WERAM Information


Tag Content
WERAM ID WERAM-Hos-0082
Ensembl Protein ID ENSP00000380024.4
Uniprot Accession Q9UNL4; ING4_HUMAN; A4KYM4; A4KYM6; D3DUR8; Q0EF62; Q0EF63; Q4VBQ6; Q96E15; Q9H3J0
Genbank Protein ID NP_001121054.1; NP_001121055.1; NP_001121056.1; NP_001121057.1; NP_001121058.1; NP_057246.2
Protein Name Inhibitor of growth protein 4
Genbank Nucleotide ID NM_001127582.1; NM_001127583.1; NM_001127584.1; NM_001127585.1; NM_001127586.1; NM_016162.3
Gene Name ING4;My036
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000111653.19 ENST00000396807.8 ENSP00000380024.4
ENSG00000111653.19 ENST00000341550.8 ENSP00000343396.4
ENSG00000111653.19 ENST00000444704.5 ENSP00000397343.2
ENSG00000111653.19 ENST00000412586.6 ENSP00000412705.2
ENSG00000111653.19 ENST00000446105.6 ENSP00000415903.2
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me3 K 24631869
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 3.60e-11 45.3 197 244
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance aopotosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).
Domain Profile
  Me_Reader PHD

            PHD.txt   2 tiClvCgkddegekemvqCde..Cd.dwfHlkCvklplsslpegkswyCpsCke 52 
t+Cl C+++++ge m+ Cd+ C+ +wfH Cv+l+ + p g +w+Cp+C +
ENSP00000380024.4 197 TYCL-CHQVSYGE--MIGCDNpdCSiEWFHFACVGLT--TKPRG-KWFCPRCSQ 244
89*9.*******6..**********************..*****.*******86 PP

Protein Sequence
(Fasta)
MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM SSARSLSSEE 60
KLALLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD 120
YDSSSSKGKK KGRTQKEKKA ARARSKGKNS DEEAPKTAQK KLKLVRTSPE YGMPSVTFGS 180
VHPSDVLDMP VDPNEPTYCL CHQVSYGEMI GCDNPDCSIE WFHFACVGLT TKPRGKWFCP 240
RCSQERKKK 249
Nucleotide Sequence
(Fasta)
TTCCGGGGCG GATCGGAAGT TGCTTTGTTT TGCTTCGAGA TGGCTGCGGG GATGTATTTG 60
GAACATTATC TGGACAGTAT TGAAAACCTT CCCTTTGAAT TACAGAGAAA CTTTCAGCTC 120
ATGAGGGACC TAGACCAAAG AACAGAGGAC CTGAAGGCTG AAATTGACAA GTTGGCCACT 180
GAGTATATGA GTAGTGCCCG CAGCCTGAGC TCCGAGGAAA AATTGGCCCT TCTCAAACAG 240
ATCCAGGAAG CCTATGGCAA GTGCAAGGAA TTTGGTGACG ACAAGGTGCA GCTTGCCATG 300
CAGACCTATG AGATGGTGGA CAAACACATT CGGCGGCTGG ACACAGACCT GGCCCGTTTT 360
GAGGCTGATC TCAAGGAGAA ACAGATTGAG TCAAGTGACT ATGACAGCTC TTCCAGCAAA 420
GGCAAAAAGA AAGGCCGGAC TCAAAAGGAG AAGAAAGCTG CTCGTGCTCG TTCCAAAGGG 480
AAAAACTCGG ATGAAGAAGC CCCCAAGACT GCCCAGAAGA AGTTAAAGCT CGTGCGCACA 540
AGTCCTGAGT ATGGGATGCC CTCAGTGACC TTTGGCAGTG TCCACCCCTC TGATGTGTTG 600
GATATGCCTG TGGATCCCAA CGAACCCACC TATTGCCTTT GTCACCAGGT CTCCTATGGA 660
GAGATGATTG GCTGTGACAA CCCTGATTGT TCCATTGAGT GGTTCCATTT TGCCTGTGTG 720
GGGCTGACAA CCAAGCCTCG GGGGAAATGG TTTTGCCCAC GCTGCTCCCA AGAACGGAAG 780
AAGAAATAGA TAAGGGCCTT GGATTCCAAC ACAGTTTCTT CCACATCCCC TGACTTGGGC 840
TAGTGGGCAG AGGAATGCCT GTGCTGGGGC CAGGGGTTCA GGGAGGAGTG GATGGCACAG 900
TGCTGTCATC CCTTCTCCTC CCCTCTCCCC ACTCCCGGTG CTGAGGCTGC ATCAGACCCT 960
GGTAGGGAGG GGTGCCGCAG CCACTAACGG TATGTGCTCT CCTTCAGCCC TCTCCCTTCG 1020
GAGGGACGTG GTCTTGCCCA CTGTCCTTTT GCCTCCATGC TGAGGTCGGT GCTGTATTTC 1080
AGAGGGAGGG TCCTTTTCAT TCTCCTTGCT TTGTATTTAA GGACTGGGGC ATAGCATGGG 1140
GGCAGTCCCC CAGACCTCTT CATTCCCCCT CCTGTGGTGA GGGCTAGGTG TGATCAACAC 1200
TTTTCTTCTC CATTCCCTTC CTGCTTTTTT CATGGTGGGG GATCCACCAG GTCATCTAGG 1260
CTCTGGCCCT AGTTGAAGGG GCACCCCTTC CTCTGTGCCA AGAGGATTCA TCCTGGGAGA 1320
GGGGGCAAGG TGGAATGCAG ATAACTCACA TGTAAAAGGA ACTTGGGTAG GTAAATAAAA 1380
GCTATACATG TTG 1394
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0164--Citrullination
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger
--

Interpro

IPR028647--ING4
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035064--F:methylated histone binding
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007050--P:cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process
GO:0006473--P:protein acetylation

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Nol-0043 ENSNLEP00000005441.1 Nomascus leucogenys 100 8e-120 426
WERAM-Mam-0158 ENSMMUP00000022340.2 Macaca mulatta 100 8e-120 426
WERAM-Gog-0176 ENSGGOP00000015639.2 Gorilla gorilla 100 8e-120 426
WERAM-Chs-0123 ENSCSAP00000006623.1 Chlorocebus sabaeus 100 8e-120 426
WERAM-Caj-0089 ENSCJAP00000014925.1 Callithrix jacchus 100 8e-120 426
WERAM-Pat-0039 ENSPTRP00000007834.3 Pan troglodytes 100 3e-119 424
WERAM-Otg-0103 ENSOGAP00000008974.2 Otolemur garnettii 100 3e-119 424
WERAM-Loa-0090 ENSLAFP00000007029.3 Loxodonta africana 100 3e-119 424
WERAM-Fec-0076 ENSFCAP00000006388.3 Felis catus 100 3e-119 424
WERAM-Cap-0136 ENSCPOP00000011074.2 Cavia porcellus 99 3e-119 424
WERAM-Ptv-0122 ENSPVAP00000010783.1 Pteropus vampyrus 99 3e-119 424
WERAM-Eqc-0207 ENSECAP00000022343.1 Equus caballus 99 3e-119 424
WERAM-Sah-0173 ENSSHAP00000017995.1 Sarcophilus harrisii 98 3e-119 424
WERAM-Ict-0084 ENSSTOP00000008871.2 Ictidomys tridecemlineatus 99 4e-119 424
WERAM-Orc-0031 ENSOCUP00000003241.2 Oryctolagus cuniculus 99 9e-119 423
WERAM-Caf-0153 ENSCAFP00000021782.3 Canis familiaris 99 9e-119 423
WERAM-Mod-0170 ENSMODP00000022570.2 Monodelphis domestica 98 1e-118 422
WERAM-Paa-0054 ENSPANP00000015836.1 Papio anubis 97 1e-118 422
WERAM-Ran-0149 ENSRNOP00000024116.6 Rattus norvegicus 95 4e-118 421
WERAM-Tub-0041 ENSTBEP00000005072.1 Tupaia belangeri 96 5e-118 420
WERAM-Mim-0061 ENSMICP00000006050.1 Microcebus murinus 96 5e-118 420
WERAM-Aim-0161 ENSAMEP00000014918.1 Ailuropoda melanoleuca 96 5e-118 420
WERAM-Mum-0107 ENSMUSP00000032480.7 Mus musculus 96 5e-118 420
WERAM-Tag-0163 ENSTGUP00000013715.1 Taeniopygia guttata 97 2e-117 419
WERAM-Gaga-0133 ENSGALP00000023298.1 Gallus gallus 97 2e-117 419
WERAM-Anc-0060 ENSACAP00000006051.2 Anolis carolinensis 97 2e-117 419
WERAM-Ova-0071 ENSOARP00000007637.1 Ovis aries 95 1e-116 416
WERAM-Bot-0153 ENSBTAP00000022686.3 Bos taurus 95 1e-116 416
WERAM-Dan-0169 ENSDNOP00000024199.1 Dasypus novemcinctus 96 3e-112 401
WERAM-Anp-0152 ENSAPLP00000015676.1 Anas platyrhynchos 94 4e-112 400
WERAM-Meg-0142 ENSMGAP00000014916.1 Meleagris gallopavo 94 9e-112 400
WERAM-Fia-0066 ENSFALP00000004954.1 Ficedula albicollis 93 1e-110 395
WERAM-Myl-0222 ENSMLUP00000018963.1 Myotis lucifugus 92 2e-110 395
WERAM-Mae-0101 ENSMEUP00000009824.1 Macropus eugenii 98 5e-110 394
WERAM-Poa-0041 ENSPPYP00000004780.2 Pongo abelii 100 3e-109 391
WERAM-Pes-0145 ENSPSIP00000017141.1 Pelodiscus sinensis 96 1e-106 383
WERAM-Sus-0009 ENSSSCP00000000747.2 Sus scrofa 93 2e-103 372
WERAM-Ocp-0059 ENSOPRP00000005127.2 Ochotona princeps 92 9e-103 370
WERAM-Asm-0095 ENSAMXP00000009783.1 Astyanax mexicanus 82 1e-101 366
WERAM-Gam-0113 ENSGMOP00000011971.1 Gadus morhua 81 7e-101 363
WERAM-Orn-0154 ENSONIP00000016230.1 Oreochromis niloticus 82 1e-100 363
WERAM-Dar-0068 ENSDARP00000045244.4 Danio rerio 81 1e-100 363
WERAM-Tar-0028 ENSTRUP00000005742.1 Takifugu rubripes 80 2e-100 362
WERAM-Pof-0162 ENSPFOP00000013201.1 Poecilia formosa 81 1e-99 360
WERAM-Gaa-0107 ENSGACP00000013626.1 Gasterosteus aculeatus 80 3e-97 352
WERAM-Ere-0110 ENSEEUP00000011689.1 Erinaceus europaeus 81 5e-94 341
WERAM-Orla-0124 ENSORLP00000015230.1 Oryzias latipes 77 5e-91 330
WERAM-Ten-0097 ENSTNIP00000010867.1 Tetraodon nigroviridis 80 1e-90 329
WERAM-Dio-0158 ENSDORP00000014787.1 Dipodomys ordii 84 4e-88 321
WERAM-Mup-0002 ENSMPUP00000000187.1 Mustela putorius furo 65 3e-81 298
WERAM-Leo-0061 ENSLOCP00000008031.1 Lepisosteus oculatus 65 6e-80 294
WERAM-Xim-0139 ENSXMAP00000011311.1 Xiphophorus maculatus 63 3e-79 291
WERAM-Xet-0023 ENSXETP00000006501.3 Xenopus tropicalis 65 3e-79 291
WERAM-Prc-0133 ENSPCAP00000012004.1 Procavia capensis 67 3e-76 281
WERAM-Ora-0105 ENSOANP00000020022.2 Ornithorhynchus anatinus 65 7e-74 274
WERAM-Cii-0033 ENSCINP00000012930.3 Ciona intestinalis 62 4e-72 268
WERAM-Cis-0004 ENSCSAVP00000000651.1 Ciona savignyi 55 3e-69 258
WERAM-Tut-0137 ENSTTRP00000011144.1 Tursiops truncatus 99 2e-63 239
WERAM-Drm-0046 FBpp0080103 Drosophila melanogaster 43 5e-55 211
WERAM-Soa-0068 ENSSARP00000006811.1 Sorex araneus 61 4e-53 205
WERAM-Sem-0058 EFJ35540 Selaginella moellendorffii 32 2e-37 153
WERAM-Ors-0028 OS03T0143600-01 Oryza sativa 34 9e-37 150
WERAM-Hov-0088 MLOC_66032.4 Hordeum vulgare 36 3e-36 149
WERAM-Brd-0037 BRADI1G75507.1 Brachypodium distachyon 35 3e-36 149
WERAM-Orm-0033 OMERI03G03370.1 Oryza meridionalis 35 2e-35 146
WERAM-Orni-0030 ONIVA03G03130.1 Oryza nivara 35 4e-35 145
WERAM-Ori-0037 BGIOSGA011837-PA Oryza indica 35 4e-35 145
WERAM-Sot-0036 PGSC0003DMT400030294 Solanum tuberosum 35 5e-35 145
WERAM-Orgl-0033 OGLUM03G03290.1 Oryza glumaepatula 35 5e-35 145
WERAM-Org-0031 ORGLA03G0031600.1 Oryza glaberrima 35 5e-35 145
WERAM-Tra-0133 Traes_4AL_78F1233CC.2 Triticum aestivum 35 5e-35 144
WERAM-Sob-0014 Sb01g047350.1 Sorghum bicolor 35 6e-35 144
WERAM-Orp-0029 OPUNC03G03150.1 Oryza punctata 34 9e-35 144
WERAM-Amt-0044 ERN15806 Amborella trichopoda 34 1e-34 144
WERAM-Lep-0035 LPERR03G03140.1 Leersia perrieri 35 1e-34 144
WERAM-Glm-0112 GLYMA10G25620.1 Glycine max 31 1e-34 143
WERAM-Php-0066 PP1S277_88V6.1 Physcomitrella patens 33 1e-34 143
WERAM-Sol-0119 Solyc09g091190.2.1 Solanum lycopersicum 35 2e-34 143
WERAM-Sei-0135 Si037216m Setaria italica 36 2e-34 143
WERAM-Lac-0118 ENSLACP00000014384.1 Latimeria chalumnae 34 3e-34 142
WERAM-Orbr-0038 OB03G13430.1 Oryza brachyantha 35 3e-34 142
WERAM-Mua-0030 GSMUA_Achr1P03410_001 Musa acuminata 34 1e-33 140
WERAM-Prp-0084 EMJ28765 Prunus persica 32 4e-33 138
WERAM-Thc-0053 EOY05425 Theobroma cacao 32 8e-33 137
WERAM-Chr-0037 EDP04619 Chlamydomonas reinhardtii 32 2e-32 136
WERAM-Cym-0027 CMQ358CT Cyanidioschyzon merolae 33 2e-32 136
WERAM-Brr-0075 Bra015016.1-P Brassica rapa 31 5e-32 134
WERAM-Viv-0027 VIT_05s0051g00350.t01 Vitis vinifera 32 6e-32 134
WERAM-Tru-0022 TRIUR3_10173-P1 Triticum urartu 32 8e-32 134
WERAM-Bro-0124 Bo7g036450.1 Brassica oleracea 31 1e-31 133
WERAM-Chh-0082 ENSCHOP00000008858.1 Choloepus hoffmanni 36 6e-31 131
WERAM-Pot-0039 POPTR_0003s17260.1 Populus trichocarpa 30 4e-29 125
WERAM-Art-0077 AT3G24010.1 Arabidopsis thaliana 31 5e-29 125
WERAM-Arl-0064 fgenesh2_kg.3__ 2635__ AT3G24010.1 Arabidopsis lyrata 31 1e-28 124
WERAM-Vip-0056 ENSVPAP00000005332.1 Vicugna pacos 32 1e-28 124
WERAM-Zem-0151 GRMZM5G813111_P01 Zea mays 33 1e-28 123
WERAM-Met-0153 AES80833 Medicago truncatula 32 5e-28 122
WERAM-Ect-0093 ENSETEP00000011108.1 Echinops telfairi 35 2e-27 120
WERAM-Osl-0027 ABO99843 Ostreococcus lucimarinus 36 3e-26 116
Created Date 25-Jun-2016