WERAM Information

Tag Content
WERAM ID WERAM-Hos-0105
Ensembl Protein ID ENSP00000340507.4
Uniprot Accession O15164; TIF1A_HUMAN; A4D1R7; A4D1R8; O95854
Genbank Protein ID NP_003843.3; NP_056989.2
Protein Name Transcription intermediary factor 1-alpha
Genbank Nucleotide ID NM_003852.3; NM_015905.2
Gene Name TRIM24;TIF1A;PTC6;RNF82;TIF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000122779.16 ENST00000343526.8 ENSP00000340507.4
ENSG00000122779.16 ENST00000415680.6 ENSP00000390829.2
ENSG00000122779.16 ENST00000620194.1 ENSP00000484482.1
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain H3K24; H3K27 K 22464331
Me_Reader PHD PHD-type H3K4me0 K 21164480
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 3.90e-26 93.2 916 986
Me_Reader PHD 1.30e-07 34 55 871
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
Domain Profile
  Ac_Reader Bromodomain
          BROMO.txt   1 kehevsepFrepvdpqleipdYydiikePmdLstikerleegn..YsspeefvkDvrlifnNakaynenkssv 71 
                        ++he s +F+ pv +   +pdYy+iik+PmdLstik+rl+e +  Ys+pe+fv+D+rlif+N+ ++ne++s+v
  ENSP00000340507.4 916 YCHEMSLAFQDPVPL--TVPDYYKIIKNPMDLSTIKKRLQEDYsmYSKPEDFVADFRLIFQNCAEFNEPDSEV 986
                        8*************9..8***********************9999*************************997 PP
  Me_Reader PHD
            PHD.txt  3 iClvC.gkddegekemvqCde..CddwfHlkC 31
                       +C vC ++ + ++++++ C +  C+     +C
  ENSP00000340507.4 55 TCAVChQNIQSRAPKLLPCLHsfCQ-----RC 81
                       799**33445555568887776666.....44 PP
            PHD.txt  12 egekemvqCdeCddwfHlkCvklpls 37 
                        ++e+  ++C++Cd+    +C  l+ +
  ENSP00000340507.4 227 KKEQLKLYCETCDKLTCRDCQLLEHK 252
                        23333699999998887777766644 PP
            PHD.txt   2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 
                        + C vC +++ +   +++C++C++ fHl+C+ ++l++ p+g +w+C  C+
  ENSP00000340507.4 827 DWCAVC-QNGGE---LLCCEKCPKVFHLSCHVPTLTNFPSG-EWICTFCR 871
                        57****.44443...9*************************.*******8 PP
Protein Sequence
(Fasta)		MEVAVEKAVA AAAAASAAAS GGPSAAPSGE NEAESRQGPD SERGGEAARL NLLDTCAVCH 60
QNIQSRAPKL LPCLHSFCQR CLPAPQRYLM LPAPMLGSAE TPPPVPAPGS PVSGSSPFAT 120
QVGVIRCPVC SQECAERHII DNFFVKDTTE VPSSTVEKSN QVCTSCEDNA EANGFCVECV 180
EWLCKTCIRA HQRVKFTKDH TVRQKEEVSP EAVGVTSQRP VFCPFHKKEQ LKLYCETCDK 240
LTCRDCQLLE HKEHRYQFIE EAFQNQKVII DTLITKLMEK TKYIKFTGNQ IQNRIIEVNQ 300
NQKQVEQDIK VAIFTLMVEI NKKGKALLHQ LESLAKDHRM KLMQQQQEVA GLSKQLEHVM 360
HFSKWAVSSG SSTALLYSKR LITYRLRHLL RARCDASPVT NNTIQFHCDP SFWAQNIINL 420
GSLVIEDKES QPQMPKQNPV VEQNSQPPSG LSSNQLSKFP TQISLAQLRL QHMQQQVMAQ 480
RQQVQRRPAP VGLPNPRMQG PIQQPSISHQ QPPPRLINFQ NHSPKPNGPV LPPHPQQLRY 540
PPNQNIPRQA IKPNPLQMAF LAQQAIKQWQ ISSGQGTPST TNSTSSTPSS PTITSAAGYD 600
GKAFGSPMID LSSPVGGSYN LPSLPDIDCS STIMLDNIVR KDTNIDHGQP RPPSNRTVQS 660
PNSSVPSPGL AGPVTMTSVH PPIRSPSASS VGSRGSSGSS SKPAGADSTH KVPVVMLEPI 720
RIKQENSGPP ENYDFPVVIV KQESDEESRP QNANYPRSIL TSLLLNSSQS STSEETVLRS 780
DAPDSTGDQP GLHQDNSSNG KSEWLDPSQK SPLHVGETRK EDDPNEDWCA VCQNGGELLC 840
CEKCPKVFHL SCHVPTLTNF PSGEWICTFC RDLSKPEVEY DCDAPSHNSE KKKTEGLVKL 900
TPIDKRKCER LLLFLYCHEM SLAFQDPVPL TVPDYYKIIK NPMDLSTIKK RLQEDYSMYS 960
KPEDFVADFR LIFQNCAEFN EPDSEVANAG IKLENYFEEL LKNLYPEKRF PKPEFRNESE 1020
DNKFSDDSDD DFVQPRKKRL KSIEERQLLK
Nucleotide Sequence
(Fasta)		GACAGATACC CTCCTTCCGG CCGCGCCACT CGGGAGGCGG ATCCCGTGGG CCTGAGGAGG 60
CTTCCCCCGC CCGGTTTGCT TTCCCTCCCT CGCTGGCGCT GCCGCGAGTC CACCGAGCGG 120
CCTCTGAGGA GCAGCCGCAG GAGGAGGAGG AGGTCGTCGG GGGCGGCGGG CGGAGACCGC 180
GCTCTCGCTT CCCCGGCGGC GGCAAGGGCA GGACAATGGA GGTGGCGGTG GAGAAGGCGG 240
TGGCGGCGGC GGCAGCGGCC TCGGCTGCGG CCTCCGGGGG GCCCTCGGCG GCGCCGAGCG 300
GGGAGAACGA GGCCGAGAGT CGGCAGGGCC CGGACTCGGA GCGCGGCGGC GAGGCGGCCC 360
GGCTCAACCT GTTGGACACT TGCGCCGTGT GCCACCAGAA CATCCAGAGC CGGGCGCCCA 420
AGCTGCTGCC CTGCCTGCAC TCTTTCTGCC AGCGCTGCCT GCCCGCGCCC CAGCGCTACC 480
TCATGCTGCC CGCGCCCATG CTGGGCTCGG CCGAGACCCC GCCACCCGTC CCTGCCCCCG 540
GCTCGCCGGT CAGCGGCTCG TCGCCGTTCG CCACCCAAGT TGGAGTCATT CGTTGCCCAG 600
TTTGCAGCCA AGAATGTGCA GAGAGACACA TCATAGATAA CTTTTTTGTG AAGGACACTA 660
CTGAGGTTCC CAGCAGTACA GTAGAAAAGT CAAATCAGGT ATGTACAAGC TGTGAGGACA 720
ACGCAGAAGC CAATGGGTTT TGTGTAGAGT GTGTTGAATG GCTCTGCAAG ACGTGTATCA 780
GAGCTCATCA GAGGGTAAAG TTCACAAAAG ACCACACTGT CAGACAGAAA GAGGAAGTAT 840
CTCCAGAGGC AGTTGGTGTC ACCAGCCAGC GACCAGTGTT TTGTCCTTTT CATAAAAAGG 900
AGCAGCTGAA GCTGTACTGT GAGACATGTG ACAAACTGAC ATGTCGAGAC TGTCAGTTGT 960
TAGAACATAA AGAGCATAGA TACCAATTTA TAGAAGAAGC TTTTCAGAAT CAGAAAGTGA 1020
TCATAGATAC ACTAATCACC AAACTGATGG AAAAAACAAA ATACATAAAA TTCACAGGAA 1080
ATCAGATCCA AAACAGAATT ATTGAAGTAA ATCAAAATCA AAAGCAGGTG GAACAGGATA 1140
TTAAAGTTGC TATATTTACA CTGATGGTAG AAATAAATAA AAAAGGAAAA GCTCTACTGC 1200
ATCAGTTAGA GAGCCTTGCA AAGGACCATC GCATGAAACT TATGCAACAA CAACAGGAAG 1260
TGGCTGGACT CTCTAAACAA TTGGAGCATG TCATGCATTT TTCTAAATGG GCAGTTTCCA 1320
GTGGCAGCAG TACAGCATTA CTTTATAGCA AACGACTGAT TACATACCGG TTACGGCACC 1380
TCCTTCGTGC AAGGTGTGAT GCATCCCCAG TGACCAACAA CACCATCCAA TTTCACTGTG 1440
ATCCTAGTTT CTGGGCTCAA AATATCATCA ACTTAGGTTC TTTAGTAATC GAGGATAAAG 1500
AGAGCCAGCC ACAAATGCCT AAGCAGAATC CTGTCGTGGA ACAGAATTCA CAGCCACCAA 1560
GTGGTTTATC ATCAAACCAG TTATCCAAGT TCCCAACACA GATCAGCCTA GCTCAATTAC 1620
GGCTCCAGCA TATGCAGCAA CAGGTAATGG CTCAGAGGCA ACAGGTGCAA CGGAGGCCAG 1680
CACCTGTGGG TTTACCAAAC CCTAGAATGC AGGGGCCCAT CCAGCAACCT TCCATCTCTC 1740
ATCAGCAACC GCCTCCACGT TTGATAAACT TTCAGAATCA CAGCCCCAAA CCCAATGGAC 1800
CAGTTCTTCC TCCTCATCCT CAACAACTGA GATATCCACC AAACCAGAAC ATACCACGAC 1860
AAGCAATAAA GCCAAACCCC CTACAGATGG CTTTCTTGGC TCAACAAGCC ATAAAACAGT 1920
GGCAGATCAG CAGTGGACAG GGAACCCCAT CAACTACCAA CAGCACATCC TCTACTCCTT 1980
CCAGCCCCAC GATTACTAGT GCAGCAGGAT ATGATGGAAA GGCTTTTGGT TCACCTATGA 2040
TCGATTTGAG CTCACCAGTG GGAGGGTCTT ATAATCTTCC CTCTCTTCCG GATATTGACT 2100
GTTCAAGTAC TATTATGCTG GACAATATTG TGAGGAAAGA TACTAATATA GATCATGGCC 2160
AGCCAAGACC ACCCTCAAAC AGAACGGTCC AGTCACCAAA TTCATCAGTG CCATCTCCAG 2220
GCCTTGCAGG ACCTGTTACT ATGACTAGTG TACACCCCCC AATACGTTCA CCTAGTGCCT 2280
CCAGCGTTGG AAGCCGAGGA AGCTCTGGCT CTTCCAGCAA ACCAGCAGGA GCTGACTCTA 2340
CACACAAAGT CCCAGTGGTC ATGCTGGAGC CAATTCGAAT AAAACAAGAA AACAGTGGAC 2400
CACCGGAAAA TTATGATTTC CCTGTTGTTA TAGTGAAGCA AGAATCAGAT GAAGAATCTA 2460
GGCCTCAAAA TGCCAATTAT CCAAGAAGCA TACTCACCTC CCTGCTCTTA AATAGCAGTC 2520
AGAGCTCTAC TTCTGAGGAG ACTGTGCTAA GATCAGATGC CCCTGATAGT ACAGGAGATC 2580
AACCTGGACT TCACCAGGAC AATTCCTCAA ATGGAAAGTC TGAATGGTTG GATCCTTCCC 2640
AGAAGTCACC TCTTCATGTT GGAGAGACAA GGAAAGAGGA TGACCCCAAT GAGGACTGGT 2700
GTGCAGTTTG TCAAAACGGA GGGGAACTCC TCTGCTGTGA AAAGTGCCCC AAAGTATTCC 2760
ATCTTTCTTG TCATGTGCCC ACATTGACAA ATTTTCCAAG TGGAGAGTGG ATTTGCACTT 2820
TCTGCCGAGA CTTATCTAAA CCAGAAGTTG AATATGATTG TGATGCTCCC AGTCACAACT 2880
CAGAAAAAAA GAAAACTGAA GGCCTTGTTA AGTTAACACC TATAGATAAA AGGAAGTGTG 2940
AGCGCCTACT TTTATTTCTT TACTGCCATG AAATGAGCCT GGCTTTTCAA GACCCTGTTC 3000
CTCTAACTGT GCCTGATTAT TACAAAATAA TTAAAAATCC AATGGATTTG TCAACCATCA 3060
AGAAAAGACT ACAAGAAGAT TATTCCATGT ACTCAAAACC TGAAGATTTT GTAGCTGATT 3120
TTAGATTGAT CTTTCAAAAC TGTGCTGAAT TCAATGAGCC TGATTCAGAA GTAGCCAATG 3180
CTGGTATAAA ACTTGAAAAT TATTTTGAAG AACTTCTAAA GAACCTCTAT CCAGAAAAAA 3240
GGTTTCCCAA ACCAGAATTC AGGAATGAAT CAGAAGATAA TAAATTTAGT GATGATTCAG 3300
ATGATGACTT TGTACAGCCC CGGAAGAAAC GCCTCAAAAG CATTGAAGAA CGCCAGTTGC 3360
TTAAATAATA TGCAGCACCA CTAGCTTGTG CTGGTTTTTA GATTTTTTTG TTTTCAAAAA 3420
AACATTTGTC AGTAATTTAA CATCACTACA AAAAGAAGAG TTTGTGACTA TTCTCATCTC 3480
TGTTTTGGAC GTTTACTAGA CTTTGATTTC CTTAATAGCC CATTTCTGTT AACCTCTTAT 3540
CACTAAGAAA GAAAGGAAAG AAGGAGATGA ATAGAAGAAA GAAAATGGAA AGAAGGAAAA 3600
AAGGAGGATA GAAAAAGGAT GGAAGAAAGA AGCATTGAAA ACAAAGACAT TCTTCCCACT 3660
TCTTGGATTT TTAAACCACA GTCTGGAGTG ATAGCTACTG TAGAAAGGAA ATAGACTTTG 3720
TATGAACTCT TTAAGTTGAA AAGTAAAAAA TATATGTGGT TTGGATGTGT GCTTTAATTC 3780
AGCTTTAGAA ATTAATACCA CTACCCGTGA ATTATATGGC CTGACAATAT GAATTAGGTG 3840
TACTGTACTG AAGAACAGTA CTCCACAAAC ATGGGTGGTA ACAAGAGTTC CATCCCAGGA 3900
GGCCAAACGG TGCAACAGAA GGGTAGGTTA GATGCTATTA AGAAGGCACT TAATAGTACA 3960
TCATGTAAGA TGGCAACTGT ATTAAAGAAA AATCCGGAAA ACAAATGTTT GATTTTTGTT 4020
TTTGTTTTTA TCTTGTCTGT AGAGGTATTT TGGTATAGCA GGTTTTCAAG GCCATTTTTT 4080
ATACATTTCT AGATCTAGAT TTTCAACTTC TTCCACTGAG GGAAGTATAT ACATTTGGGT 4140
TTGCTGTGTG TCTATGTGAG GTTTAATTGT ACAGGTGATC CTTTTACAAC AAGCCTCATT 4200
GTTTGCAGTA TAGCTTTTAG TGGAACTACC CAAAATATAA ATACAGCAGC GTGCACTGTA 4260
TTTGATGTGA GGGTTCTTCA TCATATACCC TACTGGGCAT TAAATATAAG TTCCTCTGAA 4320
AGGGACTCGT TTTTGTGGTT TTCATCTGTC TATAATTTGG AATGAAAATG TGTTGTAGGA 4380
TTTTGGGAGC AGGCAGCTGG GGGGAATTAA TAGTGATTTT TTTTTTTTCC TGAAGCATCT 4440
ATCTCATGTT TTTCTTTTGA GAGTCAGAAC ATCAAACTTA ATCTTTGATC TGACTTCTGA 4500
TTTTATTCTT CTGATTGATT GATAGAGGTA CAAAAGACTT ATCTTCTGAG GACAAGCATA 4560
TTCTTAATGT GCCAGACCTA CCCGGTTCAG CTGATATAGA TAGATAGATA GATAGAAGAA 4620
AATTGCTGTG CCATACATTA ATCCAGCATT TGACACAATA TCTAAATGGT TTGCCGAAGT 4680
TAATCTGTAT TTATAAAACA TTAACTGGAG TAAATTTTTC TCCTTAGGAT GATAGAATAA 4740
AAAGAGCTCA CTTGAAAGAA GGCTATTATT TGCATTATAT CACCTGCCAT AAATTTAACA 4800
TAGAAGACTT GGTTTTATCT ACATGGCTTT ACTTCTTAAA GTGGAAAATA TCCTGTGGCT 4860
AATTCATTGG GTTTTCAGGT ACTGCTAAAG ATAAAATACA GGGAGAAAAT AACTTGTTAG 4920
CAATAGATCC CCATTGTTTA TATATATAGG TCTTGTTCAT AATATGTCAA TTATGTATTG 4980
TTAAAAAGTC CTACTCACTT TTCAAATATG TGTTACATGG TAATGTTTGT CATTGTTGTT 5040
TTAAAGTTGC ATTTGACATT TGTTCTCCAA AGAGTGTTTG AACAGATTTT GATAACAGTG 5100
CATACACCTT TTGTCTTTTT TTGCTCCAGC ATTTTATTTT TAGCACAGCA GCTGTGGAGC 5160
TTTTGCTGAT AATTTTATTG TTGGTATCTT AGAATACTGT TCGTCTGACA GTTTATTCTT 5220
CCATACTTGT CTCCCAAGTT AAAACAGAGC AAAACAGATA AATTATTTTG AGAATCATCA 5280
CAAAAGGGAG TTAGAACTTG TGAGACTAAA ACTATAATTT CCTAAATGTG ACTAATGAAC 5340
CCCAAACTGT CACTATTACA TTCAGTGCCA TATTTATCTT TCAAAACAGT ATTTGTTTCA 5400
CCCTAACCAT CTTTGGCTGA ATGAAAGGCA GTTGAGAACC ATCTTTTGGT CATACATAAT 5460
ATAATTATAT TAAAAGTAAA GATCGGGGCT GGGCGCAGTG GCTCACACCT GCAATCCCAC 5520
CAGCACTTTG GGAGGCCAAG GTGGGCGGAT CACAAAGTCA AGAGTTCGAG ATCAGCCTGG 5580
CCAACATTGT GAAACCCCGC CTCTACAAAA AATACAAAAA TTAGCCGGAC ATGGTGGCGT 5640
GCAACTGTAA TCCCAACTAC TCAGGAGGCT GAGACAGGAG AATCACTTGA ACGCAGGAGG 5700
CAGAAGTTGC AGTGAGCCAA GATCTCACCA TTGCACTCCA GCCTGAGTGA CAGAGACTCA 5760
GTCTCAAAAA CAAAAAGTAA AGGTCTTGGG TTTCTCTCTG TAAATAGCCT TTGTGTAATG 5820
GTCTTTAGAT TAATATCCTT TGACTTTATT AATAAGTACC TGTGTGCCCA GGTGGATCTC 5880
AGCTAAGTCA TCCTTAAATT CTGTTCAAAT AGAAATAAAC CATAAAATGA GCCTAACTAT 5940
AACCCACACT CACTTATCAA GCATTCCCCC AAAAGTTCAG TGCGATTCAG GTAACCTTGA 6000
CCTAAACTTG TACACTCCGG TGTACATCTT TGACCATAAA CTCTGGGAGA TTTCCCTCTG 6060
GATTTGGGAT CAGGAGCCCA GTAGGGCCCC ATTGCTGAAT GTTTATCACA CTTCTGGCTA 6120
GGGCTTATGG ATGAGCAGAC CACGTAGGAG CTAGGATTTA CTCAGTTCCA CCTCACTGAC 6180
AGCTTTTCTA GGTGCCAAGC AACTGACTTT TCCTGTGTAA GGAAGCCCAA GTACTTGACC 6240
AGTGATATAT ATGGCCATGG CAAAAGTATA AATGGATGGA TGTAGACCAT ATTCAACGCA 6300
GAATACATTT TAGATCGGTA TCTGGCATTG TAATCATTTT GTCTTTTGAA TTAACATGCC 6360
CTGCTTGTCT TTTCTGAATG GAAGGGTAGG AAAGTGGAAG GTACTAAAAA GGAAAATGTA 6420
GTTTTAGTTT CTTTTCTAAG CTAAAGAACT GGCTTTACTA CTGCTATATT TTACTACCAC 6480
ATAGTAGTGT AGATGTAGTA TAACTTGCTT AGGAATGCTT TCAAAAAGGT TACCTCCATA 6540
GTCAAAAAAA GGGGGAGTAT ACAGCTGATT GTTGCATTTA TGAAACTGCA TTTCAATATG 6600
CTATGCTGTT ACTGTGCTTA GACACTTCCT TACGTTTGAG TTCCAAGGAG AGAGAGTGAG 6660
AAGAGGAACT CCTTTTGCTG AGCTCTGGTC CAAATTAATG TGAATCCCCA AAGTAAATTG 6720
CTGCATATGA ACAACAGGTT TTAGGTTTAA ATTGAAGATA CATTCATTTT ATATGTATTT 6780
GTTGTGAATG AGAGAAATTG AGTGATCTGA TTGGCCATTA AAATTATGGT GAATGGGTCG 6840
GGCGCAGTGG CTCACGCCTG TAATCCCAGC ACTTTGGGAG GCCGAGGTGG GTAGATACCT 6900
GAGGTCAGGA GTTTGAGACC AGCCTGACCA ACATGGTGAA ACCCCATCTC TACTAAAAAT 6960
ACCAAAATCA CCAGGGTGTG GTGGCCCATG CCTGTAATCC TAGCTACTCG GGAGGCTGAG 7020
GCAGGAGAAT CGGCTTGAAC CCAGGAGGCA GAGGTTGCAG TGAGCTGAGA TCGCACCACT 7080
GTAGTCCAGC CTGGGTGTCA GAGCAAGACT CTGTCACAAA AAGAAAAATT ATGGGGAATG 7140
GCCGGGCGCG GTGGCTCACA CCTGTAATCC CAGCACTTTG GGAGGCCGAG GTGGGTGGAT 7200
CACCTGAAGT CAGGAGCTCA AGACCAGCCT GGCCAACATG GTGAAACCCC ACCTCAACAG 7260
AATATACAAA AAAATTAGCT GGGTGTGGTG GCGGGTGCCT GTAATCTCAG CTACTTTGGG 7320
ATGCTGAGGC AGGAGAATAG CTTGAACCCA GGAGGTGGAG GTTGCAGTGA GTCGAGATTG 7380
CACCATTGCA CTCCAGCCTG GGCAACAAGA GCAAAACTCT GTCTCAAAAA AAAAAAAAAA 7440
TGGTGACCAT GCGTTCAACC ATATAATTTC TTACTGAAAT TGAGCTCCTC CTTTTGAATA 7500
ACCATGTACA TATTTTTAAA AGTATTTTAT AGCCCTATGT AAATTAATAG TTGATGTCTT 7560
TTTATAAATG TTTATTGCAT ATTCATCTTG AATGTGAATT TACTGTTGTA ATTCACATAC 7620
TGGTGTCATG TTTCTGAGTG AGAATAATGC TAGTCAGTCA GATCACAGAT TTTTCTCCAT 7680
GAAGGTTTTA CTTATTGAGA GGGACATCTG AGGCAGTAGT CTTCGTCTTT AATTTTTGGG 7740
GGCAGATTGG TGCTTTGGTT TTAATAAAAA CTAACTTTGA TGGATTTTTA CTGTCAATAT 7800
TTTACCACAA GGATTTTTTA ATAGAAAAAT TACTGAATGT TACTTCAGCA GAGTTCTATC 7860
TACTTTGAGT CTCCATTACT ACTACTGTTG TTCCCCTAGC TGTAACATTG ATCCATATAG 7920
GGGCAAGCTA CTAGTCCATA AATAGCTGTA ATAGGAAAAC AGTTTTTTAA AATTCTAACA 7980
CGTGTATTTC ACCAGCCTTA AAAGATTTAA AAAAAAATCT GACAGGAAGG AAAGCGGGTG 8040
GTAAGTATCT TGGATTATTC TGCCTCATAC CAGCCACTCC CAAAGTAGGA GGACCAAAGA 8100
TGCCATGAAG ACTTCTAGTT GTCTGGAAGT TATTTGGGGA AGGGGGGAAA GACACAGAGT 8160
GGGGACCTTT GGAAGTCATT TTAAAAATTT AGCTATGTTA ATTCCACTTG TAAAGTTTGA 8220
AAGGTTTTGA TTCTTGTAAT TTCTGAGAAT TACTATGTTT TAAATTTACT ATTGGATATT 8280
TAACAGATCT TTCATGGGGC CAACCTATTT GCTTCCTTAA TTTTCAAATT AAGTCCTAAT 8340
TTGAGTCCTA AAAAAATCTT TCCTTGTTAG TTGCAAGTTA AACATTTAAT AAAATTATTT 8400
TCCCACGTTT 8411
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR019786--Zinc_finger_PHD-type_CS
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00439--Bromodomain
PF00628--PHD
PF00643--zf-B_box
Gene Ontology

GO:0005829--C:cytosol
GO:0005719--C:nuclear euchromatin
GO:0005634--C:nucleus
GO:0005726--C:perichromatin fibrils
GO:0003682--F:chromatin binding
GO:0034056--F:estrogen response element binding
GO:0016874--F:ligase activity
GO:0070577--F:lysine-acetylated histone binding
GO:0002039--F:p53 binding
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0043565--F:sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0055074--P:calcium ion homeostasis
GO:0071391--P:cellular response to estrogen stimulus
GO:0008285--P:negative regulation of cell proliferation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0046777--P:protein autophosphorylation
GO:0030163--P:protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0031647--P:regulation of protein stability
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0070562--P:regulation of vitamin D receptor signaling pathway
GO:0006366--P:transcription from RNA polymerase II promoter
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0165 ENSPTRP00000033816.4 Pan troglodytes 100 0.0 1801
WERAM-Nol-0156 ENSNLEP00000016764.1 Nomascus leucogenys 100 0.0 1799
WERAM-Gog-0150 ENSGGOP00000013137.2 Gorilla gorilla 100 0.0 1799
WERAM-Mam-0021 ENSMMUP00000004003.2 Macaca mulatta 100 0.0 1798
WERAM-Chs-0103 ENSCSAP00000004990.1 Chlorocebus sabaeus 100 0.0 1798
WERAM-Paa-0045 ENSPANP00000011645.1 Papio anubis 100 0.0 1794
WERAM-Caj-0128 ENSCJAP00000023722.2 Callithrix jacchus 99 0.0 1781
WERAM-Caf-0215 ENSCAFP00000006456.3 Canis familiaris 98 0.0 1769
WERAM-Poa-0167 ENSPPYP00000020240.2 Pongo abelii 99 0.0 1768
WERAM-Otg-0179 ENSOGAP00000015340.2 Otolemur garnettii 97 0.0 1766
WERAM-Bot-0029 ENSBTAP00000003151.5 Bos taurus 97 0.0 1742
WERAM-Mum-0103 ENSMUSP00000031859.7 Mus musculus 93 0.0 1720
WERAM-Ict-0033 ENSSTOP00000002659.2 Ictidomys tridecemlineatus 97 0.0 1720
WERAM-Aim-0208 ENSAMEP00000019019.1 Ailuropoda melanoleuca 97 0.0 1718
WERAM-Loa-0103 ENSLAFP00000008690.3 Loxodonta africana 94 0.0 1711
WERAM-Mod-0121 ENSMODP00000017283.2 Monodelphis domestica 89 0.0 1644
WERAM-Mup-0040 ENSMPUP00000003902.1 Mustela putorius furo 98 0.0 1640
WERAM-Tas-0018 ENSTSYP00000002128.1 Tarsius syrichta 98 0.0 1638
WERAM-Dan-0052 ENSDNOP00000005072.3 Dasypus novemcinctus 98 0.0 1627
WERAM-Eqc-0180 ENSECAP00000019623.1 Equus caballus 98 0.0 1620
WERAM-Cap-0127 ENSCPOP00000010171.2 Cavia porcellus 96 0.0 1603
WERAM-Ova-0109 ENSOARP00000010918.1 Ovis aries 97 0.0 1602
WERAM-Myl-0124 ENSMLUP00000010110.2 Myotis lucifugus 95 0.0 1598
WERAM-Ptv-0126 ENSPVAP00000011069.1 Pteropus vampyrus 90 0.0 1594
WERAM-Orc-0070 ENSOCUP00000006290.2 Oryctolagus cuniculus 94 0.0 1590
WERAM-Vip-0082 ENSVPAP00000007497.1 Vicugna pacos 95 0.0 1570
WERAM-Fec-0047 ENSFCAP00000003774.3 Felis catus 94 0.0 1521
WERAM-Sah-0053 ENSSHAP00000006146.1 Sarcophilus harrisii 87 0.0 1430
WERAM-Tag-0149 ENSTGUP00000012648.1 Taeniopygia guttata 78 0.0 1409
WERAM-Soa-0121 ENSSARP00000011616.1 Sorex araneus 95 0.0 1397
WERAM-Pes-0149 ENSPSIP00000017710.1 Pelodiscus sinensis 82 0.0 1370
WERAM-Anp-0028 ENSAPLP00000003258.1 Anas platyrhynchos 81 0.0 1370
WERAM-Gaga-0120 ENSGALP00000020886.4 Gallus gallus 81 0.0 1348
WERAM-Meg-0128 ENSMGAP00000013880.2 Meleagris gallopavo 80 0.0 1345
WERAM-Fia-0053 ENSFALP00000003821.1 Ficedula albicollis 80 0.0 1316
WERAM-Dio-0037 ENSDORP00000004316.1 Dipodomys ordii 94 0.0 1219
WERAM-Tut-0142 ENSTTRP00000011720.1 Tursiops truncatus 93 0.0 1198
WERAM-Ora-0037 ENSOANP00000006008.1 Ornithorhynchus anatinus 81 0.0 1046
WERAM-Xet-0078 ENSXETP00000025313.3 Xenopus tropicalis 63 0.0 1005
WERAM-Prc-0095 ENSPCAP00000008532.1 Procavia capensis 88 0.0 974
WERAM-Mae-0096 ENSMEUP00000009328.1 Macropus eugenii 78 0.0 917
WERAM-Ect-0131 ENSETEP00000014815.1 Echinops telfairi 87 0.0 916
WERAM-Lac-0178 ENSLACP00000020861.1 Latimeria chalumnae 50 0.0 809
WERAM-Leo-0095 ENSLOCP00000012853.1 Lepisosteus oculatus 48 0.0 787
WERAM-Anc-0023 ENSACAP00000002604.2 Anolis carolinensis 51 0.0 786
WERAM-Ere-0103 ENSEEUP00000010800.1 Erinaceus europaeus 93 0.0 767
WERAM-Tub-0040 ENSTBEP00000005075.1 Tupaia belangeri 85 0.0 758
WERAM-Ocp-0054 ENSOPRP00000004711.1 Ochotona princeps 83 0.0 674
WERAM-Ran-0121 ENSRNOP00000025600.5 Rattus norvegicus 63 3e-157 553
WERAM-Sus-0123 ENSSSCP00000017502.3 Sus scrofa 95 1e-146 518
WERAM-Dar-0038 ENSDARP00000025140.8 Danio rerio 56 2e-140 498
WERAM-Chh-0017 ENSCHOP00000001525.1 Choloepus hoffmanni 64 3e-134 477
WERAM-Orn-0109 ENSONIP00000011616.1 Oreochromis niloticus 54 6e-134 476
WERAM-Gaa-0050 ENSGACP00000006576.1 Gasterosteus aculeatus 54 9e-131 465
WERAM-Tar-0093 ENSTRUP00000018722.1 Takifugu rubripes 54 5e-130 463
WERAM-Mim-0019 ENSMICP00000001662.1 Microcebus murinus 88 3e-129 460
WERAM-Xim-0152 ENSXMAP00000012685.1 Xiphophorus maculatus 53 4e-129 460
WERAM-Pof-0192 ENSPFOP00000016145.2 Poecilia formosa 53 4e-129 460
WERAM-Gam-0174 ENSGMOP00000017205.1 Gadus morhua 54 1e-128 458
WERAM-Orla-0005 ENSORLP00000000400.1 Oryzias latipes 53 1e-126 451
WERAM-Asm-0128 ENSAMXP00000012606.1 Astyanax mexicanus 60 4e-120 430
WERAM-Ten-0081 ENSTNIP00000009576.1 Tetraodon nigroviridis 45 7e-108 389
WERAM-Drm-0020 FBpp0083320 Drosophila melanogaster 29 4e-46 184
WERAM-Cii-0027 ENSCINP00000010542.3 Ciona intestinalis 30 1e-42 172
Created Date 25-Jun-2016