| Tag |
Content |
| WERAM ID |
WERAM-Drm-0097 |
| Ensembl Protein ID |
FBpp0082511 |
| Uniprot Accession |
Q24572; CAF1_DROME; A0AP04; Q9VFB4
|
| Genbank Protein ID |
NP_524354.1
|
| Protein Name |
Probable histone-binding protein Caf1 |
| Genbank Nucleotide ID |
NM_079630.4
|
| Gene Name |
RbAp48,Caf1CG4236 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
WD40 |
WD1-6 |
unmodifiedH3 |
|
26667624
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
WD40 |
2.60e-89 |
300.4 |
126 |
407 |
|
| Organism |
Drosophila melanogaster |
| NCBI Taxa ID |
7227 |
Functional Description
(View)Functional Description
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2. |
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2.
|
| Domain Profile |
Me_Reader WD40
WD40.txt 1 dhekelsavkfepaseegaslvaatvgseavtvydcqtq.......geikllqkykghdeefysvawtadsnkrhslLasAgdrglirlldvea 87
+he e++++++ ++++a+++a++++s++v+v+d++++ ge++++ +++gh++e+y+++w+++ n+ +L+sA+d+++i+l+d++a
FBpp0082511 126 NHEGEVNRARY---MPQNACVIATKTPSSDVLVFDYTKHpskpepsGECQPDLRLRGHQKEGYGLSWNPNLNG---YLLSASDDHTICLWDINA 213
7**********...**********************************************************7...****************98 PP
WD40.txt 122 rvrlWdiktdklkkifeahsdevldvdyd.lrgslivScgmdgslkiWdvrskrrvcevklvddenpeksnrrVdcvrfs.ngdlils.gsldntivl 216
rv+ ++k+if++h+++v+dv+++ l++sl++S+++d++l+iWd+r++++++++++vd++++e V+c++f+ ++++il+ gs+d+t++l
FBpp0082511 219 RVI-------DAKNIFTGHTAVVEDVAWHlLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAE-----VNCLSFNpYSEFILAtGSADKTVAL 304
444.......899*******************************************************.....************************* PP
WD40.txt 217 WdirkikqsevavvvLkrfeyskteiyyislsfsvdnkkilvsgdedgkvyvwdls........veaalkakelllklgkvtakimqtsvspnesiii 306
Wd+r++k ++L++fe++k+ei+++ ++s++n++il+s+++d++++vwdls ++a+++++ell+++g++taki+++s++pne++ii
FBpp0082511 305 WDLRNLK------LKLHSFESHKDEIFQV--QWSPHNETILASSGTDRRLHVWDLSkigeeqstEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWII 394
*******......****************..********************************99********************************* PP
WD40.txt 307 ltaltddnivkiWd 320
+++++dni+++W+
FBpp0082511 395 -CSVSEDNIMQVWQ 407
.************8 PP
|
Protein Sequence
(Fasta) | MVDRSDNAAE SFDDAVEERV INEEYKIWKK NTPFLYDLVM THALEWPSLT AQWLPDVTKQ 60
DGKDYSVHRL ILGTHTSDEQ NHLLIASVQL PSEDAQFDGS HYDNEKGEFG GFGSVCGKIE 120
IEIKINHEGE VNRARYMPQN ACVIATKTPS SDVLVFDYTK HPSKPEPSGE CQPDLRLRGH 180
QKEGYGLSWN PNLNGYLLSA SDDHTICLWD INATPKEHRV IDAKNIFTGH TAVVEDVAWH 240
LLHESLFGSV ADDQKLMIWD TRNNNTSKPS HTVDAHTAEV NCLSFNPYSE FILATGSADK 300
TVALWDLRNL KLKLHSFESH KDEIFQVQWS PHNETILASS GTDRRLHVWD LSKIGEEQST 360
EDAEDGPPEL LFIHGGHTAK ISDFSWNPNE PWIICSVSED NIMQVWQMAE NVYNDEEPEI 420
PASELETNTA Protein Fasta Sequence
>FBpp0082511|RbAp48,Caf1CG4236|Drosophila melanogaster
MVDRSDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETNTA |
Nucleotide Sequence
(Fasta) | GCAGTCGTCT CGACAATCTT TAGCATTGCA TCTCTATCAT CGACGACGCG CTTGCAAAAA 60
AACGAAGGAA ATTAGCCAAT TTCTATTTTG CCCTGACGTT ACGCCGTTTA AAGTGTAAGT 120
TCCCGGCCAG GATTCGACTC AATCCCTGCC ACAACGACTT TCGGTCAAGT GTTCGTTGCG 180
AGAGCTTTAA CTACGTAGCG AACTTTCGTA GTTTTTCTGC ACACGTTTTG CCGCTTCGGC 240
TTTTGTTTTG GCGCCCGATT TTTTCGGCTG CCGACTTTTG ACGCAGACTG AGAAATTGCG 300
TGCCTAAAAG CCTCGAAATG GTGGATCGCA GCGATAATGC AGCGGAATCC TTCGACGACG 360
CCGTCGAGGA GCGCGTGATC AATGAGGAGT ATAAGATTTG GAAAAAGAAC ACGCCGTTCC 420
TGTACGATCT GGTCATGACG CATGCCCTGG AATGGCCCTC GTTGACTGCC CAGTGGCTGC 480
CGGACGTGAC CAAGCAGGAT GGCAAGGACT ACTCGGTACA TCGTCTTATA CTGGGCACAC 540
ACACATCTGA CGAGCAGAAC CATCTACTCA TCGCCAGCGT TCAGTTGCCC AGCGAGGATG 600
CCCAGTTCGA TGGTTCGCAC TACGATAACG AGAAGGGCGA GTTTGGAGGC TTTGGATCGG 660
TGTGCGGCAA AATCGAAATC GAGATTAAGA TCAACCACGA GGGCGAAGTG AACAGGGCCC 720
GCTACATGCC CCAGAACGCC TGTGTAATCG CCACCAAGAC GCCGTCGAGT GATGTCCTGG 780
TCTTCGACTA CACGAAGCAT CCCAGCAAGC CGGAACCGTC TGGCGAGTGC CAGCCTGACC 840
TGCGGCTGCG CGGTCATCAA AAGGAAGGCT ACGGACTCTC TTGGAATCCC AACCTCAATG 900
GCTATTTGCT GTCAGCCTCT GATGATCACA CCATCTGCTT GTGGGACATC AATGCCACAC 960
CCAAGGAGCA TAGGGTTATT GATGCCAAGA ACATCTTCAC CGGCCACACC GCCGTTGTTG 1020
AGGACGTGGC TTGGCATCTG CTACATGAGT CTCTGTTCGG ATCGGTGGCT GACGACCAGA 1080
AGCTGATGAT CTGGGACACG CGCAACAACA ACACCTCGAA GCCCTCGCAT ACAGTGGACG 1140
CTCACACAGC GGAAGTCAAT TGCTTGAGCT TTAATCCCTA CTCGGAGTTC ATTCTGGCCA 1200
CGGGCTCCGC TGACAAGACT GTAGCTCTAT GGGATCTGCG CAACCTCAAG CTAAAACTAC 1260
ATTCCTTCGA GTCGCACAAG GACGAGATCT TCCAAGTGCA GTGGTCGCCG CATAACGAGA 1320
CTATTCTCGC CTCCTCCGGC ACTGACCGCC GCCTACACGT CTGGGATTTG TCCAAAATCG 1380
GCGAGGAGCA GAGTACGGAG GATGCTGAGG ACGGACCACC CGAGCTGCTC TTCATCCATG 1440
GCGGTCACAC TGCCAAGATT AGCGATTTCT CGTGGAACCC CAATGAGCCA TGGATCATTT 1500
GCTCCGTGTC CGAGGACAAT ATTATGCAGG TCTGGCAGAT GGCCGAGAAT GTTTACAACG 1560
ACGAGGAGCC AGAGATTCCC GCCTCCGAGT TAGAAACCAA TACCGCTTAA AGCATCTGTT 1620
CCGCCTCCTA TAATACACAC CAAACTACAA CTGAATCCGA TAATGTTTTG GCCGTGCCCC 1680
GTGTCCAGCT ATCCAGCCTA AATGGCAATG GGTACTCATT TTAATTTATA TATATTTACA 1740
TATTTTTAAA AACAAAATTT AATTAAGCTC TCATTTGTCA GCAGATTGTA CAATCTATGA 1800
ATTTTTAATT AAAAATGATT AAAAAGTC
1829Nucleotide Fasta Sequence
>FBpp0082511|WD40|Drosophila melanogaster
GCAGTCGTCTCGACAATCTTTAGCATTGCATCTCTATCATCGACGACGCGCTTGCAAAAAAACGAAGGAAATTAGCCAATTTCTATTTTGCCCTGACGTTACGCCGTTTAAAGTGTAAGTTCCCGGCCAGGATTCGACTCAATCCCTGCCACAACGACTTTCGGTCAAGTGTTCGTTGCGAGAGCTTTAACTACGTAGCGAACTTTCGTAGTTTTTCTGCACACGTTTTGCCGCTTCGGCTTTTGTTTTGGCGCCCGATTTTTTCGGCTGCCGACTTTTGACGCAGACTGAGAAATTGCGTGCCTAAAAGCCTCGAAATGGTGGATCGCAGCGATAATGCAGCGGAATCCTTCGACGACGCCGTCGAGGAGCGCGTGATCAATGAGGAGTATAAGATTTGGAAAAAGAACACGCCGTTCCTGTACGATCTGGTCATGACGCATGCCCTGGAATGGCCCTCGTTGACTGCCCAGTGGCTGCCGGACGTGACCAAGCAGGATGGCAAGGACTACTCGGTACATCGTCTTATACTGGGCACACACACATCTGACGAGCAGAACCATCTACTCATCGCCAGCGTTCAGTTGCCCAGCGAGGATGCCCAGTTCGATGGTTCGCACTACGATAACGAGAAGGGCGAGTTTGGAGGCTTTGGATCGGTGTGCGGCAAAATCGAAATCGAGATTAAGATCAACCACGAGGGCGAAGTGAACAGGGCCCGCTACATGCCCCAGAACGCCTGTGTAATCGCCACCAAGACGCCGTCGAGTGATGTCCTGGTCTTCGACTACACGAAGCATCCCAGCAAGCCGGAACCGTCTGGCGAGTGCCAGCCTGACCTGCGGCTGCGCGGTCATCAAAAGGAAGGCTACGGACTCTCTTGGAATCCCAACCTCAATGGCTATTTGCTGTCAGCCTCTGATGATCACACCATCTGCTTGTGGGACATCAATGCCACACCCAAGGAGCATAGGGTTATTGATGCCAAGAACATCTTCACCGGCCACACCGCCGTTGTTGAGGACGTGGCTTGGCATCTGCTACATGAGTCTCTGTTCGGATCGGTGGCTGACGACCAGAAGCTGATGATCTGGGACACGCGCAACAACAACACCTCGAAGCCCTCGCATACAGTGGACGCTCACACAGCGGAAGTCAATTGCTTGAGCTTTAATCCCTACTCGGAGTTCATTCTGGCCACGGGCTCCGCTGACAAGACTGTAGCTCTATGGGATCTGCGCAACCTCAAGCTAAAACTACATTCCTTCGAGTCGCACAAGGACGAGATCTTCCAAGTGCAGTGGTCGCCGCATAACGAGACTATTCTCGCCTCCTCCGGCACTGACCGCCGCCTACACGTCTGGGATTTGTCCAAAATCGGCGAGGAGCAGAGTACGGAGGATGCTGAGGACGGACCACCCGAGCTGCTCTTCATCCATGGCGGTCACACTGCCAAGATTAGCGATTTCTCGTGGAACCCCAATGAGCCATGGATCATTTGCTCCGTGTCCGAGGACAATATTATGCAGGTCTGGCAGATGGCCGAGAATGTTTACAACGACGAGGAGCCAGAGATTCCCGCCTCCGAGTTAGAAACCAATACCGCTTAAAGCATCTGTTCCGCCTCCTATAATACACACCAAACTACAACTGAATCCGATAATGTTTTGGCCGTGCCCCGTGTCCAGCTATCCAGCCTAAATGGCAATGGGTACTCATTTTAATTTATATATATTTACATATTTTTAAAAACAAAATTTAATTAAGCTCTCATTTGTCAGCAGATTGTACAATCTATGAATTTTTAATTAAAAATGATTAAAAAGTC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
--
|
| Interpro |
IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
|
| PROSITE |
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
|
| Pfam |
PF12265--CAF1C_H4-bd
PF00400--WD40
|
| Gene Ontology |
GO:0033186--C:CAF-1 complex
GO:0035098--C:ESC/E(Z) complex
GO:0035097--C:histone methyltransferase complex
GO:0031523--C:Myb complex
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0016589--C:NURF complex
GO:0005700--C:polytene chromosome
GO:0070822--C:Sin3-type complex
GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0035035--F:histone acetyltransferase binding
GO:0042393--F:histone binding
GO:0042826--F:histone deacetylase binding
GO:0042803--F:protein homodimerization activity
GO:0031497--P:chromatin assembly
GO:0006342--P:chromatin silencing
GO:0048813--P:dendrite morphogenesis
GO:0006281--P:DNA repair
GO:0006335--P:DNA replication-dependent nucleosome assembly
GO:0007307--P:eggshell chorion gene amplification
GO:0016573--P:histone acetylation
GO:0070734--P:histone H3-K27 methylation
GO:0051567--P:histone H3-K9 methylation
GO:0016571--P:histone methylation
GO:0000281--P:mitotic cytokinesis
GO:0007517--P:muscle organ development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048666--P:neuron development
GO:0048812--P:neuron projection morphogenesis
GO:0006334--P:nucleosome assembly
GO:0042766--P:nucleosome mobilization
GO:0016584--P:nucleosome positioning
GO:0008284--P:positive regulation of cell proliferation
GO:0007346--P:regulation of mitotic cell cycle
GO:0007379--P:segment specification
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
