WERAM Information

Tag Content
WERAM ID WERAM-Mum-0169
Ensembl Protein ID ENSMUSP00000127653.1
Uniprot Accession Q80TJ7; PHF8_MOUSE; A2ABU8; A2ABV0; A2ABV2; Q8BLX8; Q8BLY0; Q8BZ61; Q8CG26
Genbank Protein ID NP_001009544.1; NP_001106825.1; NP_796175.1; XP_006528938.1; XP_006528939.1; XP_006528940.1; XP_006528943.1; XP_011246133.1
Protein Name Histone lysine demethylase PHF8
Genbank Nucleotide ID NM_001009544.2; NM_001113354.1; NM_177201.5; XM_006528875.2; XM_006528876.2; XM_006528877.2; XM_006528880.2; XM_011247831.1
Gene Name PHF8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000041229.15 ENSMUST00000168501.7 ENSMUSP00000127653.1
ENSMUSG00000041229.15 ENSMUST00000046950.12 ENSMUSP00000040765.6
ENSMUSG00000041229.15 ENSMUST00000046962.10 ENSMUSP00000041312.4
ENSMUSG00000041229.15 ENSMUST00000112662.8 ENSMUSP00000108281.2
ENSMUSG00000041229.15 ENSMUST00000112666.7 ENSMUSP00000108285.1
ENSMUSG00000041229.15 ENSMUST00000112668.8 ENSMUSP00000108287.2
ENSMUSG00000041229.15 ENSMUST00000112670.7 ENSMUSP00000108289.1
ENSMUSG00000041229.15 ENSMUST00000148622.2 ENSMUSP00000122974.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDM PHF2_PHF8 Jmjc H3K9me2 K 26866517
Status Reviewed
Classification
Type Family E-value Score Start End
HDM PHF2_PHF8 3.50e-95 317.6 195 351
Me_Reader PHD 6.10e-12 47 6 54
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3 (By similarity).
Domain Profile
  HDM PHF2_PHF8
              PHF2.txt   1 fsdtklselveppdivkklslvenlwpdeavlekpkvekycligvkdsytdfhidfggasvyyhvlkgekifylirpteanlalyeawe 89 
                           fsdt+ls+lve+p+iv+kls+venlwp+e+v+e+p+v+kycl++v+dsytdfhidfgg+sv+yhvlkgekifylirpt+anl+l+e+w+
  ENSMUSP00000127653.1 195 FSDTRLSNLVETPRIVRKLSWVENLWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWS 283
                           79*************************************************************************************** PP
              PHF2.txt  90 sssdqsevffgdkvdkaykvvvkqgqtllipagwihavltpvdclafggnflhslniemqlrayelek 157
                           sss+q+e+ffgd+v+k+yk++vkqgqtl+ip+gwihavltpvdclafggnflhslniemql+aye+ek
  ENSMUSP00000127653.1 284 SSSNQNEMFFGDQVEKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEK 351
                           ******************************************************************97 PP
  Me_Reader PHD
               PHD.txt  2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51
                           +Cl C+ +++ +++m++Cd C+dwfH++Cv+++++++ + + ++Cp+C+
  ENSMUSP00000127653.1  6 VYCL-CRLPYDVTRFMIECDMCQDWFHGSCVGVEEEKAADIDLYHCPNCE 54
                          69*9.*****************************777775558******7 PP
Protein Sequence
(Fasta)		MASVPVYCLC RLPYDVTRFM IECDMCQDWF HGSCVGVEEE KAADIDLYHC PNCEVLHGPS 60
IMKKRRGSSK GHDNHKGKPL KTGSSMFIRE LRGRTFDSSD EVILKPTGSQ LTVEFLEENS 120
FSVPILVLKK DGLGMTLPSP SFTVRDVEHY VGSDKEIDVI DVARQADCKM KLGDFVKYYY 180
SGKREKVLNV ISLEFSDTRL SNLVETPRIV RKLSWVENLW PEECVFERPN VQKYCLMSVR 240
DSYTDFHIDF GGTSVWYHVL KGEKIFYLIR PTNANLTLFE CWSSSSNQNE MFFGDQVEKC 300
YKCSVKQGQT LFIPTGWIHA VLTPVDCLAF GGNFLHSLNI EMQLKAYEIE KRLSTADLFK 360
FPNFETICWY VGKHILDIFR GLRENRRHPA SYLVHGGKAL NLAFRAWTKK EALPDHEDEI 420
PETVRTVQLI KDLAREIRLV EDIFQQNVGK TSNIFGLQRI FPAGSIPLTK PAHSTSVSMS 480
KLSLPSKNGS KKKGLKPKDI FKKAERKGKQ SSALGPAGQL SYNLMDPYSH QALKTGPSQK 540
AKFNMSGTSL NDSDDDSADM DLDGSENPLA LLMANGSTKR MKSVSKSRRA KIAKKVDSAR 600
LVAEQVMGDE FDLDSDDELQ IDERLGKEKA NLLIRSKFPR KLPRAKPCSD PNRIREPGEV 660
EFDIEEDYTT DEDMVEGVES KLGNGSGAGG ILDLLKASRQ VGGPDYAALT EAPASPSTQE 720
AIQGMLCMAN LQSSSSSPAT SSLQAWWTGG QERSSGSSSS GLGTVSSSPA SQRTPGKRPI 780
KRPAYWKNES EEEENASLDE QDSLGACFKD AEYIYPSLES DDDDPALKSR PKKKKNSDDA 840
PWSPKARVTP TLPKQDRPVR EGTRVASIET GLAAAAAKLA QQELQKAQKK KYIKKKPLLK 900
EVEQPRPQDS NPIMTMPAPT VATTPQPDTS SSPQPPPEPK QEALSGSLAD HEYTARPNAF 960
GMAQANRSTT PMAPGVFLTQ RRPSVGSQSS QAGQGKRPKK GLATAKQRLG RILKIHRNGK 1020
LLL 1023
Nucleotide Sequence
(Fasta)		GTGCCCGAGC CTCGTAAGAT GGCGGCGGGC TCGTCTCTTT CCCAGAACGC CGCCACTCTC 60
AATATGGTAG CTGTTTACCA TATCTCTCCA CCCCTCTCCG CCTCAACTGC CTCGCGATTT 120
TGAATAAACT TTATTGATTG CTTTGAATCT CCTACAACCC CCCGAGAGTG GCTTCTCCCG 180
GCGACCTCTC CGGCGGTCTT TCTCCAGCCG CCGCAAGCCT GTCTCGCGAA GGGGGCAGCG 240
ACAAAGCCAC TTGCCAGTGC GCCCGGCGGC CCCGACCCCG ACCCCCAGCC CCGGCTGAGA 300
CCTCGGTCTC TAGAAGGCTC TGAGGGCCAG ACGGTGGGAG GGCTGAGGTG GACACTGCCC 360
GAAAGCCCCG TCAGAGCCCG GGCACTGCGT GACGCGGCAT GTGGTTTCTA GGAGAAGGCA 420
AGTCAGCTTC ACAGTTTGGC AGCGGCAATC CCAGCATTCA GCGCGCGCCG CCTCGGGCCG 480
GAACTGCCCG GCCAGCCTGT GCTTAGCGCA GAGCTGGGTT GCCCCGGAGC GAGCCCAGCG 540
GCAGGCGAGT CTCTGGGGCT GAGCTCTGTT CCCTGAGGAC TTGCCCCCTG CAGCCTCGGG 600
CATGAAGAGA GCTCTGTAGC GTTTGGGACC GTGGACATTT TTTATCAGGT TTGGGGCATA 660
AAAAAGGTTC CTGTCAGTGT GTGTGTGGGG AGGCGTAGAG AGCTCCTCGT AAGTTTTGGG 720
GGCTGCAAGC AAGCTGCGTT CTAATTTAAG ACGAGACGTC TGTCAGCCAT CGTCTAGAGA 780
AGGCGCTTGT TGCTGCCTTC AGACCCAGTA AAGCTTCAAA ACTGGCACGG CGCAAAACGA 840
TCCAACCCCC TGTGAAGATG GCCTCGGTGC CTGTGTATTG CCTCTGTCGA CTGCCTTATG 900
ATGTGACCCG CTTCATGATC GAGTGTGACA TGTGCCAGGA CTGGTTTCAC GGCAGTTGTG 960
TTGGTGTTGA GGAGGAGAAG GCTGCTGATA TTGATCTTTA CCACTGCCCT AACTGTGAGG 1020
TCTTACATGG ACCTTCCATT ATGAAAAAAC GTCGTGGATC TTCCAAAGGA CATGATAATC 1080
ACAAGGGGAA GCCACTGAAG ACTGGAAGCT CTATGTTTAT CCGAGAACTT CGGGGCAGAA 1140
CTTTTGACAG CTCAGATGAA GTGATTCTGA AGCCCACTGG AAGTCAGCTG ACTGTGGAAT 1200
TCTTGGAAGA GAATAGCTTC AGCGTGCCTA TCCTTGTCTT GAAGAAGGAT GGGTTGGGGA 1260
TGACATTACC CTCTCCATCA TTCACTGTGA GGGATGTGGA ACACTATGTT GGTTCTGACA 1320
AAGAGATTGA TGTGATTGAT GTGGCCCGCC AGGCTGACTG CAAGATGAAA CTCGGTGATT 1380
TTGTCAAATA CTATTACAGT GGGAAGAGGG AAAAAGTCCT CAATGTCATT AGTTTGGAAT 1440
TCTCCGATAC CAGGCTTTCA AACCTCGTGG AAACACCCAG GATTGTTCGC AAGCTGTCAT 1500
GGGTGGAGAA CTTGTGGCCA GAGGAATGTG TCTTTGAGAG ACCCAATGTG CAGAAGTACT 1560
GCCTCATGAG TGTGCGGGAT AGCTATACAG ATTTTCACAT TGACTTTGGT GGGACCTCAG 1620
TTTGGTACCA TGTGCTTAAG GGTGAGAAGA TCTTCTACCT GATCCGCCCA ACAAATGCTA 1680
ATCTGACTCT CTTTGAGTGC TGGAGTAGCT CCTCCAATCA GAACGAGATG TTCTTTGGTG 1740
ACCAAGTGGA AAAGTGCTAC AAGTGTTCTG TGAAGCAAGG ACAAACACTG TTTATTCCTA 1800
CAGGATGGAT ACATGCTGTG TTAACACCCG TGGACTGCTT AGCATTCGGA GGGAACTTCT 1860
TACACAGTCT TAACATTGAA ATGCAACTCA AGGCTTATGA AATTGAGAAG AGGCTGAGCA 1920
CAGCAGACCT TTTCAAGTTT CCCAACTTCG AGACCATCTG TTGGTATGTG GGAAAACATA 1980
TTCTGGACAT CTTTCGAGGC TTACGAGAAA ATAGAAGACA CCCTGCCTCC TACCTGGTCC 2040
ATGGTGGTAA AGCTCTGAAC TTGGCATTTA GAGCTTGGAC AAAGAAAGAA GCTTTGCCAG 2100
ACCACGAGGA TGAGATCCCA GAGACAGTGC GGACTGTACA GCTCATTAAA GATCTGGCTA 2160
GGGAGATCCG TCTGGTTGAA GACATCTTCC AACAGAACGT TGGGAAGACG AGCAATATCT 2220
TTGGGCTGCA GAGGATCTTC CCAGCTGGCT CCATCCCCTT AACCAAGCCA GCCCATTCCA 2280
CTTCAGTATC CATGTCCAAG CTGTCACTGC CCTCCAAAAA TGGTTCAAAG AAGAAAGGCC 2340
TGAAGCCCAA GGATATCTTC AAGAAGGCAG AGCGAAAGGG CAAGCAGAGT TCAGCCTTGG 2400
GGCCTGCTGG CCAGTTGAGC TATAATCTCA TGGACCCATA CAGTCATCAG GCACTGAAGA 2460
CAGGCCCTTC CCAGAAAGCA AAGTTCAACA TGAGTGGTAC CAGCTTGAAT GATTCAGATG 2520
ATGACTCAGC AGACATGGAC CTTGATGGCA GTGAGAACCC TCTGGCCCTG TTGATGGCTA 2580
ATGGCAGTAC GAAGAGGATG AAGAGTGTAT CCAAATCTCG GAGAGCCAAA ATTGCAAAGA 2640
AGGTAGACAG TGCAAGACTG GTAGCAGAAC AGGTCATGGG AGATGAATTT GACTTGGATT 2700
CAGATGATGA GCTGCAGATT GACGAGAGAT TGGGAAAGGA AAAGGCGAAC CTGTTAATAA 2760
GATCAAAATT TCCCCGGAAG TTGCCCCGTG CAAAACCTTG CTCTGACCCC AACCGAATTC 2820
GTGAACCTGG AGAAGTTGAG TTTGACATTG AGGAGGACTA TACCACAGAT GAGGACATGG 2880
TGGAAGGGGT TGAAAGCAAG CTTGGGAATG GGAGTGGAGC CGGTGGAATT CTTGATCTAC 2940
TTAAGGCCAG CAGGCAGGTG GGGGGACCTG ACTATGCTGC CCTCACTGAG GCCCCAGCCT 3000
CCCCCAGCAC TCAAGAGGCC ATCCAGGGCA TGTTGTGTAT GGCCAACCTG CAGTCCTCAT 3060
CATCCTCACC AGCTACCTCC AGTCTGCAGG CTTGGTGGAC TGGAGGGCAA GAAAGAAGCA 3120
GCGGGAGCTC CAGCAGTGGC CTGGGCACTG TGTCTAGTAG TCCTGCTTCC CAGCGCACCC 3180
CAGGGAAGCG GCCCATCAAG AGGCCAGCAT ACTGGAAAAA CGAGAGTGAA GAGGAGGAGA 3240
ATGCCAGTCT TGATGAGCAA GACAGCTTGG GAGCATGCTT CAAGGATGCT GAGTATATCT 3300
ATCCATCTCT GGAGTCTGAT GATGATGACC CTGCTTTGAA ATCTCGACCC AAGAAAAAGA 3360
AGAATTCAGA TGATGCTCCA TGGAGTCCTA AAGCCCGTGT GACTCCAACC CTACCCAAGC 3420
AGGACCGTCC TGTTCGTGAG GGGACCAGAG TTGCCTCCAT TGAGACAGGC TTGGCTGCAG 3480
CAGCTGCAAA GCTTGCCCAG CAGGAGCTAC AAAAGGCCCA AAAGAAGAAA TATATCAAGA 3540
AGAAGCCTTT GCTGAAGGAG GTAGAACAGC CGCGCCCTCA AGATTCCAAT CCCATCATGA 3600
CAATGCCTGC ACCAACTGTG GCTACAACAC CCCAGCCTGA CACCTCCTCC TCACCCCAGC 3660
CACCTCCTGA GCCTAAACAA GAGGCTCTGT CAGGAAGTCT TGCTGACCAT GAGTACACTG 3720
CTCGTCCCAA TGCCTTTGGC ATGGCTCAGG CAAATCGCAG CACCACACCC ATGGCCCCTG 3780
GAGTCTTCCT CACCCAGCGG CGCCCTTCAG TTGGTTCCCA GAGCAGTCAG GCAGGACAAG 3840
GAAAGCGTCC TAAAAAGGGC CTGGCCACAG CAAAGCAGAG ACTCGGCCGC ATCCTGAAAA 3900
TCCACAGAAA TGGCAAGTTA CTTCTGTGAG ACGAGCCCCA TCATGTCCTA CTCCTTCATC 3960
CCTTCACCCC CATTGCCTTC TTCGTTGTCA ACTCGGGGCA CTCCTGGATC CTATGAGCCC 4020
CGGACAAGGT GCATTGTCCT GCTTTCTTGG GACTGACCAA AGGCACGGAC TATCTCCAAC 4080
TCCCTTTCCC ACTTCCCCTA TGAGTATCCT ACCTTCTTTT TCCATATCCA TAAATAGCAG 4140
GTAAATGGGA GACATTTCCA ACTGACAAGA ACCTTTTCCT GCTCCACCCA CATATTTCAC 4200
TTACACCTTG TCTTTATTCT TTTCCACTGC TCCTCTATAT GGAAGGAATG AGGAGGAGCA 4260
ACATAAAGGG AGTCTGGGCC TGTCAGTTTC CTCAGCCATG GAGTGAGAAG CCCAGTGCTC 4320
AACATTTTCT GCACCTCCAG CCCTGTCTCT AAGCCTGCCC ACCTCCACCC ATTCCTACCC 4380
CTTCCTCACA ACCGATGGAT ATACCCTACC TTCATTCTTG TTCCTGATAG AAGGTTGTGG 4440
TCTTTATCTT CTTTTACCTC TTTTTCATGA CAAAATGAAG AGGGTCTTTA TGACCCTATT 4500
ATGGGACAAC TCCAGAGCTG GCCTAGAAAA GCTGACTTTA TCTGTCTTTG GGGGAGGGGG 4560
AGGAGATTCC TTTTACTTTT CGAGGTGGGA AAAAGGACAG ATACCCAAGC CTTTGACCAT 4620
GATTGTTGCT TAGCCCACCA GAGGAAACTA CTTTTGTCTG ACTGCAAATG AAACCCCTAT 4680
GATGATCTTC AGGAATTTGC CTGTATTTTT GAGGCCCTGT AGAACATTAT CCCCATAGCT 4740
ATAACTGGGT TCAAGCAGGT ACAAACTCAC CTCCTAGAAA TCTGAAGTAC CTGGCACATT 4800
GAGAACTATG GCCCCTGCCA CCCCACAAAG CACAGCCTGG ACCTTCTGAA GAGGGTGTGG 4860
TGAGATAACC CTGAAGGGTC ATTATCAGGA ACTTCCATGT TTCTTTCCCC ATCTAAGCTT 4920
AGTCTAAAGA AGATTTCAGT ACTAAGATCT TCACCCCTGG GACTTTCCAC TTCCAGACCA 4980
CAGGCCAACT ATTCAAGCAT AGTACAGATA GGCTATTGAA GTCTGAAGTT AGAAACAATG 5040
CCCATATGTG AAGTAGCAGA TATTCTGATC CGCTTTTCTC TGCTTTCCTT TGTGATTGTC 5100
ACTATTTTCC AGACAATGTC CCCACCTCCC TCTTGTCTTG CCTTACTGGC AATCTGGGCT 5160
TGATGGAGAC TGCCCCTTCT GAACAACCCA TTTTGGCACT GCCCAAGTGG GAGTGTCCTC 5220
TACCTTCCAC TCGTCCTCAT CCCAGCTTGC CTAGTGCTTC TGGGGAATTT AACAGCTATG 5280
ATGCAGACCA CAGGGAATTT GTGAGGCCTC TGTGTTATCT TTTATGTTTG TGGCTTATCT 5340
TTCTTTTTTC TATAGATGTA TCACCTCCAT CCTTGTTGGG ATGGGGGGAT ACTTTAGCAT 5400
ATTTGCTTTT TCTACCTTGG GGACCCCCAG GGGCCAAGCA GTCCTCCTTT AGTCACACCA 5460
AAGGCAAAAG GCCTGGCTAC CTCCCCTTTA GCACGTGAGG TCCCTATTCC CCTCCTTTCT 5520
ACTCAGCTTT GCTTATCTTG GAGATTTCAA GGCAGCAGTA GGGAAGTAAG GGGAAAGCAG 5580
GAGAAGCTCC TAACCCTGTA TGGGCAACTT CCTGACTAAA GACTGACTGT TGTCACCAAA 5640
AACAGGTCCC TAGCCCTTTC ACCCACTAAA ACTCCCTCTT GATCTTTCAA TGGCAGCTAA 5700
TTGCTAGCAC CCTCACCCCA CCCATTCCAG GCCTCTTTTC CCTCTGTTTC TTTGTTAGAA 5760
GGTTCTGTGG AGCTGAAACC CAGCCTCTAA TGGGGTTTGT TTAGTTTAGT TGGGTTCTCA 5820
GAGTCTCCTG TTATTTTGTG TTGTTTCCAA TGAAAAGCAA GTTTACCCTC AAAGTTATGC 5880
TTTTCCAAAG AAGCTAGTGT GTTAGTGGTG TTGTTGCTGT TGTTGCTGTT GTTGTTGTTG 5940
TTTTGTTTGT TTTGTTTTTA TGTTTCAGGT TCTAAGTGAA GTGAGGTGGA GAGGAGTTGG 6000
GAATAACCAA GGTTTAGAAC ATGGTGAGAT AGTTAACCTC TGATCTGCAA TCCCCAGCAG 6060
AGAGTTGGGG TAGGATAAGA GGGCAGAGAG GATTTCTATT CACCTTTAAT ATATTTTTAC 6120
AAAAAAGCAA ACAATTTAAA AACAAACCCA CCGCTTCTGT ACATGTCTAA ATATATTTTT 6180
AGAAGTGGGT AGGATTGTGA TTTCTGATGC AGGGCCTTTT TATAAATAGG TTAGAGTAGC 6240
CTCATCCAGA TTTCTCTGTT GTTTGTTCCC CTTGTTTTTT CTTATGTTGT GTTACTAATG 6300
TAATTTATAT ATTTTTTAGA TCTCCCTTTC CTGTAGAGAT AAAAGTGATT TATCTTGGC 6360
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR003347--JmjC_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF02373--JmjC
PF00628--PHD
Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0032452--F:histone demethylase activity
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0035575--F:histone demethylase activity (H4-K20 specific)
GO:0005506--F:iron ion binding
GO:0035064--F:methylated histone binding
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270--F:zinc ion binding
GO:0007420--P:brain development
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0071557--P:histone H3-K27 demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0035574--P:histone H4-K20 demethylation
GO:0061188--P:negative regulation of chromatin silencing at rDNA
GO:0045943--P:positive regulation of transcription from RNA polymerase I promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0022 ENSRNOP00000040672.4 Rattus norvegicus 98 0.0 1771
WERAM-Hos-0203 ENSP00000350676.5 Homo sapiens 95 0.0 1715
WERAM-Chs-0149 ENSCSAP00000008671.1 Chlorocebus sabaeus 94 0.0 1712
WERAM-Paa-0022 ENSPANP00000018377.1 Papio anubis 94 0.0 1709
WERAM-Fec-0005 ENSFCAP00000000567.3 Felis catus 94 0.0 1708
WERAM-Mup-0130 ENSMPUP00000011455.1 Mustela putorius furo 94 0.0 1707
WERAM-Gog-0162 ENSGGOP00000014352.2 Gorilla gorilla 94 0.0 1706
WERAM-Nol-0174 ENSNLEP00000019631.2 Nomascus leucogenys 94 0.0 1704
WERAM-Eqc-0214 ENSECAP00000022798.1 Equus caballus 94 0.0 1702
WERAM-Orc-0019 ENSOCUP00000002278.2 Oryctolagus cuniculus 93 0.0 1695
WERAM-Mam-0070 ENSMMUP00000011473.2 Macaca mulatta 93 0.0 1687
WERAM-Caf-0169 ENSCAFP00000024137.2 Canis familiaris 93 0.0 1674
WERAM-Cap-0130 ENSCPOP00000010443.2 Cavia porcellus 94 0.0 1665
WERAM-Sus-0089 ENSSSCP00000013121.2 Sus scrofa 94 0.0 1655
WERAM-Ova-0070 ENSOARP00000007621.1 Ovis aries 94 0.0 1654
WERAM-Myl-0006 ENSMLUP00000000462.2 Myotis lucifugus 91 0.0 1653
WERAM-Dan-0011 ENSDNOP00000001170.3 Dasypus novemcinctus 91 0.0 1621
WERAM-Bot-0124 ENSBTAP00000017673.4 Bos taurus 91 0.0 1607
WERAM-Soa-0095 ENSSARP00000008902.1 Sorex araneus 89 0.0 1583
WERAM-Loa-0154 ENSLAFP00000013594.3 Loxodonta africana 94 0.0 1555
WERAM-Tut-0006 ENSTTRP00000000351.1 Tursiops truncatus 89 0.0 1523
WERAM-Aim-0075 ENSAMEP00000006562.1 Ailuropoda melanoleuca 94 0.0 1507
WERAM-Tub-0093 ENSTBEP00000010730.1 Tupaia belangeri 93 0.0 1494
WERAM-Caj-0235 ENSCJAP00000050740.1 Callithrix jacchus 84 0.0 1487
WERAM-Poa-0198 ENSPPYP00000022810.2 Pongo abelii 85 0.0 1458
WERAM-Otg-0029 ENSOGAP00000001922.2 Otolemur garnettii 95 0.0 1457
WERAM-Pat-0187 ENSPTRP00000042192.3 Pan troglodytes 94 0.0 1449
WERAM-Ptv-0061 ENSPVAP00000006309.1 Pteropus vampyrus 81 0.0 1384
WERAM-Mod-0187 ENSMODP00000026122.3 Monodelphis domestica 71 0.0 1288
WERAM-Tas-0113 ENSTSYP00000011554.1 Tarsius syrichta 87 0.0 1263
WERAM-Dio-0011 ENSDORP00000001369.1 Dipodomys ordii 77 0.0 1174
WERAM-Lac-0125 ENSLACP00000014816.1 Latimeria chalumnae 69 0.0 1165
WERAM-Xet-0141 ENSXETP00000047696.4 Xenopus tropicalis 67 0.0 1157
WERAM-Anc-0126 ENSACAP00000011870.3 Anolis carolinensis 68 0.0 1127
WERAM-Vip-0022 ENSVPAP00000002066.1 Vicugna pacos 89 0.0 1101
WERAM-Ect-0006 ENSETEP00000000305.1 Echinops telfairi 94 0.0 1085
WERAM-Dar-0017 ENSDARP00000007140.7 Danio rerio 63 0.0 1060
WERAM-Xim-0128 ENSXMAP00000010848.1 Xiphophorus maculatus 63 0.0 1043
WERAM-Mae-0004 ENSMEUP00000000188.1 Macropus eugenii 70 0.0 1043
WERAM-Ict-0005 ENSSTOP00000000259.2 Ictidomys tridecemlineatus 95 0.0 1040
WERAM-Orn-0143 ENSONIP00000015119.1 Oreochromis niloticus 62 0.0 1037
WERAM-Pof-0120 ENSPFOP00000010415.2 Poecilia formosa 62 0.0 1035
WERAM-Gam-0086 ENSGMOP00000008905.1 Gadus morhua 62 0.0 1031
WERAM-Ten-0185 ENSTNIP00000018140.1 Tetraodon nigroviridis 61 0.0 1017
WERAM-Tar-0180 ENSTRUP00000037980.1 Takifugu rubripes 57 0.0 980
WERAM-Prc-0121 ENSPCAP00000010850.1 Procavia capensis 90 0.0 940
WERAM-Ora-0007 ENSOANP00000001114.1 Ornithorhynchus anatinus 78 0.0 867
WERAM-Asm-0138 ENSAMXP00000013325.1 Astyanax mexicanus 80 0.0 837
WERAM-Gaa-0089 ENSGACP00000011590.1 Gasterosteus aculeatus 79 0.0 810
WERAM-Orla-0070 ENSORLP00000008997.1 Oryzias latipes 76 0.0 801
WERAM-Sah-0047 ENSSHAP00000005380.1 Sarcophilus harrisii 76 0.0 796
WERAM-Leo-0144 ENSLOCP00000017335.1 Lepisosteus oculatus 66 0.0 662
WERAM-Gaga-0056 ENSGALP00000008273.4 Gallus gallus 62 0.0 661
WERAM-Tag-0055 ENSTGUP00000003831.1 Taeniopygia guttata 62 0.0 659
WERAM-Fia-0091 ENSFALP00000007322.1 Ficedula albicollis 61 0.0 658
WERAM-Pem-0097 ENSPMAP00000010124.1 Petromyzon marinus 67 0.0 642
WERAM-Anp-0115 ENSAPLP00000013232.1 Anas platyrhynchos 59 2e-169 594
WERAM-Meg-0060 ENSMGAP00000005425.2 Meleagris gallopavo 60 2e-168 590
WERAM-Pes-0093 ENSPSIP00000011413.1 Pelodiscus sinensis 60 4e-159 560
WERAM-Ere-0005 ENSEEUP00000000200.1 Erinaceus europaeus 60 8e-146 515
WERAM-Mim-0110 ENSMICP00000010445.1 Microcebus murinus 54 6e-136 483
WERAM-Drm-0062 FBpp0289915 Drosophila melanogaster 49 2e-78 291
WERAM-Ocp-0120 ENSOPRP00000012395.2 Ochotona princeps 48 2e-77 288
Created Date 25-Jun-2016