Saccharomyces cerevisiae      Ac_Reader      Bromodomain

※ Bromodomain family introduction

    Bromodomain: Bromodomains (BRDs) are protein interaction modules that exclusively recognize acetylation motifs. BRDs are evolutionarily conserved and present in diverse nuclear proteins comprising HATs (GCN5, PCAF), ATP-dependent chromatin-remodeling complexes (BAZ1B), helicases (SMARCA), methyltransferases (MLL, ASH1L), transcriptional coactivators (TRIM/TIF1, TAFs) transcriptional mediators (TAF1), nuclear-scaffolding proteins(PB1), and the BET family. Despite large sequence variations, all BRD modules share a conserved fold that comprises a left-handed bundle of four a helices, linked by loop regions of variablelength, which line the Kac binding site and determine binding specificity. (1)

Reference
1. P. Filippakopoulos, S. Picaud, M. Mangos, T. Keates, J.P. Lambert, D. Barsyte-Lovejoy, I. Felletar, R. Volkmer, S. Müller, T. Pawson,et al.Histone recognition and large-scale structural analysis of the human bromodomain family. Cell.2012;149(1):214-231. PMID: 22464331.



There are 10 genes.  Reviewed (10 or Unreviewed (0

No.StatusWERAM IDGene/Alias Name
1
WERAM-Sac-0002
SPT7; YBR081C; YBR0739
2
WERAM-Sac-0006
BDF2; YDL070W
3
WERAM-Sac-0017
RSC1; YGR056W
4
WERAM-Sac-0018
GCN5; ADA4; SWI9; YGR252W
5
WERAM-Sac-0019
YTA7; TBP7; YGR270W
6
WERAM-Sac-0022
STH1; NPS1; YIL126W
7
WERAM-Sac-0026
RSC4; YKR008W; YK107
8
WERAM-Sac-0030
RSC2; YLR357W; L9638.1
9
WERAM-Sac-0031
BDF1; YLR399C; L8084.18
10
WERAM-Sac-0044
SNF2; GAM1; RIC1; SWI2; TYE3; YOR290C