Physcomitrella patens      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 20 genes.  Reviewed (0 or Unreviewed (20

No.StatusWERAM IDGene/Alias Name
1
WERAM-Php-0001
PHYPADRAFT_63700
2
WERAM-Php-0002
HAM1502 PHYPADRAFT_111033
3
WERAM-Php-0003
PHYPADRAFT_159214
4
WERAM-Php-0008
PHYPADRAFT_133637
5
WERAM-Php-0012
SDG1515 PHYPADRAFT_84444
6
WERAM-Php-0016
SDG1503 PHYPADRAFT_85315
7
WERAM-Php-0033
PHYPADRAFT_186998
8
WERAM-Php-0036
SDG1517 PHYPADRAFT_89432
9
WERAM-Php-0048
PHYPADRAFT_194183
10
WERAM-Php-0051
PHYPADRAFT_145070
11
WERAM-Php-0068
SDG1512 PHYPADRAFT_197069
12
WERAM-Php-0069
PHYPADRAFT_95550
13
WERAM-Php-0082
CHR1512 PHYPADRAFT_120666
14
WERAM-Php-0085
HDA1511 PHYPADRAFT_71876
15
WERAM-Php-0094
SDG1537 PHYPADRAFT_227225
16
WERAM-Php-0106
SDG1511 PHYPADRAFT_130275
17
WERAM-Php-0121
PHYPADRAFT_229540
18
WERAM-Php-0123
SDG1509 PHYPADRAFT_132080
19
WERAM-Php-0125
SDG1506 PHYPADRAFT_80174
20
WERAM-Php-0133
PHYPADRAFT_95530