRCSDHCRN RVVQKGLQFH FQVFKTHKKG WGLRTLEFIP KGRFVCEYAG EVLGFSEVQR 180
RIHLQTKSDS NYIIAIREHV YNGQVMETFV DPTYIGNIGR FLNHSCEPNL LMIPVRIDSM 240
VPKLALFAAK DIVPEEELSY DYSGRYLNLT VSEDKERLDH GKLRKPCYCG AKSCTAFLPF 300
DSSLYCPVEK SNISCGNEKE PSMCGSAPSV FPSCKRLTLE TMKMMLDKKQ IRAIFLFEFK 360
MGRKAAETTR NINNAFGPGT ANERTVQWWF KKFCKGDESL EDEERSGRPS EVDNDQLRAI 420
IEADPLTTTR EVAEELNVNH STVVRHLKQI GKVKKLDKWV PHELTENQKN RRFEVSSSLI 480
LRNHNEPFLD RIVTCDEKWI LYDNRRRSAQ WLDQEEAPKH FPKPILHPKK VMVTIWWSAA 540
GLIHYSFLNP GETITSEKYA QEIDEMNQKL QRLQLALVNR KGPILLHDNA RPHVAQPTLQ 600
KLNELGYEVL PHPPYSPDLL PTNYHVFKHL NNFLQGKRFH NQQDAENAFQ EFVESQSTDF 660
YATGINQLIS RWQKCVDCNG SYFD 684
Nucleotide Sequence
(Fasta)		ACAAGTCCCA GCATCCACCG CGCGGCCCAG GACTGTCAGG GTAGTGGGCG TTGCGTGAGG 60
CGGGTAAATG TTCGCGGAAG CGGCAAAGAC GACACGGCCT TGTGGGATGG CGGAGTTTAA 120
GGAGAAGCCT GAGGCCCCGA CTGAGCAGCT GGATGTCGCG TGCGGCCAGG AAAACTTGCC 180
GGTGGGCGCG TGGCCCCCGG GGGCCGCGCC GGCGCCCTTC CAGTACACTC CTGATCATGT 240
AGTTGGACCT GGAGCAGACA TTGATCCCAC TCAAATAACC TTTCCCGGAT GCATTTGTGT 300
CAAAACTCCC TGCCTCCCTG GCACTTGCTC CTGTCTCCGC CATGGAGAGA ACTATGATGA 360
TAACTCATGC CTTAGAGATA TAGGATCTGG AGGAAAGTAT GCAGAGCCTG TTTTTGAATG 420
CAATGTCCTG TGCCGATGCA GTGACCACTG CAGAAACAGA GTGGTCCAGA AAGGTCTACA 480
GTTCCACTTC CAAGTGTTCA AGACGCATAA AAAAGGCTGG GGACTTCGTA CCTTGGAATT 540
TATACCGAAA GGAAGGTTTG TCTGTGAATA TGCTGGTGAG GTTTTAGGAT TCTCTGAAGT 600
TCAGAGAAGA ATTCACTTAC AAACAAAATC CGACTCCAAT TACATTATAG CCATCAGGGA 660
ACATGTTTAT AATGGGCAGG TAATGGAAAC ATTTGTTGAC CCTACTTATA TAGGAAATAT 720
TGGAAGATTC CTTAATCATT CTTGTGAGCC AAACCTTTTG ATGATTCCTG TCCGAATTGA 780
CTCAATGGTA CCTAAGTTGG CACTTTTTGC AGCCAAAGAT ATTGTGCCAG AAGAAGAACT 840
CTCTTATGAT TATTCAGGAA GATATCTTAA TCTAACAGTC AGTGAAGACA AAGAAAGGCT 900
AGATCATGGG AAACTAAGGA AACCTTGTTA CTGTGGTGCC AAATCATGTA CTGCTTTCCT 960
GCCTTTTGAC AGTTCTCTGT ACTGCCCCGT AGAAAAGTCG AACATCAGTT GTGGAAATGA 1020
GAAGGAACCC AGCATGTGTG GCTCAGCCCC TTCTGTGTTC CCCTCCTGCA AGCGATTGAC 1080
CCTTGAGACT ATGAAAATGA TGTTAGACAA AAAGCAAATT CGAGCAATTT TCTTATTCGA 1140
GTTCAAAATG GGTCGTAAAG CAGCAGAAAC AACTCGCAAC ATCAACAATG CATTTGGCCC 1200
AGGAACTGCT AACGAACGTA CAGTGCAGTG GTGGTTCAAG AAGTTTTGCA AAGGAGATGA 1260
GAGCCTTGAA GATGAGGAGC GTAGTGGCCG GCCATCAGAA GTTGACAACG ACCAGTTGAG 1320
AGCAATCATC GAAGCTGATC CCCTTACAAC TACACGAGAA GTTGCTGAAG AACTCAATGT 1380
CAACCATTCT ACGGTCGTTC GACATTTGAA GCAAATTGGA AAGGTGAAAA AGCTCGATAA 1440
GTGGGTGCCT CATGAGCTGA CTGAAAATCA AAAAAATCGT CGTTTTGAAG TGTCATCTTC 1500
TCTTATTCTA CGCAACCACA ACGAACCATT TCTCGATCGG ATTGTGACGT GTGATGAAAA 1560
GTGGATTTTA TATGACAACC GGCGACGATC AGCTCAGTGG TTGGATCAAG AAGAAGCTCC 1620
AAAGCACTTC CCAAAGCCAA TCTTGCACCC AAAAAAGGTC ATGGTCACTA TTTGGTGGTC 1680
TGCTGCTGGT CTGATCCACT ACAGCTTTCT GAATCCCGGT GAAACCATTA CATCTGAGAA 1740
GTATGCTCAG GAAATCGATG AGATGAACCA AAAACTGCAA CGCCTGCAGC TGGCATTGGT 1800
CAACAGAAAG GGCCCAATTC TTCTCCACGA CAATGCCCGA CCGCATGTTG CACAACCCAC 1860
ACTTCAAAAG TTGAATGAAT TGGGCTATGA AGTTTTGCCT CATCCACCGT ATTCACCTGA 1920
CCTCTTGCCA ACCAACTACC ACGTCTTTAA GCATCTCAAC AACTTTTTGC AGGGAAAACG 1980
CTTCCACAAC CAGCAGGATG CAGAAAATGC TTTCCAAGAG TTCGTCGAAT CCCAAAGCAC 2040
GGATTTTTAC GCTACAGGAA TAAACCAACT TATTTCTCGT TGGCAAAAAT GTGTTGATTG 2100
TAATGGTTCC TATTTTGATT AATAAAAATG CGTTGAGCCT AGTTATAATG ATTTAAAATT 2160
CACAGTCCAA AACCGCAGTT AGTTTTGCAC CAACCCAATA TCTTCATAGA TTGAAATATA 2220
AATTAAAATT GCATTTGAAG TAGATTCCAC GGACTTTATT AAGAATGTAG AAATGTGGCC 2280
TGGCATGGTG GCTTACAACT GTAATCCCAG CACTTTGGGA GGCCCAGGCG GGCAGATCAC 2340
TTGAGTCCAA TTGTTCAGGA CCAGCCTGGG CAACATAGTG AGACCCTGAC TCTAATAAAA 2400
TAATTTTTTA AAAAAAGATT AAAACATGTA CCTTGAAAAG CAT 2444
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0255--Endonuclease
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0488--Methylation
KW-0489--Methyltransferase
KW-0511--Multifunctional enzyme
KW-0540--Nuclease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
--
Interpro

IPR003616--Post-SET_dom
IPR007728--Pre-SET_dom
IPR001214--SET_dom
IPR001888--Transposase_1
PROSITE

PS50868--POST_SET
PS50867--PRE_SET
PS50280--SET
Pfam

PF05033--Pre-SET
PF00856--SET
PF01359--Transposase_1
Gene Ontology

GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0044547--F:DNA topoisomerase binding
GO:0003690--F:double-stranded DNA binding
GO:0004519--F:endonuclease activity
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0042803--F:protein homodimerization activity
GO:0003697--F:single-stranded DNA binding
GO:0000014--F:single-stranded DNA endodeoxyribonuclease activity
GO:0043566--F:structure-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:0000737--P:DNA catabolic process, endonucleolytic
GO:0000729--P:DNA double-strand break processing
GO:0015074--P:DNA integration
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0097676--P:histone H3-K36 dimethylation
GO:0010452--P:histone H3-K36 methylation
GO:0051568--P:histone H3-K4 methylation
GO:0044774--P:mitotic DNA integrity checkpoint
GO:0071157--P:negative regulation of cell cycle arrest
GO:2001251--P:negative regulation of chromosome organization
GO:0090305--P:nucleic acid phosphodiester bond hydrolysis
GO:2000373--P:positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO:2001034--P:positive regulation of double-strand break repair via nonhomologous end joining
GO:0031297--P:replication fork processing
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Poa-0122 ENSPPYP00000015320.2 Pongo abelii 99 0.0 1392
WERAM-Nol-0033 ENSNLEP00000004028.1 Nomascus leucogenys 98 0.0 1383
WERAM-Chs-0135 ENSCSAP00000007249.1 Chlorocebus sabaeus 97 0.0 1373
WERAM-Mam-0168 ENSMMUP00000023438.2 Macaca mulatta 98 0.0 1353
WERAM-Caj-0160 ENSCJAP00000028548.2 Callithrix jacchus 95 0.0 1337
WERAM-Paa-0031 ENSPANP00000005668.1 Papio anubis 96 0.0 674
WERAM-Otg-0182 ENSOGAP00000016448.1 Otolemur garnettii 83 2e-151 533
WERAM-Aim-0178 ENSAMEP00000016768.1 Ailuropoda melanoleuca 85 2e-147 520
WERAM-Gog-0056 ENSGGOP00000024733.1 Gorilla gorilla 100 3e-147 519
WERAM-Cap-0176 ENSCPOP00000021158.1 Cavia porcellus 83 2e-143 506
WERAM-Sus-0080 ENSSSCP00000012291.2 Sus scrofa 83 4e-143 506
WERAM-Caf-0072 ENSCAFP00000008925.3 Canis familiaris 86 1e-142 504
WERAM-Mup-0196 ENSMPUP00000016915.1 Mustela putorius furo 82 1e-142 504
WERAM-Loa-0193 ENSLAFP00000029152.1 Loxodonta africana 81 2e-142 503
WERAM-Ova-0089 ENSOARP00000009190.1 Ovis aries 82 2e-142 503
WERAM-Bot-0166 ENSBTAP00000025200.4 Bos taurus 83 1e-141 501
WERAM-Dan-0150 ENSDNOP00000026815.1 Dasypus novemcinctus 83 1e-140 497
WERAM-Eqc-0076 ENSECAP00000009319.1 Equus caballus 81 1e-139 494
WERAM-Ran-0041 ENSRNOP00000008892.5 Rattus norvegicus 76 2e-138 490
WERAM-Mum-0134 ENSMUSP00000048225.5 Mus musculus 79 1e-136 484
WERAM-Ict-0180 ENSSTOP00000017444.1 Ictidomys tridecemlineatus 81 3e-135 480
WERAM-Fec-0215 ENSFCAP00000022192.1 Felis catus 84 2e-133 473
WERAM-Orc-0204 ENSOCUP00000016069.1 Oryctolagus cuniculus 77 3e-120 430
WERAM-Ora-0036 ENSOANP00000005979.1 Ornithorhynchus anatinus 64 1e-119 428
WERAM-Sah-0121 ENSSHAP00000012743.1 Sarcophilus harrisii 72 1e-118 424
WERAM-Myl-0212 ENSMLUP00000018384.1 Myotis lucifugus 71 3e-117 419
WERAM-Mod-0035 ENSMODP00000005462.1 Monodelphis domestica 68 8e-113 405
WERAM-Anp-0008 ENSAPLP00000001113.1 Anas platyrhynchos 67 3e-102 370
WERAM-Pes-0171 ENSPSIP00000020014.1 Pelodiscus sinensis 64 6e-102 369
WERAM-Anc-0108 ENSACAP00000010140.2 Anolis carolinensis 64 7e-95 345
WERAM-Leo-0102 ENSLOCP00000013582.1 Lepisosteus oculatus 55 8e-91 332
WERAM-Fia-0166 ENSFALP00000014137.1 Ficedula albicollis 60 6e-89 326
WERAM-Tag-0128 ENSTGUP00000010537.1 Taeniopygia guttata 58 3e-88 323
WERAM-Tar-0182 ENSTRUP00000038189.1 Takifugu rubripes 54 3e-82 303
WERAM-Orn-0237 ENSONIP00000025547.1 Oreochromis niloticus 52 3e-78 290
WERAM-Lac-0073 ENSLACP00000009546.1 Latimeria chalumnae 68 2e-77 288
WERAM-Pof-0068 ENSPFOP00000006049.1 Poecilia formosa 49 3e-76 283
WERAM-Asm-0238 ENSAMXP00000026460.1 Astyanax mexicanus 50 3e-75 280
WERAM-Xet-0177 ENSXETP00000059218.1 Xenopus tropicalis 51 1e-74 278
WERAM-Dar-0169 ENSDARP00000101881.1 Danio rerio 47 1e-71 268
WERAM-Pem-0094 ENSPMAP00000009711.1 Petromyzon marinus 49 1e-69 261
WERAM-Gaa-0125 ENSGACP00000015762.1 Gasterosteus aculeatus 54 8e-48 189
WERAM-Sei-0060 Si016095m Setaria italica 32 5e-37 153
WERAM-Php-0005 PP1S100_44V6.1 Physcomitrella patens 38 1e-36 152
WERAM-Brd-0091 BRADI3G52950.1 Brachypodium distachyon 34 8e-36 149
WERAM-Amt-0069 ERN17623 Amborella trichopoda 34 1e-35 149
WERAM-Art-0043 AT2G23740.2 Arabidopsis thaliana 33 1e-35 149
WERAM-Thc-0036 EOY22741 Theobroma cacao 38 5e-35 146
WERAM-Ten-0057 ENSTNIP00000007499.1 Tetraodon nigroviridis 34 7e-35 146
WERAM-Arl-0080 fgenesh2_kg.4__ 295__ AT2G23740.1 Arabidopsis lyrata 32 9e-35 145
WERAM-Xim-0157 ENSXMAP00000012895.1 Xiphophorus maculatus 35 1e-34 145
WERAM-Tra-0248 Traes_6AL_7EEE7AB33.2 Triticum aestivum 34 1e-34 145
WERAM-Mua-0082 GSMUA_Achr5P08830_001 Musa acuminata 30 2e-34 145
WERAM-Lep-0031 LPERR02G24120.1 Leersia perrieri 34 2e-34 145
WERAM-Met-0121 AES94344 Medicago truncatula 36 4e-34 144
WERAM-Ori-0028 BGIOSGA008898-PA Oryza indica 36 6e-34 143
WERAM-Orla-0205 ENSORLP00000024603.1 Oryzias latipes 35 1e-33 142
WERAM-Ors-0025 OS02T0708600-01 Oryza sativa 36 2e-33 142
WERAM-Prp-0011 EMJ05999 Prunus persica 36 2e-33 141
WERAM-Meg-0025 ENSMGAP00000001979.2 Meleagris gallopavo 34 4e-33 140
WERAM-Cis-0021 ENSCSAVP00000004474.1 Ciona savignyi 35 5e-33 140
WERAM-Scj-0038 EEB09372 Schizosaccharomyces japonicus 35 6e-33 139
WERAM-Gam-0093 ENSGMOP00000009644.1 Gadus morhua 33 7e-33 139
WERAM-Gaga-0086 ENSGALP00000013792.4 Gallus gallus 34 9e-33 139
WERAM-Glm-0257 GLYMA20G16736.1 Glycine max 38 1e-32 139
WERAM-Brr-0158 Bra032148.1-P Brassica rapa 31 1e-32 139
WERAM-Orl-0050 KN538984.1_FGP012 Oryza longistaminata 36 1e-32 139
WERAM-Orr-0045 ORUFI04G22060.1 Oryza rufipogon 36 2e-32 138
WERAM-Org-0046 ORGLA04G0175400.1 Oryza glaberrima 36 2e-32 138
WERAM-Orgl-0045 OGLUM04G20420.1 Oryza glumaepatula 36 2e-32 138
WERAM-Sob-0077 Sb04g033260.1 Sorghum bicolor 34 2e-32 138
WERAM-Orbr-0033 OB02G36880.1 Oryza brachyantha 34 2e-32 137
WERAM-Orp-0046 OPUNC04G18130.1 Oryza punctata 36 3e-32 137
WERAM-Zem-0017 GRMZM2G021044_P01 Zea mays 35 3e-32 137
WERAM-Bro-0079 Bo4g151840.1 Brassica oleracea 31 4e-32 137
WERAM-Tru-0035 TRIUR3_17558-P1 Triticum urartu 33 5e-32 137
WERAM-Aet-0064 EMT10878 Aegilops tauschii 36 7e-32 136
WERAM-Orni-0042 ONIVA04G18710.1 Oryza nivara 37 8e-32 136
WERAM-Orb-0045 OBART04G20480.1 Oryza barthii 37 8e-32 136
WERAM-Viv-0059 VIT_08s0056g01660.t01 Vitis vinifera 37 1e-31 135
WERAM-Tut-0161 ENSTTRP00000013419.1 Tursiops truncatus 35 1e-31 135
WERAM-Dio-0109 ENSDORP00000010714.1 Dipodomys ordii 35 2e-31 135
WERAM-Pat-0148 ENSPTRP00000050361.3 Pan troglodytes 35 2e-31 135
WERAM-Sol-0033 Solyc02g089970.2.1 Solanum lycopersicum 29 2e-31 134
WERAM-Pot-0064 POPTR_0005s13810.1 Populus trichocarpa 34 2e-31 134
WERAM-Ocp-0041 ENSOPRP00000003534.2 Ochotona princeps 35 3e-31 134
WERAM-Mim-0034 ENSMICP00000003271.1 Microcebus murinus 35 3e-31 134
WERAM-Ptv-0045 ENSPVAP00000004855.1 Pteropus vampyrus 35 4e-31 134
WERAM-Soa-0126 ENSSARP00000012347.1 Sorex araneus 36 5e-31 133
WERAM-Sem-0016 EFJ12590 Selaginella moellendorffii 39 5e-31 133
WERAM-Orm-0029 OMERI02G28560.1 Oryza meridionalis 33 9e-31 132
WERAM-Sot-0083 PGSC0003DMT400068350 Solanum tuberosum 35 1e-30 132
Created Date 25-Jun-2016