WERAM Information

Tag Content
WERAM ID WERAM-Mum-0095
Ensembl Protein ID ENSMUSP00000080278.4
Uniprot Accession Q02395; MTF2_MOUSE; Q05C61; Q569Z8; Q6PG89; Q8BGP9; Q8BSJ7
Genbank Protein ID NP_001240806.1; NP_001240807.1; NP_001240808.1; NP_001240809.1; NP_038855.2; XP_006534874.1; XP_011247715.1; XP_011247716.1; XP_011247717.1; XP_011247718.1
Protein Name Metal-response element-binding transcription factor 2
Genbank Nucleotide ID NM_001253877.1; NM_001253878.1; NM_001253879.1; NM_001253880.1; NM_013827.3; XM_006534811.2; XM_011249413.1; XM_011249414.1; XM_011249415.1; XM_011249416.1
Gene Name MTF2;Pcl2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029267.17 ENSMUST00000081567.10 ENSMUSP00000080278.4
ENSMUSG00000029267.17 ENSMUST00000112626.7 ENSMUSP00000108245.1
ENSMUSG00000029267.17 ENSMUST00000137996.7 ENSMUSP00000121697.1
ENSMUSG00000029267.17 ENSMUST00000124195.7 ENSMUSP00000126297.1
ENSMUSG00000029267.17 ENSMUST00000172045.7 ENSMUSP00000126452.1
ENSMUSG00000029267.17 ENSMUST00000134026.7 ENSMUSP00000128797.1
ENSMUSG00000029267.17 ENSMUST00000170319.7 ENSMUSP00000130536.1
ENSMUSG00000029267.17 ENSMUST00000143412.7 ENSMUSP00000132596.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Tudor Tudor H3K36me2/3 K 23104054
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Tudor 3.60e-12 47.8 46 98
Me_Reader PHD 5.50e-12 47.2 103 253
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter.
Domain Profile
  Me_Reader Tudor
             Tudor.txt  2 skvGlrVvakwssdGyfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlreq 61
                          +++G++V+a+ws dG+fY g+i    ++++  ++ ++i +ed +k ++  L+k+++  ++
  ENSMUSP00000080278.4 46 FEEGQDVLARWS-DGLFYLGTI----KKINILKQSCFIIFEDSSKSWV--LWKDIQTGAT 98
                          789*********.*********....**********************..9***998775 PP
  Me_Reader PHD
               PHD.txt   2 tiClvCgkddegeke.mvqCdeCddwfHlkCvklp.lsslp..egkswyCpsCk 51 
                           ++C +C++++ +++  mv Cd+C + +H+ C+++    s    ++++w+C++C+
  ENSMUSP00000080278.4 103 MVCTICQEEYSEAPNeMVICDKCGQGYHQLCHTPHiD-SSVidSDEKWLCRQCV 155
                           68****7666654445*******************53.433224488******7 PP
               PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpeg...kswyCpsCk 51 
                           +C+ Cg +++   +m+qC +C++wfH  Cv++ ++++  g     ++C  C 
  ENSMUSP00000080278.4 203 YCY-CGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLFGdrfYTFICSVCS 253
                           899.*766666667*******************7777755455567799996 PP
Protein Sequence
(Fasta)		MRDSTGAGNS LVHKRSPLRR NQKTSASLNK LSLQDGHKAK KPACKFEEGQ DVLARWSDGL 60
FYLGTIKKIN ILKQSCFIIF EDSSKSWVLW KDIQTGATGS GEMVCTICQE EYSEAPNEMV 120
ICDKCGQGYH QLCHTPHIDS SVIDSDEKWL CRQCVFATTT KRGGALKKGP NAKALQVMKQ 180
TLPYSVADLE WDAGHKTNVQ QCYCYCGGPG DWYLKMLQCC KCKQWFHEAC VQCLQKPMLF 240
GDRFYTFICS VCSSGPEYLK RLPLQWVDIA HLCLYNLSVI HKKKYFDSEL ELMTYINENW 300
DRLHPGELAD TPKSERYEHV LEALNDYKTM FMSGKEIKKK KHLFGLRIRV PPVPPNVAFK 360
AEKEPEGTSH EFKIKGRKAS KPTSDSREVS NGIEKKGKKK SVGRPPGPYT RKMIQKTAEL 420
PLDKESVSEN PTLDLPCSIG RTEGIAHSSN TSDVDLTGAS SANETTSASI SRHCGLSDSR 480
KRTRTGRSWP AAIPHLRRRR GRLPRRALQT QNSEVVKDDE GKEDYQFEEL NTEILNNLAD 540
QELQLNHLKN SITSYFGAAG RIACGEKYRV LARRVTLDGK VQYLVEWEGA TAS 593
Nucleotide Sequence
(Fasta)		GGGCTGTTGC GAAGTGGTCT GTGTTTGAGG CCGGTGTGAG CACGCACATT CTCCTTCCTA 60
ACCCTCGTCC CCAAGGAACT CGGTGTGTGT GTGCGTGTGC GCAGGGCTCC CGCTGGGGCG 120
GGTGCCCAGG GAGTGCCCGG ACTCGCGGGG GAGCGCCCAC GGGAACGAGA TTGCTTCTAT 180
TTTCCTGTAT GAAGCGGTTG GCACCACTTA AGTGACCGAA TGAGAGACTC TACAGGAGCA 240
GGTAATTCAC TGGTCCACAA GCGGTCTCCT TTACGTCGAA ACCAAAAGAC CTCAGCATCC 300
TTGAACAAGC TGTCTTTACA GGATGGACAT AAAGCCAAAA AACCAGCATG TAAATTTGAA 360
GAGGGTCAAG ATGTCTTAGC TAGATGGTCA GATGGCTTGT TTTATCTTGG AACTATCAAA 420
AAGATAAACA TATTGAAACA GAGCTGCTTC ATCATATTTG AGGACAGTTC CAAATCCTGG 480
GTTCTCTGGA AGGACATCCA AACAGGAGCC ACTGGGAGTG GGGAAATGGT CTGTACAATA 540
TGTCAAGAAG AGTATTCAGA AGCTCCCAAT GAAATGGTTA TATGTGATAA GTGTGGTCAA 600
GGATATCATC AGCTGTGTCA CACACCTCAT ATTGACTCGA GTGTGATTGA TTCAGATGAA 660
AAGTGGCTTT GTCGACAGTG CGTTTTTGCA ACAACTACAA AGAGGGGTGG TGCGCTTAAG 720
AAAGGACCAA ATGCCAAAGC ATTGCAAGTC ATGAAGCAGA CATTACCCTA TAGTGTGGCT 780
GACCTTGAAT GGGATGCAGG CCATAAAACC AATGTCCAGC AGTGCTACTG CTATTGTGGA 840
GGCCCTGGAG ACTGGTATTT AAAGATGCTG CAGTGCTGCA AATGTAAGCA GTGGTTTCAT 900
GAAGCTTGTG TCCAATGCCT TCAGAAGCCA ATGCTGTTTG GAGATAGGTT TTATACATTT 960
ATTTGCTCTG TCTGCAGTTC TGGACCAGAA TACCTCAAAC GTCTACCGTT ACAGTGGGTA 1020
GATATAGCAC ACCTATGCCT TTACAACCTA AGTGTTATTC ACAAGAAGAA ATACTTTGAT 1080
TCTGAACTTG AGCTTATGAC ATACATTAAT GAAAACTGGG ATAGATTGCA CCCTGGAGAG 1140
CTGGCAGACA CACCCAAATC TGAAAGATAT GAGCATGTTC TGGAGGCATT AAATGATTAC 1200
AAGACCATGT TTATGTCTGG GAAAGAAATA AAGAAGAAGA AGCATTTGTT TGGGTTGCGA 1260
ATTCGTGTTC CTCCTGTGCC ACCAAATGTG GCTTTCAAAG CAGAGAAAGA ACCAGAAGGA 1320
ACATCCCATG AATTTAAAAT TAAAGGCAGA AAGGCATCCA AACCTACATC TGACTCAAGG 1380
GAAGTAAGCA ATGGGATAGA AAAAAAAGGA AAGAAAAAAT CTGTAGGTCG TCCTCCTGGC 1440
CCATATACAA GAAAAATGAT TCAAAAAACT GCTGAGCTAC CTTTGGATAA GGAATCAGTT 1500
TCAGAGAATC CTACGTTGGA TTTACCTTGT TCTATAGGGA GAACTGAGGG AATTGCACAT 1560
TCATCCAATA CCTCAGATGT GGACCTCACG GGTGCTTCCA GTGCAAACGA AACTACCTCG 1620
GCTAGCATTT CCAGGCATTG TGGATTATCA GACTCTAGAA AAAGAACTCG CACAGGAAGA 1680
TCATGGCCTG CTGCAATACC ACATTTGCGG AGAAGAAGAG GTCGCCTTCC ACGAAGAGCA 1740
CTCCAGACTC AGAACTCAGA AGTTGTGAAA GATGATGAAG GCAAAGAAGA TTATCAGTTT 1800
GAAGAACTTA ACACAGAAAT TCTGAATAAC TTAGCAGATC AGGAGTTGCA GCTCAATCAC 1860
CTGAAAAACT CCATCACTAG TTATTTTGGT GCCGCAGGTA GAATAGCATG TGGCGAAAAA 1920
TACAGAGTTT TGGCTCGTCG GGTGACGCTT GATGGGAAGG TGCAGTATCT TGTGGAATGG 1980
GAAGGAGCGA CTGCATCCTG ACTGTAGGAC TGAACGTAAT GTTCACTGCA CTCGTTTTCT 2040
GTTGGTACAG TTAAAAAAAA AAAAAACAAA AAACAGAGTG TGGGTTTTAT TATCTTTCTT 2100
AGAAAAACAA ACAAAGAGAA AACACAAAAA TATTCACAAA AGGAGATGAT ACTGGCCTTA 2160
AAACATGTTC TTGTCAATGT TATGGATATT GTCATAAAAA AAGATATCTT TTAAAAATCA 2220
GAGGAGAGAC TTAATTTTTT TAAATCTTAA GATTTGTAGA CTGTTTCTAG GATAGGCTAT 2280
TAAACATGAT TCATACCCAT GCATGGTGTT AGATACTTTT TATAATTATT CCATTGAGTC 2340
AATTTTTGTG ATTAGTGGTT ATCAGAGCAA ACAGATCATG TAGATAGCAC AAGTATTTGG 2400
AGAAACATTG TGTGTTTTGT TAACAAAATG TTGGAAAGAT TTATTTCAAT ACCCTTTAGA 2460
TTTCATAAAG TGCAGTGTAT ATAATGTCTA CTGAAAGACT GTAAAATATT GAAATTTCTT 2520
TCAAGCAAAA TGTAAAAAAA TATATTGAGC CTGTAAATTG CTCTGTGACT AGACTTCATT 2580
GTCGTCTTAA TATATTCTTT GCATGTACAT GTATATACAC ACATGTGTAT ATATATGTGT 2640
GTGATTATGT GACCTATGCA ATACAAATTA TGGGAATGGG CAGCTTTGGA GTATATATCC 2700
CATAATTCTT ATTTCAGGAA TAGTTGCAGT ATTTACACAG CAGCATTTCT TCTCAGGCGT 2760
TTATTGGGTG CTGTTGCTTG CTATGTATGA AGAGAAATGT GTCAAGTTTA GTGTGTACTG 2820
AAGAAGGGTG TGAACAACAG TGTACATGGG CTTTTAGAGG GCTTTTCAGT CCTTGTAACT 2880
CAGCTGTTGA ATACCTAAAA CAAATTCGAG TGATAACTAC ATTATTTCCT ATTAGAAGTG 2940
ACGTTTTCAA GTGATTGTGG CACATTATGA TTGTAAATGT CTCAGTTTTA ACAGCAAGTC 3000
TGTGGGAGCC CAGTGAAGAC TCCTGAAATG TCTGTAGTAA CTGTTAGTCA TGTTTGAGTA 3060
AGCGTAGTAT GAACAAAGTC TTTTATTGCA CAGGGTTAAC AAACAGTATG TTGCTAGCTG 3120
AGGCTAACTG CTGTTTTATT ACAACATTAC CTCTTGTTTT TATAAAATGT ACCAAGATTT 3180
TAAATTGATA TCTTTATTTT ACGTGTTAAA AAAAAGTTTC TTTTATCACC AGTGTTAGAG 3240
TTGTCTTCTG TTTTTTTGGT TTGTTTTGGT TTGGTTTTTT TCTTGTTGTT TTCTTTCTTA 3300
GCCAAAGAGT AAACAGAAGA ATATTATTTT GGTAGCTCTT CATTTTACTT TTATAATGAT 3360
TGGTGGATTT TAGACTAAAA ATTGGGGAAA TTTCTGCCAA AATGAAAAAA TATGTGACGT 3420
GTATTGATGA CAGAATGCTA AAATTGTGGT TAGTGCTTAT TTATTCCATT AATTGATTAT 3480
TTGCCTGTTT TTAAAGAAAC ATGCTTTATT TCCTTAAGCA TCTTCAAAAG ATGACTTTTC 3540
TTGTCACATT GTAGCCAAAA GAAGCAGAGA ATTTCTTGTC CTGCTTTTGG TTCCTGGTTA 3600
ACCAGGTATA ATGAGCTTTA CAAAGTGCAA ATTACAAACT GTCACTTCTG TTCACCTCCA 3660
CCAAAACTTG ATTTCCCCTA GCTATTAATT TAAAGTTGCC TTTCCTGCAG CTGCAATATT 3720
TTGAATAACA CAGAGATTGT GTTAATTTTT GAATGTTTGT TTATATCTAG GGGTAATGGA 3780
AAATGTAATT CCCGTGTAAC CTTATTCACT CCAGCTGTAT CATATTTCAT TTTTCCCAAA 3840
GTTCTTTAAT TTTAACTGAA CACCAGCAGT ATTTTTAGTA ATTCTTTAAG ATACTTGGAA 3900
GACAATTTAT CAAGCTGAAC TGTCTCTAGA CTTAATTATT GTGAATGTCT GTTTTCTTTT 3960
ATCATGGTGG TTCACATGGC TCTGATGTTC AGTTTGTATT TTTGAAATTG CTTTACTTAG 4020
AATTAAAACA GACCAACATT AAATGTGTGT ATTTTTAAAA 4061
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR025894--Mtf2_C_dom
IPR002999--Tudor
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF14061--Mtf2_C
PF00628--PHD
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0061086--P:negative regulation of histone H3-K27 methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007379--P:segment specification
GO:0048863--P:stem cell differentiation
GO:0019827--P:stem cell population maintenance
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0001 ENSRNOP00000000086.4 Rattus norvegicus 98 0.0 1182
WERAM-Paa-0155 ENSPANP00000014968.1 Papio anubis 98 0.0 1181
WERAM-Poa-0008 ENSPPYP00000001332.2 Pongo abelii 98 0.0 1181
WERAM-Pat-0008 ENSPTRP00000052062.2 Pan troglodytes 98 0.0 1181
WERAM-Hos-0143 ENSP00000359321.4 Homo sapiens 98 0.0 1181
WERAM-Gog-0014 ENSGGOP00000001295.2 Gorilla gorilla 98 0.0 1181
WERAM-Chs-0016 ENSCSAP00000016551.1 Chlorocebus sabaeus 98 0.0 1181
WERAM-Sus-0046 ENSSSCP00000007353.2 Sus scrofa 97 0.0 1180
WERAM-Ict-0003 ENSSTOP00000000203.2 Ictidomys tridecemlineatus 98 0.0 1180
WERAM-Aim-0106 ENSAMEP00000010360.1 Ailuropoda melanoleuca 98 0.0 1180
WERAM-Caj-0190 ENSCJAP00000032691.2 Callithrix jacchus 98 0.0 1180
WERAM-Ova-0176 ENSOARP00000017821.1 Ovis aries 97 0.0 1179
WERAM-Mup-0044 ENSMPUP00000004047.1 Mustela putorius furo 97 0.0 1179
WERAM-Caf-0208 ENSCAFP00000029874.3 Canis familiaris 97 0.0 1179
WERAM-Nol-0113 ENSNLEP00000012861.1 Nomascus leucogenys 97 0.0 1177
WERAM-Loa-0139 ENSLAFP00000012594.3 Loxodonta africana 97 0.0 1177
WERAM-Tut-0081 ENSTTRP00000006586.1 Tursiops truncatus 97 0.0 1176
WERAM-Mam-0155 ENSMMUP00000022097.2 Macaca mulatta 97 0.0 1172
WERAM-Eqc-0133 ENSECAP00000015346.1 Equus caballus 97 0.0 1172
WERAM-Myl-0064 ENSMLUP00000005346.2 Myotis lucifugus 97 0.0 1170
WERAM-Fec-0148 ENSFCAP00000013936.3 Felis catus 97 0.0 1161
WERAM-Orc-0138 ENSOCUP00000011819.2 Oryctolagus cuniculus 97 0.0 1160
WERAM-Tas-0127 ENSTSYP00000013465.1 Tarsius syrichta 97 0.0 1160
WERAM-Soa-0012 ENSSARP00000001273.1 Sorex araneus 94 0.0 1126
WERAM-Otg-0035 ENSOGAP00000002173.2 Otolemur garnettii 93 0.0 1112
WERAM-Anp-0157 ENSAPLP00000016170.1 Anas platyrhynchos 90 0.0 1095
WERAM-Pes-0077 ENSPSIP00000009455.1 Pelodiscus sinensis 89 0.0 1094
WERAM-Meg-0085 ENSMGAP00000008238.1 Meleagris gallopavo 89 0.0 1090
WERAM-Gaga-0061 ENSGALP00000009493.4 Gallus gallus 90 0.0 1090
WERAM-Tag-0089 ENSTGUP00000006148.1 Taeniopygia guttata 88 0.0 1076
WERAM-Ptv-0106 ENSPVAP00000009446.1 Pteropus vampyrus 87 0.0 1024
WERAM-Anc-0057 ENSACAP00000005650.3 Anolis carolinensis 88 0.0 1022
WERAM-Bot-0011 ENSBTAP00000001831.5 Bos taurus 98 0.0 979
WERAM-Cap-0135 ENSCPOP00000010957.2 Cavia porcellus 84 0.0 964
WERAM-Mod-0043 ENSMODP00000006119.3 Monodelphis domestica 94 0.0 946
WERAM-Lac-0080 ENSLACP00000010316.1 Latimeria chalumnae 80 0.0 919
WERAM-Fia-0028 ENSFALP00000001770.1 Ficedula albicollis 90 0.0 911
WERAM-Xet-0151 ENSXETP00000049747.3 Xenopus tropicalis 74 0.0 889
WERAM-Prc-0076 ENSPCAP00000006770.1 Procavia capensis 86 0.0 838
WERAM-Leo-0034 ENSLOCP00000005569.1 Lepisosteus oculatus 70 0.0 803
WERAM-Vip-0089 ENSVPAP00000008163.1 Vicugna pacos 96 0.0 740
WERAM-Dar-0013 ENSDARP00000109280.2 Danio rerio 63 0.0 730
WERAM-Chh-0106 ENSCHOP00000011829.1 Choloepus hoffmanni 90 0.0 712
WERAM-Dan-0184 ENSDNOP00000013781.3 Dasypus novemcinctus 98 0.0 642
WERAM-Ere-0109 ENSEEUP00000011678.1 Erinaceus europaeus 76 2e-178 623
WERAM-Ten-0083 ENSTNIP00000009767.1 Tetraodon nigroviridis 57 1e-175 613
WERAM-Orn-0132 ENSONIP00000013277.1 Oreochromis niloticus 53 2e-171 600
WERAM-Tar-0058 ENSTRUP00000012607.1 Takifugu rubripes 52 8e-165 577
WERAM-Gam-0193 ENSGMOP00000018531.1 Gadus morhua 52 4e-161 565
WERAM-Gaa-0169 ENSGACP00000020670.1 Gasterosteus aculeatus 52 1e-158 557
WERAM-Pof-0216 ENSPFOP00000017463.2 Poecilia formosa 51 2e-158 556
WERAM-Xim-0043 ENSXMAP00000004092.1 Xiphophorus maculatus 51 3e-158 556
WERAM-Orla-0052 ENSORLP00000006459.1 Oryzias latipes 51 1e-155 547
WERAM-Ect-0033 ENSETEP00000002999.1 Echinops telfairi 88 4e-150 528
WERAM-Ora-0084 ENSOANP00000014085.1 Ornithorhynchus anatinus 96 1e-140 497
WERAM-Asm-0056 ENSAMXP00000006882.1 Astyanax mexicanus 48 1e-140 497
WERAM-Pem-0006 ENSPMAP00000000578.1 Petromyzon marinus 64 4e-133 472
WERAM-Mae-0132 ENSMEUP00000013110.1 Macropus eugenii 84 2e-129 460
WERAM-Dio-0090 ENSDORP00000009372.1 Dipodomys ordii 44 5e-119 426
WERAM-Sah-0011 ENSSHAP00000001156.1 Sarcophilus harrisii 96 2e-118 423
WERAM-Mim-0031 ENSMICP00000002842.1 Microcebus murinus 92 6e-112 402
WERAM-Tub-0055 ENSTBEP00000006833.1 Tupaia belangeri 98 4e-92 336
WERAM-Ocp-0008 ENSOPRP00000000997.1 Ochotona princeps 50 7e-87 318
WERAM-Drm-0007 FBpp0085914 Drosophila melanogaster 33 3e-47 187
WERAM-Cis-0011 ENSCSAVP00000001651.1 Ciona savignyi 49 2e-28 124
WERAM-Cii-0087 ENSCINP00000031571.1 Ciona intestinalis 49 1e-27 122
WERAM-Gag-0024 GGTG_08466T0 Gaeumannomyces graminis 47 3e-09 60.8
WERAM-Map-0017 MAPG_05228T0 Magnaporthe poae 46 2e-08 58.5
WERAM-Mao-0030 MGG_11196T0 Magnaporthe oryzae 39 2e-07 55.1
WERAM-Trr-0020 EGR52659 Trichoderma reesei 41 4e-07 54.3
Created Date 25-Jun-2016