| Tag |
Content |
| WERAM ID |
WERAM-Hos-0113 |
| Ensembl Protein ID |
ENSP00000395654.1 |
| Uniprot Accession |
P51532; SMCA4_HUMAN; B1A8Z4; B1A8Z5; B1A8Z6; B1A8Z7; E9PBR8; O95052; Q9HBD3
|
| Genbank Protein ID |
NP_001122316.1; NP_001122317.1; NP_001122318.1; NP_001122319.1; NP_001122320.1; NP_003063.2; XP_005260089.1; XP_005260090.1; XP_005260091.1; XP_005260092.1
|
| Protein Name |
Transcription activator BRG1 |
| Genbank Nucleotide ID |
NM_001128844.1; NM_001128845.1; NM_001128846.1; NM_001128847.1; NM_001128848.1; NM_003072.3; XM_005260032.2; XM_005260033.2; XM_005260034.2; XM_005260035.2
|
| Gene Name |
SMARCA4;BAF190A;BRG1;SNF2B;SNF2L4 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Ac_Reader |
Bromodomain |
Bromodomain |
H2BK5; H3K9; H3K14; H4K8; H4K12; H4K16 |
K |
22464331
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Ac_Reader |
Bromodomain |
1.80e-17 |
65.5 |
1479 |
1546 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. |
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1.
|
| Domain Profile |
Ac_Reader Bromodomain
BROMO.txt 3 hevsepF.repvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71
+++se+F + p+++ e+p+Yy++i++P+d+++iker+++++Y+s++++ kDv l+++Na+++n ++s +
ENSP00000395654.1 1479 RQLSEVFiQLPSRK--ELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLI 1546
789****7777777..9***********************************************988766 PP
|
Protein Sequence
(Fasta) | MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP SAGHPIPTQG 60
PGGYPQDNMH QMHKPMESMH EKGMSDDPRY NQMKGMGMRS GGHAGMGPPP SPMDQHSQGY 120
PSPLGGSEHA SSPVPASGPS SGPQMSSGPG GAPLDGADPQ ALGQQNRGPT PFNQNQLHQL 180
RAQIMAYKML ARGQPLPDHL QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP 240
GPGPAPPNYS RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ 300
KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PMVPLHQKQS RITPIQKPRG 360
LDPVEILQER EYRLQARIAH RIQELENLPG SLAGDLRTKA TIELKALRLL NFQRQLRQEV 420
VVCMRRDTAL ETALNAKAYK RSKRQSLREA RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL 480
QHAKDFKEYH RSVTGKIQKL TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK 540
LIDQKKDKRL AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KKKKKKKKAE NAEGQTPAIG 600
PDGEPLDETS QMSDLPVKVI HVESGKILTG TDAPKAGQLE AWLEMNPGYE VAPRSDSEES 660
GSEEEEEEEE EEQPQAAQPP TLPVEEKKKI PDPDSDDVSE VDARHIIENA KQDVDDEYGV 720
SQALARGLQS YYAVAHAVTE RVDKQSALMV NGVLKQYQIK GLEWLVSLYN NNLNGILADE 780
MGLGKTIQTI ALITYLMEHK RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA 840
RRAFVPQLRS GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH 900
YVAPRRLLLT GTPLQNKLPE LWALLNFLLP TIFKSCSTFE QWFNAPFAMT GEKVDLNEEE 960
TILIIRRLHK VLRPFLLRRL KKEVEAQLPE KVEYVIKCDM SALQRVLYRH MQAKGVLLTD 1020
GSEKDKKGKG GTKTLMNTIM QLRKICNHPY MFQHIEESFS EHLGFTGGIV QGLDLYRASG 1080
KFELLDRILP KLRATNHKVL LFCQMTSLMT IMEDYFAYRG FKYLRLDGTT KAEDRGMLLK 1140
TFNEPGSEYF IFLLSTRAGG LGLNLQSADT VIIFDSDWNP HQDLQAQDRA HRIGQQNEVR 1200
VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ AGMFDQKSSS HERRAFLQAI LEHEEQDESR 1260
HCSTGSGSAS FAHTAPPPAG VNPDLEEPPL KEEDEVPDDE TVNQMIARHE EEFDLFMRMD 1320
LDRRREEARN PKRKPRLMEE DELPSWIIKD DAEVERLTCE EEEEKMFGRG SRHRKEVDYS 1380
DSLTEKQWLK AIEEGTLEEI EEEVRQKKSS RKRKRDSDAG SSTPTTSTRS RDKDDESKKQ 1440
KKRGRPPAEK LSPNPPNLTK KMKKIVDAVI KYKDSSSGRQ LSEVFIQLPS RKELPEYYEL 1500
IRKPVDFKKI KERIRNHKYR SLNDLEKDVM LLCQNAQTFN LEGSLIYEDS IVLQSVFTSV 1560
RQKIEKEDDS EGEESEEEEE GEEEGSESES RSVKVKIKLG RKEKAQDRLK GGRRRPSRGS 1620
RAKPVVSDDD SEEEQEEDRS GSGSEED 1647Protein Fasta Sequence
>ENSP00000395654.1|SMARCA4;BAF190A;BRG1;SNF2B;SNF2L4|Homo sapiens
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED |
Nucleotide Sequence
(Fasta) | GTGAAGGGGG GGCGGTGGCC GAGGCGGGCG GGCGCGCGCG CGAGGCTTCC CCTCGTTTGG 60
CGGCGGCGGC GGCTTCTTTG TTTCGTGAAG AGAAGCGAGA CGCCCATTCT GCCCCCGGCC 120
CCGCGCGGAG GGGCGGGGGA GGCGCCGGGA AGTCGACGGC GCCGGCGGCT CCTGCGTCTC 180
GCCCTTTTGC CCAGGCTAGA GTGCAGTGGT GCGGTCATGG TTCACTGCAG CCTCAACCTC 240
CTGGACTCAG CAGGAGGCCA CTGTCTGCAG CTCCCGTGAA GATGTCCACT CCAGACCCAC 300
CCCTGGGCGG AACTCCTCGG CCAGGTCCTT CCCCGGGCCC TGGCCCTTCC CCTGGAGCCA 360
TGCTGGGCCC TAGCCCGGGT CCCTCGCCGG GCTCCGCCCA CAGCATGATG GGGCCCAGCC 420
CAGGGCCGCC CTCAGCAGGA CACCCCATCC CCACCCAGGG GCCTGGAGGG TACCCTCAGG 480
ACAACATGCA CCAGATGCAC AAGCCCATGG AGTCCATGCA TGAGAAGGGC ATGTCGGACG 540
ACCCGCGCTA CAACCAGATG AAAGGAATGG GGATGCGGTC AGGGGGCCAT GCTGGGATGG 600
GGCCCCCGCC CAGCCCCATG GACCAGCACT CCCAAGGTTA CCCCTCGCCC CTGGGTGGCT 660
CTGAGCATGC CTCTAGTCCA GTTCCAGCCA GTGGCCCGTC TTCGGGGCCC CAGATGTCTT 720
CCGGGCCAGG AGGTGCCCCG CTGGATGGTG CTGACCCCCA GGCCTTGGGG CAGCAGAACC 780
GGGGCCCAAC CCCATTTAAC CAGAACCAGC TGCACCAGCT CAGAGCTCAG ATCATGGCCT 840
ACAAGATGCT GGCCAGGGGG CAGCCCCTCC CCGACCACCT GCAGATGGCG GTGCAGGGCA 900
AGCGGCCGAT GCCCGGGATG CAGCAGCAGA TGCCAACGCT ACCTCCACCC TCGGTGTCCG 960
CAACAGGACC CGGCCCTGGC CCTGGCCCTG GCCCCGGCCC GGGTCCCGGC CCGGCACCTC 1020
CAAATTACAG CAGGCCTCAT GGTATGGGAG GGCCCAACAT GCCTCCCCCA GGACCCTCGG 1080
GCGTGCCCCC CGGGATGCCA GGCCAGCCTC CTGGAGGGCC TCCCAAGCCC TGGCCTGAAG 1140
GACCCATGGC GAATGCTGCT GCCCCCACGA GCACCCCTCA GAAGCTGATT CCCCCGCAGC 1200
CAACGGGCCG CCCTTCCCCC GCGCCCCCTG CCGTCCCACC CGCCGCCTCG CCCGTGATGC 1260
CACCGCAGAC CCAGTCCCCC GGGCAGCCGG CCCAGCCCGC GCCCATGGTG CCACTGCACC 1320
AGAAGCAGAG CCGCATCACC CCCATCCAGA AGCCGCGGGG CCTCGACCCT GTGGAGATCC 1380
TGCAGGAGCG CGAGTACAGG CTGCAGGCTC GCATCGCACA CCGAATTCAG GAACTTGAAA 1440
ACCTTCCCGG GTCCCTGGCC GGGGATTTGC GAACCAAAGC GACCATTGAG CTCAAGGCCC 1500
TCAGGCTGCT GAACTTCCAG AGGCAGCTGC GCCAGGAGGT GGTGGTGTGC ATGCGGAGGG 1560
ACACAGCGCT GGAGACAGCC CTCAATGCTA AGGCCTACAA GCGCAGCAAG CGCCAGTCCC 1620
TGCGCGAGGC CCGCATCACT GAGAAGCTGG AGAAGCAGCA GAAGATCGAG CAGGAGCGCA 1680
AGCGCCGGCA GAAGCACCAG GAATACCTCA ATAGCATTCT CCAGCATGCC AAGGATTTCA 1740
AGGAATATCA CAGATCCGTC ACAGGCAAAA TCCAGAAGCT GACCAAGGCA GTGGCCACGT 1800
ACCATGCCAA CACGGAGCGG GAGCAGAAGA AAGAGAACGA GCGGATCGAG AAGGAGCGCA 1860
TGCGGAGGCT CATGGCTGAA GATGAGGAGG GGTACCGCAA GCTCATCGAC CAGAAGAAGG 1920
ACAAGCGCCT GGCCTACCTC TTGCAGCAGA CAGACGAGTA CGTGGCTAAC CTCACGGAGC 1980
TGGTGCGGCA GCACAAGGCT GCCCAGGTCG CCAAGGAGAA AAAGAAGAAA AAGAAAAAGA 2040
AGAAGGCAGA AAATGCAGAA GGACAGACGC CTGCCATTGG GCCGGATGGC GAGCCTCTGG 2100
ACGAGACCAG CCAGATGAGC GACCTCCCGG TGAAGGTGAT CCACGTGGAG AGTGGGAAGA 2160
TCCTCACAGG CACAGATGCC CCCAAAGCCG GGCAGCTGGA GGCCTGGCTC GAGATGAACC 2220
CGGGGTATGA AGTAGCTCCG AGGTCTGATA GTGAAGAAAG TGGCTCAGAA GAAGAGGAAG 2280
AGGAGGAGGA GGAAGAGCAG CCGCAGGCAG CACAGCCTCC CACCCTGCCC GTGGAGGAGA 2340
AGAAGAAGAT TCCAGATCCA GACAGCGATG ACGTCTCTGA GGTGGACGCG CGGCACATCA 2400
TTGAGAATGC CAAGCAAGAT GTCGATGATG AATATGGCGT GTCCCAGGCC CTTGCACGTG 2460
GCCTGCAGTC CTACTATGCC GTGGCCCATG CTGTCACTGA GAGAGTGGAC AAGCAGTCAG 2520
CGCTTATGGT CAATGGTGTC CTCAAACAGT ACCAGATCAA AGGTTTGGAG TGGCTGGTGT 2580
CCCTGTACAA CAACAACCTG AACGGCATCC TGGCCGACGA GATGGGCCTG GGGAAGACCA 2640
TCCAGACCAT CGCGCTCATC ACGTACCTCA TGGAGCACAA ACGCATCAAT GGGCCCTTCC 2700
TCATCATCGT GCCTCTCTCA ACGCTGTCCA ACTGGGCGTA CGAGTTTGAC AAGTGGGCCC 2760
CCTCCGTGGT GAAGGTGTCT TACAAGGGAT CCCCAGCAGC AAGACGGGCC TTTGTCCCCC 2820
AGCTCCGGAG TGGGAAGTTC AACGTCTTGC TGACGACGTA CGAGTACATC ATCAAAGACA 2880
AGCACATCCT CGCCAAGATC CGTTGGAAGT ACATGATTGT GGACGAAGGT CACCGCATGA 2940
AGAACCACCA CTGCAAGCTG ACGCAGGTGC TCAACACGCA CTATGTGGCA CCCCGCCGCC 3000
TGCTGCTGAC GGGCACACCG CTGCAGAACA AGCTTCCCGA GCTCTGGGCG CTGCTCAACT 3060
TCCTGCTGCC CACCATCTTC AAGAGCTGCA GCACCTTCGA GCAGTGGTTT AACGCACCCT 3120
TTGCCATGAC CGGGGAAAAG GTGGACCTGA ATGAGGAGGA AACCATTCTC ATCATCCGGC 3180
GTCTCCACAA AGTGCTGCGG CCCTTCTTGC TCCGACGACT CAAGAAGGAA GTCGAGGCCC 3240
AGTTGCCCGA AAAGGTGGAG TACGTCATCA AGTGCGACAT GTCTGCGCTG CAGCGAGTGC 3300
TCTACCGCCA CATGCAGGCC AAGGGCGTGC TGCTGACTGA TGGCTCCGAG AAGGACAAGA 3360
AGGGCAAAGG CGGCACCAAG ACCCTGATGA ACACCATCAT GCAGCTGCGG AAGATCTGCA 3420
ACCACCCCTA CATGTTCCAG CACATCGAGG AGTCCTTTTC CGAGCACTTG GGGTTCACTG 3480
GCGGCATTGT CCAAGGGCTG GACCTGTACC GAGCCTCGGG TAAATTTGAG CTTCTTGATA 3540
GAATTCTTCC CAAACTCCGA GCAACCAACC ACAAAGTGCT GCTGTTCTGC CAAATGACCT 3600
CCCTCATGAC CATCATGGAA GATTACTTTG CGTATCGCGG CTTTAAATAC CTCAGGCTTG 3660
ATGGAACCAC GAAGGCGGAG GACCGGGGCA TGCTGCTGAA AACCTTCAAC GAGCCCGGCT 3720
CTGAGTACTT CATCTTCCTG CTCAGCACCC GGGCTGGGGG GCTCGGCCTG AACCTCCAGT 3780
CGGCAGACAC TGTGATCATT TTTGACAGCG ACTGGAATCC TCACCAGGAC CTGCAAGCGC 3840
AGGACCGAGC CCACCGCATC GGGCAGCAGA ACGAGGTGCG TGTGCTCCGC CTCTGCACCG 3900
TCAACAGCGT GGAGGAGAAG ATCCTAGCTG CAGCCAAGTA CAAGCTCAAC GTGGACCAGA 3960
AGGTGATCCA GGCCGGCATG TTCGACCAGA AGTCCTCCAG CCATGAGCGG CGCGCCTTCC 4020
TGCAGGCCAT CCTGGAGCAC GAGGAGCAGG ATGAGAGCAG ACACTGCAGC ACGGGCAGCG 4080
GCAGTGCCAG CTTCGCCCAC ACTGCCCCTC CGCCAGCGGG CGTCAACCCC GACTTGGAGG 4140
AGCCACCTCT AAAGGAGGAA GACGAGGTGC CCGACGACGA GACCGTCAAC CAGATGATCG 4200
CCCGGCACGA GGAGGAGTTT GATCTGTTCA TGCGCATGGA CCTGGACCGC AGGCGCGAGG 4260
AGGCCCGCAA CCCCAAGCGG AAGCCGCGCC TCATGGAGGA GGACGAGCTC CCCTCGTGGA 4320
TCATCAAGGA CGACGCGGAG GTGGAGCGGC TGACCTGTGA GGAGGAGGAG GAGAAGATGT 4380
TCGGCCGTGG CTCCCGCCAC CGCAAGGAGG TGGACTACAG CGACTCACTG ACGGAGAAGC 4440
AGTGGCTCAA GGCCATCGAG GAGGGCACGC TGGAGGAGAT CGAAGAGGAG GTCCGGCAGA 4500
AGAAATCATC ACGGAAGCGC AAGCGAGACA GCGACGCCGG CTCCTCCACC CCGACCACCA 4560
GCACCCGCAG CCGCGACAAG GACGACGAGA GCAAGAAGCA GAAGAAGCGC GGGCGGCCGC 4620
CTGCCGAGAA ACTCTCCCCT AACCCACCCA ACCTCACCAA GAAGATGAAG AAGATTGTGG 4680
ATGCCGTGAT CAAGTACAAG GACAGCAGCA GTGGACGTCA GCTCAGCGAG GTCTTCATCC 4740
AGCTGCCCTC GCGAAAGGAG CTGCCCGAGT ACTACGAGCT CATCCGCAAG CCCGTGGACT 4800
TCAAGAAGAT AAAGGAGCGC ATTCGCAACC ACAAGTACCG CAGCCTCAAC GACCTAGAGA 4860
AGGACGTCAT GCTCCTGTGC CAGAACGCAC AGACCTTCAA CCTGGAGGGC TCCCTGATCT 4920
ATGAAGACTC CATCGTCTTG CAGTCGGTCT TCACCAGCGT GCGGCAGAAA ATCGAGAAGG 4980
AGGATGACAG TGAAGGCGAG GAGAGTGAGG AGGAGGAAGA GGGCGAGGAG GAAGGCTCCG 5040
AATCCGAATC TCGGTCCGTC AAAGTGAAGA TCAAGCTTGG CCGGAAGGAG AAGGCACAGG 5100
ACCGGCTGAA GGGCGGCCGG CGGCGGCCGA GCCGAGGGTC CCGAGCCAAG CCGGTCGTGA 5160
GTGACGATGA CAGTGAGGAG GAACAAGAGG AGGACCGCTC AGGAAGTGGC AGCGAAGAAG 5220
ACTGAGCCCC GACATTCCAG TCTCGACCCC GAGCCCCTCG TTCCAGAGCT GAGATGGCAT 5280
AGGCCTTAGC AGTAACGGGT AGCAGCAGAT GTAGTTTCAG ACTTGGAGTA AAACTGTATA 5340
AACAAAAGAA TCTTCCATAT TTATACAGCA GAGAAGCTGT AGGACTGTTT GTGACTGGCC 5400
CTGTCCTGGC ATCAGTAGCA TCTGTAACAG CATTAACTGT CTTAAAGAGA GAGAGAGAGA 5460
ATTCCGAATT GGGGAACACA CGATACCTGT TTTTCTTTTC CGTTGCTGGC AGTACTGTTG 5520
CGCCGCAGTT TGGAGTCACT GTAGTTAAGT GTGGATGCAT GTGCGTCACC GTCCACTCCT 5580
CCTACTGTAT TTTATTGGAC AGGTCAGACT CGCCGGGGGC CCGGCGAGGG TATGTCAGTG 5640
TCACTGGATG TCAAACAGTA ATAAATTAAA CCAACAACAA AACGCACAGC C
5692Nucleotide Fasta Sequence
>ENSP00000395654.1|Bromodomain|Homo sapiens
GTGAAGGGGGGGCGGTGGCCGAGGCGGGCGGGCGCGCGCGCGAGGCTTCCCCTCGTTTGGCGGCGGCGGCGGCTTCTTTGTTTCGTGAAGAGAAGCGAGACGCCCATTCTGCCCCCGGCCCCGCGCGGAGGGGCGGGGGAGGCGCCGGGAAGTCGACGGCGCCGGCGGCTCCTGCGTCTCGCCCTTTTGCCCAGGCTAGAGTGCAGTGGTGCGGTCATGGTTCACTGCAGCCTCAACCTCCTGGACTCAGCAGGAGGCCACTGTCTGCAGCTCCCGTGAAGATGTCCACTCCAGACCCACCCCTGGGCGGAACTCCTCGGCCAGGTCCTTCCCCGGGCCCTGGCCCTTCCCCTGGAGCCATGCTGGGCCCTAGCCCGGGTCCCTCGCCGGGCTCCGCCCACAGCATGATGGGGCCCAGCCCAGGGCCGCCCTCAGCAGGACACCCCATCCCCACCCAGGGGCCTGGAGGGTACCCTCAGGACAACATGCACCAGATGCACAAGCCCATGGAGTCCATGCATGAGAAGGGCATGTCGGACGACCCGCGCTACAACCAGATGAAAGGAATGGGGATGCGGTCAGGGGGCCATGCTGGGATGGGGCCCCCGCCCAGCCCCATGGACCAGCACTCCCAAGGTTACCCCTCGCCCCTGGGTGGCTCTGAGCATGCCTCTAGTCCAGTTCCAGCCAGTGGCCCGTCTTCGGGGCCCCAGATGTCTTCCGGGCCAGGAGGTGCCCCGCTGGATGGTGCTGACCCCCAGGCCTTGGGGCAGCAGAACCGGGGCCCAACCCCATTTAACCAGAACCAGCTGCACCAGCTCAGAGCTCAGATCATGGCCTACAAGATGCTGGCCAGGGGGCAGCCCCTCCCCGACCACCTGCAGATGGCGGTGCAGGGCAAGCGGCCGATGCCCGGGATGCAGCAGCAGATGCCAACGCTACCTCCACCCTCGGTGTCCGCAACAGGACCCGGCCCTGGCCCTGGCCCTGGCCCCGGCCCGGGTCCCGGCCCGGCACCTCCAAATTACAGCAGGCCTCATGGTATGGGAGGGCCCAACATGCCTCCCCCAGGACCCTCGGGCGTGCCCCCCGGGATGCCAGGCCAGCCTCCTGGAGGGCCTCCCAAGCCCTGGCCTGAAGGACCCATGGCGAATGCTGCTGCCCCCACGAGCACCCCTCAGAAGCTGATTCCCCCGCAGCCAACGGGCCGCCCTTCCCCCGCGCCCCCTGCCGTCCCACCCGCCGCCTCGCCCGTGATGCCACCGCAGACCCAGTCCCCCGGGCAGCCGGCCCAGCCCGCGCCCATGGTGCCACTGCACCAGAAGCAGAGCCGCATCACCCCCATCCAGAAGCCGCGGGGCCTCGACCCTGTGGAGATCCTGCAGGAGCGCGAGTACAGGCTGCAGGCTCGCATCGCACACCGAATTCAGGAACTTGAAAACCTTCCCGGGTCCCTGGCCGGGGATTTGCGAACCAAAGCGACCATTGAGCTCAAGGCCCTCAGGCTGCTGAACTTCCAGAGGCAGCTGCGCCAGGAGGTGGTGGTGTGCATGCGGAGGGACACAGCGCTGGAGACAGCCCTCAATGCTAAGGCCTACAAGCGCAGCAAGCGCCAGTCCCTGCGCGAGGCCCGCATCACTGAGAAGCTGGAGAAGCAGCAGAAGATCGAGCAGGAGCGCAAGCGCCGGCAGAAGCACCAGGAATACCTCAATAGCATTCTCCAGCATGCCAAGGATTTCAAGGAATATCACAGATCCGTCACAGGCAAAATCCAGAAGCTGACCAAGGCAGTGGCCACGTACCATGCCAACACGGAGCGGGAGCAGAAGAAAGAGAACGAGCGGATCGAGAAGGAGCGCATGCGGAGGCTCATGGCTGAAGATGAGGAGGGGTACCGCAAGCTCATCGACCAGAAGAAGGACAAGCGCCTGGCCTACCTCTTGCAGCAGACAGACGAGTACGTGGCTAACCTCACGGAGCTGGTGCGGCAGCACAAGGCTGCCCAGGTCGCCAAGGAGAAAAAGAAGAAAAAGAAAAAGAAGAAGGCAGAAAATGCAGAAGGACAGACGCCTGCCATTGGGCCGGATGGCGAGCCTCTGGACGAGACCAGCCAGATGAGCGACCTCCCGGTGAAGGTGATCCACGTGGAGAGTGGGAAGATCCTCACAGGCACAGATGCCCCCAAAGCCGGGCAGCTGGAGGCCTGGCTCGAGATGAACCCGGGGTATGAAGTAGCTCCGAGGTCTGATAGTGAAGAAAGTGGCTCAGAAGAAGAGGAAGAGGAGGAGGAGGAAGAGCAGCCGCAGGCAGCACAGCCTCCCACCCTGCCCGTGGAGGAGAAGAAGAAGATTCCAGATCCAGACAGCGATGACGTCTCTGAGGTGGACGCGCGGCACATCATTGAGAATGCCAAGCAAGATGTCGATGATGAATATGGCGTGTCCCAGGCCCTTGCACGTGGCCTGCAGTCCTACTATGCCGTGGCCCATGCTGTCACTGAGAGAGTGGACAAGCAGTCAGCGCTTATGGTCAATGGTGTCCTCAAACAGTACCAGATCAAAGGTTTGGAGTGGCTGGTGTCCCTGTACAACAACAACCTGAACGGCATCCTGGCCGACGAGATGGGCCTGGGGAAGACCATCCAGACCATCGCGCTCATCACGTACCTCATGGAGCACAAACGCATCAATGGGCCCTTCCTCATCATCGTGCCTCTCTCAACGCTGTCCAACTGGGCGTACGAGTTTGACAAGTGGGCCCCCTCCGTGGTGAAGGTGTCTTACAAGGGATCCCCAGCAGCAAGACGGGCCTTTGTCCCCCAGCTCCGGAGTGGGAAGTTCAACGTCTTGCTGACGACGTACGAGTACATCATCAAAGACAAGCACATCCTCGCCAAGATCCGTTGGAAGTACATGATTGTGGACGAAGGTCACCGCATGAAGAACCACCACTGCAAGCTGACGCAGGTGCTCAACACGCACTATGTGGCACCCCGCCGCCTGCTGCTGACGGGCACACCGCTGCAGAACAAGCTTCCCGAGCTCTGGGCGCTGCTCAACTTCCTGCTGCCCACCATCTTCAAGAGCTGCAGCACCTTCGAGCAGTGGTTTAACGCACCCTTTGCCATGACCGGGGAAAAGGTGGACCTGAATGAGGAGGAAACCATTCTCATCATCCGGCGTCTCCACAAAGTGCTGCGGCCCTTCTTGCTCCGACGACTCAAGAAGGAAGTCGAGGCCCAGTTGCCCGAAAAGGTGGAGTACGTCATCAAGTGCGACATGTCTGCGCTGCAGCGAGTGCTCTACCGCCACATGCAGGCCAAGGGCGTGCTGCTGACTGATGGCTCCGAGAAGGACAAGAAGGGCAAAGGCGGCACCAAGACCCTGATGAACACCATCATGCAGCTGCGGAAGATCTGCAACCACCCCTACATGTTCCAGCACATCGAGGAGTCCTTTTCCGAGCACTTGGGGTTCACTGGCGGCATTGTCCAAGGGCTGGACCTGTACCGAGCCTCGGGTAAATTTGAGCTTCTTGATAGAATTCTTCCCAAACTCCGAGCAACCAACCACAAAGTGCTGCTGTTCTGCCAAATGACCTCCCTCATGACCATCATGGAAGATTACTTTGCGTATCGCGGCTTTAAATACCTCAGGCTTGATGGAACCACGAAGGCGGAGGACCGGGGCATGCTGCTGAAAACCTTCAACGAGCCCGGCTCTGAGTACTTCATCTTCCTGCTCAGCACCCGGGCTGGGGGGCTCGGCCTGAACCTCCAGTCGGCAGACACTGTGATCATTTTTGACAGCGACTGGAATCCTCACCAGGACCTGCAAGCGCAGGACCGAGCCCACCGCATCGGGCAGCAGAACGAGGTGCGTGTGCTCCGCCTCTGCACCGTCAACAGCGTGGAGGAGAAGATCCTAGCTGCAGCCAAGTACAAGCTCAACGTGGACCAGAAGGTGATCCAGGCCGGCATGTTCGACCAGAAGTCCTCCAGCCATGAGCGGCGCGCCTTCCTGCAGGCCATCCTGGAGCACGAGGAGCAGGATGAGAGCAGACACTGCAGCACGGGCAGCGGCAGTGCCAGCTTCGCCCACACTGCCCCTCCGCCAGCGGGCGTCAACCCCGACTTGGAGGAGCCACCTCTAAAGGAGGAAGACGAGGTGCCCGACGACGAGACCGTCAACCAGATGATCGCCCGGCACGAGGAGGAGTTTGATCTGTTCATGCGCATGGACCTGGACCGCAGGCGCGAGGAGGCCCGCAACCCCAAGCGGAAGCCGCGCCTCATGGAGGAGGACGAGCTCCCCTCGTGGATCATCAAGGACGACGCGGAGGTGGAGCGGCTGACCTGTGAGGAGGAGGAGGAGAAGATGTTCGGCCGTGGCTCCCGCCACCGCAAGGAGGTGGACTACAGCGACTCACTGACGGAGAAGCAGTGGCTCAAGGCCATCGAGGAGGGCACGCTGGAGGAGATCGAAGAGGAGGTCCGGCAGAAGAAATCATCACGGAAGCGCAAGCGAGACAGCGACGCCGGCTCCTCCACCCCGACCACCAGCACCCGCAGCCGCGACAAGGACGACGAGAGCAAGAAGCAGAAGAAGCGCGGGCGGCCGCCTGCCGAGAAACTCTCCCCTAACCCACCCAACCTCACCAAGAAGATGAAGAAGATTGTGGATGCCGTGATCAAGTACAAGGACAGCAGCAGTGGACGTCAGCTCAGCGAGGTCTTCATCCAGCTGCCCTCGCGAAAGGAGCTGCCCGAGTACTACGAGCTCATCCGCAAGCCCGTGGACTTCAAGAAGATAAAGGAGCGCATTCGCAACCACAAGTACCGCAGCCTCAACGACCTAGAGAAGGACGTCATGCTCCTGTGCCAGAACGCACAGACCTTCAACCTGGAGGGCTCCCTGATCTATGAAGACTCCATCGTCTTGCAGTCGGTCTTCACCAGCGTGCGGCAGAAAATCGAGAAGGAGGATGACAGTGAAGGCGAGGAGAGTGAGGAGGAGGAAGAGGGCGAGGAGGAAGGCTCCGAATCCGAATCTCGGTCCGTCAAAGTGAAGATCAAGCTTGGCCGGAAGGAGAAGGCACAGGACCGGCTGAAGGGCGGCCGGCGGCGGCCGAGCCGAGGGTCCCGAGCCAAGCCGGTCGTGAGTGACGATGACAGTGAGGAGGAACAAGAGGAGGACCGCTCAGGAAGTGGCAGCGAAGAAGACTGAGCCCCGACATTCCAGTCTCGACCCCGAGCCCCTCGTTCCAGAGCTGAGATGGCATAGGCCTTAGCAGTAACGGGTAGCAGCAGATGTAGTTTCAGACTTGGAGTAAAACTGTATAAACAAAAGAATCTTCCATATTTATACAGCAGAGAAGCTGTAGGACTGTTTGTGACTGGCCCTGTCCTGGCATCAGTAGCATCTGTAACAGCATTAACTGTCTTAAAGAGAGAGAGAGAGAATTCCGAATTGGGGAACACACGATACCTGTTTTTCTTTTCCGTTGCTGGCAGTACTGTTGCGCCGCAGTTTGGAGTCACTGTAGTTAAGTGTGGATGCATGTGCGTCACCGTCCACTCCTCCTACTGTATTTTATTGGACAGGTCAGACTCGCCGGGGGCCCGGCGAGGGTATGTCAGTGTCACTGGATGTCAAACAGTAATAAATTAAACCAACAACAAAACGCACAGCC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0347--Helicase
KW-0378--Hydrolase
KW-0991--Mental retardation
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR030100--BRG1
IPR006576--BRK_domain
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR014978--Gln-Leu-Gln_QLQ
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR014012--HSA_dom
IPR027417--P-loop_NTPase
IPR029295--SnAC
IPR000330--SNF2_N
|
| PROSITE |
PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51204--HSA
PS51666--QLQ
|
| Pfam |
PF07533--BRK
PF00439--Bromodomain
PF00271--Helicase_C
PF07529--HSA
PF08880--QLQ
PF14619--SnAC
PF00176--SNF2_N
|
| Gene Ontology |
GO:0005615--C:extracellular space
GO:0016020--C:membrane
GO:0071565--C:nBAF complex
GO:0071564--C:npBAF complex
GO:0000790--C:nuclear chromatin
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0016514--C:SWI/SNF complex
GO:0050681--F:androgen receptor binding
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0070182--F:DNA polymerase binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0004386--F:helicase activity
GO:0070577--F:lysine-acetylated histone binding
GO:0002039--F:p53 binding
GO:0047485--F:protein N-terminus binding
GO:0001164--F:RNA polymerase I CORE element sequence-specific DNA binding
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0030957--F:Tat protein binding
GO:0003713--F:transcription coactivator activity
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:1904837--P:beta-catenin-TCF complex assembly
GO:0006338--P:chromatin remodeling
GO:0060766--P:negative regulation of androgen receptor signaling pathway
GO:0030308--P:negative regulation of cell growth
GO:2000134--P:negative regulation of G1/S transition of mitotic cell cycle
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007070--P:negative regulation of transcription from RNA polymerase II promoter during mitosis
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007399--P:nervous system development
GO:0003407--P:neural retina development
GO:0006337--P:nucleosome disassembly
GO:0043923--P:positive regulation by host of viral transcription
GO:1902661--P:positive regulation of glucose mediated signaling pathway
GO:1902895--P:positive regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1901838--P:positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030177--P:positive regulation of Wnt signaling pathway
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0007286--P:spermatid development
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
