WERAM Information

Tag Content
WERAM ID WERAM-Sac-0030
Ensembl Protein ID YLR357W
Uniprot Accession Q06488; RSC2_YEAST; D6VYZ5
Genbank Protein ID NP_013461.1
Protein Name Chromatin structure-remodeling complex subunit RSC2
Genbank Nucleotide ID NM_001182246.1
Gene Name RSC2;YLR357W;L9638.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YLR357W YLR357W YLR357W
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain K 12419247
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 2.30e-27 93.3 39 839
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)		 Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in meiotic sporulation through regulating IME2 expression, and is also essential for 2-micron plasmid maintenance and for normal REP1 protein localization.
Domain Profile
  Ac_Reader Bromodomain
  BROMO.txt   5 vsepFrepvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssvq 72 
                +s +F+    + +++pdYy +ik+P+ ++t k+r+    Y+++++f++Dv +i +Nak+yn ++s ++
    YLR357W  39 ISPIFNVLPPK-KDYPDYYAVIKNPVSFNTLKKRIPH--YTDAQQFMNDVVQIPWNAKTYNTRDSGIY 103
                67777444444.49*********************99..***********************998765 PP
  BROMO.txt   7 epFrepvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakayne 66 
                + F++  d+     +Yy +i +P+ L+ i +++++++Y++ +ef +D++l+++N++   +
    YLR357W 301 DLFERLPDR-HRDANYYIMIANPISLQDINKKVKTRRYKTFQEFQNDFNLMLTNFRISHR 359
                678888888.6999*****************************************98765 PP
  BROMO.txt  40 eegnYsspeefvkDv 54 
                ++ +Y+++ee ++Dv
    YLR357W 825 RKLEYEEVEETMEDV 839
                3556**********9 PP
Protein Sequence
(Fasta)		MMPDDNSNSS TQNSSALYKD LRKEYESLFT LKEDSGLEIS PIFNVLPPKK DYPDYYAVIK 60
NPVSFNTLKK RIPHYTDAQQ FMNDVVQIPW NAKTYNTRDS GIYKYALVLE KYLKDTIYPN 120
LKEKYPQLVY PDLGPLPDEP GYEEFQQKLR EKAEEVARAN AARAESSSSM NSTEAARRLR 180
KTRTSVKRES EPGTDTNNDE DYEATDMDID NPKDADFPDL IRKPLININP YTRKPLRDNR 240
STTPSHSGTP QPLGPRHRQV SRTQVKRGRP PIIDLPYIQR MKNVMKVLKK EVLDSGIGLT 300
DLFERLPDRH RDANYYIMIA NPISLQDINK KVKTRRYKTF QEFQNDFNLM LTNFRISHRG 360
DPESIKISNI LEKTFTSLAR FELSKPDRSF IPEGELRYPL DEVIVNNISY HVGDWALLRN 420
QNDPQKPIVG QIFRLWKTPD GKQWLNACWY YRPEQTVHRV DRLFYKNEVM KTGQYRDHLV 480
SNLVGKCYVI HFTRYQRGNP DMKLEGPLFV CEFRYNESDK IFNKIRTWKA CLPEEIRDLD 540
EATIPVNGRK FFKYPSPIRH LLPANATPHD RVPEPTMGSP DAPPLVGAVY MRPKMQRDDL 600
GEYATSDDCP RYIIRPNDSP EEGQVDIETG TITTNTPTAN ALPKTGYSSS KLSSLRYNRS 660
SMSLENQNAI GQQQIPLSRV GSPGAGGPLT VQGLKQHQLQ RLQQQQHQYQ QQKRSQASRY 720
NIPTIIDDLT SQASRGNLGN IMIDAASSFV LPISITKNVD VLQRTDLHSQ TKRSGREEMF 780
PWKKTKGEIL WFRGPSVIVN ERIINSGDPH LSLPLNRWFT TNKKRKLEYE EVEETMEDVT 840
GKDKDDDGLE PDVENEKESL PGPFVLGLRP SAKFTAHRLS MLRPPSSSS 889
Nucleotide Sequence
(Fasta)		ATGATGCCTG ATGACAATTC AAACTCGTCC ACTCAAAACT CAAGCGCATT ATACAAGGAC 60
CTGAGGAAAG AATATGAATC TCTTTTCACT TTAAAGGAAG ATTCTGGGTT AGAGATTTCA 120
CCAATATTCA ATGTCCTTCC ACCTAAAAAG GATTATCCTG ACTACTACGC AGTGATCAAG 180
AACCCTGTAT CTTTCAATAC TTTAAAAAAG CGTATTCCAC ATTATACAGA TGCTCAACAG 240
TTTATGAACG ATGTTGTCCA GATTCCATGG AATGCCAAGA CTTACAATAC AAGAGATTCA 300
GGAATTTATA AATACGCCTT AGTCCTTGAG AAATATTTAA AGGACACAAT CTATCCAAAT 360
TTAAAAGAAA AATATCCTCA ATTAGTGTAT CCTGATTTGG GTCCTCTACC CGATGAACCA 420
GGTTATGAAG AGTTTCAACA GAAATTAAGA GAAAAAGCTG AGGAAGTAGC GAGAGCTAAT 480
GCAGCCAGAG CCGAGTCGAG CTCTTCAATG AATTCAACAG AAGCAGCCAG AAGATTAAGA 540
AAGACTCGTA CTTCCGTCAA AAGAGAATCA GAACCAGGAA CCGATACAAA TAATGATGAG 600
GACTATGAGG CGACGGATAT GGATATCGAT AACCCTAAGG ATGCTGATTT TCCTGATTTG 660
ATAAGAAAGC CACTAATAAA TATTAATCCA TATACTCGGA AACCATTAAG AGACAACAGG 720
TCCACTACTC CATCTCACTC AGGCACCCCT CAGCCGTTAG GCCCAAGGCA TAGACAGGTA 780
TCCAGAACTC AGGTAAAGCG TGGGAGACCC CCAATCATCG ACTTACCGTA TATTCAAAGA 840
ATGAAAAATG TTATGAAAGT ACTAAAAAAA GAGGTGCTAG ATAGTGGAAT TGGTCTAACT 900
GATCTTTTTG AAAGATTGCC CGATAGACAC AGAGATGCAA ATTACTACAT CATGATTGCT 960
AATCCAATTA GTCTTCAAGA CATAAATAAA AAGGTAAAGA CTCGTCGTTA TAAAACGTTC 1020
CAGGAGTTCC AGAATGATTT TAATCTTATG TTAACCAACT TTAGAATTTC GCACAGAGGT 1080
GATCCTGAAA GCATAAAAAT TTCAAATATC TTAGAAAAGA CCTTTACTAG TCTGGCAAGA 1140
TTCGAACTAT CCAAACCTGA TAGAAGTTTC ATTCCAGAAG GCGAGCTAAG ATACCCTCTA 1200
GATGAAGTCA TTGTAAATAA TATATCATAC CACGTGGGAG ATTGGGCACT TCTTCGAAAT 1260
CAAAATGATC CTCAAAAACC TATAGTGGGC CAAATATTCA GGCTATGGAA GACACCAGAT 1320
GGGAAACAAT GGTTAAACGC TTGTTGGTAT TACAGACCCG AACAAACTGT GCATAGAGTG 1380
GATAGATTGT TTTACAAAAA CGAAGTTATG AAAACAGGTC AGTACCGTGA TCATTTAGTG 1440
TCAAACTTAG TTGGGAAATG CTATGTGATT CACTTTACTA GATATCAACG TGGTAATCCC 1500
GATATGAAAT TGGAGGGTCC CTTGTTCGTT TGCGAATTCC GTTATAATGA ATCCGATAAA 1560
ATTTTTAACA AGATTAGAAC CTGGAAGGCT TGCTTACCAG AGGAAATTCG TGATTTGGAC 1620
GAAGCTACCA TTCCGGTAAA TGGTAGAAAG TTCTTCAAAT ATCCTTCCCC CATAAGACAT 1680
CTACTACCAG CTAATGCAAC GCCGCATGAT CGCGTTCCTG AACCAACGAT GGGATCCCCG 1740
GACGCGCCAC CATTGGTCGG TGCCGTTTAT ATGAGACCTA AAATGCAGCG TGACGATTTG 1800
GGGGAATATG CAACCTCTGA TGACTGTCCC AGGTATATTA TCAGACCCAA CGATTCTCCC 1860
GAAGAGGGAC AAGTGGATAT AGAAACAGGT ACGATCACCA CAAACACGCC AACAGCAAAT 1920
GCTCTTCCTA AAACAGGATA CTCAAGTAGT AAACTATCCA GTTTAAGATA TAACAGGTCA 1980
TCTATGTCTT TAGAAAACCA AAATGCTATT GGCCAGCAAC AAATACCACT GTCAAGAGTT 2040
GGTTCCCCTG GCGCGGGAGG CCCGCTTACT GTACAAGGTT TAAAGCAACA CCAATTGCAA 2100
AGGTTACAAC AGCAGCAACA TCAATACCAA CAACAGAAAA GATCCCAAGC ATCACGTTAT 2160
AATATCCCAA CAATAATCGA TGATTTAACA TCGCAGGCAT CAAGAGGTAA TTTGGGTAAT 2220
ATAATGATCG ATGCAGCCTC CTCGTTTGTC TTACCTATCT CTATAACCAA AAACGTAGAT 2280
GTTTTGCAGC GTACTGATCT GCACAGCCAA ACCAAGAGAT CTGGAAGAGA AGAGATGTTT 2340
CCATGGAAAA AAACAAAGGG TGAAATATTA TGGTTCAGAG GACCTAGTGT GATAGTAAAT 2400
GAACGAATAA TAAATTCAGG TGACCCACAC CTAAGCCTGC CACTGAATAG GTGGTTTACC 2460
ACTAACAAGA AAAGAAAACT AGAATACGAA GAAGTTGAAG AAACCATGGA AGATGTGACT 2520
GGAAAGGACA AAGATGATGA TGGCTTAGAA CCGGATGTTG AAAATGAGAA AGAGTCCTTG 2580
CCAGGCCCAT TTGTCCTTGG ATTAAGACCC TCGGCTAAGT TCACGGCGCA CAGACTCTCT 2640
ATGCTGCGGC CTCCTTCGTC GTCTTCATGA 2671
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0749--Sporulation
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR001025--BAH_dom
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
PROSITE

PS51038--BAH
PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
Pfam

PF01426--BAH
PF00439--Bromodomain
Gene Ontology

GO:0016586--C:RSC complex
GO:0003682--F:chromatin binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0007059--P:chromosome segregation
GO:0000724--P:double-strand break repair via homologous recombination
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0006337--P:nucleosome disassembly
GO:0006276--P:plasmid maintenance
GO:0042173--P:regulation of sporulation resulting in formation of a cellular spore
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007062--P:sister chromatid cohesion
GO:0030435--P:sporulation resulting in formation of a cellular spore
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0070914--P:UV-damage excision repair
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Cag-0004 CAG57994 Candida glabrata 52 0.0 794
WERAM-Asg-0002 AAS50766 Ashbya gossypii 49 0.0 751
WERAM-Kll-0012 CAH02513 Kluyveromyces lactis 63 2e-141 501
WERAM-Caa-0002 KGT72463 Candida albicans 39 9e-113 405
WERAM-Kop-0018 CAY69884 Komagataella pastoris 49 8e-95 345
WERAM-Yal-0009 CAG81276 Yarrowia lipolytica 47 7e-86 316
WERAM-Gag-0018 GGTG_05183T0 Gaeumannomyces graminis 45 2e-80 298
WERAM-Map-0011 MAPG_03557T0 Magnaporthe poae 45 2e-78 291
WERAM-Coi-0013 EAS36730 Coccidioides immitis 44 5e-77 286
WERAM-Trv-0007 EHK19049 Trichoderma virens 44 5e-77 286
WERAM-Fuo-0019 FOXG_03701P0 Fusarium oxysporum 45 6e-76 283
WERAM-Asn-0037 CADANIAP00009586 Aspergillus nidulans 43 1e-75 282
WERAM-Mao-0037 MGG_13532T0 Magnaporthe oryzae 43 7e-75 280
WERAM-Ast-0019 CADATEAP00006441 Aspergillus terreus 43 9e-75 279
WERAM-Tum-0020 CAZ83686 Tuber melanosporum 42 3e-74 278
WERAM-Trr-0029 EGR48342 Trichoderma reesei 44 4e-74 277
WERAM-Asc-0016 CADACLAP00003898 Aspergillus clavatus 44 4e-74 277
WERAM-Nec-0019 EFNCRP00000003186 Neurospora crassa 42 7e-74 276
WERAM-Asfu-0020 CADAFUAP00005112 Aspergillus fumigatus 43 1e-73 275
WERAM-Ved-0009 EGY20303 Verticillium dahliae 42 2e-73 275
WERAM-Pyt-0014 EFQ92509 Pyrenophora teres 42 4e-73 274
WERAM-Asf-0035 CADAFLAP00012117 Aspergillus flavus 43 4e-73 273
WERAM-Pytr-0022 EDU49374 Pyrenophora triticirepentis 42 1e-72 272
WERAM-Asni-0028 CADANGAP00009247 Aspergillus niger 43 3e-72 271
WERAM-Phn-0023 SNOT_11997 Phaeosphaeria nodorum 41 1e-71 269
WERAM-Lem-0030 CBX97973 Leptosphaeria maculans 42 1e-71 268
WERAM-Chg-0002 EAQ92149 Chaetomium globosum 44 2e-71 268
WERAM-Zyt-0008 Mycgr3P111322 Zymoseptoria tritici 40 1e-66 252
WERAM-Scj-0030 EEB08625 Schizosaccharomyces japonicus 37 1e-65 248
WERAM-Scp-0035 SPBC4B4.03.1:pep Schizosaccharomyces pombe 39 2e-58 224
WERAM-Spr-0039 CBQ69967 Sporisorium reilianum 29 1e-37 155
WERAM-Miv-0026 MVLG_03897T0 Microbotryum violaceum 31 1e-36 152
WERAM-Usm-0032 UM05557P0 Ustilago maydis 29 2e-36 152
WERAM-Pug-0004 EFP75536 Puccinia graminis 30 2e-34 145
WERAM-Lab-0037 EDR00710 Laccaria bicolor 27 2e-29 129
WERAM-Leo-0097 ENSLOCP00000012945.1 Lepisosteus oculatus 34 3e-22 104
WERAM-Ect-0069 ENSETEP00000007816.1 Echinops telfairi 32 3e-21 101
WERAM-Orla-0007 ENSORLP00000000719.1 Oryzias latipes 33 7e-21 100
WERAM-Orn-0046 ENSONIP00000005237.1 Oreochromis niloticus 37 7e-21 100
WERAM-Ran-0165 ENSRNOP00000016581.6 Rattus norvegicus 38 1e-20 99.8
WERAM-Aim-0095 ENSAMEP00000008972.1 Ailuropoda melanoleuca 38 1e-20 99.8
WERAM-Mup-0193 ENSMPUP00000016659.1 Mustela putorius furo 38 1e-20 99.8
WERAM-Myl-0100 ENSMLUP00000008015.2 Myotis lucifugus 38 1e-20 99.8
WERAM-Caf-0099 ENSCAFP00000013411.3 Canis familiaris 38 1e-20 99.8
WERAM-Fec-0154 ENSFCAP00000014578.3 Felis catus 38 1e-20 99.8
WERAM-Orc-0094 ENSOCUP00000008471.3 Oryctolagus cuniculus 38 1e-20 99.4
WERAM-Hos-0176 ENSP00000296302.7 Homo sapiens 38 2e-20 99.4
WERAM-Otg-0052 ENSOGAP00000003653.2 Otolemur garnettii 38 2e-20 99.4
WERAM-Paa-0106 ENSPANP00000005285.1 Papio anubis 38 2e-20 99.0
WERAM-Cap-0001 ENSCPOP00000000245.2 Cavia porcellus 38 2e-20 99.0
WERAM-Chs-0163 ENSCSAP00000009501.1 Chlorocebus sabaeus 38 2e-20 99.0
WERAM-Caj-0076 ENSCJAP00000012664.2 Callithrix jacchus 38 2e-20 99.0
WERAM-Poa-0124 ENSPPYP00000015444.1 Pongo abelii 38 2e-20 99.0
WERAM-Loa-0149 ENSLAFP00000013467.3 Loxodonta africana 38 2e-20 99.0
WERAM-Gog-0174 ENSGGOP00000015624.2 Gorilla gorilla 38 2e-20 99.0
WERAM-Eqc-0003 ENSECAP00000002821.1 Equus caballus 38 2e-20 99.0
WERAM-Dio-0033 ENSDORP00000003590.1 Dipodomys ordii 38 2e-20 99.0
WERAM-Nol-0072 ENSNLEP00000008739.1 Nomascus leucogenys 38 2e-20 99.0
WERAM-Lac-0004 ENSLACP00000000435.1 Latimeria chalumnae 38 2e-20 99.0
WERAM-Sah-0062 ENSSHAP00000007287.1 Sarcophilus harrisii 33 2e-20 99.0
WERAM-Mod-0092 ENSMODP00000014158.3 Monodelphis domestica 33 2e-20 99.0
WERAM-Prc-0022 ENSPCAP00000001837.1 Procavia capensis 38 2e-20 99.0
WERAM-Mum-0174 ENSMUSP00000022471.5 Mus musculus 38 2e-20 99.0
WERAM-Pat-0127 ENSPTRP00000040860.3 Pan troglodytes 38 2e-20 99.0
WERAM-Mam-0166 ENSMMUP00000022859.2 Macaca mulatta 38 2e-20 99.0
WERAM-Tar-0060 ENSTRUP00000012797.1 Takifugu rubripes 34 2e-20 99.0
WERAM-Ptv-0139 ENSPVAP00000011863.1 Pteropus vampyrus 38 2e-20 98.6
WERAM-Mae-0062 ENSMEUP00000005823.1 Macropus eugenii 37 2e-20 98.6
WERAM-Tag-0085 ENSTGUP00000006047.1 Taeniopygia guttata 37 2e-20 98.6
WERAM-Ova-0018 ENSOARP00000002926.1 Ovis aries 38 3e-20 98.6
WERAM-Bot-0136 ENSBTAP00000019672.5 Bos taurus 38 3e-20 98.6
WERAM-Asm-0183 ENSAMXP00000017832.1 Astyanax mexicanus 32 3e-20 98.2
WERAM-Soa-0017 ENSSARP00000001974.1 Sorex araneus 38 3e-20 98.2
WERAM-Pof-0215 ENSPFOP00000017402.2 Poecilia formosa 34 4e-20 98.2
WERAM-Meg-0004 ENSMGAP00000000289.2 Meleagris gallopavo 37 4e-20 97.8
WERAM-Fia-0110 ENSFALP00000009340.1 Ficedula albicollis 37 5e-20 97.8
WERAM-Anp-0045 ENSAPLP00000005113.1 Anas platyrhynchos 37 5e-20 97.8
WERAM-Gaga-0016 ENSGALP00000002412.3 Gallus gallus 37 5e-20 97.8
WERAM-Pes-0103 ENSPSIP00000013011.1 Pelodiscus sinensis 37 5e-20 97.8
WERAM-Dar-0008 ENSDARP00000045970.6 Danio rerio 39 6e-20 97.4
WERAM-Ten-0178 ENSTNIP00000017661.1 Tetraodon nigroviridis 37 8e-20 97.1
WERAM-Xim-0011 ENSXMAP00000001291.1 Xiphophorus maculatus 36 8e-20 97.1
WERAM-Gaa-0008 ENSGACP00000001272.1 Gasterosteus aculeatus 36 1e-19 96.7
WERAM-Anc-0076 ENSACAP00000007182.3 Anolis carolinensis 36 1e-19 96.3
WERAM-Xet-0091 ENSXETP00000029930.3 Xenopus tropicalis 37 2e-19 95.9
WERAM-Vip-0074 ENSVPAP00000006860.1 Vicugna pacos 32 3e-19 94.7
WERAM-Pem-0008 ENSPMAP00000001026.1 Petromyzon marinus 34 8e-19 93.6
WERAM-Gam-0080 ENSGMOP00000008515.1 Gadus morhua 36 2e-16 85.9
WERAM-Dan-0006 ENSDNOP00000000791.3 Dasypus novemcinctus 36 8e-16 83.6
WERAM-Mim-0025 ENSMICP00000002632.1 Microcebus murinus 39 4e-14 78.2
WERAM-Ere-0137 ENSEEUP00000014195.1 Erinaceus europaeus 39 5e-14 77.8
WERAM-Tut-0097 ENSTTRP00000008126.1 Tursiops truncatus 34 8e-14 77.0
WERAM-Chh-0024 ENSCHOP00000002413.1 Choloepus hoffmanni 39 2e-13 75.5
WERAM-Tas-0069 ENSTSYP00000006269.1 Tarsius syrichta 39 3e-13 75.1
WERAM-Cae-0033 C26C6.1a Caenorhabditis elegans 29 9e-13 73.6
WERAM-Drm-0071 FBpp0084115 Drosophila melanogaster 27 7e-12 70.5
WERAM-Ocp-0093 ENSOPRP00000008540.1 Ochotona princeps 30 1e-11 69.3
WERAM-Cis-0074 ENSCSAVP00000015952.1 Ciona savignyi 37 4e-10 64.7
WERAM-Scs-0025 EDO04534 Sclerotinia sclerotiorum 36 6e-10 63.9
WERAM-Ora-0094 ENSOANP00000028835.1 Ornithorhynchus anatinus 33 8e-10 63.5
WERAM-Sus-0035 ENSSSCP00000005624.2 Sus scrofa 32 1e-09 63.5
WERAM-Ict-0071 ENSSTOP00000006128.2 Ictidomys tridecemlineatus 32 1e-09 63.2
WERAM-Tub-0092 ENSTBEP00000010737.1 Tupaia belangeri 31 5e-09 61.2
WERAM-Crn-0004 AAW41166 Cryptococcus neoformans 36 6e-09 60.8
Created Date 25-Jun-2016