WERAM Information

Tag Content
WERAM ID WERAM-Hos-0143
Ensembl Protein ID ENSP00000359321.4
Uniprot Accession Q9Y483; MTF2_HUMAN; A6NGQ9; A8K2Q3; B1AKT5; B1AKT6; Q9UES9; Q9UP40
Genbank Protein ID NP_001157863.1; NP_001157865.1; NP_031384.1; XP_011539318.1
Protein Name Metal-response element-binding transcription factor 2
Genbank Nucleotide ID NM_001164391.1; NM_001164393.1; NM_007358.3; XM_011541016.1
Gene Name MTF2;PCL2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000143033.17 ENST00000370298.8 ENSP00000359321.4
ENSG00000143033.17 ENST00000370303.4 ENSP00000359326.4
ENSG00000143033.17 ENST00000540243.5 ENSP00000443295.1
ENSG00000143033.17 ENST00000545708.5 ENSP00000444962.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Tudor Tudor H3K36me2/3 K 23142980
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Tudor 6.60e-12 47.8 46 98
Me_Reader PHD 1.00e-11 47.1 103 253
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).
Domain Profile
  Me_Reader Tudor
          Tudor.txt  2 skvGlrVvakwssdGyfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlreq 61
                       +++G++V+a+ws dG+fY g+i    ++++  ++ ++i +ed +k ++  L+k+++  ++
  ENSP00000359321.4 46 FEEGQDVLARWS-DGLFYLGTI----KKINILKQSCFIIFEDSSKSWV--LWKDIQTGAT 98
                       789*********.*********....**********************..9***998775 PP
  Me_Reader PHD
            PHD.txt   2 tiClvCgkddegeke.mvqCdeCddwfHlkCvklp.lsslp..egkswyCpsCk 51 
                        ++C +C++++ +++  mv Cd+C + +H+ C+++    s    ++++w+C++C+
  ENSP00000359321.4 103 MVCTICQEEYSEAPNeMVICDKCGQGYHQLCHTPHiD-SSVidSDEKWLCRQCV 155
                        68****7666654445*******************53.433224488******7 PP
            PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpeg...kswyCpsCk 51 
                        +C+ Cg +++   +m+qC +C++wfH  Cv++ ++++  g     ++C  C 
  ENSP00000359321.4 203 YCY-CGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLFGdrfYTFICSVCS 253
                        899.*766666667*******************7777755455567799996 PP
Protein Sequence
(Fasta)		MRDSTGAGNS LVHKRSPLRR NQKTPTSLTK LSLQDGHKAK KPACKFEEGQ DVLARWSDGL 60
FYLGTIKKIN ILKQSCFIIF EDSSKSWVLW KDIQTGATGS GEMVCTICQE EYSEAPNEMV 120
ICDKCGQGYH QLCHTPHIDS SVIDSDEKWL CRQCVFATTT KRGGALKKGP NAKALQVMKQ 180
TLPYSVADLE WDAGHKTNVQ QCYCYCGGPG DWYLKMLQCC KCKQWFHEAC VQCLQKPMLF 240
GDRFYTFICS VCSSGPEYLK RLPLQWVDIA HLCLYNLSVI HKKKYFDSEL ELMTYINENW 300
DRLHPGELAD TPKSERYEHV LEALNDYKTM FMSGKEIKKK KHLFGLRIRV PPVPPNVAFK 360
AEKEPEGTSH EFKIKGRKAS KPISDSREVS NGIEKKGKKK SVGRPPGPYT RKMIQKTAEP 420
LLDKESISEN PTLDLPCSIG RTEGTAHSSN TSDVDFTGAS SAKETTSSSI SRHYGLSDSR 480
KRTRTGRSWP AAIPHLRRRR GRLPRRALQT QNSEIVKDDE GKEDYQFDEL NTEILNNLAD 540
QELQLNHLKN SITSYFGAAG RIACGEKYRV LARRVTLDGK VQYLVEWEGA TAS 593
Nucleotide Sequence
(Fasta)		GCCATTCGGC ACCGGAGTCG CTCCGCGCTC CCAGAATGCA CCGGCAGTCC GCGGGAAACC 60
AAAATGGCGA GGGGCTGTAT TGAAGTGGGC TGTGTTTGAG GCCGGTGTAA GAACGCTCAT 120
TCTACCCCCA ACCCTTGTCT CCAAGGACCT CGGTTTGTGC GTGCATATGT GCCGGGTACC 180
CGGTGGGGCG GGTGCCCAGT AAGTGCTCGG ACTCGCAGGG GAAGCGCCCA CGGGGACGGA 240
TTGGTTGTTT TTTCCTGTAT GAAGCGGTTG GCACCACTGA AGTGACCGAA TGAGAGACTC 300
TACAGGGGCA GGTAATTCAC TGGTCCACAA GCGGTCTCCT TTACGTCGAA ACCAAAAGAC 360
CCCAACATCC TTGACCAAGC TGTCTTTACA GGATGGACAT AAAGCCAAAA AGCCAGCATG 420
TAAATTTGAA GAGGGTCAGG ATGTCCTAGC TAGATGGTCA GATGGCTTGT TTTATCTTGG 480
CACTATCAAA AAGATAAACA TATTGAAACA GAGCTGCTTC ATCATATTTG AAGACAGTTC 540
TAAATCCTGG GTTCTCTGGA AGGACATTCA AACAGGAGCC ACTGGAAGTG GGGAAATGGT 600
CTGTACAATA TGTCAAGAAG AGTATTCAGA AGCTCCCAAT GAAATGGTTA TATGTGACAA 660
GTGTGGCCAA GGATATCATC AGTTGTGTCA CACACCTCAT ATTGATTCCA GTGTGATTGA 720
TTCAGATGAA AAATGGCTCT GTCGGCAGTG TGTTTTTGCA ACAACAACAA AGAGGGGTGG 780
TGCACTTAAG AAAGGACCAA ATGCCAAAGC ATTGCAAGTC ATGAAGCAGA CATTACCCTA 840
TAGTGTGGCA GACCTTGAAT GGGATGCAGG TCATAAAACC AATGTCCAGC AGTGTTACTG 900
CTATTGTGGA GGCCCTGGAG ACTGGTATTT GAAGATGCTA CAGTGCTGCA AATGTAAGCA 960
GTGGTTTCAT GAGGCTTGTG TGCAATGCCT TCAAAAGCCA ATGCTATTTG GAGACAGATT 1020
TTATACGTTT ATATGCTCTG TCTGCAGTTC TGGACCAGAA TACCTCAAAC GTCTACCATT 1080
ACAGTGGGTA GATATAGCAC ACCTATGCCT TTACAACCTA AGTGTTATTC ATAAGAAGAA 1140
ATACTTTGAT TCTGAACTTG AGCTTATGAC ATACATTAAT GAAAACTGGG ATAGATTGCA 1200
CCCTGGAGAG CTGGCAGACA CACCAAAATC TGAAAGATAT GAGCATGTTC TGGAGGCATT 1260
AAATGATTAC AAGACCATGT TTATGTCTGG GAAAGAAATA AAGAAGAAGA AGCATTTGTT 1320
TGGGTTGCGA ATTCGTGTTC CTCCTGTGCC ACCAAATGTG GCTTTCAAAG CAGAGAAAGA 1380
ACCTGAAGGA ACATCTCATG AATTTAAAAT TAAAGGCAGA AAGGCATCCA AACCTATATC 1440
TGATTCAAGG GAAGTAAGCA ATGGCATAGA AAAAAAAGGA AAGAAAAAAT CTGTAGGTCG 1500
TCCACCTGGC CCATATACAA GAAAAATGAT TCAAAAAACT GCTGAGCCAC TTTTGGATAA 1560
GGAATCAATT TCAGAGAATC CTACTTTGGA TTTACCTTGT TCTATAGGGA GAACTGAGGG 1620
AACTGCACAT TCATCCAATA CCTCAGATGT GGATTTCACG GGTGCTTCCA GTGCAAAAGA 1680
AACTACCTCG TCTAGCATTT CCAGGCATTA TGGATTATCT GACTCCAGAA AAAGAACGCG 1740
TACAGGAAGA TCTTGGCCTG CTGCAATACC ACATTTGCGG AGAAGAAGAG GTCGTCTTCC 1800
AAGAAGAGCA CTCCAGACTC AGAACTCAGA AATTGTAAAA GATGATGAAG GCAAAGAAGA 1860
TTATCAGTTT GATGAACTCA ACACAGAGAT TCTGAATAAC TTAGCAGATC AGGAGTTACA 1920
ACTCAATCAT CTAAAGAACT CCATTACCAG TTATTTTGGT GCTGCAGGTA GAATAGCATG 1980
TGGCGAAAAA TACCGAGTTT TGGCACGTCG GGTGACACTT GATGGAAAGG TGCAGTATCT 2040
TGTGGAATGG GAAGGAGCAA CTGCATCCTG ACTGTAGGAC TGAACATTAT GTTCACTGCA 2100
CTCTGATTTT CTGTAGGTAC AGTTCAAAGC CCTAAAGGAG TCTGGCTTTT ACTATCTTTC 2160
TTAAAAAAAA AAAAAAGTCA AAAAAATTCA AAAAAGGGGA TGATACTAGC CTTAACATGT 2220
ACCTGTCAAT GTTATGGATA TTGTCATAAA AAGGTATCTT TTAAAAATCA GAACAGAGAC 2280
TTAATTTTTT AAATCTTAAG ATTTGTAGAA TGTTTCTAGG ATAGGATATT AAAAATGATT 2340
GAAACCCATG CATGGTGTTA GACAATTTTT CTAATTATTC CATTGAGTCA GTTTTTTGTG 2400
ATTAGTGATT ATCAGAGCAA ACATCATGTA GATAGCACAA GTATTTGGAG AAACGTTGTT 2460
TGTTTTGTTA CCAAAATGTT GGAAAAATTT ATTTCAATAC CTTTTAGATT TCATAAAGTG 2520
CAGTGTATAT AATGCCTACT GAAAGACTGT AAAATATTGA AATTTTCTTT CAAGCAAAGT 2580
GTAAAAAAAT ATATTGAGCC TGTAAATTGC TCTGTGACTA GACTTCATTG TCGTCTTAAT 2640
ATATTCTTGC ATGTGCATAT ATATACACAC GTGTATATAT ATGTGTGTGA TTATGTGACC 2700
TATGCAATAC AAATTATGGG AATGGGCAGC TTTGGAGTAT ATATCCCATA ATTCTTTTTT 2760
CAGGAATAGT TGCAGTATTT ACACAGCAGC ATTTCTTCTC AGGCTTTTAT TGGGTGCTGT 2820
TGCTTGCTAT GTATGAAGAG AAATGTGTCA GACAAGTTTA GTGTGTTCTG AAGAAGGGTG 2880
TGAACAACAG TGTTCATGGG CTTTTAGAAT GCTTTTCACT TTTAGTCCTT GTAACTCAGC 2940
TGTTCAGTAC CTAAAACAAA TTCAAATAAT ATGAACATTA TCTCCTACTA GAAGTAACGT 3000
TTTCAAGTTT TCATGGCACA TTATGATTGT AAATGTCTCT CATTTTTAAC AGTAAGTCTA 3060
TAGGAGTCCC GTGAAGATTC CTGAAATGTC TGTAGTAACT GTTAGTCATG TTTGAATAAG 3120
TGTAGTATGA ACAAAGTATT TTATTGCACA GGGTTAACAA ACAGTATGTT GCCAGCTGAG 3180
GCTACTGCTG TTTTATTACA ACATTACCTC TTGTTTTTAT AAAGTGTACC AAGATTTAAA 3240
TTGATAACTT TATTTTACTT GTAAAAAAAA AGTTTCTTTT ATCACCAGTG TTACAGTTGT 3300
CTTCTGTTTC TTTTTGTTTT GTTTTATTTG TTTTCCTTTT TAGCCAAAGA GTGAACAGAA 3360
GATTTTCTTA TTTTGGTGGC TATTCATTTT ACTTTTAAAA GTGATTGGTG GATTTTAGAC 3420
TAATTATGGG GGAATTTGCC ACCAAAATAA AAAATATGTA AAGTGTAGTG ATTACAGAGT 3480
GGTTAAAATG TGGGTTAGTA CTTATTTATT CCATTAATTG ATTATTTGAC TGTTTATAAA 3540
GAAAGTTGCT TTATTTCTTT AAACATCTTC AAAAGATGAT CCTTTCTTGT CACATTATAG 3600
CCAAAAGAAG CAGAGAACTT CATTGTCTGC ATTTGGTTCC TGGTTGGCCA GGTATAAATG 3660
AGCTTTACAA AAGTGCAAAT TAAAAACTGT TACTTCTGTT TACCTCCACC AAAACTTGAT 3720
TTTCCCCTAG CTATTAATTT AAGGTTGCCT TTCCTGCAGC TGCAATATTT TGAATAACAC 3780
ACAGAGTTTG TGTTGATTTT TGAATGTTTG TTTATATCTA GGGGTAATGA AAAATGTAAA 3840
TCCCGTGTAT CCTTATTCAC TCCACCTGTA TCATATTATT TCATTTTCCC CAAAGTCCTT 3900
TAATTCTAAC TGAACACCAG CAGTATTTTT AGAAATTTTT CTTTAACATA CTTGGAAGAT 3960
GATTTATCCA GCTGAACTGT CTTTAGACGT AATTATTGTG AATGTCTGTT TTATTTTCTC 4020
ATGGTGGTTC ACATGGCTCT GATGTTCAGT TTGTATTTTT GGAATTGCTT TACTTAGAAA 4080
TTAAAACAGA CCAACATTAA ATGTGTGTAT TTTTTAAAGA GCTAA 4126
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR025894--Mtf2_C_dom
IPR002999--Tudor
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF14061--Mtf2_C
PF00628--PHD
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035098--C:ESC/E(Z) complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0061086--P:negative regulation of histone H3-K27 methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007379--P:segment specification
GO:0048863--P:stem cell differentiation
GO:0019827--P:stem cell population maintenance
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Poa-0008 ENSPPYP00000001332.2 Pongo abelii 100 0.0 1182
WERAM-Pat-0008 ENSPTRP00000052062.2 Pan troglodytes 100 0.0 1182
WERAM-Gog-0014 ENSGGOP00000001295.2 Gorilla gorilla 100 0.0 1182
WERAM-Paa-0155 ENSPANP00000014968.1 Papio anubis 100 0.0 1182
WERAM-Chs-0016 ENSCSAP00000016551.1 Chlorocebus sabaeus 100 0.0 1181
WERAM-Nol-0113 ENSNLEP00000012861.1 Nomascus leucogenys 100 0.0 1181
WERAM-Caj-0190 ENSCJAP00000032691.2 Callithrix jacchus 100 0.0 1181
WERAM-Ova-0176 ENSOARP00000017821.1 Ovis aries 99 0.0 1175
WERAM-Aim-0106 ENSAMEP00000010360.1 Ailuropoda melanoleuca 100 0.0 1175
WERAM-Mam-0155 ENSMMUP00000022097.2 Macaca mulatta 99 0.0 1174
WERAM-Mup-0044 ENSMPUP00000004047.1 Mustela putorius furo 99 0.0 1174
WERAM-Fec-0148 ENSFCAP00000013936.3 Felis catus 99 0.0 1173
WERAM-Caf-0208 ENSCAFP00000029874.3 Canis familiaris 99 0.0 1172
WERAM-Sus-0046 ENSSSCP00000007353.2 Sus scrofa 99 0.0 1172
WERAM-Loa-0139 ENSLAFP00000012594.3 Loxodonta africana 99 0.0 1172
WERAM-Tut-0081 ENSTTRP00000006586.1 Tursiops truncatus 99 0.0 1170
WERAM-Ict-0003 ENSSTOP00000000203.2 Ictidomys tridecemlineatus 99 0.0 1170
WERAM-Eqc-0133 ENSECAP00000015346.1 Equus caballus 99 0.0 1169
WERAM-Orc-0138 ENSOCUP00000011819.2 Oryctolagus cuniculus 99 0.0 1169
WERAM-Myl-0064 ENSMLUP00000005346.2 Myotis lucifugus 99 0.0 1167
WERAM-Mum-0095 ENSMUSP00000080278.4 Mus musculus 98 0.0 1157
WERAM-Tas-0127 ENSTSYP00000013465.1 Tarsius syrichta 99 0.0 1154
WERAM-Ran-0001 ENSRNOP00000000086.4 Rattus norvegicus 97 0.0 1150
WERAM-Soa-0012 ENSSARP00000001273.1 Sorex araneus 95 0.0 1110
WERAM-Otg-0035 ENSOGAP00000002173.2 Otolemur garnettii 95 0.0 1107
WERAM-Pes-0077 ENSPSIP00000009455.1 Pelodiscus sinensis 91 0.0 1090
WERAM-Anp-0157 ENSAPLP00000016170.1 Anas platyrhynchos 90 0.0 1077
WERAM-Gaga-0061 ENSGALP00000009493.4 Gallus gallus 90 0.0 1071
WERAM-Meg-0085 ENSMGAP00000008238.1 Meleagris gallopavo 90 0.0 1071
WERAM-Tag-0089 ENSTGUP00000006148.1 Taeniopygia guttata 89 0.0 1060
WERAM-Ptv-0106 ENSPVAP00000009446.1 Pteropus vampyrus 89 0.0 1019
WERAM-Anc-0057 ENSACAP00000005650.3 Anolis carolinensis 89 0.0 1018
WERAM-Cap-0135 ENSCPOP00000010957.2 Cavia porcellus 85 0.0 972
WERAM-Bot-0011 ENSBTAP00000001831.5 Bos taurus 99 0.0 968
WERAM-Mod-0043 ENSMODP00000006119.3 Monodelphis domestica 95 0.0 937
WERAM-Lac-0080 ENSLACP00000010316.1 Latimeria chalumnae 80 0.0 919
WERAM-Fia-0028 ENSFALP00000001770.1 Ficedula albicollis 91 0.0 897
WERAM-Xet-0151 ENSXETP00000049747.3 Xenopus tropicalis 75 0.0 869
WERAM-Prc-0076 ENSPCAP00000006770.1 Procavia capensis 88 0.0 832
WERAM-Leo-0034 ENSLOCP00000005569.1 Lepisosteus oculatus 71 0.0 804
WERAM-Vip-0089 ENSVPAP00000008163.1 Vicugna pacos 98 0.0 729
WERAM-Dar-0013 ENSDARP00000109280.2 Danio rerio 64 0.0 725
WERAM-Chh-0106 ENSCHOP00000011829.1 Choloepus hoffmanni 91 0.0 719
WERAM-Dan-0184 ENSDNOP00000013781.3 Dasypus novemcinctus 99 0.0 647
WERAM-Ere-0109 ENSEEUP00000011678.1 Erinaceus europaeus 78 6e-175 611
WERAM-Ten-0083 ENSTNIP00000009767.1 Tetraodon nigroviridis 57 3e-174 609
WERAM-Orn-0132 ENSONIP00000013277.1 Oreochromis niloticus 53 1e-171 600
WERAM-Tar-0058 ENSTRUP00000012607.1 Takifugu rubripes 54 3e-163 572
WERAM-Gam-0193 ENSGMOP00000018531.1 Gadus morhua 53 1e-160 563
WERAM-Pof-0216 ENSPFOP00000017463.2 Poecilia formosa 51 3e-158 555
WERAM-Xim-0043 ENSXMAP00000004092.1 Xiphophorus maculatus 51 1e-157 553
WERAM-Gaa-0169 ENSGACP00000020670.1 Gasterosteus aculeatus 52 1e-156 550
WERAM-Orla-0052 ENSORLP00000006459.1 Oryzias latipes 51 4e-152 535
WERAM-Ect-0033 ENSETEP00000002999.1 Echinops telfairi 88 4e-150 529
WERAM-Ora-0084 ENSOANP00000014085.1 Ornithorhynchus anatinus 98 3e-142 503
WERAM-Asm-0056 ENSAMXP00000006882.1 Astyanax mexicanus 47 3e-136 482
WERAM-Pem-0006 ENSPMAP00000000578.1 Petromyzon marinus 64 1e-132 471
WERAM-Mae-0132 ENSMEUP00000013110.1 Macropus eugenii 85 5e-131 465
WERAM-Sah-0011 ENSSHAP00000001156.1 Sarcophilus harrisii 97 3e-120 429
WERAM-Mim-0031 ENSMICP00000002842.1 Microcebus murinus 94 1e-113 407
WERAM-Dio-0028 ENSDORP00000003049.1 Dipodomys ordii 57 2e-106 384
WERAM-Tub-0055 ENSTBEP00000006833.1 Tupaia belangeri 99 7e-94 342
WERAM-Ocp-0008 ENSOPRP00000000997.1 Ochotona princeps 50 1e-86 318
WERAM-Drm-0007 FBpp0085914 Drosophila melanogaster 33 4e-47 187
WERAM-Cis-0011 ENSCSAVP00000001651.1 Ciona savignyi 49 4e-28 123
WERAM-Cii-0087 ENSCINP00000031571.1 Ciona intestinalis 49 1e-27 122
WERAM-Gag-0024 GGTG_08466T0 Gaeumannomyces graminis 47 4e-09 60.8
WERAM-Map-0017 MAPG_05228T0 Magnaporthe poae 46 2e-08 58.2
WERAM-Mao-0030 MGG_11196T0 Magnaporthe oryzae 39 2e-07 54.7
WERAM-Trr-0020 EGR52659 Trichoderma reesei 41 3e-07 54.3
Created Date 25-Jun-2016