Brassica rapa      HMT      SUV39

※ SUV39 family introduction

    SUV39: The Su(var)3-9 gene was originally identified in a genetic screen as a suppressor of position effect variegation in Drosophila. This was the first hint that the Su(var)3-9 protein might be involved in regulating chromatin structure. In mice, there are two highly related homologues of the Drosophila Su(var)3-9, Suv39h1 and Suv39h2. Following the identification of Suv39h1 as a lysine methyltransferase capable of methylating Lys9 of histone H3 (H3K9), confirmation that this protein can modulate chromatin architecture came with the finding that it creates a specific binding site for the heterochromatin protein HP1. As Suv39h1 and HP1 interact, it is thought that Suv39h1 methylating H3 K9, and then HP1 binding to the methylated H3, forms a positive feedback loop allowing HP1 and H3 K9 methylation to spread along chromatin, generating repressive heterochromatin in the process. (1)

Reference
1. Schneider R, Bannister AJ, Kouzarides T.Unsafe SETs: histone lysine methyltransferases and cancer. Trends Biochem Sci.2002;27(8):396-402. PMID: 12151224.



There are 19 genes.  Reviewed (0 or Unreviewed (19

No.StatusWERAM IDGene/Alias Name
1
WERAM-Brr-0006
2
WERAM-Brr-0018
3
WERAM-Brr-0023
SUVH5
4
WERAM-Brr-0025
5
WERAM-Brr-0027
6
WERAM-Brr-0031
SUVH4
7
WERAM-Brr-0035
SDG22
8
WERAM-Brr-0047
9
WERAM-Brr-0048
10
WERAM-Brr-0081
SUVH3
11
WERAM-Brr-0113
12
WERAM-Brr-0128
13
WERAM-Brr-0143
14
WERAM-Brr-0150
SUVH6
15
WERAM-Brr-0157
SUVR3
16
WERAM-Brr-0158
17
WERAM-Brr-0164
18
WERAM-Brr-0182
19
WERAM-Brr-0203