WERAM Information

Tag Content
WERAM ID WERAM-Hos-0203
Ensembl Protein ID ENSP00000350676.5
Uniprot Accession Q9UPP1; PHF8_HUMAN; B3KMV4; B7Z911; Q5H9U5; Q5JPR9; Q5JPS0; Q5JPS2; Q5JPS3; Q5VUJ4; Q7Z6D4; Q9HAH2
Genbank Protein ID NP_001171825.1; NP_001171826.1; NP_055922.1
Protein Name Histone lysine demethylase PHF8
Genbank Nucleotide ID NM_001184896.1; NM_001184897.1; NM_015107.2
Gene Name PHF8;KIAA1111;ZNF422
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000172943.18 ENST00000357988.9 ENSP00000350676.5
ENSG00000172943.18 ENST00000322659.12 ENSP00000319473.8
ENSG00000172943.18 ENST00000338154.10 ENSP00000338868.6
ENSG00000172943.18 ENST00000338946.10 ENSP00000340051.6
ENSG00000172943.18 ENST00000396282.6 ENSP00000379578.2
ENSG00000172943.18 ENST00000437224.5 ENSP00000398995.1
ENSG00000172943.18 ENST00000415025.5 ENSP00000404117.1
ENSG00000172943.18 ENST00000453905.5 ENSP00000405897.1
ENSG00000172943.18 ENST00000425862.5 ENSP00000408113.1
ENSG00000172943.18 ENST00000433120.5 ENSP00000410100.1
ENSG00000172943.18 ENST00000445025.1 ENSP00000416546.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDM PHF2_PHF8 Jmjc H3K9; H4K20 K 26674421; 25204660
Me_Reader PHD PHD-type H3K4me2/3 K 20622854
Status Reviewed
Classification
Type Family E-value Score Start End
HDM PHF2_PHF8 8.40e-95 317.1 40 387
Me_Reader PHD 1.10e-11 46.9 42 90
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3.
Domain Profile
  HDM PHF2_PHF8
           PHF2.txt 37 vekycligvkdsytdfhidfggasvyyh 64
                       v  ycl  +    t f i+   +  ++h
  ENSP00000350676.5 40 VPVYCLCRLPYDVTRFMIECDMCQDWFH 67
                       6779***999999***999999999988 PP
           PHF2.txt   1 fsdtklselveppdivkklslvenlwpdeavlekpkvekycligvkdsytdfhidfggasvyyhvlkgekifylirpteanlalyeawesss 92 
                        fsdt+ls+lve+p+iv+kls+venlwp+e+v+e+p+v+kycl++v+dsytdfhidfgg+sv+yhvlkgekifylirpt+anl+l+e+w+sss
  ENSP00000350676.5 231 FSDTRLSNLVETPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSS 322
                        79****************************************************************************************** PP
           PHF2.txt  93 dqsevffgdkvdkaykvvvkqgqtllipagwihavltpvdclafggnflhslniemqlrayelek 157
                        +q+e+ffgd+vdk+yk++vkqgqtl+ip+gwihavltpvdclafggnflhslniemql+aye+ek
  ENSP00000350676.5 323 NQNEMFFGDQVDKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEK 387
                        ***************************************************************97 PP
  Me_Reader PHD
            PHD.txt  2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51
                        +Cl C+ +++ +++m++Cd C+dwfH++Cv+++++++ + + ++Cp+C+
  ENSP00000350676.5 42 VYCL-CRLPYDVTRFMIECDMCQDWFHGSCVGVEEEKAADIDLYHCPNCE 90
                       69*9.*****************************777775558******7 PP
Protein Sequence
(Fasta)		MNRSRAIVQR GRVLPPPAPL DTTNLAGRRT LQGRAKMASV PVYCLCRLPY DVTRFMIECD 60
MCQDWFHGSC VGVEEEKAAD IDLYHCPNCE VLHGPSIMKK RRGSSKGHDT HKGKPVKTGS 120
PTFVRELRSR TFDSSDEVIL KPTGNQLTVE FLEENSFSVP ILVLKKDGLG MTLPSPSFTV 180
RDVEHYVGSD KEIDVIDVTR QADCKMKLGD FVKYYYSGKR EKVLNVISLE FSDTRLSNLV 240
ETPKIVRKLS WVENLWPEEC VFERPNVQKY CLMSVRDSYT DFHIDFGGTS VWYHVLKGEK 300
IFYLIRPTNA NLTLFECWSS SSNQNEMFFG DQVDKCYKCS VKQGQTLFIP TGWIHAVLTP 360
VDCLAFGGNF LHSLNIEMQL KAYEIEKRLS TADLFRFPNF ETICWYVGKH ILDIFRGLRE 420
NRRHPASYLV HGGKALNLAF RAWTRKEALP DHEDEIPETV RTVQLIKDLA REIRLVEDIF 480
QQNVGKTSNI FGLQRIFPAG SIPLTRPAHS TSVSMSRLSL PSKNGSKKKG LKPKELFKKA 540
ERKGKESSAL GPAGQLSYNL MDTYSHQALK TGSFQKAKFN ITGACLNDSD DDSPDLDLDG 600
NESPLALLMS NGSTKRVKSL SKSRRTKIAK KVDKARLMAE QVMEDEFDLD SDDELQIDER 660
LGKEKATLII RPKFPRKLPR AKPCSDPNRV REPGEVEFDI EEDYTTDEDM VEGVEGKLGN 720
GSGAGGILDL LKASRQVGGP DYAALTEAPA SPSTQEAIQG MLCMANLQSS SSSPATSSLQ 780
AWWTGGQDRS SGSSSSGLGT VSNSPASQRT PGKRPIKRPA YWRTESEEEE ENASLDEQDS 840
LGACFKDAEY IYPSLESDDD DPALKSRPKK KKNSDDAPWS PKARVTPTLP KQDRPVREGT 900
RVASIETGLA AAAAKLAQQE LQKAQKKKYI KKKPLLKEVE QPRPQDSNLS LTVPAPTVAA 960
TPQLVTSSSP LPPPEPKQEA LSGSLADHEY TARPNAFGMA QANRSTTPMA PGVFLTQRRP 1020
SVGSQSNQAG QGKRPKKGLA TAKQRLGRIL KIHRNGKLLL
Nucleotide Sequence
(Fasta)		TTTCCTCTCA TCCCCCCTCC TCTCCCCTCC CCTCAGGCTA TAGTCAGAAA ATTGTGGGAC 60
AGGTGCAAAC AAATCCTTGA ACTGTATTTG AACTGAAGTG AAACAGTAGG GTCAAAGAAG 120
AGTTCAGAGG GAGTTGTGGA GTTGGCAGCA GCTTTACAGA GGAACTACAC TGAGGGCCTG 180
GGGACAGAAC GCGGGTAGCA CAGGGCACAA GGTTCAACGT CCCTGCTCCG GGACTCAAGT 240
CACTTGGCTT CTCGAAGCCC CTGCCTTCAT TTGGTGATAA TCACAGAGCT TCCTTCACAG 300
GGGGAAGAAC CAACAACGCA GAGACCGTGG GAAAGAGCCC AGCCTATCGA AGGTGCTCAA 360
TGAACAGGAG CCGCGCTATC GTCCAGAGAG GACGCGTGCT GCCGCCTCCC GCCCCTCTTG 420
ACACGACGAA CCTGGCCGGC CGCAGAACGC TCCAGGGCCG AGCGAAGATG GCCTCGGTGC 480
CGGTGTATTG CCTCTGCCGG CTGCCTTACG ATGTGACCCG CTTCATGATC GAGTGTGACA 540
TGTGCCAGGA CTGGTTTCAT GGCAGTTGTG TTGGTGTTGA AGAGGAGAAG GCTGCTGACA 600
TTGACCTCTA CCACTGCCCC AACTGTGAAG TCTTGCATGG GCCCTCCATT ATGAAAAAAC 660
GCCGTGGATC TTCAAAGGGG CATGATACAC ACAAGGGGAA ACCAGTGAAG ACCGGGAGCC 720
CTACGTTCGT CAGAGAGCTC CGGAGTAGGA CTTTTGACAG CTCAGATGAA GTGATTCTGA 780
AGCCCACTGG AAATCAACTG ACCGTGGAAT TCCTGGAAGA AAATAGCTTC AGTGTGCCCA 840
TCCTGGTCCT GAAGAAGGAT GGGTTGGGCA TGACGCTGCC CTCGCCATCA TTCACTGTGA 900
GGGATGTTGA ACACTATGTT GGTTCTGACA AAGAGATTGA TGTGATTGAT GTGACCCGCC 960
AGGCTGACTG CAAGATGAAG CTTGGTGATT TTGTGAAATA CTATTACAGC GGGAAGAGGG 1020
AGAAAGTCCT CAATGTCATT AGTTTGGAAT TCTCTGATAC CAGACTTTCT AACCTTGTGG 1080
AGACACCGAA GATTGTTCGA AAGCTGTCAT GGGTCGAAAA CTTGTGGCCA GAGGAATGTG 1140
TCTTTGAGAG ACCCAATGTA CAGAAGTACT GCCTCATGAG TGTGCGAGAT AGCTATACAG 1200
ACTTTCACAT TGACTTTGGT GGCACCTCTG TCTGGTACCA TGTACTCAAG GGTGAAAAGA 1260
TCTTCTACCT GATCCGCCCA ACAAATGCCA ATCTGACTCT CTTTGAGTGC TGGAGCAGTT 1320
CCTCTAATCA GAATGAGATG TTCTTTGGGG ACCAGGTGGA CAAGTGCTAC AAGTGTTCCG 1380
TGAAGCAAGG ACAGACACTT TTCATTCCCA CAGGGTGGAT CCATGCTGTG CTGACGCCTG 1440
TGGACTGCCT TGCCTTTGGA GGGAACTTCT TACACAGCCT TAACATCGAG ATGCAGCTCA 1500
AAGCCTATGA GATTGAGAAG CGGCTGAGCA CAGCAGACCT CTTCAGATTC CCCAACTTTG 1560
AGACCATCTG TTGGTATGTG GGAAAGCACA TCCTGGACAT CTTTCGCGGT TTGCGAGAGA 1620
ACAGGAGACA CCCTGCCTCC TACCTGGTCC ATGGTGGCAA AGCCTTGAAC TTGGCCTTTA 1680
GAGCCTGGAC AAGGAAAGAA GCTCTGCCAG ACCATGAGGA TGAGATCCCG GAGACAGTGC 1740
GAACCGTACA GCTCATTAAA GATCTGGCCA GGGAGATCCG CCTGGTGGAA GACATCTTCC 1800
AACAGAACGT TGGGAAGACG AGCAATATCT TTGGGCTGCA GAGGATCTTC CCAGCCGGCT 1860
CCATTCCCCT AACCAGGCCA GCCCATTCCA CTTCAGTGTC CATGTCCAGG CTGTCACTGC 1920
CCTCCAAAAA TGGTTCAAAG AAGAAAGGCC TGAAGCCCAA GGAACTCTTC AAGAAGGCAG 1980
AGCGAAAGGG CAAGGAGAGT TCAGCCTTGG GGCCTGCTGG CCAGTTGAGC TATAATCTCA 2040
TGGACACATA CAGTCATCAG GCACTGAAGA CAGGCTCTTT CCAGAAAGCA AAGTTCAACA 2100
TCACTGGTGC CTGCTTGAAT GACTCAGATG ACGACTCACC AGACTTGGAC CTTGATGGAA 2160
ATGAGAGCCC ATTGGCCCTA TTGATGTCTA ACGGCAGTAC GAAAAGGGTG AAGAGTTTAT 2220
CCAAATCTCG GCGAACCAAG ATAGCAAAGA AGGTAGACAA GGCTAGGCTG ATGGCAGAAC 2280
AGGTGATGGA AGACGAATTT GACTTGGATT CAGATGATGA GCTGCAGATT GACGAGAGAT 2340
TGGGAAAGGA GAAGGCGACC CTGATAATAA GACCAAAATT TCCCCGGAAA TTGCCCCGTG 2400
CGAAGCCTTG CTCTGACCCC AACCGAGTTC GTGAACCAGG AGAAGTTGAG TTTGACATTG 2460
AGGAGGACTA TACAACAGAT GAGGACATGG TGGAAGGGGT TGAAGGCAAG CTTGGGAATG 2520
GTAGTGGCGC TGGTGGCATT CTTGATCTGC TCAAGGCCAG CAGGCAGGTG GGGGGACCTG 2580
ACTATGCTGC CCTCACCGAG GCCCCAGCTT CTCCCAGCAC TCAGGAGGCC ATCCAGGGCA 2640
TGCTGTGCAT GGCCAACCTG CAGTCCTCAT CGTCCTCACC GGCTACCTCT AGCCTGCAGG 2700
CCTGGTGGAC TGGGGGACAG GATCGAAGCA GTGGGAGCTC CAGCAGTGGG CTGGGCACAG 2760
TGTCTAACAG TCCTGCTTCC CAGCGCACCC CAGGGAAGCG GCCCATCAAG CGGCCAGCAT 2820
ACTGGAGAAC CGAGAGCGAG GAGGAGGAGG AGAACGCCAG TCTGGATGAA CAGGACAGCT 2880
TGGGAGCGTG CTTCAAGGAT GCAGAGTATA TCTATCCTTC ACTGGAGTCT GATGATGATG 2940
ACCCTGCTTT GAAATCTCGA CCCAAGAAAA AGAAGAATTC AGATGATGCT CCATGGAGTC 3000
CTAAAGCCCG CGTGACCCCA ACTCTGCCGA AGCAGGACCG TCCTGTGCGT GAGGGGACCC 3060
GGGTAGCCTC TATTGAGACA GGTTTGGCTG CAGCAGCTGC AAAGCTGGCC CAGCAGGAGC 3120
TACAGAAGGC CCAAAAGAAG AAATATATCA AGAAGAAGCC TTTGCTGAAG GAGGTAGAAC 3180
AGCCTCGCCC TCAAGACTCC AATCTCAGTC TGACAGTACC AGCCCCCACT GTGGCTGCCA 3240
CACCACAACT TGTCACCTCC TCCTCACCCC TGCCTCCTCC TGAGCCTAAA CAAGAGGCCC 3300
TGTCAGGAAG TCTCGCTGAC CATGAGTACA CCGCTCGTCC CAATGCCTTT GGCATGGCCC 3360
AGGCAAACCG CAGCACCACA CCTATGGCCC CCGGTGTCTT CTTGACCCAG CGGCGCCCTT 3420
CAGTTGGCTC CCAGAGCAAT CAGGCAGGAC AAGGAAAGCG TCCCAAAAAG GGCCTGGCCA 3480
CAGCAAAGCA GAGACTCGGC CGTATCCTGA AAATCCACAG AAATGGCAAA CTACTTCTGT 3540
GAGCCCTCCT GTGTCCCACC CCTCACCCCT TTACCCCCAT TGCCTTCTCC ATTGTCAACT 3600
CTTGGGGCAC TCCTGGATCC TATCTGCCCT GGACAAGGTG CTGAGGTGCA TTGTCCTGCT 3660
TTCTTGGGAC TTACCAAAGG CACGGACCCC TCCACCGACT CCTTCTAGTT CCCTTCCCCA 3720
CTTTCACTAG AGCATCCTGC CTGCCTTCTC CACTGAGGAG CAGGTAAATG GGAGAGGTTT 3780
CCAGCTGACT AGAACCCTCT TTTCTACTCG TCCAAACCAC TCCCGTCACC TGCCTTGTCT 3840
GTTCTTTATT CTTCATCCCC CGCTAGAGCT GGAAGGCAGG ATGAGGAGAG GTATGAAGGA 3900
GCCTGAGCCA TGAAGTGGGA AGCCCAGTGC TTGACACTTT CTGCAACTCT AGCCCTATAT 3960
CCAGAAGCCT GCCCACCTCC ACCCATTCTG TTTGCCCCAT TTCCCCAGTC CAGTGGACAT 4020
GCCCCACCTC CAGACTTGCT CATGGGAGAA GGCTGTGGTC TCTGCCCCCT CTTGCCAAAT 4080
GCTTCATGGA AATGAAGAGG AAGGCCTAGA GCCTCCTTCC TGCCCCACTG TGGGCCATTT 4140
CCAGAAGTGG CCTAGAAATG CCAACTTCAC TTACCTTTCA AAAGAAAGGT GATTCCTATC 4200
ACTTGTCAAG GTAGGGAGAG GTCAGATGCC CAAGCCTTTG ACCACGGTTT TGTAGCCTGT 4260
TGGAGGAAGC TACTTTTAGC TGGCTACACA TGAGGCCACT TGTTTTAGGG TGAGCTCCAG 4320
GGATTTGCCT GGATTTTGAA ATCATGTAGA ACATTATCCA CGTGGCTGTG GCTGTGGCTG 4380
TGGCTGGGCC CTGGCAGGTG GAAAACCATC TCCCAGAAAC CTGAAAGCAC CTGCCAATGA 4440
CGCAGATAAC CCTGGCCCTA CAGCCTGCTT GCTCCGCCTA TACCACAGAG CACAGCCTGG 4500
ACATTATGGA GGGTGTGGCG GGACGGCCCA CACCTGGGTC CTCCATCGGG AACTTTTCAT 4560
GCTTCTTTCT CCACCTGAGG TCTTGGTCTG AAGAAGACCT CAGGACTCAC ATCTTCACTC 4620
CTGGGCCTTT GCACTTCCAG ACGACAGGTC ATCGTTCAAG CAGAATGCAG ACAGGCCATT 4680
CACGAGCCCA AGTTGAAGAG AAGAGACGCC CATCCGTGAA GGAGCAGACC ATCCATCCGA 4740
TCCTCCCCTT CCCCTGTCCT TCCTTCGTGG ATTGTCTCCA TTGTCCAGAC AGTGCCCCCA 4800
CCTCCCACCG CCTTGCCTCA CTGGCAATCT GGACTCGATG GAGAACATCC CCCCACCTCC 4860
ATTTGGCACT ACCCAAGTGG AGTGTACCCT TGCCCTTTCC ACCTGTACCA CCCACTCCAA 4920
CCTCACCCCA GCTTGCCCAA TGCTTCTGGG GAATTTAATA GCTACCATGC AGGCCACAGG 4980
GAATTTGTGA GGCTTCTTTT GTCATCTTTG TATCTCCAGT TTGTCTTTCT TTTCTCCATA 5040
GCCCTGCCTC TACTTTCCTT CCTTGGAATC AGGGGTTCCT TTAGCCCATT TGCTTTCTCT 5100
ACCTTGGGGA CCCCAGGGGC CAAGCAGTTC TCCATCTAGT CACACCAAAG GCAAAAAGCC 5160
TGGCTACCTC CCCCCTAGCA CGTGAGTCCC TACTCCCCTC CCCTCTGTTT CTGCCCAGCT 5220
TTGCTTATTT TGGGGATTTC AAGGCAGCAG AGGGTAGTGA GGGGAGAGCA GGAGAAGCCT 5280
CTGTCCTGTA TAGGCAACTG CCTGACTATG CGGTGACTGC TGTAACCAAG ATCAGGTCCC 5340
CAGCCCTTTT GTCCATTAAC ACCCCTTCTT GATCTTTCAA AGGCAGCTAA TTGCTAGCAA 5400
ATCCCCCCGA TTCCGGCCTT TTCCCTCTAT TTCTTTGTTA GAAGTTTTCT GTGGAGCTGA 5460
AACCCAGCCT CTGTTTGACT GGGTTTCATT TAGCTTAGTT GGGTTCTTAG AGCCCCCTGT 5520
TTGTTGTTTT GTGTTGTTTC CAATGAAAAG CAAGTTTACC CTCAGAGTTA TGCTTTTCCA 5580
AAGAGGCTGA TGTCTTTGTT TTTGTTTTTT TTAATGTTTC AGGTTCTAAG TGAAGTGAGT 5640
TGGGGAGGGG TTGGGAGTGT TAGTAATCAA GGTTTAGAAC ACCATGAGAT AGTTACCCCT 5700
GATCTCCAGT CCCTAGCTGG GGGCTGGACA GGGGGAAGGG AGAGAGGATT TCTATTCACC 5760
TTTAATATAT TTTTACAAAA AAAGCAAACA ATTTAAAAAC AAGCCCACCG CTTCTGTACA 5820
TGTCTAAATA TATTTTTAGA AGTGGGTAGG ATTGTGAATT TCTGATGCAG GGCCTTTTTA 5880
TAAATAGGTT AGGGTAGCAT CATTCAGACT TCTCTGTTGT TTTTGTCCCT GTCTTTTTCT 5940
TATGTTGTGT TACTAATGTA ATTTATATTT TTTTTAGATC CTCCCTTTCC TATAGAGATA 6000
AAAGTGATTT ATCTTGGCAA TTGC 6025
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0225--Disease mutation
KW-0408--Iron
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR003347--JmjC_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF02373--JmjC
PF00628--PHD
Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0032452--F:histone demethylase activity
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0035575--F:histone demethylase activity (H4-K20 specific)
GO:0005506--F:iron ion binding
GO:0035064--F:methylated histone binding
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270--F:zinc ion binding
GO:0007420--P:brain development
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0071557--P:histone H3-K27 demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0035574--P:histone H4-K20 demethylation
GO:0061188--P:negative regulation of chromatin silencing at rDNA
GO:0045943--P:positive regulation of transcription from RNA polymerase I promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Gog-0162 ENSGGOP00000014352.2 Gorilla gorilla 100 0.0 1895
WERAM-Mam-0070 ENSMMUP00000011473.2 Macaca mulatta 98 0.0 1860
WERAM-Paa-0022 ENSPANP00000018377.1 Papio anubis 99 0.0 1845
WERAM-Fec-0005 ENSFCAP00000000567.3 Felis catus 97 0.0 1832
WERAM-Caf-0169 ENSCAFP00000024137.2 Canis familiaris 95 0.0 1826
WERAM-Chs-0149 ENSCSAP00000008671.1 Chlorocebus sabaeus 99 0.0 1824
WERAM-Nol-0174 ENSNLEP00000019631.2 Nomascus leucogenys 99 0.0 1822
WERAM-Eqc-0214 ENSECAP00000022798.1 Equus caballus 96 0.0 1820
WERAM-Cap-0130 ENSCPOP00000010443.2 Cavia porcellus 96 0.0 1791
WERAM-Mup-0130 ENSMPUP00000011455.1 Mustela putorius furo 97 0.0 1787
WERAM-Orc-0019 ENSOCUP00000002278.2 Oryctolagus cuniculus 96 0.0 1764
WERAM-Myl-0006 ENSMLUP00000000462.2 Myotis lucifugus 93 0.0 1761
WERAM-Ova-0070 ENSOARP00000007621.1 Ovis aries 97 0.0 1757
WERAM-Ran-0022 ENSRNOP00000040672.4 Rattus norvegicus 95 0.0 1753
WERAM-Mum-0169 ENSMUSP00000127653.1 Mus musculus 95 0.0 1744
WERAM-Sus-0089 ENSSSCP00000013121.2 Sus scrofa 97 0.0 1733
WERAM-Soa-0095 ENSSARP00000008902.1 Sorex araneus 91 0.0 1710
WERAM-Bot-0124 ENSBTAP00000017673.4 Bos taurus 94 0.0 1709
WERAM-Dan-0011 ENSDNOP00000001170.3 Dasypus novemcinctus 94 0.0 1681
WERAM-Loa-0154 ENSLAFP00000013594.3 Loxodonta africana 95 0.0 1610
WERAM-Tut-0006 ENSTTRP00000000351.1 Tursiops truncatus 93 0.0 1595
WERAM-Caj-0235 ENSCJAP00000050740.1 Callithrix jacchus 89 0.0 1593
WERAM-Tub-0093 ENSTBEP00000010730.1 Tupaia belangeri 97 0.0 1588
WERAM-Aim-0075 ENSAMEP00000006562.1 Ailuropoda melanoleuca 97 0.0 1578
WERAM-Poa-0198 ENSPPYP00000022810.2 Pongo abelii 90 0.0 1566
WERAM-Otg-0029 ENSOGAP00000001922.2 Otolemur garnettii 98 0.0 1520
WERAM-Pat-0187 ENSPTRP00000042192.3 Pan troglodytes 100 0.0 1497
WERAM-Ptv-0061 ENSPVAP00000006309.1 Pteropus vampyrus 83 0.0 1490
WERAM-Tas-0113 ENSTSYP00000011554.1 Tarsius syrichta 91 0.0 1336
WERAM-Mod-0187 ENSMODP00000026122.3 Monodelphis domestica 71 0.0 1302
WERAM-Lac-0125 ENSLACP00000014816.1 Latimeria chalumnae 68 0.0 1266
WERAM-Dio-0011 ENSDORP00000001369.1 Dipodomys ordii 79 0.0 1241
WERAM-Xet-0141 ENSXETP00000047696.4 Xenopus tropicalis 65 0.0 1240
WERAM-Vip-0022 ENSVPAP00000002066.1 Vicugna pacos 93 0.0 1165
WERAM-Ect-0006 ENSETEP00000000305.1 Echinops telfairi 94 0.0 1132
WERAM-Dar-0017 ENSDARP00000007140.7 Danio rerio 60 0.0 1129
WERAM-Anc-0126 ENSACAP00000011870.3 Anolis carolinensis 69 0.0 1109
WERAM-Orn-0143 ENSONIP00000015119.1 Oreochromis niloticus 59 0.0 1099
WERAM-Xim-0128 ENSXMAP00000010848.1 Xiphophorus maculatus 60 0.0 1086
WERAM-Ict-0005 ENSSTOP00000000259.2 Ictidomys tridecemlineatus 97 0.0 1061
WERAM-Asm-0138 ENSAMXP00000013325.1 Astyanax mexicanus 63 0.0 1056
WERAM-Gam-0086 ENSGMOP00000008905.1 Gadus morhua 64 0.0 1042
WERAM-Mae-0004 ENSMEUP00000000188.1 Macropus eugenii 71 0.0 1042
WERAM-Pof-0120 ENSPFOP00000010415.2 Poecilia formosa 62 0.0 1031
WERAM-Ten-0185 ENSTNIP00000018140.1 Tetraodon nigroviridis 61 0.0 1014
WERAM-Prc-0121 ENSPCAP00000010850.1 Procavia capensis 94 0.0 959
WERAM-Ora-0007 ENSOANP00000001114.1 Ornithorhynchus anatinus 79 0.0 871
WERAM-Gaa-0089 ENSGACP00000011590.1 Gasterosteus aculeatus 81 0.0 817
WERAM-Orla-0070 ENSORLP00000008997.1 Oryzias latipes 77 0.0 810
WERAM-Tar-0180 ENSTRUP00000037980.1 Takifugu rubripes 78 0.0 801
WERAM-Sah-0047 ENSSHAP00000005380.1 Sarcophilus harrisii 76 0.0 799
WERAM-Leo-0144 ENSLOCP00000017335.1 Lepisosteus oculatus 67 0.0 670
WERAM-Gaga-0056 ENSGALP00000008273.4 Gallus gallus 63 0.0 667
WERAM-Tag-0055 ENSTGUP00000003831.1 Taeniopygia guttata 63 0.0 664
WERAM-Fia-0091 ENSFALP00000007322.1 Ficedula albicollis 61 0.0 664
WERAM-Pem-0097 ENSPMAP00000010124.1 Petromyzon marinus 68 0.0 645
WERAM-Anp-0115 ENSAPLP00000013232.1 Anas platyrhynchos 59 2e-171 600
WERAM-Meg-0060 ENSMGAP00000005425.2 Meleagris gallopavo 61 8e-170 595
WERAM-Pes-0093 ENSPSIP00000011413.1 Pelodiscus sinensis 59 8e-160 562
WERAM-Ere-0005 ENSEEUP00000000200.1 Erinaceus europaeus 59 1e-145 514
WERAM-Mim-0110 ENSMICP00000010445.1 Microcebus murinus 54 2e-137 488
WERAM-Drm-0062 FBpp0289915 Drosophila melanogaster 49 8e-79 293
WERAM-Ocp-0120 ENSOPRP00000012395.2 Ochotona princeps 46 8e-79 293
Created Date 25-Jun-2016