Tag |
Content |
WERAM ID |
WERAM-Mum-0103 |
Ensembl Protein ID |
ENSMUSP00000031859.7 |
Uniprot Accession |
Q64127; TIF1A_MOUSE; Q64126 |
Genbank Protein ID |
NP_001258993.1; NP_001259005.1; NP_659542.3 |
Protein Name |
Transcription intermediary factor 1-alpha |
Genbank Nucleotide ID |
NM_001272064.1; NM_001272076.1; NM_145076.4 |
Gene Name |
TRIM24;Tif1;Tif1a |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
Ac_Reader |
Bromodomain |
Bromodomain |
H3K23 |
K |
19909775 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
Ac_Reader |
Bromodomain |
2.00e-26 |
93.3 |
917 |
987 |
Me_Reader |
PHD |
8.90e-08 |
33.7 |
161 |
872 |
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Organism |
Mus musculus |
NCBI Taxa ID |
10090 |
Functional Description (View)Functional Description
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes. |
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes.
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Domain Profile |
Ac_Reader Bromodomain
BROMO.txt 1 kehevsepFrepvdpqleipdYydiikePmdLstikerleegn..YsspeefvkDvrlifnNakaynenkssv 71 ++he s +F+ pv + +pdYy+iik+PmdLstik+rl+e + Y++pe+fv+D+rlif+N+ ++ne++s+v ENSMUSP00000031859.7 917 YCHEMSLAFQDPVPL--TVPDYYKIIKNPMDLSTIKKRLQEDYcmYTKPEDFVADFRLIFQNCAEFNEPDSEV 987 8*************9..8***********************9899*************************997 PP
Me_Reader PHD
PHD.txt 2 tiClvCgkddegekemvqCdeCddwfHlkCvk 33 ++C C+++ e + + C eC +w +C+ ENSMUSP00000031859.7 161 QVCTSCEDNAEANGF---CVECVEWLCKTCIR 189 689999666666664...55555555556654 PP PHD.txt 12 egekemvqCdeCddwfHlkCvklpls 37 ++e+ ++C++Cd+ +C l+ + ENSMUSP00000031859.7 227 KKEQLKLYCETCDKLTCRDCQLLEHK 252 23333699999998887777766644 PP PHD.txt 2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 + C vC +++ + +++C++C++ fHl+C+ ++l++ p+g +w+C C+ ENSMUSP00000031859.7 828 DWCAVC-QNGGE---LLCCEKCPKVFHLTCHVPTLTNFPSG-EWICTFCR 872 57****.44443...9*************************.*******8 PP
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Protein Sequence (Fasta) | MEVAVEKAAA AAAPAGGPAA AAPSGENEAE SRQGPDSESG GEASRLNLLD TCAVCHQNIQ 60 SRVPKLLPCL HSFCQRCLPA PQRYLMLTAP ALGSAETPPP APAPAPAPGS PAGGPSPFAT 120 QVGVIRCPVC SQECAERHII DNFFVKDTTE VPSSTVEKSN QVCTSCEDNA EANGFCVECV 180 EWLCKTCIRA HQRVKFTKDH TVRQKEEVSP EAVGVTSQRP VFCPFHKKEQ LKLYCETCDK 240 LTCRDCQLLE HKEHRYQFIE EAFQNQKVII DTLITKLMEK TKYIKYTGNQ IQNRIIEINQ 300 NQKQVEQDIK VAIFTLMVEI NKKGKALLHQ LESLAKDHRM KLMQQQQEVA GLSKQLEHVM 360 HFSKWAVSSG SSTALLYSKR LITYRLRHLL RARCDASPVT NTTIQFHCDP SFWAQNIINL 420 GSLVIEDKES QPQMPKQNPV VEQSSQPPGG LPSNQLSKFP TQISLAQLRL QHIQQQVMAQ 480 RQQVQRRPAP VGLPNPRMQG PIQQPSISHQ HPPPRLINFQ NHSPKPNGPV LPPYPQQLRY 540 SPSQNVPRQT TIKPNPLQMA FLAQQAIKQW QISSVQAPPT TASSSSSTPS SPTITSAAGY 600 DGKAFSSPMI DLSAPVGGSY NLPSLPDIDC SSTIMLDNIA RKDTGVDHAQ PRPPSNRTVQ 660 SPNSSVPSPG LAGPVTMTSV HPPIRSPSAS SVGSRGSSGS SSKPAGADST HKVPVVMLEP 720 IRIKQENSGP PENYDFPVVI VKQESDEESR PQNTNYPRSI LTSLLLNSSQ SSASEETVLR 780 SDAPDSTGDQ PGLHQENSSN GKSEWSDASQ KSPVHVGETR KEDDPNEDWC AVCQNGGELL 840 CCEKCPKVFH LTCHVPTLTN FPSGEWICTF CRDLSKPEVD YDCDVPSHHS EKRKSEGLTK 900 LTPIDKRKCE RLLLFLYCHE MSLAFQDPVP LTVPDYYKII KNPMDLSTIK KRLQEDYCMY 960 TKPEDFVADF RLIFQNCAEF NEPDSEVANA GIKLESYFEE LLKNLYPEKR FPKVEFRHEA 1020 EDCKFSDDSD DDFVQPRKKR LKSTEDRQLL K 1051Protein Fasta Sequence
>ENSMUSP00000031859.7|TRIM24;Tif1;Tif1a|Mus musculus MEVAVEKAAAAAAPAGGPAAAAPSGENEAESRQGPDSESGGEASRLNLLDTCAVCHQNIQSRVPKLLPCLHSFCQRCLPAPQRYLMLTAPALGSAETPPPAPAPAPAPGSPAGGPSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKYTGNQIQNRIIEINQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNTTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQSSQPPGGLPSNQLSKFPTQISLAQLRLQHIQQQVMAQRQQVQRRPAPVGLPNPRMQGPIQQPSISHQHPPPRLINFQNHSPKPNGPVLPPYPQQLRYSPSQNVPRQTTIKPNPLQMAFLAQQAIKQWQISSVQAPPTTASSSSSTPSSPTITSAAGYDGKAFSSPMIDLSAPVGGSYNLPSLPDIDCSSTIMLDNIARKDTGVDHAQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNTNYPRSILTSLLLNSSQSSASEETVLRSDAPDSTGDQPGLHQENSSNGKSEWSDASQKSPVHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLTCHVPTLTNFPSGEWICTFCRDLSKPEVDYDCDVPSHHSEKRKSEGLTKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYCMYTKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLESYFEELLKNLYPEKRFPKVEFRHEAEDCKFSDDSDDDFVQPRKKRLKSTEDRQLLK
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Nucleotide Sequence (Fasta) | GGTGGTCCAA GGGGCCCGAG AGAAAGGCTG CTAGGCACGG GCGGGCGCGC TGGGCGGAAT 60 CGAGCGTCTC GGTGGCGGTT TGCCTATCGG CCCGCGCGGC GGCGTCGCGG TGCGGGAACC 120 GGTCCCCGTT GACAGCTCCG CGTCTTCCGG CCGCGCCACT CGGGAGGTGG CTTCCTCCCT 180 GTGCTCCCTC CGCGAGTCCG TTCGGCCTCG GAGAAGCGGG AGGCGGCGGC GGCTGCGGAG 240 GTCGTCGGGG GCGGCGGGCG GTGAGCGCGC TCCCGCTTCC CCGGCGGCGG CCGCAGGACA 300 ATGGAGGTGG CTGTGGAGAA GGCGGCGGCG GCAGCGGCTC CGGCCGGAGG CCCCGCAGCG 360 GCGGCGCCGA GCGGGGAGAA TGAGGCCGAG AGCCGGCAGG GCCCGGACTC GGAGAGCGGC 420 GGCGAGGCGT CCCGGCTCAA CCTGTTGGAC ACTTGCGCCG TGTGCCACCA GAACATCCAG 480 AGCCGGGTGC CCAAGCTGCT GCCCTGCCTG CACTCGTTCT GCCAGCGCTG TTTGCCCGCG 540 CCGCAGCGCT ATCTCATGCT GACGGCGCCC GCGCTGGGCT CGGCAGAGAC CCCTCCACCC 600 GCTCCCGCCC CCGCCCCCGC CCCGGGCTCC CCGGCCGGTG GTCCTTCGCC ATTCGCCACC 660 CAAGTTGGAG TCATTCGATG CCCAGTTTGC AGTCAAGAGT GTGCTGAGAG ACACATCATA 720 GACAACTTTT TTGTGAAGGA CACCACTGAA GTTCCTAGTA GTACAGTAGA AAAGTCTAAT 780 CAGGTATGTA CAAGCTGTGA AGACAATGCA GAAGCTAATG GGTTTTGTGT AGAGTGTGTT 840 GAATGGCTCT GCAAGACATG TATTAGAGCT CACCAGAGGG TGAAGTTCAC AAAAGACCAC 900 ACAGTCAGGC AGAAAGAAGA AGTATCTCCA GAGGCAGTTG GGGTGACCAG TCAGCGACCA 960 GTGTTTTGTC CCTTCCATAA AAAGGAGCAG TTGAAACTTT ACTGTGAAAC ATGTGATAAA 1020 CTGACCTGTC GAGACTGCCA GCTGCTAGAA CACAAAGAAC ACAGGTATCA ATTTATAGAA 1080 GAAGCTTTTC AGAATCAAAA AGTGATCATA GATACTCTAA TCACCAAACT GATGGAAAAA 1140 ACAAAATATA TAAAGTATAC AGGAAATCAG ATCCAAAATA GGATAATTGA AATAAATCAA 1200 AACCAAAAGC AGGTGGAACA GGATATTAAA GTTGCCATCT TCACATTGAT GGTGGAGATA 1260 AACAAAAAAG GGAAAGCTCT GCTGCACCAG CTTGAGAGTC TTGCAAAGGA CCATCGAATG 1320 AAACTCATGC AACAACAGCA GGAAGTGGCT GGGCTTTCTA AGCAGTTAGA GCACGTCATG 1380 CATTTTTCTA AATGGGCTGT TTCCAGTGGC AGCAGCACAG CCTTGCTGTA CAGCAAGCGG 1440 CTGATTACAT ACAGGTTACG GCACCTTCTT CGTGCAAGGT GTGATGCTTC TCCTGTGACC 1500 AACACCACCA TCCAGTTTCA CTGTGATCCT AGTTTCTGGG CTCAAAATAT TATCAACTTG 1560 GGTTCTTTAG TAATCGAGGA TAAAGAGAGC CAGCCACAAA TGCCTAAGCA GAATCCTGTC 1620 GTGGAGCAGA GTTCACAGCC ACCAGGTGGT TTACCTTCCA ACCAGTTATC CAAGTTCCCA 1680 ACACAGATCA GCCTAGCTCA GTTACGACTC CAGCATATTC AGCAACAGGT AATGGCTCAG 1740 AGGCAACAGG TGCAACGGAG GCCAGCACCT GTGGGTTTAC CAAACCCTAG AATGCAGGGG 1800 CCCATCCAGC AGCCTTCCAT CTCTCATCAG CATCCGCCAC CACGCTTAAT AAACTTTCAG 1860 AATCACAGCC CTAAGCCCAA TGGACCAGTT CTTCCTCCTT ATCCTCAGCA GCTGAGATAT 1920 TCACCAAGCC AGAATGTACC TCGGCAGACA ACAATAAAGC CCAACCCCTT GCAAATGGCT 1980 TTTTTGGCTC AACAGGCCAT AAAACAGTGG CAGATCAGCA GTGTACAGGC TCCGCCCACA 2040 ACTGCCAGCA GCTCCTCCTC CACGCCGTCC AGCCCCACAA TCACAAGTGC AGCTGGGTAC 2100 GATGGAAAAG CTTTTAGTTC ACCCATGATT GATCTGAGTG CACCGGTGGG AGGGTCTTAC 2160 AATCTTCCTT CTCTTCCAGA TATTGATTGT TCAAGTACTA TAATGTTGGA CAACATTGCA 2220 AGGAAAGACA CAGGTGTAGA TCACGCCCAG CCGAGGCCTC CGTCAAACAG AACGGTGCAG 2280 TCACCAAATT CATCAGTGCC ATCTCCAGGC CTTGCAGGGC CTGTTACTAT GACTAGCGTC 2340 CATCCCCCAA TACGTTCACC TAGTGCCTCC AGTGTTGGAA GTCGAGGAAG CTCTGGCTCT 2400 TCCAGCAAAC CAGCAGGAGC TGATTCTACT CACAAGGTCC CAGTAGTCAT GCTGGAGCCA 2460 ATTCGAATAA AACAGGAAAA CAGTGGACCA CCTGAAAATT ATGATTTTCC TGTTGTTATA 2520 GTAAAACAAG AATCAGATGA AGAATCTAGA CCTCAAAATA CTAACTATCC AAGAAGCATA 2580 CTTACCTCCC TCCTCTTAAA CAGCAGTCAG AGCTCTGCTT CTGAGGAAAC CGTGTTACGA 2640 TCTGATGCCC CTGATAGTAC AGGAGATCAG CCTGGACTCC ATCAAGAAAA TTCCTCAAAT 2700 GGAAAGTCTG AGTGGTCGGA TGCCTCCCAG AAGTCCCCTG TGCATGTCGG AGAGACGAGG 2760 AAGGAGGATG ACCCCAATGA AGACTGGTGT GCTGTTTGTC AAAATGGTGG GGAACTCCTA 2820 TGCTGTGAGA AATGTCCTAA AGTATTCCAT CTTACTTGTC ATGTGCCCAC CTTGACAAAT 2880 TTTCCAAGTG GAGAATGGAT CTGTACTTTC TGCCGAGACT TATCTAAGCC AGAGGTTGAC 2940 TATGATTGTG ATGTTCCCAG TCACCACTCA GAGAAACGGA AAAGTGAAGG CCTTACTAAG 3000 TTAACGCCAA TAGACAAAAG GAAATGTGAA CGCCTACTTC TGTTTCTTTA CTGCCATGAA 3060 ATGAGCCTGG CTTTCCAAGA CCCTGTTCCT CTAACTGTGC CTGATTATTA TAAAATAATT 3120 AAAAACCCAA TGGACTTGTC AACCATCAAG AAAAGACTTC AGGAGGATTA TTGCATGTAT 3180 ACAAAGCCTG AAGACTTTGT AGCTGATTTT AGATTGATCT TTCAAAACTG TGCTGAATTC 3240 AATGAGCCTG ATTCTGAAGT AGCCAATGCT GGTATAAAAC TTGAAAGCTA TTTTGAAGAA 3300 CTTCTAAAGA ATCTTTATCC AGAAAAAAGG TTTCCTAAGG TAGAATTCAG GCATGAAGCA 3360 GAAGACTGTA AGTTCAGTGA CGACTCAGAC GATGACTTTG TACAGCCCCG GAAGAAGCGT 3420 CTCAAGAGCA CCGAGGATCG CCAGCTGCTT AAGTAACGCC GCACTGGGCC AGCGCGCTGT 3480 GCTAGAGATT TCTCATCAAA ACTAAAGACA GCAAAAGGCT TGTCAGTGAT CTAAGGGTTT 3540 GTGAGCTCTC TGCTCTGTTT TTGCTGTTTA CTGGACTTTG GTTTCTTTCA TAACCCATTT 3600 CTTTAACCTC TTGTCAATGA AAATAAAAAG AAGAGGAAGG AAGGAAATGT GTACAAGAAT 3660 AAAAGAAGGA AGAGAAGGTA GAAAAAGAAG AAAGAGCAAA GAAGGAAAAG ACATTCTTCC 3720 CCTTGTTGGA TTTCATACAG GAGCCTGGAG TGAGTGCTAC ACTAAGAAAG AAATAGAGTT 3780 TGACATAAGT TGAGATTTTA GTGTGATCTG GATGTGTGAT AATCCATTTT TAGAATATTA 3840 ATTTCATTAC CCATTAATTA TGGCCAACTG TAAGGAGATA GTCCTGTTAC TATTCTTAAA 3900 TGAAGTCCTC CCCAAACGTG AATGGAAGCA GAGTTCTTTG CCAGGCTGCC TGCCGGAAAA 3960 GGTGTAGACA GATGCTACTA AGACACCAAA TAGTGTCCAT GTAAGATGGC AACTGCATTA 4020 AAAAAAAATC AGGAAAAACA AA
4043Nucleotide Fasta Sequence
>ENSMUSP00000031859.7|PHD|Mus musculus GGTGGTCCAAGGGGCCCGAGAGAAAGGCTGCTAGGCACGGGCGGGCGCGCTGGGCGGAATCGAGCGTCTCGGTGGCGGTTTGCCTATCGGCCCGCGCGGCGGCGTCGCGGTGCGGGAACCGGTCCCCGTTGACAGCTCCGCGTCTTCCGGCCGCGCCACTCGGGAGGTGGCTTCCTCCCTGTGCTCCCTCCGCGAGTCCGTTCGGCCTCGGAGAAGCGGGAGGCGGCGGCGGCTGCGGAGGTCGTCGGGGGCGGCGGGCGGTGAGCGCGCTCCCGCTTCCCCGGCGGCGGCCGCAGGACAATGGAGGTGGCTGTGGAGAAGGCGGCGGCGGCAGCGGCTCCGGCCGGAGGCCCCGCAGCGGCGGCGCCGAGCGGGGAGAATGAGGCCGAGAGCCGGCAGGGCCCGGACTCGGAGAGCGGCGGCGAGGCGTCCCGGCTCAACCTGTTGGACACTTGCGCCGTGTGCCACCAGAACATCCAGAGCCGGGTGCCCAAGCTGCTGCCCTGCCTGCACTCGTTCTGCCAGCGCTGTTTGCCCGCGCCGCAGCGCTATCTCATGCTGACGGCGCCCGCGCTGGGCTCGGCAGAGACCCCTCCACCCGCTCCCGCCCCCGCCCCCGCCCCGGGCTCCCCGGCCGGTGGTCCTTCGCCATTCGCCACCCAAGTTGGAGTCATTCGATGCCCAGTTTGCAGTCAAGAGTGTGCTGAGAGACACATCATAGACAACTTTTTTGTGAAGGACACCACTGAAGTTCCTAGTAGTACAGTAGAAAAGTCTAATCAGGTATGTACAAGCTGTGAAGACAATGCAGAAGCTAATGGGTTTTGTGTAGAGTGTGTTGAATGGCTCTGCAAGACATGTATTAGAGCTCACCAGAGGGTGAAGTTCACAAAAGACCACACAGTCAGGCAGAAAGAAGAAGTATCTCCAGAGGCAGTTGGGGTGACCAGTCAGCGACCAGTGTTTTGTCCCTTCCATAAAAAGGAGCAGTTGAAACTTTACTGTGAAACATGTGATAAACTGACCTGTCGAGACTGCCAGCTGCTAGAACACAAAGAACACAGGTATCAATTTATAGAAGAAGCTTTTCAGAATCAAAAAGTGATCATAGATACTCTAATCACCAAACTGATGGAAAAAACAAAATATATAAAGTATACAGGAAATCAGATCCAAAATAGGATAATTGAAATAAATCAAAACCAAAAGCAGGTGGAACAGGATATTAAAGTTGCCATCTTCACATTGATGGTGGAGATAAACAAAAAAGGGAAAGCTCTGCTGCACCAGCTTGAGAGTCTTGCAAAGGACCATCGAATGAAACTCATGCAACAACAGCAGGAAGTGGCTGGGCTTTCTAAGCAGTTAGAGCACGTCATGCATTTTTCTAAATGGGCTGTTTCCAGTGGCAGCAGCACAGCCTTGCTGTACAGCAAGCGGCTGATTACATACAGGTTACGGCACCTTCTTCGTGCAAGGTGTGATGCTTCTCCTGTGACCAACACCACCATCCAGTTTCACTGTGATCCTAGTTTCTGGGCTCAAAATATTATCAACTTGGGTTCTTTAGTAATCGAGGATAAAGAGAGCCAGCCACAAATGCCTAAGCAGAATCCTGTCGTGGAGCAGAGTTCACAGCCACCAGGTGGTTTACCTTCCAACCAGTTATCCAAGTTCCCAACACAGATCAGCCTAGCTCAGTTACGACTCCAGCATATTCAGCAACAGGTAATGGCTCAGAGGCAACAGGTGCAACGGAGGCCAGCACCTGTGGGTTTACCAAACCCTAGAATGCAGGGGCCCATCCAGCAGCCTTCCATCTCTCATCAGCATCCGCCACCACGCTTAATAAACTTTCAGAATCACAGCCCTAAGCCCAATGGACCAGTTCTTCCTCCTTATCCTCAGCAGCTGAGATATTCACCAAGCCAGAATGTACCTCGGCAGACAACAATAAAGCCCAACCCCTTGCAAATGGCTTTTTTGGCTCAACAGGCCATAAAACAGTGGCAGATCAGCAGTGTACAGGCTCCGCCCACAACTGCCAGCAGCTCCTCCTCCACGCCGTCCAGCCCCACAATCACAAGTGCAGCTGGGTACGATGGAAAAGCTTTTAGTTCACCCATGATTGATCTGAGTGCACCGGTGGGAGGGTCTTACAATCTTCCTTCTCTTCCAGATATTGATTGTTCAAGTACTATAATGTTGGACAACATTGCAAGGAAAGACACAGGTGTAGATCACGCCCAGCCGAGGCCTCCGTCAAACAGAACGGTGCAGTCACCAAATTCATCAGTGCCATCTCCAGGCCTTGCAGGGCCTGTTACTATGACTAGCGTCCATCCCCCAATACGTTCACCTAGTGCCTCCAGTGTTGGAAGTCGAGGAAGCTCTGGCTCTTCCAGCAAACCAGCAGGAGCTGATTCTACTCACAAGGTCCCAGTAGTCATGCTGGAGCCAATTCGAATAAAACAGGAAAACAGTGGACCACCTGAAAATTATGATTTTCCTGTTGTTATAGTAAAACAAGAATCAGATGAAGAATCTAGACCTCAAAATACTAACTATCCAAGAAGCATACTTACCTCCCTCCTCTTAAACAGCAGTCAGAGCTCTGCTTCTGAGGAAACCGTGTTACGATCTGATGCCCCTGATAGTACAGGAGATCAGCCTGGACTCCATCAAGAAAATTCCTCAAATGGAAAGTCTGAGTGGTCGGATGCCTCCCAGAAGTCCCCTGTGCATGTCGGAGAGACGAGGAAGGAGGATGACCCCAATGAAGACTGGTGTGCTGTTTGTCAAAATGGTGGGGAACTCCTATGCTGTGAGAAATGTCCTAAAGTATTCCATCTTACTTGTCATGTGCCCACCTTGACAAATTTTCCAAGTGGAGAATGGATCTGTACTTTCTGCCGAGACTTATCTAAGCCAGAGGTTGACTATGATTGTGATGTTCCCAGTCACCACTCAGAGAAACGGAAAAGTGAAGGCCTTACTAAGTTAACGCCAATAGACAAAAGGAAATGTGAACGCCTACTTCTGTTTCTTTACTGCCATGAAATGAGCCTGGCTTTCCAAGACCCTGTTCCTCTAACTGTGCCTGATTATTATAAAATAATTAAAAACCCAATGGACTTGTCAACCATCAAGAAAAGACTTCAGGAGGATTATTGCATGTATACAAAGCCTGAAGACTTTGTAGCTGATTTTAGATTGATCTTTCAAAACTGTGCTGAATTCAATGAGCCTGATTCTGAAGTAGCCAATGCTGGTATAAAACTTGAAAGCTATTTTGAAGAACTTCTAAAGAATCTTTATCCAGAAAAAAGGTTTCCTAAGGTAGAATTCAGGCATGAAGCAGAAGACTGTAAGTTCAGTGACGACTCAGACGATGACTTTGTACAGCCCCGGAAGAAGCGTCTCAAGAGCACCGAGGATCGCCAGCTGCTTAAGTAACGCCGCACTGGGCCAGCGCGCTGTGCTAGAGATTTCTCATCAAAACTAAAGACAGCAAAAGGCTTGTCAGTGATCTAAGGGTTTGTGAGCTCTCTGCTCTGTTTTTGCTGTTTACTGGACTTTGGTTTCTTTCATAACCCATTTCTTTAACCTCTTGTCAATGAAAATAAAAAGAAGAGGAAGGAAGGAAATGTGTACAAGAATAAAAGAAGGAAGAGAAGGTAGAAAAAGAAGAAAGAGCAAAGAAGGAAAAGACATTCTTCCCCTTGTTGGATTTCATACAGGAGCCTGGAGTGAGTGCTACACTAAGAAAGAAATAGAGTTTGACATAAGTTGAGATTTTAGTGTGATCTGGATGTGTGATAATCCATTTTTAGAATATTAATTTCATTACCCATTAATTATGGCCAACTGTAAGGAGATAGTCCTGTTACTATTCTTAAATGAAGTCCTCCCCAAACGTGAATGGAAGCAGAGTTCTTTGCCAGGCTGCCTGCCGGAAAAGGTGTAGACAGATGCTACTAAGACACCAAATAGTGTCCATGTAAGATGGCAACTGCATTAAAAAAAAATCAGGAAAAACAAA
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Sequence Source |
Ensembl |
Keyword |
KW-0025--Alternative splicing KW-0103--Bromodomain KW-0160--Chromosomal rearrangement KW-0175--Coiled coil KW-0181--Complete proteome KW-0963--Cytoplasm KW-0238--DNA-binding KW-1017--Isopeptide bond KW-0436--Ligase KW-0479--Metal-binding KW-0539--Nucleus KW-0597--Phosphoprotein KW-0656--Proto-oncogene KW-1185--Reference proteome KW-0677--Repeat KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation KW-0043--Tumor suppressor KW-0832--Ubl conjugation KW-0833--Ubl conjugation pathway KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR003649--Bbox_C IPR001487--Bromodomain IPR018359--Bromodomain_CS IPR019786--Zinc_finger_PHD-type_CS IPR000315--Znf_B-box IPR011011--Znf_FYVE_PHD IPR001965--Znf_PHD IPR019787--Znf_PHD-finger IPR001841--Znf_RING IPR013083--Znf_RING/FYVE/PHD IPR017907--Znf_RING_CS
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PROSITE |
PS00633--BROMODOMAIN_1 PS50014--BROMODOMAIN_2 PS50119--ZF_BBOX PS01359--ZF_PHD_1 PS50016--ZF_PHD_2 PS00518--ZF_RING_1 PS50089--ZF_RING_2
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Pfam |
PF00439--Bromodomain PF00628--PHD PF00643--zf-B_box
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0005719--C:nuclear euchromatin GO:0005634--C:nucleus GO:0005726--C:perichromatin fibrils GO:0003682--F:chromatin binding GO:0034056--F:estrogen response element binding GO:0016922--F:ligand-dependent nuclear receptor binding GO:0016874--F:ligase activity GO:0070577--F:lysine-acetylated histone binding GO:0002039--F:p53 binding GO:0004672--F:protein kinase activity GO:0043565--F:sequence-specific DNA binding GO:0003713--F:transcription coactivator activity GO:0061630--F:ubiquitin protein ligase activity GO:0004842--F:ubiquitin-protein transferase activity GO:0008270--F:zinc ion binding GO:0055074--P:calcium ion homeostasis GO:0071391--P:cellular response to estrogen stimulus GO:0008285--P:negative regulation of cell proliferation GO:0045892--P:negative regulation of transcription, DNA-templated GO:0010628--P:positive regulation of gene expression GO:0045893--P:positive regulation of transcription, DNA-templated GO:0046777--P:protein autophosphorylation GO:0030163--P:protein catabolic process GO:0006468--P:protein phosphorylation GO:0016567--P:protein ubiquitination GO:0042981--P:regulation of apoptotic process GO:0031647--P:regulation of protein stability GO:1901796--P:regulation of signal transduction by p53 class mediator GO:0070562--P:regulation of vitamin D receptor signaling pathway GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |